T-2 toxin-induced apoptosis and c-fos mRNA expression in Con A-stimulated mouse thymocyte primary cultures

Journal of Toxicologic Pathology

Volumn 14, Issue 3, 2001, Pages 247-251

  Shinozuka, Junko ^a   Suzuki, Hodaka ^a   Tsutsui, Shigeki ^a   Nakayama, Hiroyuki ^a   Doi, Kunio ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; c fos; Calcium iron; PKC; Primary thymocyte culture; T 2 toxin

Indexed keywords

EID: 4444275468     PISSN: 09149198     EISSN: 09149198     Source Type: Journal    
DOI: 10.1293/tox.14.247     Document Type: Article

References (22)

1. Nelson PE, Dignani MC, and Anaissie EJ. Taxonomy, biology, and clinical aspects of Fusarium species. Clin Microbiol Rev 1994; 7: 479-504.
2. Stanford GK, Hood RD, and Hayes AW. Effect of prenatal administration of T-2 toxin to mice. Res Commun Chem Pathol Pharmacol 1975; 10: 743-746.
3. Williams PP. Effects of T-2 mycotoxin on gastrointestinal tissues: a review of in vivo and in vitro models. Arch Environ Toxicol 1989; 18: 374-387.
4. IARC. Evaluation of the Carcinogenic Risk of Chemicals. In: IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans. Lyon, France, 467-488, 1993.
5. Sharman RP. Immunotoxicity of mycotoxins. J Dairy Sei 1993; 76: 892-897.
6. Shinozuka J, Uetsuka K, Nakayama H, and Doi K. T-2 toxin-induced apoptosis in lymphoid organs of mice. Exp Toxicol Pathol 1997; 49: 387-389.
7. Shinozuka J, Li GM, Uetsuka K, Nakayama H, and Doi K. Process of the development of T-2 toxin-induced apoptosis in lymphoid organs of mice. Exp Anim 1997; 46: 11 1117-1126.
8. Li GM, Shinozuka J, Uetsuka K, Nakayama H, and Doi K. T-2 toxin-induced apoptosis in Peyer's patches of mice. J Toxicol Pathol 1997; 10: 59-61.
9. Shinozuka J, Suzuki M, Noguchi N, Sugimoto T, Uetsuka K, Nakayama H, and Doi K. T-2 toxin-induced apoptosis in hematopoietic tissues of mice. Toxicol Pathol 1998; 26: 674-681.
10. Li GM, Shinozuka J, Uetsuka K, Nakayama H, and Doi K. T-2 toxin-induced apoptosis in intestinal crypt epithelial cells in mice. Exp Toxicol Pathol 1997; 49: 447-450.
11. Shinozuka J, Tsutsui S, Ishigami N, Ueno-Yamanouchi A, Nakayama H, and Doi K. Development of apoptosis and changes in apoptosis-related genes expression in the mouse thymus following T-2 toxin-inoculation. J Toxicol Pathol 1999; 12:77-81.
12. Colotta F, Polentarutti N, Sironi M, and Mantovani A. Expression and involvement of c-fos and c-jun protooncogenes in programmed cell death induced by growth factor deprivation in lymphoid cell lines. J Biol Chem 1992; 267: 18278-18283.
13. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GG, Schilling K, Robertson EM, Curran T, and Morgan JI. Continuous c-fos expression precedes programmed cell death in vivo. Nature 1993; 363: 166-169.
14. Marti A, Jehn B, Costello E, Keon N, Ke G, Martin F, and Jaggi R. Protein kinase A and AP-1 (c-fos/JunD) are induced during apoptosis of mouse mammary epithelial cells. Oncogene 1994; 9: 1213-1223.
15. Hu L, Hatano M, Ruther U, and Tokuhisa T. Overexpression of c-fos induces apoptosis of CD43+ pro-B cells. J Immunol 1996; 157: 3804-3811.
16. Mils V, Piette J, Barette C, Veyrune J, Tesniere A, Escot C, Guilhou JJ, and Basset-Seguin N. The proto-oncogene c-fos increases the sensitivity of keratinocytes to apoptosis. Oncogene 1997; 14: 1555-1561.
17. Tsuda T, Hamamori Y, Yamashita T, Fukumoto Y, and Takai Y. Involvement of three intracellular messenger systems, protein kinase C, calcium ion and cyclic AMP, in the regulation of c-fos gene expression in Swiss 3T3 cells. FEBS Lett 1986; 208: 39-420
18. Morgan JI, and Curran T. Calcium as a modulator of the immediate-early gene cascade in neurons. Cell Calcium 1988; 9: 303-311.
19. Cohen DR, and Curran T. The structure and function of the fos protooncogene. Crit rev Oncog 1989; 1: 65-88.
20. i in induction of c-fos, c-jun and c-myc mRNA in rat PTE after oxidative stress. FASEB J 1992; 6: 919-924.
21. 2+ and protein kinases in the induction of the hsp70 gene. Kidney Int 1994; 45: 1093-1104.
22. Yoshino N, Takizawa M, Akiba H, Okumura H, Tashiro F, Honda M, and Ueno Y. Transient elevation of intracellular calcium ion levels as an early event in T-2 toxin-induced apoptosis in human promyelitic cell line HE-60. Nat Toxins 1996; 4: 234-241.