Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis

Journal of Biological Chemistry

Volumn 283, Issue 39, 2008, Pages 26538-26547

  Sai, Jiqing ^a   Raman, Dayanidhi ^a   Liu, Yuxin ^b   Wikswo, John ^b   Richmond, Ann ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE;

BONE MARROWS; CELL MOTILITIES; CELL POLARITIES; CELL TYPES; FUNCTIONAL ROLES; HL60 CELLS; PHOSPHATIDYLINOSITOL; SMALL MOLECULES; WORTMANNIN; WORTMANNIN INHIBITIONS;

BIOCHEMISTRY;

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 8; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN DOCK2; PROTEIN TYROSINE KINASE; RAC2 PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; WORTMANNIN; ANDROSTANE DERIVATIVE; CHEMOKINE RECEPTOR CXCR2; DOCK2 PROTEIN, HUMAN; DOCK3 PROTEIN, HUMAN; FGD1 RELATED CDC42 GEF PROTEIN, HUMAN; FGD1-RELATED CDC42-GEF PROTEIN, HUMAN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; HCK PROTEIN, HUMAN; HCK PROTEIN, MOUSE; HEMATOPOIETIC CELL KINASE; IL8 PROTEIN, HUMAN; LYN PROTEIN-TYROSINE KINASE; NERVE PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE INHIBITOR; PROTEIN KINASE LYN; PYRIMIDINE DERIVATIVE; RAC PROTEIN;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL MOTILITY; CELL POLARITY; CELL STRAIN HL 60; CONTROLLED STUDY; ENZYME ACTIVITY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CHEMOTAXIS; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; SIGNAL TRANSDUCTION;

MUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELL POLARITY; CHEMOTAXIS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HL-60 CELLS; HUMANS; INTERLEUKIN-8; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEUTROPHILS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-HCK; PYRIMIDINES; RAC GTP-BINDING PROTEINS; RECEPTORS, INTERLEUKIN-8B; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES;

EID: 55549147533     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M805611200     Document Type: Article

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