-
1
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira, S., Uematsu, S. and Takeuchi, O. 2006. Pathogen recognition and innate immunity. Cell 124:783.
-
(2006)
Cell
, vol.124
, pp. 783
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
3
-
-
0033120081
-
Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
-
Hoshino, K., Takeuchi, O., Kawai, T. et al. 1999. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749.
-
(1999)
J. Immunol.
, vol.162
, pp. 3749
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
-
4
-
-
33750831778
-
TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease
-
Liu, B., Yang, Y., Dai, J. et al. 2006. TLR4 up-regulation at protein or gene level is pathogenic for lupus-like autoimmune disease. J. Immunol. 177:6880.
-
(2006)
J. Immunol.
, vol.177
, pp. 6880
-
-
Liu, B.1
Yang, Y.2
Dai, J.3
-
5
-
-
77954237776
-
Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus
-
Lartigue, A., Colliou, N., Calbo, S. et al. 2009. Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus. J. Immunol. 183:6207.
-
(2009)
J. Immunol.
, vol.183
, pp. 6207
-
-
Lartigue, A.1
Colliou, N.2
Calbo, S.3
-
6
-
-
0037450737
-
Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling
-
Choe, J. Y., Crain, B., Wu, S. R. and Corr, M. 2003. Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling. J. Exp. Med. 197:537.
-
(2003)
J. Exp. Med.
, vol.197
, pp. 537
-
-
Choe, J.Y.1
Crain, B.2
Wu, S.R.3
Corr, M.4
-
7
-
-
79959447465
-
Structural biology of the toll-like receptor family
-
Kang, J. Y. and Lee, J. O. 2011. Structural biology of the toll-like receptor family. Annu. Rev. Biochem. 80:917.
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 917
-
-
Kang, J.Y.1
Lee, J.O.2
-
8
-
-
0036301797
-
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
-
Nagai, Y., Akashi, S., Nagafuku, M. et al. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 667
-
-
Nagai, Y.1
Akashi, S.2
Nagafuku, M.3
-
9
-
-
34548222514
-
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
-
Kim, H. M., Park, B. S., Kim, J. I. et al. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130:906.
-
(2007)
Cell
, vol.130
, pp. 906
-
-
Kim, H.M.1
Park, B.S.2
Kim, J.I.3
-
10
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park, B. S., Song, D. H., Kim, H. M., Choi, B. S., Lee, H. and Lee, J. O. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458:1191.
-
(2009)
Nature
, vol.458
, pp. 1191
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
Choi, B.S.4
Lee, H.5
Lee, J.O.6
-
11
-
-
0037127309
-
MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor
-
da Silva Correia, J. and Ulevitch, R. J. 2002. MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. J. Biol. Chem. 277:1845.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1845
-
-
da Silva Correia, J.1
Ulevitch, R.J.2
-
12
-
-
9144228167
-
The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface
-
Fujimoto, T., Yamazaki, S., Eto-Kimura, A., Takeshige, K. and Muta, T. 2004. The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface. J. Biol. Chem. 279:47431.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47431
-
-
Fujimoto, T.1
Yamazaki, S.2
Eto-Kimura, A.3
Takeshige, K.4
Muta, T.5
-
13
-
-
67649386535
-
Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin
-
Resman, N., Vasl, J., Oblak, A. et al. 2009. Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin. J. Biol. Chem. 284:15052.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 15052
-
-
Resman, N.1
Vasl, J.2
Oblak, A.3
-
14
-
-
77950591965
-
MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation
-
Meng, J., Lien, E. and Golenbock, D. T. 2010. MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation. J. Biol. Chem. 285:8695.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 8695
-
-
Meng, J.1
Lien, E.2
Golenbock, D.T.3
-
15
-
-
33845982600
-
Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40
-
Nishitani, C., Mitsuzawa, H., Sano, H., Shimizu, T., Matsushima, N. and Kuroki, Y. 2006. Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40. J. Biol. Chem. 281:38322.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 38322
-
-
Nishitani, C.1
Mitsuzawa, H.2
Sano, H.3
Shimizu, T.4
Matsushima, N.5
Kuroki, Y.6
-
16
-
-
10844287952
-
The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1
-
Tsuneyoshi, N., Fukudome, K., Kohara, J. et al. 2005. The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J. Immunol. 174:340.
-
(2005)
J. Immunol.
, vol.174
, pp. 340
-
-
Tsuneyoshi, N.1
Fukudome, K.2
Kohara, J.3
-
17
-
-
0037372661
-
Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist
-
Mullarkey, M., Rose, J. R., Bristol, J. et al. 2003. Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist. J. Pharmacol. Exp. Ther. 304:1093.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.304
, pp. 1093
-
-
Mullarkey, M.1
Rose, J.R.2
Bristol, J.3
-
18
-
-
0028941067
-
E5531, a pure endotoxin antagonist of high potency
-
Christ, W. J., Asano, O., Robidoux, A. L. et al. 1995. E5531, a pure endotoxin antagonist of high potency. Science 268:80.
-
(1995)
Science
, vol.268
, pp. 80
-
-
Christ, W.J.1
Asano, O.2
Robidoux, A.L.3
-
19
-
-
0025193891
-
Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo
-
Kovach, N. L., Yee, E., Munford, R. S., Raetz, C. R. and Harlan, J. M. 1990. Lipid IVA inhibits synthesis and release of tumor necrosis factor induced by lipopolysaccharide in human whole blood ex vivo. J. Exp. Med. 172:77.
-
(1990)
J. Exp. Med.
, vol.172
, pp. 77
-
-
Kovach, N.L.1
Yee, E.2
Munford, R.S.3
Raetz, C.R.4
Harlan, J.M.5
-
20
-
-
0034607049
-
Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2
-
Akashi, S., Ogata, H., Kirikae, F. et al. 2000. Regulatory roles for CD14 and phosphatidylinositol in the signaling via toll-like receptor 4-MD-2. Biochem. Biophys. Res. Commun. 268:172.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.268
, pp. 172
-
-
Akashi, S.1
Ogata, H.2
Kirikae, F.3
-
21
-
-
36849069342
-
Pivotal involvement of Fcc receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1
-
Dunn-Siegrist, I., Leger, O., Daubeuf, B. et al. 2007. Pivotal involvement of Fcc receptor IIA in the neutralization of lipopolysaccharide signaling via a potent novel anti-TLR4 monoclonal antibody 15C1. J. Biol. Chem. 282:34817.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 34817
-
-
Dunn-Siegrist, I.1
Leger, O.2
Daubeuf, B.3
-
22
-
-
34247482403
-
Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction
-
Tsuneyoshi, N., Kohara, J., Bahrun, U. et al. 2006. Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction. Cell. Immunol. 244:57.
-
(2006)
Cell. Immunol.
, vol.244
, pp. 57
-
-
Tsuneyoshi, N.1
Kohara, J.2
Bahrun, U.3
-
23
-
-
37549067669
-
Preparation and characterization of agonistic monoclonal antibodies against Toll-like receptor 4-MD-2 complex
-
Bahrun, U., Kimoto, M., Tsukamoto, H., Tsuneyoshi, N., Kohara, J. and Fukudome, K. 2007. Preparation and characterization of agonistic monoclonal antibodies against Toll-like receptor 4-MD-2 complex. Hybridoma (Larchmt) 26:393.
-
(2007)
Hybridoma (Larchmt)
, vol.26
, pp. 393
-
-
Bahrun, U.1
Kimoto, M.2
Tsukamoto, H.3
Tsuneyoshi, N.4
Kohara, J.5
Fukudome, K.6
-
24
-
-
77954036715
-
Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells
-
Tsukamoto, H., Fukudome, K., Takao, S., Tsuneyoshi, N. and Kimoto, M. 2010. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int. Immunol. 22:271.
-
(2010)
Int. Immunol.
, vol.22
, pp. 271
-
-
Tsukamoto, H.1
Fukudome, K.2
Takao, S.3
Tsuneyoshi, N.4
Kimoto, M.5
-
25
-
-
78651433978
-
Inhibition of homodimerization of toll-like receptor 4 by 4-oxo-4-(2-oxo-oxazolidin- 3-yl)-but-2-enoic acid ethyl ester
-
Park, S. J., Kang, S. H., Kang, Y. K. et al. 2011. Inhibition of homodimerization of toll-like receptor 4 by 4-oxo-4-(2-oxo-oxazolidin- 3-yl)-but-2-enoic acid ethyl ester. Int. Immunopharmacol. 11:19.
-
(2011)
Int. Immunopharmacol.
, vol.11
, pp. 19
-
-
Park, S.J.1
Kang, S.H.2
Kang, Y.K.3
-
26
-
-
33744526702
-
Inhibition of homodimerization of Toll-like receptor 4 by curcumin
-
Youn, H. S., Saitoh, S. I., Miyake, K. and Hwang, D. H. 2006. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem. Pharmacol. 72:62.
-
(2006)
Biochem. Pharmacol.
, vol.72
, pp. 62
-
-
Youn, H.S.1
Saitoh, S.I.2
Miyake, K.3
Hwang, D.H.4
-
27
-
-
81055129630
-
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4
-
Zanoni, I., Ostuni, R., Marek, L. R. et al. 2011. CD14 controls the LPS-induced endocytosis of Toll-like receptor 4. Cell 147:868.
-
(2011)
Cell
, vol.147
, pp. 868
-
-
Zanoni, I.1
Ostuni, R.2
Marek, L.R.3
-
28
-
-
40949134086
-
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
-
Kagan, J. C., Su, T., Horng, T., Chow, A., Akira, S. and Medzhitov, R. 2008. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 3 9:361.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 361
-
-
Kagan, J.C.1
Su, T.2
Horng, T.3
Chow, A.4
Akira, S.5
Medzhitov, R.6
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