T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: The association with free fatty acids composition

Physiological Research

Volumn 61, Issue 3, 2012, Pages 229-240

  Vcelak J ^a   Vejrazkova D ^a   Vankova M ^a   Lukasova P ^a   Bradnova O ^a   Halkova T ^a   Bestak J ^a   Andelova K ^b   Kvasnickova H ^a   Hoskovcova P ^a   Vondra, K ^a   Vrbikova J ^a   Bendlova B ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

^b INSTITUTE FOR THE CARE OF MOTHER AND CHILD   (Czech Republic)

Author keywords

Diabetes risk; Free fatty acids; Genetics; Gestational diabetes; Haplotypes; Polycystic ovary syndrome; Polyunsaturated fatty acids; TCF7L2; Type 2 diabetes

Indexed keywords

BIOLOGICAL MARKER; FATTY ACID; TCF7L2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLOOD; CHI SQUARE DISTRIBUTION; COMPARATIVE STUDY; CZECH REPUBLIC; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; HAPLOTYPE; HUMAN; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OVARY POLYCYSTIC DISEASE; PHENOTYPE; PREGNANCY; PREGNANCY DIABETES MELLITUS; RISK; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CHI-SQUARE DISTRIBUTION; CZECH REPUBLIC; DIABETES MELLITUS, TYPE 2; DIABETES, GESTATIONAL; FATTY ACIDS, NONESTERIFIED; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PHENOTYPE; POLYCYSTIC OVARY SYNDROME; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; RISK ASSESSMENT; RISK FACTORS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN;

EID: 84864917938     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. BARBER TM, BENNETT AJ, GROVES CJ, SOVIO U, RUOKONEN A, MARTIKAINEN H, POUTA A, HARTIKAINEN AL, ELLIOTT P, WASS JA, JARVELIN MR, ZEGGINI E, FRANKS S, MCCARTHY MI: Disparate genetic influences on polycystic ovary syndrome (PCOS) and type 2 diabetes revealed by a lack of association between common variants within the TCF7L2 gene and PCOS. Diabetologia 50: 2318-2322, 2007.
2. BARRETT JC, FRY B, MALLER J, DALY MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265, 2005.
3. BIELINSKI SJ, PANKOW JS, FOLSOM AR, NORTH KE, BOERWINKLE E: TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study. Diabetologia 51: 968-970, 2008.
4. BIYASHEVA A, LEGRO RS, DUNAIF A, URBANEK M: Evidence for association between polycystic ovary syndrome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. J Clin Endocrinol Metab 94: 2617-2625, 2009.
5. BLAHA P: ANTROPO - ein Programm fur automatische Bearbeitung anthopologischer Daten. Wiss Z Humboldt-Univ Berlin 5: 153-156, 1991.
6. CAUCHI S, FROGUEL P: TCF7L2 genetic defect and type 2 diabetes. Curr Diab Rep 8: 149-155, 2008.
7. CAUCHI S, MEYRE D, DINA C, CHOQUET H, SAMSON C, GALLINA S, BALKAU B, CHARPENTIER G, PATTOU F, STETSYUK V, SCHARFMANN R, STAELS B, FRUHBECK G, FROGUEL P: Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55: 2903-2908, 2006.
8. CHAUHAN G, SPURGEON CJ, TABASSUM R, BHASKAR S, KULKARNI SR, MAHAJAN A, CHAVALI S, KUMAR MV, PRAKASH S, DWIVEDI OP, GHOSH S, YAJNIK CS, TANDON N, BHARADWAJ D, CHANDAK GR: Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians. Diabetes 59: 2068-2074, 2010.
9. CRUZ M, VALLADARES-SALGADO A, GARCIA-MENA J, ROSS K, EDWARDS M, ANGELES-MARTINEZ J, ORTEGA-CAMARILLO C, DE LA PENA JE, BURGUETE-GARCIA AI, WACHER-RODARTE N, AMBRIZ R, RIVERA R, D'ARTOTE A.L, PERALTA J, PARRA EJ, KUMATE J: Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City. Diabetes Metab Res Rev 26: 261-270, 2010.
10. DE SILVA NM, STEELE A, SHIELDS B, KNIGHT B, PARNELL K, WEEDON MN, HATTERSLEY AT, FRAYLING TM: The transcription factor 7-like 2 (TCF7L2) gene is associated with Type 2 diabetes in UK community-based cases, but the risk allele frequency is reduced compared with UK cases selected for genetic studies. Diabet Med 24: 1067-1072, 2007.
11. DELGADO-LISTA J, PEREZ-MARTINEZ P, GARCÍA-RIOS A, PHILLIPS CM, WILLIAMS CM, GULSETH HL, HELAL O, BLAAK EE, KIEC-WILK B, BASU S, DREVON CA, DEFOORT C, SARIS WH, WYBRANSKA I, RISERUS U, LOVEGROVE JA, ROCHE HM, LOPEZ-MIRANDA J: Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: from the LIPGENE study. Atherosclerosis 214: 110-116, 2011.
12. EREQAT S, NASEREDDIN A, CAUCHI S, AZMI K, ABDEEN Z, AMIN R: Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in the Palestinian population. Acta Diabetol 47: 195-198, 2010.
13. ROTTERDAM ESHRE/ASRM-SPONSORED PCOS CONSENSUS WORKSHOP GROUP: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81: 19-25, 2004.
14. FLOREZ JC, JABLONSKI KA, BAYLEY N, POLLIN TI, DE BAKKER PI, SHULDINER AR, KNOWLER WC, NATHAN DM, ALTSHULER D; DIABETES PREVENTION PROGRAM RESEARCH GROUP: TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program. N Engl J Med 355: 241-250, 2006.
15. GAMBINO R, BO S, GENTILE L, MUSSO G, PAGANO G, CAVALLO-PERIN P, CASSADER M: Transcription factor 7-like 2 (TCF7L2) polymorphism and hyperglycemia in an adult Italian population-based cohort. Diabetes Care 33: 1233-1235, 2010.
16. GUSTAFSON B, SMITH U: WNT signalling is both an inducer and effector of glucagon-like peptide-1. Diabetologia 51: 1768-1770, 2008.
17. HUERTAS-VAZQUEZ A, PLAISIER C, WEISSGLAS-VOLKOV D, SINSHEIMER J, CANIZALES-QUINTEROS S, CRUZ-BAUTISTA I, NIKKOLA E, HERRERA-HERNANDEZ M, DAVILA-CERVANTES A, TUSIELUNA T, TASKINEN MR, AGUILAR-SALINAS C, PAJUKANTA P: TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia. Diabetologia 51: 62-69, 2008.
18. HUSEK P, SIMEK P, TVRZICKA E: Simple and rapid procedure for the determination of individual free fatty acids in serum. Anal Chim Acta 465: 433-439, 2002.
19. LAUENBORG J, GRARUP N, DAMM P, BORCH-JOHNSEN K, JORGENSEN T, PEDERSEN O, HANSEN T: Common type 2 diabetes risk gene variants associate with gestational diabetes. J Clin Endocrinol Metab 94: 145-150, 2009.
20. LEE SH, DEMETERCO C, GERON I, ABRAHAMSSON A, LEVINE F, ITKIN-ANSARI P: Islet specific Wnt activation in human type II diabetes. Exp Diabetes Res 2008: Article ID:728763, 2008.
21. LIN Y, LI P, CAI L, ZHANG B, TANG X, ZHANG X, LI Y, XIAN Y, YANG Y, WANG L, LU F, LIU X, RAO S, CHEN M, MA S, SHI Y, BAO M, WU J, YANG Y, YANG J, YANG Z: Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population. BMC Med Genet 11: 97, 2010.
22. LYSSENKO V, LUPI R, MARCHETTI P, DEL GUERRA S, ORHO-MELANDER M, ALMGREN P, SJOGREN M, LING C, ERIKSSON KF, LETHAGEN AL, MANCARELLA R, BERGLUND G, TUOMI T, NILSSON P, DEL PRATO S, GROOP L: Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117: 2155-2163, 2007.
23. MARTÍN DE SANTA OLALLA L, SÁNCHEZ MUNIZ FJ, VAQUERO MP: N-3 fatty acids in glucose metabolism and insulin sensitivity. Nutr Hosp 24: 113-127, 2009.
24. OSMARK P, HANSSON O, JONSSON A, RONN T, GROOP L, RENSTROM E: Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. Diabetologia 52: 850-854, 2009.
25. PALMER ND, HESTER JM, AN SS, ADEYEMO A, ROTIMI C, LANGEFELD CD, FREEDMAN BI, NG MC, BOWDEN DW: Re-sequencing and analysis of variation in the TCF7L2 gene in African Americans suggests the SNP rs7903146 is the causal diabetes susceptibility variant. Diabetes 60: 662-668, 2010.
26. PAPADOPOULOU S, EDLUND H: Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function. Diabetes 54: 2844-2851, 2007.
27. PAPPA KI, GAZOULI M, ECONOMOU K, DASKALAKIS G, ANASTASIOU E, ANAGNOU NP, ANTSAKLIS A: Gestational diabetes mellitus shares polymorphisms of genes associated with insulin resistance and type 2 diabetes in the Greek population. Gynecol Endocrinol 27: 267-272, 2010.
28. PEARSON ER: Translating TCF7L2: from gene to function. Diabetologia 52: 1227-1230, 2009.
29. PEREZ-MARTINEZ P, DELGADO-LISTA J, PEREZ-JIMENEZ F, LOPEZ-MIRANDA J: Update on genetics of postprandial lipemia. Atheroscler Suppl 11: 39-43, 2010.
30. SANGHERA DK, NATH SK, ORTEGA L, GAMBARELLI M, KIM-HOWARD X, SINGH JR, RALHAN SK, WANDER GS, MEHRA NK, MULVIHILL JJ, KAMBOH MI: TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels. Ann Hum Genet 72: 499-509, 2008.
31. SHAAT N, LERNMARK A, KARLSSON E, IVARSSON S, PARIKH H, BERNTORP K, GROOP L: A variant in the transcription factor 7-like 2 (TCF7L2) gene is associated with an increased risk of gestational diabetes mellitus. Diabetologia 50: 972-979, 2007.
32. SMITH U: TCF7L2 and type 2 diabetes - we WNT to know. Diabetologia 50: 5-7, 2007. STEPHENS M, DONNELLY P: A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169, 2003.
33. STEPHENS M, DONNELLY P: A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73:1162-1169, 2003.
34. TONG Y, LIN Y, ZHANG Y, YANG J, ZHANG Y, LIU H, ZHANG B: Association between TCF7L2 gene polymorphisms and susceptibility to Type 2 Diabetes Mellitus: a large HuGE review and meta-analysis. BMC Med Genet 10: 10-15, 2009.
35. UNITED KINGDOM PROSPECTIVE DIABETES STUDY GROUP: Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352: 837-853, 1998.
36. VILLAREAL DT, ROBERTSON H, BELL GI, PATTERSON BW, TRAN H, WICE B, POLONSKY KS: TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes 59: 479-485, 2010.
37. WARODOMWICHIT D, ARNETT DK, KABAGAMBE EK, TSAI MY, HIXSON JE, STRAKA RJ, PROVINCE M, AN P, LAI CQ, BORECKI I, ORDOVAS JM: Polyunsaturated fatty acids modulate the effect of TCF7L2 gene variants on postprandial lipemia. J Nutr 139: 439-446, 2009.
38. WEN J, RONN T, OLSSON A, YANG Z, LU B, DU Y, GROOP L, LING C, HU R: Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS One 5: e9153, 2010.
39. WORLD HEALTH ORGANIZATION EXPERT COMMITTEE: Definition, diagnosis and classification of diabetes mellitus and its complications. Report of a WHO Consultation, Part 1: Diagnosis and Classification of Diabetes Mellitus. World Health Organization, Geneva, 1999.
40. YAN Y, NORTH KE, BALLANTYNE CM, BRANCATI FL, CHAMBLESS LE, FRANCESCHINI N, HEISS G, KOTTGEN A, PANKOW JS, SELVIN E, WEST SL, BOERWINKLE E: Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study. Diabetes 58: 285-289, 2009.
41. ZEGGINI E, MCCARTHY MI: TCF7L2: the biggest story in diabetes genetics since HLA? Diabetologia 50: 1-4, 2007.