GCK-MODY diabetes associated with protein misfolding, cellular self-association and degradation

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 11, 2012, Pages 1705-1715

  Negahdar, Maria ^a,b   Aukrust, Ingvild ^a,b,c   Johansson, Bente B ^a,b   Molnes, Janne ^a,b   Molven, Anders ^a,b   Matschinsky, Franz M ^d   Søvik, Oddmund ^a   Kulkarni, Rohit N ^c   Flatmark, Torgeir ^a   Njølstad, Pål Rasmus ^a,b   Bjørkhaug, Lise ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^c JOSLIN DIABETES CENTER   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Catalytic activity; Degradation; Dimerization; GCK MODY; Protein misfolding; Self association

Indexed keywords

GLUCOKINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CELL AGGREGATION; CELL FRACTIONATION; COMPUTER MODEL; CONFORMATIONAL TRANSITION; DIMERIZATION; EMBRYO; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MATURITY ONSET DIABETES MELLITUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN QUALITY; PROTEIN STABILITY; STEADY STATE;

DIABETES MELLITUS, TYPE 2; GLUCOKINASE; HEK293 CELLS; HUMANS; MUTANT PROTEINS; MUTATION; OCTOXYNOL; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEOLYSIS; PROTEOSTASIS DEFICIENCIES; RETICULOCYTES;

EID: 84865071870     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.07.005     Document Type: Article

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