N-O-Isopropyl sulfonamido-based hydroxamates: Kinetic characterisation of a series of MMP-12/MMP-13 dual target inhibitors

Biochemical Pharmacology

Volumn 84, Issue 6, 2012, Pages 813-820

  Santamaria, Salvatore ^a,d,e   Nuti, Elisa ^a   Cercignani, Giovanni ^a,b   Marinelli, Luciana ^c   La Pietra, Valeria ^c   Novellino, Ettore ^c   Rossello, Armando ^a  

^a UNIVERSITY OF PISA   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Enzyme kinetics; Matrix metalloproteinase; MMP 12; MMP 13; Rheumatoid arthritis; Slow binding inhibition

Indexed keywords

COLLAGENASE 3; GELATINASE A; HYDROXAMIC ACID DERIVATIVE; INTERSTITIAL COLLAGENASE; MACROPHAGE ELASTASE; MATRILYSIN; METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; RECOMBINANT PROTEIN; STROMELYSIN; SULFONAMIDE;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL;

HUMANS; HYDROXAMIC ACIDS; KINETICS; MATRIX METALLOPROTEINASE 12; MATRIX METALLOPROTEINASE 13; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84864942604     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.06.026     Document Type: Article

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