Adenosine A2A receptor gene disruption provokes marked changes in melanocortin content and pro-opiomelanocortin gene expression

Journal of Neuroendocrinology

Volumn 15, Issue 12, 2003, Pages 1171-1177

  Jégou, Sylvie ^a   El Yacoubi, M ^a   Mounien, L ^a   Ledent, C ^b   Parmentier, M ^b   Costentin, J ^a   Vaugeois, J M ^a   Vaudry, H ^a  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

A2A receptors; ACTH; Adenosine; POMC; MSH

Indexed keywords

ADENOSINE; ADENOSINE A2A RECEPTOR; ALPHA INTERMEDIN; CORTICOSTERONE; CORTICOTROPIN; MELANOCORTIN; MESSENGER RNA; PROOPIOMELANOCORTIN;

ADENOHYPOPHYSIS; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; BRAIN REGION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; GENE DISRUPTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HORMONE RELEASE; HYPOPHYSIS ADRENAL SYSTEM; HYPOPHYSIS CELL; HYPOTHALAMUS; MALE; MEDULLA OBLONGATA; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PERIKARYON; PRIORITY JOURNAL; ANIMAL; CYTOLOGY; GENETICS; METABOLISM; MOUSE MUTANT; MOUSE STRAIN; PHYSIOLOGY;

ALPHA-MSH; ANIMALS; GENE EXPRESSION; HYPOTHALAMUS; MALE; MEDULLA OBLONGATA; MICE; MICE, INBRED STRAINS; MICE, KNOCKOUT; PITUITARY GLAND, ANTERIOR; PRO-OPIOMELANOCORTIN; RECEPTOR, ADENOSINE A2A; RNA, MESSENGER;

EID: 0348013206     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2003.01116.x     Document Type: Article

References (60)

1. Daval JL, Nehlig A, Nicolas F. Physiological and pharmacological properties of adenosine: therapeutic implications. Life Sci 1991; 49: 1435 1453.
2. Collis MG, Hourani SM. Adenosine receptor subtypes. Trends Pharmacol Sci 1993; 14: 360-366.
3. Fredholm BB. Adenosine receptors in the central nervous system. News Physiol Sci 1995; 10: 122-128.
4. 2-adenosine receptor subtype. Mol Endocrinol 1992; 6: 384-393.
5. 1-adenosine receptor that is widely expressed in brain and spinal cord. Mol Endocrinol 1991; 5: 1037-1048.
6. Fredholm BB, Ijzerman AP, Jacobson KA, Klotz KN, Linden J. Nomenclature and classification of adenosine receptors. Pharmacol Rev 2001; 53: 527-552.
7. 3H]CGS 21680. Eur J Pharmacol 1989; 168: 243-346.
8. 2 receptors in the rat hippocampus. Neurosci Lett 1992; 138: 41-44.
9. Barraco RA, El-Ridi MR, Ergene E, Phillis JW. Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns. Brain Res Bull 1991; 26: 59-84.
10. 3H]-CGS 21680 binding sites in the rat striatum and cortex. Br J Pharmacol 1995; 114: 537-543.
11. Dixon AK, Gubitz AK, Sirinathsinghji DJS, Richardson PJ, Freeman TC. Tissue distribution of adenosine receptor mRNA in the rat. Br J Pharmacol 1996; 118: 1461-1468.
12. 2 adenosine receptors: their presence and neuromodulatory role in the central nervous system. Gen Pharmacol 1996; 27: 925-933.
13. Fredholm BB. Adenosine, adenosine receptors and the actions of caffeine. Pharmacol Toxicol 1995; 76: 93-101.
14. 2 receptors regulate the gene expression of striatopallidal and striatonigral neurons. J Neurosci 1993; 13: 1080-1087.
15. 2a receptor. Nature 1997; 388: 674-678.
16. Gramsch C, Kleber G, Höllt V, Pasi A, Mehraein P, Herz A. Proopiocortin fragments in human and rat brain. β-endorphin and α-MSH are predominant peptides. Brain Res 1980; 192: 109-119.
17. Patterson AT, Rickerby J, Simpson J, Vickers C. α-MSH and the pineal in the control of territorial aggression. J Physiol 1978; 285: 45P.
18. File SE. Contrasting effects of ORG 2766 and α-MSH on social and exploratory behavior in the rat. Peptides 1981; 2: 255-260.
19. Gonzales MI, Vaziri S, Wilson CA. Behavioral effects of α-MSH and MCH after central administration in the female rat. Peptides 1996; 17: 171-177.
20. Jacobovitz DM, O'Donohue TI. α-Melanocyte-stimulating hormone: immunocytochemical identification and mapping in neurons of the rat brain. Proc Natl Acad Sci USA 1978; 75: 6300-6304.
21. Joseph SA, Pilcher WH, Bennett-Clarke C. Immunocytochemical localization of ACTH perikarya in nucleus tractus solitarius: evidence for a second opiocortin neuronal system. Neurosci Lett 1983; 38: 221-225.
22. Umegaki K, Shiosaka S, Kawai Y, Shinoda K, Yagura A, Shibasaki T, Ling N, Tohyama M. The distribution of alpha-melanocyte stimulating hormone (alpha-MSH) in the central nervous system of the rat: an immunohistochemical study - I. Forebrain and upper brainstem. Cell Mol Biol 1983; 29: 377-386.
23. Gee CE, Chen CLC, Roberts JL, Thompson R, Watson SJ. Identification of pro-opiomelanocortin neurons in rat hypothalamus by in situ cDNA-mRNA hybridization. Nature 1983; 306: 374-376.
24. Anand-Srivastava MB, Gutowska J, Cantin M. Adenosine-sensitive adenylate cyclase in rat pituitary. Neuroendocrinology 1985; 41: 110-115.
25. Anand-Srivastava MB, Cantin M, Gutowska J. Adenosine regulates the release of adrenocorticotropic hormone (ACTH) from cultured anterior pituitary cells. Mol Cell Biochem 1989; 89: 21-28.
26. Scaccianoce S, Navarra D, Di Sciullo AD, Angelucci L, Endröczi E. Adenosine and pituitary-adrenocortical axis activity in the rat. Neuroendocrinology 1989; 50: 464-468.
27. 1 adenosine receptors negatively coupled to adenylate cyclase. J Neuroendocrinol 1992; 4: 751-757.
28. 1 purinergic receptors. J Physiol 1994; 481: 349-355.
29. 2a adenosine receptor gene expression in developing rat brain. Mol Brain Res 1993; 20: 313-327.
30. Vaudry H, Tonon MC, Delarue C, Vaillant R, Kraicer J. Biological and radioimmunological evidence for melanocyte-stimulating hormone (MSH) of extrapituitary origin in the rat brain. Neuroendocrinology 1978; 27: 9-24.
31. A receptors on proopiomelanocortin-producing neurons in the rat hypothalamus. Endocrinology 1994; 135: 2759-2764.
32. Leboulenger F, Delarue C, Belanger A, Perroteau I, Netchitailo P, Leroux P, Jégou S, Tonon MC, Vaudry H. Direct radioimmunoassays for plasma corticosterone and aldosterone in frog. I. Validation of the methods and evidence for daily rhythms in a natural environment. Gen Comp Endocrinol 1982; 45: 521-532.
33. Fodor M, Csaba Z, Epelbaum J, Vaudry H, Jégou S. Interrelations between hypothalamic somatostatin and proopiomelanocortin neurons. J Neuroendocrinol 1998; 10: 75-78.
34. Pelletier G. Regulation of proopiomelanocortin gene expression in rat brain and pituitary as studied by in situ hybridization. Ann NY Acad Sci 1993; 680: 246-259.
35. Jégou S, Blasquez C, Delbende C, Tranchand-Bunel D, Vaudry H. Regulation of α-melanocyte-stimulating hormone release from hypothalamic neurons. Ann NY Acad Sci 1993; 680: 260-278.
36. 2A receptors in the rat central nervous system. J Comp Neurol 1998; 401: 163-186.
37. 3H]-CGS 21680 as a ligand. Naunyn Schmiedeberg's Arch Pharmacol 1990; 342: 85-89.
38. 2 receptor-mediated excitatory actions on the nervous system. Prog Neurobiol 1996; 48: 167-189.
39. 2A receptor stimulation enhances striatal extracellular glutamate levels in rats. Eur J Pharmacol 1995; 287: 215-217.
40. Tranchand Bunel D, Delbende C, Blasquez C, Jégou S, Vaudry H. Characterization of α-melanocyte-stimulating hormone (α-MSH)-like peptides in discrete regions of the rat brain. In vitro release of α-MSH from perifused hypothalamus and amygdala. Brain Res 1990; 513: 299-307.
41. 3H]CGS 21680 to rat brain using autoradiography. Neuropharmacology 1995; 34: 393-403.
42. Svenningsson P, Hall H, Sedvall G, Fredholm BB. Distribution of adenosine receptors in the postmortem humain brain: an extended autoradiographic study. Synapse 1997; 27: 322-335.
43. 3H]SCH 58261. Eur J Neurosci 2001; 14: 1567-1570.
44. Kozasa K, Nakai Y. Electron-microscopic cytochemistry of the catecholaminergic innervation of ACTH-containing neurons in the rat hypothalamic arcuate nucleus. Acta Anat 1987; 128: 243-249.
45. Horvath TL, Naftolin F, Leranth C. GABAergic and catecholaminergic innervation of mediobasal hypothalamic β-endorphin cells projecting to the medial preoptic area. Neuroscience 1992; 51: 391-399.
46. Hisano S, Okamura Y, Daikoku S. Synaptic regulation of hypothalamic neurons containing ACTH by substance P. Brain Res 1984; 308: 162-165.
47. Zhang R, Hisano S, Chikamori-Aoyama M, Daikoku S. Synaptic association between enkephalin-containing axon terminals and proopiomelanocortin-containing neurons in the arcuate nucleus of rat hypothalamus. Neurosci Lett 1987; 82: 151-156.
48. Tiligada E, Wilson JF. Ionic, neuronal and endocrine influences on the proopiomelanocortin system of the hypothalamus. Life Sci 1990; 46: 81-90.
49. Clarke A, File SE. Social and exploratory behaviour in the rat after septal administration of ORG 2766 and ACTH 4-10. Psychoneuroendocrinology 1983; 8: 343-350.
50. Tizabi Y, O'Donohue TL, Jacobowitz DM. Changes in α-melanotropin in discrete brain areas of isolated aggressive mice. Peptides 1982; 3: 429-431.
51. Wolterink G, Van Ree JM. Opioid systems in the amygdala can serve as substrate for the behavioral effects of ACTH-(4-9) analog ORG 2766. Neuropeptides 1989; 14: 129-136.
52. Holsboer F, Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev 1996; 17: 187-205.
53. Landgraf R, Wigger A, Holsboer F, Neumann ID. Hyper-reactive hypothalamo-pituitary-adrenocortical axis in rats bred for high anxiety-related behaviour. J Neuroendocrinol 1999; 11: 405-407.
54. Szabo J, Kosa E, Toth IE, Bruckner GG. Effect of adenosine and its metabolites on the hypothalamo-pituitary-adrenal axis. Nutrit Biochem 1995; 6: 334-339.
55. Kumari M, Cover OO, Poyser RH, Buckingham JC. Stimulation of the hypothalamo-pituitary-adrenal axis in the rat by three selective type-4 phosphodiesterase inhibitors: in vitro and in vivo studies. Br J Pharmacol 1997; 121: 459-468.
56. Przegalinski E, Budziszewska B, Grochmal A. Effect of adenosine analogues on plasma corticosterone concentration in rats. Acta Endocrinol 1992; 127: 471-475.
57. Bonifacj JF, Hasni H, Laborit H. Action of N6 (amido-3-propyl) adenosine hydrochloride (Agr 529) on plasma corticostrone levels in rats. Res Commun Chem Pathol Pharmacol 1990; 68: 299-305.
58. 2B adenosine receptors. Endocrinology 2002; 143: 2427-2436.
59. Nicholson SA. The effect of caffeine on plasma corticosterone and pituitary adrenocorticotrophin release in the rat is antagonized by adenosine. J Physiol 1987; 394: 32P.
60. Nicholson SA. Stimulatory effect of caffeine on the hypothalamo-pituitary-adrenocortical axis in the rat. J Endocrinol 1989; 122: 535-543.