Phosphorylation and functional desensitization of the α(2A)-adrenergic receptor by protein kinase C

Molecular Pharmacology

Volumn 54, Issue 1, 1998, Pages 44-49

  Liang, Mei ^a   Eason, Margaret G ^a   Jewell Motz, Elizabeth A ^a   Williams, Mark A ^a   Theiss, Cheryl T ^a   Dorn II, Gerald W ^a   Liggett, Stephen B ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; BISINDOLYLMALEIMIDE; BRIMONIDINE; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PHOSPHOTRANSFERASE; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; CERCOPITHECIDAE; CHO CELL; CONTROLLED STUDY; DESENSITIZATION; ENZYME ACTIVITY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL;

EID: 0031817517     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.54.1.44     Document Type: Article

References (27)

1. 2-Adrenergic Receptors. Structure, Function and Therapeutic Implications (Lanier SM and Limbird LE, eds) pp. 85-94, Harwood Academic Publishers, Reading, UK
2. 2-adrenergic receptor by the β-adrenergic kinase. J Biol Chem 262:17251-17253.
3. s. FEBS Lett 279:243-248.
4. 2-adrenergic receptors in NG 108 15 cells by (-)adrenaline and phorbol 12-myristate 13-acetate. Biochem J 262:245-251.
5. D'Angelo DD, Sakata Y, Lorenz JN, Boivin GP, Walsh RA, Liggett SB, and Dorn GW II (1997) Transgenic Gαq overexpression induces cardiac contractile failure in mice. Proc Natl Acad Sci USA 94:8121-8126.
6. Deblasi A, Parruti G. and Sallese M (1995) Regulation of G protein-coupled receptor kinase subtypes in activated T lymphocytes. Selective increase of beta-adrenergic receptor kinase 1 and 2. J Clin Invest 95:203-210.
7. i-associated G(βγ)-mediated activation of phospholipase C. Biochemistry 36:6415-6423.
8. 2C2. J Biol Chem 267:25473-25479.
9. 2A-adrenergic receptor. J Biol Chem 271:12826-12832.
10. 2A-adrenergic receptor. J Biol Chem 270:4681-4688.
11. Freund WR, Krasel C, Hoppe E, and Lohse MJ (1996) Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C. Proc Natl Acad Sci USA 93:2105-2109.
12. 2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization. J Biol Chem 264:12657-12665.
13. Hug H and Sarre TF (1993) Protein kinase C isoenzymes: divergence in signal transduction? Biochem J 291:329-343.
14. 2-adrenergic receptor subtypes. J Biol Chem 271:18082-18087.
15. Katada T, Gilman AG, Watanabe Y, Bauer S, and Jakobs KH (1985) Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem 151:431-437.
16. 2-adrenergic receptor subtype-specific antibodies. Mol Pharmacol 43:444-450.
17. 2-adrenergic receptor subtypes. J Biol Chem 269:10093-10099.
18. Leeb-Lundberg LM, Cotecchia S, Deblasi A, Caron MG, and Lefkowitz RJ (1987) Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells. J Biol Chem 262:3098-3105.
19. Lembo PM and Albert PR (1995) Multiple phosphorylation sites are required for pathway-selective uncoupling of the 5-hydroxytryptamine 1A receptor by protein kinase C. Mol Pharmacol 48:1024-1029.
20. 2-Adrenergic Receptors: Structure, Function and Therapeutic Implications (Lanier S and Limbird L, eds) pp. 113-121, Harwood Academic Publishers, Reading, UK.
21. Liggett SB (1997) Molecular basis of G-protein coupled receptor signalling, in The Lung: Scientific Foundations (Crystal R, West JB, Weibel ER, and Barnes PJ, eds) pp. 19-36, Raven Press, New York.
22. Liggett SB and Lefkowitz RJ (1993) Adrenergic receptor-coupled adenylyl cyclase systems: regulation of receptor function by phosphorylation, sequestration and downregulation, in Regulation of Cellular Signal Transduction Pathways by Desensitization and Amplification (Sibley D and Houslay M, eds) pp. 71-97, John Wiley and Sons, London.
23. 2A-adrenergic receptor confer short term agonist-promoted desensitization: evidence for a receptor kinase-mediated mechanism. J Biol Chem 267:4740-4746.
24. Limbird LE (1988) Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. FASEB J 2:2686-2695.
25. 1A receptor. J Biol Chem 266:14747-14753.
26. Ryu SH, Kim UH, Wahl MI, Brown AB, Carpenter G, Huang KP, and Rhee SG (1990) Feedback regulation of phospholipase C-beta by protein kinase C. J Biol Chem 265:17941-17945.
27. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, and Klenk DC (1985) Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85.