Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice

Biochimie

Volumn 92, Issue 11, 2010, Pages 1674-1680

  Sevenich, Lisa ^a   Hagemann, Sascha ^a,b   Stoeckle, Christina ^c   Tolosa, Eva ^c,d   Peters, Christoph ^a   Reinheckel, Thomas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF TÜBINGEN   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Antigen presentation; Endosome; Invariant chain; Lysosome; Proteolysis

Indexed keywords

CATHEPSIN L; CATHEPSIN V; CYTOKERATIN 14;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; EPITHELIUM; HELPER CELL; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; THYMUS; TISSUE SPECIFICITY; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

EID: 78149359763     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2010.03.014     Document Type: Article

References (22)

1. Rawlings N.D., Morton F.R., Kok C.Y., Kong J., Barrett A.J. MEROPS: the peptidase database. Nucleic Acids Res. 2008, 36:D320-D325.
2. Puente X.S., Sanchez L.M., Overall C.M., Lopez-Otin C. Human and mouse proteases: a comparative genomic approach. Nat. Rev. Genet. 2003, 4:544-558.
3. Deussing J., Kouadio M., Rehman S., et al. Identification and characterization of a dense cluster of placenta-specific cysteine peptidase genes and related genes on mouse chromosome 13. Genomics 2002, 79:225-240.
4. Mason R.W. Emerging functions of placental cathepsins. Placenta 2008, 29:385-390.
5. Brömme D. Cathepsin V. Handbook of Proteolytic Enzymes 2004, 1107-1110. Elsevier, London. A.J. Barrett, N.D. Rawlings, J.F. Woessner (Eds.).
6. Yasuda Y., Li Z., Greenbaum D., et al. Cathepsin V, a novel and potent elastolytic activity expressed in activated macrophages. J. Biol. Chem. 2004, 279:36761-36770.
7. Tolosa E., Li W., Yasuda Y., et al. Cathepsin V is involved in the degradation of invariant chain in human thymus and is overexpressed in myasthenia gravis. J. Clin. Invest. 2003, 112:517-526.
8. Cheng T., Hitomi K., van Vlijmen-Willems I.M., et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J. Biol. Chem. 2006, 281:15893-15899.
9. Bernard D., Mehul B., Thomas-Collignon A., et al. Analysis of proteins with caseinolytic activity in a human stratum corneum extract revealed a yet unidentified cysteine protease and identified the so-called "stratum corneum thiol protease" as cathepsin l2. J. Invest. Dermatol. 2003, 120:592-600.
10. Nakagawa T., Roth W., Wong P., et al. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science 1998, 280:450-453.
11. Denzin L.K., Cresswell P. HLA-DM induces CLIP dissociation from MHC class II alpha beta dimers and facilitates peptide loading. Cell 1995, 82:155-165.
12. Villadangos J.A., Bryant R.A., Deussing J., et al. Proteases involved in MHC class II antigen presentation. Immunol. Rev. 1999, 172:109-120.
13. Hsieh C.S., deRoos P., Honey K., Beers C., Rudensky A.Y. A role for cathepsin L and cathepsin S in peptide generation for MHC class II presentation. J. Immunol. 2002, 168:2618-2625.
14. Honey K., Nakagawa T., Peters C., Rudensky A. Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligands. J. Exp. Med. 2002, 195:1349-1358.
15. Maehr R., Mintern J.D., Herman A.E., et al. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. J. Clin. Invest. 2005, 115:2934-2943.
16. Houseweart M.K., Pennacchio L.A., Vilaythong A., et al. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J. Neurobiol. 2003, 56:315-327.
17. Hagemann S., Günther T., Dennemärker J., et al. The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. Eur. J. Cell Biol. 2004, 83:775-780.
18. Roth W., Deussing J., Botchkarev V.A., et al. Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling. FASEB J. 2000, 14:2075-2086.
19. Sevenich L., Pennacchio L.A., Peters C., Reinheckel T. Human cathepsin L rescues the neurodegeneration and lethality in cathepsin B/L double-deficient mice. Biol. Chem. 2006, 387:885-891.
20. Sakaguchi S., Ono M., Setoguchi R., et al. Foxp3+ CD25+ CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 2006, 212:8-27.
21. Hsing L.C., Kirk E.A., McMillen T.S., et al. Roles for cathepsins S, L, and B in insulitis and diabetes in the NOD mouse. J. Autoimmun. 2009, 96-104.
22. Bethel P.A., Gerhardt S., Jones E.V., et al. Design of selective Cathepsin inhibitors. Bioorg. Med. Chem. Lett. 2009, 19:4622-4625.