A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: A staged high-throughput biophysical screening

Respiratory Research

Volumn 12, Issue , 2011, Pages

  An, Steven S ^a   Askovich, Peter S ^b   Zarembinski, Thomas I ^b   Ahn, Kwangmi ^c   Peltier, John M ^b   von Rechenberg, Moritz ^b   Sahasrabudhe, Sudhir ^b   Fredberg, Jeffrey J ^d  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b Prolexys Pharmaceuticals Inc   (United States)

^c PENN STATE COLLEGE OF MEDICINE   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

14 3 3 GAMMA PROTEIN; COFILIN; CYCLODEXTRIN; HEAT SHOCK PROTEIN 20; ISOPRENALINE; MOLECULAR SCAFFOLD; PRLX 24905; PROTEIN; UNCLASSIFIED DRUG; BRONCHODILATING AGENT; PROTEIN 14 3 3;

AIRWAY OBSTRUCTION; ANIMAL CELL; ARTICLE; ASTHMA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TARGETING; EX VIVO STUDY; FLUORESCENCE POLARIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; IN VITRO STUDY; MALE; MOLECULARLY TARGETED THERAPY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; RAT; SMOOTH MUSCLE; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECT; FISCHER 344 RAT; FOURIER ANALYSIS; HIGH THROUGHPUT SCREENING; LUNG; MAGNETISM; METABOLISM; METHODOLOGY; MOLECULAR LIBRARY; MUSCLE RELAXATION; PHOSPHORYLATION; REPRODUCIBILITY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; TIME;

14-3-3 PROTEINS; ANIMALS; BRONCHODILATOR AGENTS; CATTLE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; FLUORESCENCE POLARIZATION; FOURIER ANALYSIS; HIGH-THROUGHPUT SCREENING ASSAYS; HSP20 HEAT-SHOCK PROTEINS; HUMANS; LUNG; LUNG DISEASES, OBSTRUCTIVE; MAGNETICS; MALE; MOLECULAR STRUCTURE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PHOSPHORYLATION; RATS; RATS, INBRED F344; REPRODUCIBILITY OF RESULTS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TIME FACTORS;

EID: 78651310497     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-12-8     Document Type: Article

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