Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents

Journal of Medicinal Chemistry

Volumn 50, Issue 15, 2007, Pages 3674-3680

  Wei, Linyi ^a   Shi, Qian ^b   Bastow, Kenneth F ^a   Brossi, Arnold ^a   Morris Natschke, Susan L ^a   Nakagawa Goto, Kyoko ^a   Wu, Tian Shung ^c   Pan, Shiow Lin ^d   Teng, Che Ming ^d   Lee, Kuo Hsiung ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b AndroScience Corporation   (United States)

^c NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4 PIPERIDINEETHANOL; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4 PIPERIDINEMETHANOL; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 6 AMINOHEXANOL; PHENANTHRENE DERIVATIVE; TYLOPHORINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER MODEL; CELL STRAIN KB; CONTROLLED STUDY; CULTURE MEDIUM; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; EVALUATION; HUMAN; HUMAN CELL; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; NUDE MOUSE; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; SCID MOUSE; STRUCTURE ANALYSIS; TUMOR XENOGRAFT;

ALKALOIDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLIZINES; MALE; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHENANTHRENES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 34547610794     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061366a     Document Type: Article

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