Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: Design, synthesis, and mechanistic studies

Journal of Medicinal Chemistry

Volumn 55, Issue 15, 2012, Pages 6751-6761

  Yang, Xiaoming ^a   Shi, Qian ^a   Lai, Chin Yu ^c   Chen, Chi Yuan ^b   Ohkoshi, Emika ^a   Yang, Shuenn Chen ^b   Wang, Chih Ya ^a   Bastow, Kenneth F ^a   Wu, Tian Shung ^d   Pan, Shiow Lin ^c   Teng, Che Ming ^c   Yang, Pan Chyr ^b,c,d   Lee, Kuo Hsiung ^a,e  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c Institute of Clinical Pharmacy and Pharmaceutical Sciences   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

11 OXO 14 HYDROXYLCRYPTOPLEURINE; 12 HYDROXYANTOFINE; 12 HYDROXYCRYPTOPLEURINE; 12 METHOXYANTOFINE 12 ENE; 12 OXOANTOFINE; 12 OXOCRYPTOPLEURINE; 12,13 DIHYDROXYCRYPTOPLEURINE; 13 ETHYL 13 HYDROXYCRYPTOPLEURINE; 13 HYDROXYANTOFINE; 13 HYDROXYCRYPTOPLEURINE; 13 METHOXYCRYPTOPLEURINE; 13 OXOCRYPTOPLEURINE; ANTINEOPLASTIC AGENT; ANTOFINE; ANTOFINE DERIVATIVE; BETA CATENIN; CRYPTOPLEURINE; CRYPTOPLEURINE DERIVATIVE; HEAT SHOCK PROTEIN 90; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARCINOGENESIS; CELL STRUCTURE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG CONFORMATION; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROXYLATION; IC 50; ISOMER; LUNG NON SMALL CELL CANCER; STRUCTURE ACTIVITY RELATION;

ADENOCARCINOMA; ALKALOIDS; ANTINEOPLASTIC AGENTS; BETA CATENIN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HSP90 HEAT-SHOCK PROTEINS; HUMANS; INDOLES; LUNG NEOPLASMS; PHENANTHROLINES; QUINOLIZIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84864960006     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm3001218     Document Type: Article

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