TCF7L2 is associated with high serum triacylglycerol and differentially expressed in adipose tissue in families with familial combined hyperlipidaemia

Diabetologia

Volumn 51, Issue 1, 2008, Pages 62-69

  Huertas Vazquez, A ^a   Plaisier, C ^a   Weissglas Volkov, D ^a   Sinsheimer, J ^a   Canizales Quinteros, S ^b   Cruz Bautista, I ^c   Nikkola, E ^a   Herrera Hernandez, M ^c   Davila Cervantes, A ^c   Tusie Luna, T ^b   Taskinen, M R ^d   Aguilar Salinas, C ^c   Pajukanta, P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

Author keywords

Association; Familial combined hyperlipidaemia; Gene expression; TCF7L2; Triacylglycerol

Indexed keywords

APOLIPOPROTEIN B; CHOLESTEROL; GLUCOSE; MESSENGER RNA; TRANSCRIPTION FACTOR 7; TRIACYLGLYCEROL;

ADIPOSE TISSUE; ADULT; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; FAMILIAL HYPERLIPEMIA; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEXICO; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL;

APOLIPOPROTEINS B; CHOLESTEROL; FAMILY HEALTH; FEMALE; FINLAND; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; HUMANS; HYPERLIPIDEMIAS; MALE; MEXICO; POLYMORPHISM, SINGLE NUCLEOTIDE; TCF TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 36649027501     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0850-6     Document Type: Article

References (33)

1. Grant SF, Thorleifsson G, Reynisdottir I et al (2006) Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 38:320-323
2. Groves CJ, Zeggini E, Minton J et al (2006) Association analysis of 6,736 UK subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk. Diabetes 55:2640-2644
3. Scott LJ, Bonnycastle LL, Willer CJ et al (2006) Association of transcription factor 7-like 2 (TCF7L2) variants with type 2 diabetes in a Finnish sample. Diabetes 55:2649-2653
4. Humphries SE, Gable D, Cooper JA et al (2006) Common variants in the TCF7L2 gene and predisposition to type 2 diabetes in UK European whites, Indian Asians and Afro-Caribbean men and women. J Mol Med 84(12 Suppl):1-10
5. Cauchi S, Meyre D, Dina C et al (2006) Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55:2903-2908
6. Damcott CM, Pollin TI, Reinhart LJ et al (2006) Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance. Diabetes 55:2654-2659
7. Lehman DM, Hunt KJ, Leach RJ et al (2007) Haplotypes of transcription factor 7-like 2 (TCF7L2) gene and its upstream region are associated with type 2 diabetes and age of onset in Mexican Americans. Diabetes 56:389-393
8. Nelson WJ, Nusse R (2004) Convergence of Wnt, beta-catenin, and cadherin pathways. Science 303:1483-1487
9. Clevers H (2006) Wnt/beta-catenin signaling in development and disease. Cell 127:469-480
10. Mani A, Radhakrishnan J, Wang H et al (2007) LRP6 mutation in a family with early coronary disease and metabolic risk factors. Science 315:1278-1282
11. Goldstein JL, Schrott HG, Hazzard WR, Bierman EL, Motulsky AG (1973) Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia. J Clin Invest 52:1544-1568
12. Nikkilä EA, Aro A (1973) Family study of serum lipids and lipoproteins in coronary heart-disease. Lancet 1:954-959
13. Vakkilainen J, Porkka KV, Nuotio I et al (1998) Glucose intolerance in familial combined hyperlipidaemia: EUFAM Study Group. Eur J Clin Invest 28:24-32
14. Huertas-Vazquez A, Aguilar-Salinas C, Lusis AJ et al (2005) Familial combined hyperlipidemia in Mexicans: association with upstream transcription factor 1 and linkage on chromosome 16q24.1. Arterioscler Thromb Vasc Biol 25:1985-1991
15. Weissglas-Volkov D, Huertas-Vazquez A, Suviolahti E et al (2006) Common hepatic nuclear factor-4alpha variants are associated with high serum lipid levels and the metabolic syndrome. Diabetes 55:1970-1977
16. Aguilar-Salinas CA, Olaiz G, Valles V et al (2002) High prevalence of low HDL cholesterol concentrations and mixed hyperlipidemia in a Mexican nationwide survey. J Lipid Res 42:1298-1307
17. American Diabetes Association (2006) Diagnosis and classification of diabetes mellitus. Diabetes Care 29:S43-S48
18. Pajukanta P, Nuotio I, Terwilliger JD et al (1998) Linkage of familial combined hyperlipidemia to chromosome 1q21-q23. Nat Genet 18:369-373
19. Soro A, Pajukanta P, Lilja HE et al (2002) Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families. Am J Hum Genet 70:1333-1340
20. Pajukanta P, Terwilliger JD, Perola M et al (1999) Genomewide scan for familial combined hyperlipidemia genes in Finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels. Am J Hum Genet 64:1453-1463
21. Abecasis GR, Cardon LR, Cookson WO (2000) A general test of association for quantitative traits in nuclear families. Am J Hum Genet 66:279-292
22. Almasy L, Blangero J (1998) Multipoint quantitative trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
23. Havill LM, Dyer TD, Richardson DK, Mahaney MC, Blangero J (2005) The quantitative trait linkage disequilibrium test: a more powerful alternative to the quantitative transmission disequilibrium test for use in the absence of population stratification. BMC Genet 30:1-6
24. Blangero J, Goring HH, Kent JW Jr et al (2005) Quantitative trait nucleotide analysis using Bayesian model selection. Hum Biol 77:541-559
25. Göring HH, Terwilliger JD (2000) Linkage analysis in the presence of error III: marker loci and their map as nuisance parameters. Am J Hum Genet 66:1298-1309
26. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
27. Pajukanta P, Lilja HE, Sinsheimer JS et al (2004) Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1). Nat Genet 36:371-376
28. Naukkarinen J, Gentile M, Soro-Paavonen A et al (2005) USF1 and dyslipidemias: converging evidence for a functional intronic variant. Hum Mol Genet 14:2595-2605
29. Parra EJ, Cameron E, Simmonds L et al (2007) Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City. Clin Genet 71:359-366
30. Scott LJ, Mohlke KL, Bonnycastle LL et al (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 5829:1341-1345
31. Cauchi S, Meyre D, Dina C et al (2006) Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes. Diabetes 55:2903-2908
32. Wang J, Kuusisto J, Vanttinen M et al (2007) Variants of transcription factor 7-like 2 (TCF7L2) gene predict conversion to type 2 diabetes in the Finnish Diabetes Prevention Study and are associated with impaired glucose regulation and impaired insulin secretion. Diabetologia 50:1192-1200
33. Elbein SC, Chu WS, Das SK et al (2007) Transcription factor 7-like 2 polymorphisms and type 2 diabetes, glucose homeostasis traits and gene expression in US participants of European and African descent. Diabetologia 50:1621-1630