메뉴 건너뛰기




Volumn 66, Issue 4, 2012, Pages 325-331

Hydroxyfasudil ameliorates penile dysfunction in the male spontaneously hypertensive rat

Author keywords

eNOS; Erectile dysfunction; Hydroxyfasudil; Hypertension; SHR (spontaneously hypertensive rat)

Indexed keywords

ACETYLCHOLINE; CYCLIC GMP; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HYDROXYFASUDIL; MESSENGER RNA; NITRIC OXIDE; NORADRENALIN; RHO KINASE;

EID: 84864979956     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2012.06.005     Document Type: Article
Times cited : (19)

References (34)
  • 3
    • 0033361836 scopus 로고    scopus 로고
    • Nitric oxide in endothelial dysfunction and vascular remodeling: Clinical correlates and experimental links
    • DOI 10.1086/302304
    • R.D. Rudic, and W.C. Sessa Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links American Journal of Human Genetics 64 1999 673 677 (Pubitemid 30460407)
    • (1999) American Journal of Human Genetics , vol.64 , Issue.3 , pp. 673-677
    • Rudic, R.D.1    Sessa, W.C.2
  • 5
    • 32244435178 scopus 로고    scopus 로고
    • ENOS function and dysfunction in the penis
    • B. Musicki, and A.L. Burnett eNOS function and dysfunction in the penis Experimental Biology and Medicine (Maywood) 231 2006 154 165 (Pubitemid 43213452)
    • (2006) Experimental Biology and Medicine , vol.231 , Issue.2 , pp. 154-165
    • Musicki, B.1    Burnett, A.L.2
  • 6
    • 8644277006 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: Implications in hypertension
    • DOI 10.1007/s00418-004-0696-7
    • R.M. Touyz, and E.L. Schiffrin Reactive oxygen species in vascular biology: implications in hypertension Histochemistry and Cell Biology 122 2004 339 352 (Pubitemid 39506592)
    • (2004) Histochemistry and Cell Biology , vol.122 , Issue.4 , pp. 339-352
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 7
    • 73949121819 scopus 로고    scopus 로고
    • Regulation of smooth muscle contraction by small GTPases
    • S. Puetz, L.T. Lubomirov, and G. Pfitzer Regulation of smooth muscle contraction by small GTPases Physiology (Bethesda) 24 2009 342 356
    • (2009) Physiology (Bethesda) , vol.24 , pp. 342-356
    • Puetz, S.1    Lubomirov, L.T.2    Pfitzer, G.3
  • 8
    • 14344255882 scopus 로고    scopus 로고
    • Rho-kinase inhibition improves erectile function in aging male Brown-Norway rats
    • M. Rajasekaran, S. White, A. Baquir, and N. Wilkes Rho-kinase inhibition improves erectile function in aging male Brown-Norway rats Journal of Andrology 26 2005 182 188 (Pubitemid 40293703)
    • (2005) Journal of Andrology , vol.26 , Issue.2 , pp. 182-188
    • Rajasekaran, M.1    White, S.2    Baquir, A.3    Wilkes, N.4
  • 10
    • 0036892061 scopus 로고    scopus 로고
    • Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells
    • DOI 10.1128/MCB.22.24.8467-8477.2002
    • X.F. Ming, H. Viswambharan, C. Barandier, J. Ruffieux, K. Kaibuchi, and S. Rusconi Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells Molecular and Cellular Biology 22 2002 8467 8477 (Pubitemid 35397163)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.24 , pp. 8467-8477
    • Ming, X.-F.1    Viswambharan, H.2    Barandier, C.3    Ruffieux, J.4    Kaibuchi, K.5    Rusconi, S.6    Yang, Z.7
  • 11
    • 84860490635 scopus 로고    scopus 로고
    • Hydroxyfasudil ameliorates bladder dysfunction in the male spontaneously hypertensive rat
    • S. Inoue, M. Saito, and A. Takenaka Hydroxyfasudil ameliorates bladder dysfunction in the male spontaneously hypertensive rat Urology 79 2012 1186.e9 1186.e14
    • (2012) Urology , vol.79
    • Inoue, S.1    Saito, M.2    Takenaka, A.3
  • 12
    • 34250836855 scopus 로고    scopus 로고
    • Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract
    • DOI 10.1016/j.lfs.2007.05.004, PII S0024320507003578
    • M. Yono, Y. Yamamoto, M. Yoshida, S. Ueda, and J. Latifpour Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract Life Sciences 81 2007 218 222 (Pubitemid 46976980)
    • (2007) Life Sciences , vol.81 , Issue.3 , pp. 218-222
    • Yono, M.1    Yamamoto, Y.2    Yoshida, M.3    Ueda, S.4    Latifpour, J.5
  • 13
    • 67651154097 scopus 로고    scopus 로고
    • Molecular mechanisms regulating urogenital expression of nitric oxide synthase in spontaneously hypertensive rats
    • M. Yono, M. Yoshida, Y. Yamamoto, A. Imanishi, A. Fukagawa, and J. Latifpour Molecular mechanisms regulating urogenital expression of nitric oxide synthase in spontaneously hypertensive rats Life Sciences 85 2009 334 338
    • (2009) Life Sciences , vol.85 , pp. 334-338
    • Yono, M.1    Yoshida, M.2    Yamamoto, Y.3    Imanishi, A.4    Fukagawa, A.5    Latifpour, J.6
  • 14
    • 0033281663 scopus 로고    scopus 로고
    • Observations from the spontaneously hypertensive rat. Insight into NGF regulation and noradrenergic hyper-innervation in the lower urinary tract
    • [discussion 311-20]
    • W.D. Steers, D.B. Clemow, K. Persson, T. Sherer, K.E. Andersson, and J.B. Tuttl Observations from the spontaneously hypertensive rat. Insight into NGF regulation and noradrenergic hyper-innervation in the lower urinary tract Advances in Experimental Medicine and Biology 462 1999 283 292 [discussion 311-20]
    • (1999) Advances in Experimental Medicine and Biology , vol.462 , pp. 283-292
    • Steers, W.D.1    Clemow, D.B.2    Persson, K.3    Sherer, T.4    Andersson, K.E.5    Tuttl, J.B.6
  • 16
    • 79957927415 scopus 로고    scopus 로고
    • Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat
    • F. Ohmasa, M. Saito, P. Tsounapi, F. Dimitriadis, S. Inoue, and K. Shomori Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat Journal of Sexual Medicine 8 2011 1638 1649
    • (2011) Journal of Sexual Medicine , vol.8 , pp. 1638-1649
    • Ohmasa, F.1    Saito, M.2    Tsounapi, P.3    Dimitriadis, F.4    Inoue, S.5    Shomori, K.6
  • 17
    • 2342616744 scopus 로고    scopus 로고
    • Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide
    • DOI 10.1291/hypres.27.253
    • M. Ushiyama, T. Morita, T. Kuramochi, S. Yagi, and S. Katayama Erectile dysfunction in hypertensive rats results from impairment of the relaxation evoked by neurogenic carbon monoxide and nitric oxide Hypertension Research 27 2004 253 261 (Pubitemid 38594397)
    • (2004) Hypertension Research , vol.27 , Issue.4 , pp. 253-261
    • Ushiyama, M.1    Morita, T.2    Kuramochi, T.3    Yagi, S.4    Katayama, S.5
  • 18
    • 2342621539 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats
    • DOI 10.1038/sj.ijir.3901149
    • N. Wilkes, S. White, P. Stein, J. Bernie, and M. Rajasekaran Phosphodiesterase-5 inhibition synergizes rho-kinase antagonism and enhances erectile response in male hypertensive rats International Journal of Impotence Research 16 2004 187 194 (Pubitemid 38579467)
    • (2004) International Journal of Impotence Research , vol.16 , Issue.2 , pp. 187-194
    • Wilkes, N.1    White, S.2    Stein, P.3    Bernie, J.4    Rajasekaran, M.5
  • 21
    • 84860463068 scopus 로고    scopus 로고
    • Endogenous testosterone increases leukocyte-endothelial cell interaction in spontaneously hypertensive rats
    • F.P. Filgueira, N.S. Lobato, R.A. Dossantos, M.A. Oliveira, E.H. Akamine, and R.C. Tostes Endogenous testosterone increases leukocyte-endothelial cell interaction in spontaneously hypertensive rats Life Sciences 90 2012 689 694
    • (2012) Life Sciences , vol.90 , pp. 689-694
    • Filgueira, F.P.1    Lobato, N.S.2    Dossantos, R.A.3    Oliveira, M.A.4    Akamine, E.H.5    Tostes, R.C.6
  • 22
    • 34250847145 scopus 로고    scopus 로고
    • Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension
    • DOI 10.1161/HYPERTENSIONAHA.107.089599, PII 0000426820070700000022
    • H. Singh, J. Cheng, H. Deng, R. Kemp, T. Ishizuka, and A. Nasjletti Vascular cytochrome P450 4A expression and 20-hydroxyeicosatetraenoic acid synthesis contribute to endothelial dysfunction in androgen-induced hypertension Hypertension 50 2007 123 129 (Pubitemid 46986020)
    • (2007) Hypertension , vol.50 , Issue.1 , pp. 123-129
    • Singh, H.1    Cheng, J.2    Deng, H.3    Kemp, R.4    Ishizuka, T.5    Nasjletti, A.6    Schwartzman, M.L.7
  • 23
    • 33845430884 scopus 로고    scopus 로고
    • Gonadectomy prevents endothelial dysfunction in fructose-fed male rats, a factor contributing to the development of hypertension
    • H. Vasudevan, P.R. Nagareddy, and J.H. McNeill Gonadectomy prevents endothelial dysfunction in fructose-fed male rats, a factor contributing to the development of hypertension American Journal of Physiology-Heart and Circulatory Physiology 291 2006 H3058 H3064
    • (2006) American Journal of Physiology-Heart and Circulatory Physiology , vol.291
    • Vasudevan, H.1    Nagareddy, P.R.2    McNeill, J.H.3
  • 24
    • 38049110424 scopus 로고    scopus 로고
    • Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway
    • B. Fibbi, A. Morelli, M. Marini, X.H. Zhang, R. Mancina, and L. Vignozzi Atorvastatin but not elocalcitol increases sildenafil responsiveness in spontaneously hypertensive rats by regulating the RhoA/ROCK pathway Journal of Andrology 29 2008 70 84
    • (2008) Journal of Andrology , vol.29 , pp. 70-84
    • Fibbi, B.1    Morelli, A.2    Marini, M.3    Zhang, X.H.4    Mancina, R.5    Vignozzi, L.6
  • 25
    • 0034863248 scopus 로고    scopus 로고
    • Effect of rho-kinase inhibition on vasoconstriction in the penile circulation
    • T.M. Mills, K. Chitaley, C.J. Wingard, R.W. Lewis, and R.C. Webb Effect of Rho-kinase inhibition on vasoconstriction in the penile circulation Journal of Applied Physiology 91 2001 1269 1273 (Pubitemid 32803922)
    • (2001) Journal of Applied Physiology , vol.91 , Issue.3 , pp. 1269-1273
    • Mills, T.M.1    Chitaley, K.2    Wingard, C.J.3    Lewis, R.W.4    Webb, R.C.5
  • 26
    • 0037192607 scopus 로고    scopus 로고
    • Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection
    • DOI 10.1016/S0014-2999(02)01408-5, PII S0014299902014085
    • T.M. Mills, K. Chitaley, R.W. Lewis, and R.C. Webb Nitric oxide inhibits RhoA/Rho-kinase signaling to cause penile erection European Journal of Pharmacology 439 2002 173 174 (Pubitemid 34286622)
    • (2002) European Journal of Pharmacology , vol.439 , Issue.1-3 , pp. 173-174
    • Mills, T.M.1    Chitaley, K.2    Lewis, R.W.3    Webb R.Clinton4
  • 27
    • 33745684577 scopus 로고    scopus 로고
    • Regulation of Rho proteins by phosphorylation in the cardiovascular system
    • G. Loirand, C. Guilluy, and P. Pacaud Regulation of Rho proteins by phosphorylation in the cardiovascular system Trends in Cardiovascular Medicine 16 2006 199 204
    • (2006) Trends in Cardiovascular Medicine , vol.16 , pp. 199-204
    • Loirand, G.1    Guilluy, C.2    Pacaud, P.3
  • 29
    • 0037805583 scopus 로고    scopus 로고
    • Serine phosphorylation negatively regulates RhoA in vivo
    • DOI 10.1074/jbc.M213066200
    • S.M. Ellerbroek, K. Wennerberg, and K. Burridge Serine phosphorylation negatively regulates RhoA in vivo Journal of Biological Chemistry 278 2003 19023 19031 (Pubitemid 36799287)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.21 , pp. 19023-19031
    • Ellerbroek, S.M.1    Wennerberg, K.2    Burridge, K.3
  • 30
    • 20444480169 scopus 로고    scopus 로고
    • Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome- mediated degradation in vascular smooth muscle cells
    • DOI 10.1161/01.RES.0000170084.88780.ea
    • M. Rolli-Derkinderen, V. Sauzeau, L. Boyer, E. Lemichez, C. Baron, and D. Henrion Phosphorylation of serine 188 protects RhoA from ubiquitin/proteasome- mediated degradation in vascular smooth muscle cells Circulation Research 96 2005 1152 1160 (Pubitemid 40827690)
    • (2005) Circulation Research , vol.96 , Issue.11 , pp. 1152-1160
    • Rolli-Derkinderen, M.1    Sauzeau, V.2    Boyer, L.3    Lemichez, E.4    Baron, C.5    Henrion, D.6    Loirand, G.7    Pacaud, P.8
  • 31
    • 0036302962 scopus 로고    scopus 로고
    • Negative regulation of Rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: Role of nitric oxide and cyclic guanosine monophosphate signaling pathways
    • N. Begum, O.A. Sandu, and N. Duddy Negative regulation of rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: role of nitric oxide and cyclic guanosine monophosphate signaling pathways Diabetes 51 2002 2256 2263 (Pubitemid 34729033)
    • (2002) Diabetes , vol.51 , Issue.7 , pp. 2256-2263
    • Begum, N.1    Sandu, O.A.2    Duddy, N.3
  • 32
    • 0037020262 scopus 로고    scopus 로고
    • CGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions
    • T. Gudi, J.C. Chen, D.E. Casteel, T.M. Seasholtz, G.R. Boss, and R.B. Pilz cGMP-dependent protein kinase inhibits serum-response element-dependent transcription by inhibiting rho activation and functions Journal of Biological Chemistry 277 2002 37382 37393
    • (2002) Journal of Biological Chemistry , vol.277 , pp. 37382-37393
    • Gudi, T.1    Chen, J.C.2    Casteel, D.E.3    Seasholtz, T.M.4    Boss, G.R.5    Pilz, R.B.6
  • 33
    • 0141529785 scopus 로고    scopus 로고
    • Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery
    • DOI 10.1161/01.RES.0000093220.90027.D9
    • V. Sauzeau, M. Rolli-Derkinderen, S. Lehoux, G. Loirand, and P. Pacaud Sildenafil prevents change in RhoA expression induced by chronic hypoxia in rat pulmonary artery Circulation Research 93 2003 630 637 (Pubitemid 37222159)
    • (2003) Circulation Research , vol.93 , Issue.7 , pp. 630-637
    • Sauzeau, V.1    Rolli-Derkinderen, M.2    Lehoux, S.3    Loirand, G.4    Pacaud, P.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.