Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5262-5268

  Yang, Xiaoming ^a   Shi, Qian ^a   Liu, Yi Nan ^a   Zhao, Guiyu ^a   Bastow, Kenneth F ^a   Lin, Jau Chen ^b   Yang, Shuenn Chen ^b   Yang, Pan Chyr ^c   Lee, Kuo Hsiung ^a  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 METHYLENEDIOXY 6 METHOXY 9 BROMOMETHYLPHENANTHRENE; 2,3 METHYLENEDIOXY 6 METHOXY 9 HYDROXYLMETHYLPHENANTHRENE; 2,3 METHYLENEDIOXY 6 METHOXYPHENANTHRENE 9 CARBOXYLIC ACID METHYL ESTER; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 3' AMINOMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 3' AMINOPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 3' HYDROXYLMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 3' N BUTYLOXYCARBONYLAMINOMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 3' N BUTYLOXYCARBONYLAMINOPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 3' PIPERIDONE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' AMINOMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' AMINOPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' CYANOPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' HYDROXYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' METHANESULFONYLAMINOMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' N BUTYLOXYCARBONYLAMINOMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' N BUTYLOXYCARBONYLAMINOPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' PIPERIDONE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' PIPERIDONE 3' CARBOXYLIC ACID METHYL ESTER; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL) 4' TRIFLUOROMETHYLPIPERIDINE; N (2,3 METHYLENEDIOXY 6 METHOXYPHENANTHR 9 YLMETHYL)PIPERIDINE 3' CARBOXYLIC ACID METHYL ESTER; PHENANTHRENE DERIVATIVE; PROTEIN KINASE B; TYLOPHORINE; TYLOPHORINE DERIVATIVE; UNCLASSIFIED DRUG; YXM 35; YXM 41; YXM 43; YXM 44;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INDOLIZINES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NF-KAPPA B; PHENANTHRENES; PHENANTHROLINES; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69049104190     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9009263     Document Type: Article

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