메뉴 건너뛰기




Volumn 278, Issue 2, 2009, Pages 145-155

NF-κB inhibition in human hepatocellular carcinoma and its potential as adjunct to sorafenib based therapy

Author keywords

Hepatocellular carcinoma (HCC); NF B; Sorafenib; Therapy

Indexed keywords

GELATINASE A; GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN P65; MATRIX METALLOPROTEINASE 14; PROTEIN MCL 1; SORAFENIB; UNCLASSIFIED DRUG; UROKINASE; VASCULOTROPIN; ANTINEOPLASTIC AGENT; BENZENESULFONIC ACID DERIVATIVE; I KAPPA B; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; PROTEIN BCL 2; PYRIDINE DERIVATIVE; TRANSCRIPTION FACTOR RELA;

EID: 64649087510     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2008.12.031     Document Type: Article
Times cited : (73)

References (26)
  • 1
    • 20344392430 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology, risk factors, and screening
    • Sherman M. Hepatocellular carcinoma: epidemiology, risk factors, and screening. Semin. Liver Dis. 25 (2005) 143-154
    • (2005) Semin. Liver Dis. , vol.25 , pp. 143-154
    • Sherman, M.1
  • 2
    • 0642303165 scopus 로고    scopus 로고
    • The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update
    • El-Serag H.B., Davila J.A., Petersen N.J., and McGlynn K.A. The continuing increase in the incidence of hepatocellular carcinoma in the United States: an update. Ann. Int. Med. 139 (2003) 817-823
    • (2003) Ann. Int. Med. , vol.139 , pp. 817-823
    • El-Serag, H.B.1    Davila, J.A.2    Petersen, N.J.3    McGlynn, K.A.4
  • 3
    • 43749098070 scopus 로고    scopus 로고
    • NF-kappaB and cancer-identifying targets and mechanisms
    • Naugler W.E., and Karin M. NF-kappaB and cancer-identifying targets and mechanisms. Curr. Opin. Genet. Dev. 18 (2008) 19-26
    • (2008) Curr. Opin. Genet. Dev. , vol.18 , pp. 19-26
    • Naugler, W.E.1    Karin, M.2
  • 4
    • 33744948611 scopus 로고    scopus 로고
    • Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta
    • Schomer-Miller B., Higashimoto T., Lee Y.K., and Zandi E. Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta. J. Biol. Chem. 281 (2006) 15268-15276
    • (2006) J. Biol. Chem. , vol.281 , pp. 15268-15276
    • Schomer-Miller, B.1    Higashimoto, T.2    Lee, Y.K.3    Zandi, E.4
  • 5
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 6
    • 4644324186 scopus 로고    scopus 로고
    • NF-kappaB functions as a tumour promoter in inflammation-associated cancer
    • Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., et al. NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004) 461-466
    • (2004) Nature , vol.431 , pp. 461-466
    • Pikarsky, E.1    Porat, R.M.2    Stein, I.3    Abramovitch, R.4    Amit, S.5    Kasem, S.6
  • 7
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda S., Kamata H., Luo J.L., Leffert H., and Karin M. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell 121 (2005) 977-990
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 9
    • 0141828970 scopus 로고    scopus 로고
    • Mechanisms of human hepatocarcinogenesis
    • Coleman W.B. Mechanisms of human hepatocarcinogenesis. Curr. Mol. Med. 3 (2003) 573-588
    • (2003) Curr. Mol. Med. , vol.3 , pp. 573-588
    • Coleman, W.B.1
  • 10
    • 4944249117 scopus 로고    scopus 로고
    • Et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm S.M., Carter C., Tang L., Wilkie D., McNabola A., and Rong H. Et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 64 (2004) 7099-7109
    • (2004) Cancer Res. , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3    Wilkie, D.4    McNabola, A.5    Rong, H.6
  • 12
    • 0033603461 scopus 로고    scopus 로고
    • Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells
    • Newton T.R., Patel N.M., Bhat-Nakshatri P., Stauss C.R., Goulet Jr R.J., and Nakshatri H. Negative regulation of transactivation function but not DNA binding of NF-kappaB and AP-1 by IkappaBbeta1 in breast cancer cells. J. Biol. Chem. 274 (1999) 18827-18835
    • (1999) J. Biol. Chem. , vol.274 , pp. 18827-18835
    • Newton, T.R.1    Patel, N.M.2    Bhat-Nakshatri, P.3    Stauss, C.R.4    Goulet Jr, R.J.5    Nakshatri, H.6
  • 13
    • 0036009115 scopus 로고    scopus 로고
    • NF-kappaB at the crossroads of life and death
    • Karin M., and Lin A. NF-kappaB at the crossroads of life and death. Nat. Immunol. 3 (2002) 221-227
    • (2002) Nat. Immunol. , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 14
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
    • Delhase M., Hayakawa M., Chen Y., and Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284 (1999) 309-313
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 15
    • 33745870112 scopus 로고    scopus 로고
    • Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest
    • Ralstin M.C., Gage E.A., Yip-Schneider M.T., Klein P.J., Wiebke E.A., and Schmidt C.M. Parthenolide cooperates with NS398 to inhibit growth of human hepatocellular carcinoma cells through effects on apoptosis and G0-G1 cell cycle arrest. Mol. Cancer Res. 6 (2006) 387-399
    • (2006) Mol. Cancer Res. , vol.6 , pp. 387-399
    • Ralstin, M.C.1    Gage, E.A.2    Yip-Schneider, M.T.3    Klein, P.J.4    Wiebke, E.A.5    Schmidt, C.M.6
  • 16
    • 0026425631 scopus 로고
    • Tumor invasion and metastasis: an imbalance of positive and negative regulation
    • Liotta L.A., and Stetler-Stevenson W.G. Tumor invasion and metastasis: an imbalance of positive and negative regulation. Cancer Res. 51 (1991) 5054-5059
    • (1991) Cancer Res. , vol.51 , pp. 5054-5059
    • Liotta, L.A.1    Stetler-Stevenson, W.G.2
  • 17
    • 0029741786 scopus 로고    scopus 로고
    • Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential
    • Arii S., Mise M., Harada T., Furutani M., Ishigami S., Niwano M., et al. Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential. Hepatology 24 (1996) 316-322
    • (1996) Hepatology , vol.24 , pp. 316-322
    • Arii, S.1    Mise, M.2    Harada, T.3    Furutani, M.4    Ishigami, S.5    Niwano, M.6
  • 18
    • 0034955574 scopus 로고    scopus 로고
    • Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas
    • Théret N., Musso O., Turlin B., Lotrian D., Bioulac-Sage P., Campion J.P., et al. Increased extracellular matrix remodeling is associated with tumor progression in human hepatocellular carcinomas. Hepatology 34 (2001) 82-88
    • (2001) Hepatology , vol.34 , pp. 82-88
    • Théret, N.1    Musso, O.2    Turlin, B.3    Lotrian, D.4    Bioulac-Sage, P.5    Campion, J.P.6
  • 19
    • 33947152499 scopus 로고    scopus 로고
    • Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma
    • Ip Y.C., Cheung S.T., and Fan S.T. Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma. Mol. Carcinogen. 46 (2007) 225-230
    • (2007) Mol. Carcinogen. , vol.46 , pp. 225-230
    • Ip, Y.C.1    Cheung, S.T.2    Fan, S.T.3
  • 20
    • 0034255520 scopus 로고    scopus 로고
    • Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma
    • Poon R.T., Fan S.T., Ng I.O., Lo C.M., Liu C.L., and Wong J. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 89 (2000) 500-507
    • (2000) Cancer , vol.89 , pp. 500-507
    • Poon, R.T.1    Fan, S.T.2    Ng, I.O.3    Lo, C.M.4    Liu, C.L.5    Wong, J.6
  • 21
    • 0242456170 scopus 로고    scopus 로고
    • Axis of evil: molecular mechanisms of cancer metastasis
    • Bogenrieder T., and Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 22 (2003) 6524-6536
    • (2003) Oncogene , vol.22 , pp. 6524-6536
    • Bogenrieder, T.1    Herlyn, M.2
  • 22
    • 20344371480 scopus 로고    scopus 로고
    • Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma
    • Yao D.F., Wu X.H., Zhu Y., Shi G.S., Dong Z.Z., Yao D.B., et al. Quantitative analysis of vascular endothelial growth factor, microvascular density and their clinicopathologic features in human hepatocellular carcinoma. Hepatobiliary Pancreat. Dis. Int. 4 (2005) 220-226
    • (2005) Hepatobiliary Pancreat. Dis. Int. , vol.4 , pp. 220-226
    • Yao, D.F.1    Wu, X.H.2    Zhu, Y.3    Shi, G.S.4    Dong, Z.Z.5    Yao, D.B.6
  • 23
    • 33751160860 scopus 로고    scopus 로고
    • Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells
    • Jane E.P., Premkumar D.R., and Pollack I.F. Coadministration of sorafenib with rottlerin potently inhibits cell proliferation and migration in human malignant glioma cells. J. Pharmacol. Exp. Ther. 319 (2006) 1070-1080
    • (2006) J. Pharmacol. Exp. Ther. , vol.319 , pp. 1070-1080
    • Jane, E.P.1    Premkumar, D.R.2    Pollack, I.F.3
  • 24
    • 33749573178 scopus 로고    scopus 로고
    • Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways
    • Yu C., Friday B.B., Lai J.P., Yang L., Sarkaria J., Kay N.E., et al. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Mol. Cancer Ther. 5 (2006) 2378-2387
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 2378-2387
    • Yu, C.1    Friday, B.B.2    Lai, J.P.3    Yang, L.4    Sarkaria, J.5    Kay, N.E.6
  • 26
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis
    • Elsharkawy A.M., and Mann D.A. Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46 (2007) 590-597
    • (2007) Hepatology , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.