Specificity and structure of a high affinity activin receptor-like kinase 1 (ALK1) signaling complex

Journal of Biological Chemistry

Volumn 287, Issue 33, 2012, Pages 27313-27325

  Townson, Sharon A ^a,b   Martinez Hackert, Erik ^a,c   Greppi, Chloe ^a,d   Lowden, Patricia ^a,b   Sako, Dianne ^a   Liu, June ^a   Ucran, Jeffrey A ^a   Liharska, Katia ^a   Underwood, Kathryn W ^a   Seehra, Jasbir ^a   Kumar, Ravindra ^a   Grinberg, Asya V ^a  

^a Acceleron Pharma   (United States)

^b Eleven Biotherapeutics   (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-ANGIOGENIC THERAPY; CANCER THERAPEUTICS; CLINICAL TRIAL; EXTRACELLULAR DOMAINS; HIGH AFFINITY; HIGH SPECIFICITY; RECEPTOR BINDING; RECEPTOR-LIGAND INTERACTIONS; RECEPTOR-LIKE KINASE; SIGNALING COMPLEX; SIGNALING PATHWAYS; STRUCTURAL BASIS; TERNARY COMPLEX; THERAPEUTIC TARGETS; THERMO DYNAMIC ANALYSIS; TUMOR ANGIOGENESIS; TYPE II; VESSEL DEVELOPMENT;

BLOOD VESSELS; ENDOTHELIAL CELLS; ENZYMES; GLYCOPROTEINS; THERMOANALYSIS;

SIGNALING;

ACTIVIN RECEPTOR 2A; ACTIVIN RECEPTOR 2B; ACTIVIN RECEPTOR LIKE KINASE 1; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 10; BONE MORPHOGENETIC PROTEIN 9; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; COMPLEX FORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME SPECIFICITY; ENZYME STRUCTURE; EXPRESSION VECTOR; HUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; RECEPTOR AFFINITY; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; THERMODYNAMICS;

ACTIVIN RECEPTORS, TYPE II; ANGIOGENESIS INHIBITORS; BONE MORPHOGENETIC PROTEINS; CRYSTALLOGRAPHY, X-RAY; GROWTH DIFFERENTIATION FACTORS; HEK293 CELLS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 84864990335     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.377960     Document Type: Article

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