-
2
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. and Takeda, K. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499.
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499
-
-
Akira, S.1
Takeda, K.2
-
3
-
-
0036301797
-
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
-
Nagai, Y., Akashi, S., Nagafuku, M. et al. 2002. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3:667.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 667
-
-
Nagai, Y.1
Akashi, S.2
Nagafuku, M.3
-
4
-
-
0034177888
-
Cutting edge: cell surface expression and lipopolysaccharide signaling via the tolllike receptor 4-MD-2 complex on mouse peritoneal macrophages
-
Akashi, S., Shimazu, R., Ogata, H. et al. 2000. Cutting edge: cell surface expression and lipopolysaccharide signaling via the tolllike receptor 4-MD-2 complex on mouse peritoneal macrophages. J. Immunol. 164:3471.
-
(2000)
J. Immunol.
, vol.164
, pp. 3471
-
-
Akashi, S.1
Shimazu, R.2
Ogata, H.3
-
5
-
-
34548222514
-
Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran
-
Kim, H. M., Park, B. S., Kim, J. I. et al. 2007. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130:906.
-
(2007)
Cell
, vol.130
, pp. 906
-
-
Kim, H.M.1
Park, B.S.2
Kim, J.I.3
-
6
-
-
0021798736
-
Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities
-
Galanos, C., Luderitz, O., Rietschel, E. T. et al. 1985. Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur. J. Biochem. 148:1.
-
(1985)
Eur. J. Biochem.
, vol.148
, pp. 1
-
-
Galanos, C.1
Luderitz, O.2
Rietschel, E.T.3
-
7
-
-
0035211130
-
Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition
-
Akashi, S., Nagai, Y., Ogata, H. et al. 2001. Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition. Int. Immunol. 13:1595.
-
(2001)
Int. Immunol.
, vol.13
, pp. 1595
-
-
Akashi, S.1
Nagai, Y.2
Ogata, H.3
-
8
-
-
23944493705
-
Lipopolysaccharide heterogeneity: innate host responses to bacterial modification of lipid a structure
-
Dixon, D. R. and Darveau, R. P. 2005. Lipopolysaccharide heterogeneity: innate host responses to bacterial modification of lipid a structure. J. Dent. Res. 84:584.
-
(2005)
J. Dent. Res.
, vol.84
, pp. 584
-
-
Dixon, D.R.1
Darveau, R.P.2
-
9
-
-
34247482403
-
Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction
-
Tsuneyoshi, N., Kohara, J., Bahrun, U. et al. 2006. Penta-acylated lipopolisaccharide binds to murine MD-2 but does not induce the oligomerization of TLR4 required for signal transduction. Cell. Immunol. 244:57.
-
(2006)
Cell. Immunol.
, vol.244
, pp. 57
-
-
Tsuneyoshi, N.1
Kohara, J.2
Bahrun, U.3
-
10
-
-
10844287952
-
The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1
-
Tsuneyoshi, N., Fukudome, K., Kohara, J. et al. 2005. The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1. J. Immunol. 174:340.
-
(2005)
J. Immunol.
, vol.174
, pp. 340
-
-
Tsuneyoshi, N.1
Fukudome, K.2
Kohara, J.3
-
11
-
-
0028965644
-
Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin
-
Ulevitch, R. J. and Tobias, P. S. 1995. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu. Rev. Immunol. 13:437.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 437
-
-
Ulevitch, R.J.1
Tobias, P.S.2
-
12
-
-
0026518709
-
Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein
-
Lee, J. D., Kato, K., Tobias, P. S., Kirkland, T. N. and Ulevitch, R. J. 1992. Transfection of CD14 into 70Z/3 cells dramatically enhances the sensitivity to complexes of lipopolysaccharide (LPS) and LPS binding protein. J. Exp. Med. 175:1697.
-
(1992)
J. Exp. Med.
, vol.175
, pp. 1697
-
-
Lee, J.D.1
Kato, K.2
Tobias, P.S.3
Kirkland, T.N.4
Ulevitch, R.J.5
-
13
-
-
0026552706
-
Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes
-
Heumann, D., Gallay, P., Barras, C. et al. 1992. Control of lipopolysaccharide (LPS) binding and LPS-induced tumor necrosis factor secretion in human peripheral blood monocytes. J. Immunol. 148:3505.
-
(1992)
J. Immunol.
, vol.148
, pp. 3505
-
-
Heumann, D.1
Gallay, P.2
Barras, C.3
-
14
-
-
0025896328
-
Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes
-
Bazil, V. and Strominger, J. L. 1991. Shedding as a mechanism of down-modulation of CD14 on stimulated human monocytes. J. Immunol. 147:1567.
-
(1991)
J. Immunol.
, vol.147
, pp. 1567
-
-
Bazil, V.1
Strominger, J.L.2
-
15
-
-
0028049597
-
The two soluble forms of the lipopolysaccharide receptor CD14: characterization and release by normal human monocytes
-
Durieux, J. J., Vita, N., Popescu, O. et al. 1994. The two soluble forms of the lipopolysaccharide receptor, CD14: characterization and release by normal human monocytes. Eur. J. Immunol. 24:2006.
-
(1994)
Eur. J. Immunol.
, vol.24
, pp. 2006
-
-
Durieux, J.J.1
Vita, N.2
Popescu, O.3
-
16
-
-
0028286765
-
Lipopolysaccharide (LPS) binding protein, truncated at Ile-197, binds LPS but does not transfer LPS to CD14
-
Han, J., Mathison, J. C., Ulevitch, R. J. and Tobias, P. S. 1994. Lipopolysaccharide (LPS) binding protein, truncated at Ile-197, binds LPS but does not transfer LPS to CD14. J. Biol. Chem. 269:8172.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 8172
-
-
Han, J.1
Mathison, J.C.2
Ulevitch, R.J.3
Tobias, P.S.4
-
17
-
-
0028815388
-
Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS
-
Juan, T. S., Kelley, M. J., Johnson, D. A. et al. 1995. Soluble CD14 truncated at amino acid 152 binds lipopolysaccharide (LPS) and enables cellular response to LPS. J. Biol. Chem. 270:1382.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 1382
-
-
Juan, T.S.1
Kelley, M.J.2
Johnson, D.A.3
-
18
-
-
0027955127
-
Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14
-
Hailman, E., Lichenstein, H. S., Wurfel, M. M. et al. 1994. Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J. Exp. Med. 179:269.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 269
-
-
Hailman, E.1
Lichenstein, H.S.2
Wurfel, M.M.3
-
19
-
-
0027446922
-
Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14
-
Pugin, J., Schurer-Maly, C. C., Leturcq, D., Moriarty, A., Ulevitch, R. J. and Tobias, P. S. 1993. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc. Natl Acad. Sci. USA 90:2744.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 2744
-
-
Pugin, J.1
Schurer-Maly, C.C.2
Leturcq, D.3
Moriarty, A.4
Ulevitch, R.J.5
Tobias, P.S.6
-
20
-
-
0028297677
-
An aminoterminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity
-
Theofan, G., Horwitz, A. H., Williams, R. E. et al. 1994. An aminoterminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity. J. Immunol. 152:3623.
-
(1994)
J. Immunol.
, vol.152
, pp. 3623
-
-
Theofan, G.1
Horwitz, A.H.2
Williams, R.E.3
-
22
-
-
34250698370
-
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
-
Latz, E., Verma, A., Visintin, A. et al. 2007. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nat. Immunol. 8:772.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 772
-
-
Latz, E.1
Verma, A.2
Visintin, A.3
-
23
-
-
33747360450
-
MD-2
-
Visintin, A., Iliev, D. B., Monks, B. G., Halmen, K. A. and Golenbock, D. T. 2006. MD-2. Immunobiology 211:437.
-
(2006)
Immunobiology
, vol.211
, pp. 437
-
-
Visintin, A.1
Iliev, D.B.2
Monks, B.G.3
Halmen, K.A.4
Golenbock, D.T.5
-
24
-
-
3242776258
-
MD-2 the Toll 'gatekeeper' in endotoxin signalling
-
Gangloff, M. and Gay, N. J. 2004. MD-2: the Toll 'gatekeeper' in endotoxin signalling. Trends Biochem. Sci. 29:294.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 294
-
-
Gangloff, M.1
Gay, N.J.2
-
25
-
-
0037021421
-
Integrinnucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling
-
Zhang, H., Tay, P. N., Cao, W., Li, W. and Lu, J. 2002. Integrinnucleated Toll-like receptor (TLR) dimerization reveals subcellular targeting of TLRs and distinct mechanisms of TLR4 activation and signaling. FEBS Lett. 532:171.
-
(2002)
FEBS Lett.
, vol.532
, pp. 171
-
-
Zhang, H.1
Tay, P.N.2
Cao, W.3
Li, W.4
Lu, J.5
-
26
-
-
0346850824
-
Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction
-
Visintin, A., Latz, E., Monks, B. G., Espevik, T. and Golenbock, D. T. 2003. Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction. J. Biol. Chem. 278:48313.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 48313
-
-
Visintin, A.1
Latz, E.2
Monks, B.G.3
Espevik, T.4
Golenbock, D.T.5
-
27
-
-
0036774947
-
CD14 signalling in lipid rafts: new ligands and co-receptors
-
Schmitz, G. and Orso, E. 2002. CD14 signalling in lipid rafts: new ligands and co-receptors. Curr. Opin. Lipidol. 13:513.
-
(2002)
Curr. Opin. Lipidol.
, vol.13
, pp. 513
-
-
Schmitz, G.1
Orso, E.2
-
28
-
-
17344374020
-
The dynamics of LPS recognition: complex orchestration of multiple receptors
-
Triantafilou, M. and Triantafilou, K. 2005. The dynamics of LPS recognition: complex orchestration of multiple receptors. J. Endotoxin Res. 11:5.
-
(2005)
J. Endotoxin Res.
, vol.11
, pp. 5
-
-
Triantafilou, M.1
Triantafilou, K.2
-
29
-
-
53149135472
-
Visualization of the molecular dynamics of lipopolysaccharide on the plasma membrane of murine macrophages by total internal reflection fluorescence microscopy
-
Shawkat, S., Karima, R., Tojo, T. et al. 2008. Visualization of the molecular dynamics of lipopolysaccharide on the plasma membrane of murine macrophages by total internal reflection fluorescence microscopy. J. Biol. Chem. 283:22962.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 22962
-
-
Shawkat, S.1
Karima, R.2
Tojo, T.3
-
30
-
-
67349182481
-
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
-
Park, B. S., Song, D. H., Kim, H. M., Choi, B. S., Lee, H. and Lee, J. O. 2009. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. Nature 458:1191.
-
(2009)
Nature
, vol.458
, pp. 1191
-
-
Park, B.S.1
Song, D.H.2
Kim, H.M.3
Choi, B.S.4
Lee, H.5
Lee, J.O.6
-
31
-
-
1642358911
-
Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by b-lactamase enzyme fragment complementation
-
Lee, H. K., Dunzendorfer, S. and Tobias, P. S. 2004. Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by b-lactamase enzyme fragment complementation. J. Biol. Chem. 279:10564.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10564
-
-
Lee, H.K.1
Dunzendorfer, S.2
Tobias, P.S.3
-
32
-
-
33646494167
-
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering
-
Kobayashi, M., Saitoh, S., Tanimura, N. et al. 2006. Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. J. Immunol. 176:6211.
-
(2006)
J. Immunol.
, vol.176
, pp. 6211
-
-
Kobayashi, M.1
Saitoh, S.2
Tanimura, N.3
-
33
-
-
3242690772
-
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization
-
Saitoh, S., Akashi, S., Yamada, T. et al. 2004. Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int. Immunol. 16:961.
-
(2004)
Int. Immunol.
, vol.16
, pp. 961
-
-
Saitoh, S.1
Akashi, S.2
Yamada, T.3
-
34
-
-
0141890200
-
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14
-
Akashi, S., Saitoh, S., Wakabayashi, Y. et al. 2003. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J. Exp. Med. 198:1035.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1035
-
-
Akashi, S.1
Saitoh, S.2
Wakabayashi, Y.3
-
35
-
-
37549067669
-
Preparation and characterization of agonistic monoclonal antibodies against Toll-like receptor 4-MD-2 complex
-
Bahrun, U., Kimoto, M., Tsukamoto, H., Tsuneyoshi, N., Kohara, J. and Fukudome, K. 2007. Preparation and characterization of agonistic monoclonal antibodies against Toll-like receptor 4-MD-2 complex. Hybridoma (Larchmt) 26:393.
-
(2007)
Hybridoma (Larchmt)
, vol.26
, pp. 393
-
-
Bahrun, U.1
Kimoto, M.2
Tsukamoto, H.3
Tsuneyoshi, N.4
Kohara, J.5
Fukudome, K.6
-
36
-
-
34848842132
-
Preparation of recombinant murine tumor necrosis factor-α in Escherichia coli: a rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography
-
Tsukamoto, H., Fukudome, K., Kohara, J., Nakatake, H. and Kimoto, M. 2007. Preparation of recombinant murine tumor necrosis factor-α in Escherichia coli: a rapid method to remove tags from fusion proteins by thrombin-cleavage and ion-exchange chromatography. Protein Expr. Purif. 56:138.
-
(2007)
Protein Expr. Purif.
, vol.56
, pp. 138
-
-
Tsukamoto, H.1
Fukudome, K.2
Kohara, J.3
Nakatake, H.4
Kimoto, M.5
-
37
-
-
3042709224
-
Preparation of recombinant α-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin
-
Yonemura, H., Imamura, T., Soejima, K. et al. 2004. Preparation of recombinant α-thrombin: high-level expression of recombinant human prethrombin-2 and its activation by recombinant ecarin. J. Biochem. 135:577.
-
(2004)
J. Biochem.
, vol.135
, pp. 577
-
-
Yonemura, H.1
Imamura, T.2
Soejima, K.3
-
38
-
-
0037127309
-
MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor
-
da Silva Correia, J. and Ulevitch, R. J. 2002. MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. J. Biol. Chem. 277:1845.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1845
-
-
da Silva Correia, J.1
Ulevitch, R.J.2
-
39
-
-
9144228167
-
The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface
-
Fujimoto, T., Yamazaki, S., Eto-Kimura, A., Takeshige, K. and Muta, T. 2004. The amino-terminal region of toll-like receptor 4 is essential for binding to MD-2 and receptor translocation to the cell surface. J. Biol. Chem. 279:47431.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 47431
-
-
Fujimoto, T.1
Yamazaki, S.2
Eto-Kimura, A.3
Takeshige, K.4
Muta, T.5
-
40
-
-
0037619127
-
MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylation essential for its translocation to the cell surface
-
Ohnishi, T., Muroi, M. and Tanamoto, K. 2003. MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylation essential for its translocation to the cell surface. Clin. Diagn. Lab. Immunol. 10:405.
-
(2003)
Clin. Diagn. Lab. Immunol.
, vol.10
, pp. 405
-
-
Ohnishi, T.1
Muroi, M.2
Tanamoto, K.3
-
41
-
-
0030293624
-
Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism
-
Grunwald, U., Fan, X., Jack, R. S. et al. 1996. Monocytes can phagocytose Gram-negative bacteria by a CD14-dependent mechanism. J. Immunol. 157:4119.
-
(1996)
J. Immunol.
, vol.157
, pp. 4119
-
-
Grunwald, U.1
Fan, X.2
Jack, R.S.3
-
42
-
-
0031458256
-
Phagocytosis of gram-negative bacteria by a unique CD14-dependent mechanism
-
Schiff, D. E., Kline, L., Soldau, K. et al. 1997. Phagocytosis of gram-negative bacteria by a unique CD14-dependent mechanism. J. Leukoc. Biol. 62:786.
-
(1997)
J. Leukoc. Biol.
, vol.62
, pp. 786
-
-
Schiff, D.E.1
Kline, L.2
Soldau, K.3
-
43
-
-
3142690482
-
TLR4 is the signaling but not the lipopolysaccharide uptake receptor
-
Dunzendorfer, S., Lee, H. K., Soldau, K. and Tobias, P. S. 2004. TLR4 is the signaling but not the lipopolysaccharide uptake receptor. J. Immunol. 173:1166.
-
(2004)
J. Immunol.
, vol.173
, pp. 1166
-
-
Dunzendorfer, S.1
Lee, H.K.2
Soldau, K.3
Tobias, P.S.4
-
44
-
-
2342525996
-
Regulation of phagosome maturation by signals from Toll-like receptors
-
Blander, J. M. and Medzhitov, R. 2004. Regulation of phagosome maturation by signals from Toll-like receptors. Science 304:1014.
-
(2004)
Science
, vol.304
, pp. 1014
-
-
Blander, J.M.1
Medzhitov, R.2
-
45
-
-
0347285351
-
Toll-like receptors induce a phagocytic gene program through p38
-
Doyle, S. E., O'Connell, R. M., Miranda, G. A. et al. 2004. Toll-like receptors induce a phagocytic gene program through p38. J. Exp. Med. 199:81.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 81
-
-
Doyle, S.E.1
O'Connell, R.M.2
Miranda, G.A.3
-
46
-
-
40949134086
-
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β
-
Kagan, J. C., Su, T., Horng, T., Chow, A., Akira, S. and Medzhitov, R. 2008. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β. Nat. Immunol. 9:361.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 361
-
-
Kagan, J.C.1
Su, T.2
Horng, T.3
Chow, A.4
Akira, S.5
Medzhitov, R.6
|