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Journal of the American Chemical Society

Volumn 124, Issue 37, 2002, Pages 11004-11007

The active site of a zinc-dependent metalloproteinase influences the computed pKa of ligands coordinated to the catalytic zinc ion

(4) Cross, Jason B a,b Duca, José S a Kaminski, James J a Madison, Vincent S a

a MERCK RESEARCH LABORATORIES (United States)

b WAYNE STATE UNIVERSITY (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIGANDS;

CARBOXYLIC ACIDS; CATALYST ACTIVITY; ONCOLOGY; PROTEINS; ZINC;

ENZYMES;

CARBOXYLIC ACID; HYDROXAMIC ACID; METALLOPROTEINASE; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; ZINC;

ARTICLE; CATALYSIS; DENSITY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; MODEL; PKA; PREDICTION; PROTON TRANSPORT; REACTION ANALYSIS; STRUCTURE ANALYSIS;

ADAM PROTEINS; BINDING SITES; CATIONS; ENZYME INHIBITORS; HYDROXAMIC ACIDS; KINETICS; LIGANDS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; THERMODYNAMICS; ZINC;

EID: 0037130658 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja0201810 Document Type: Article

Times cited : (83)

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