A Preliminary Study on the Effect of Manuka Honey on Second-Intention Healing of Contaminated Wounds on the Distal Aspect of the Forelimbs of Horses

Veterinary Surgery

Volumn 40, Issue 7, 2011, Pages 898-902

  Bischofberger, Andrea S ^a   Dart, Christina M ^a   Perkins, Nigel R ^b   Dart, Andrew J ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b AUSVET ANIMAL HEALTH SERVICES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; EQUIDAE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FORELIMB; HONEY; HORSE; HORSE DISEASE; INJURY; MALE; RANDOMIZED CONTROLLED TRIAL; TIME; WOUND HEALING;

ANIMALS; FORELIMB; HONEY; HORSE DISEASES; HORSES; MALE; TIME FACTORS; WOUND HEALING; WOUNDS AND INJURIES;

EID: 84864876082     PISSN: 01613499     EISSN: 1532950X     Source Type: Journal    
DOI: 10.1111/j.1532-950X.2011.00886.x     Document Type: Article

References (31)

1. Bigbie RB, Schumacher J, Swaim SF, et al: Effects of amnion and live yeast-cell derivative on 2nd-intention healing in horses. Am J Vet Res 1991;52:1376-1382
2. Wilmink JM, Stolk PWT, Van Weeren PR, et al: Differences in second-intention wound healing between horses and ponies: macroscopic aspects. Equine Vet J 1999;31:53-60
3. Wilmink JM, Van Weeren PR, Stolk PWT, et al: Differences in second-intention wound healing between horses and ponies: histological aspects. Equine Vet J 1999;31:61-67
4. Wilmink JM, van Weeren PR: Second-intention repair in the horse and pony and management of exuberant granulation tissue. Vet Clin North Am Equine Pract 2005;21:15-32
5. Dart AJ, Perkins NR, Dart CM, et al: Effect of bandaging on second intention healing of wounds of the distal limb in horses. Aust Vet J 2009;87:215-218
6. Farstvedt E, Stashak TS, Othic A: Update on topical wound medications. Clin Tech Equine Pract 2004;3:164-172
7. Dart AJ, Dowling BA, Smith CL: Topical treatments in equine wound management. Vet Clin North Am Equine Pract 2005;21:77-89
8. Majno G: Grease, honey and lint, in The healing hand, man and wound in the ancient days. Cambridge, MA, Harvard University Press, 1975, pp 115-120
9. Molan PC: The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 2006;5:40-54
10. Gethin G, Cowman S: Manuka honey vs. hydrogel-a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs 2009;18:466-474
11. Wijesinghe M, Weatherall M, Perrin K, et al: Honey in the treatment of burns: a systematic review and meta-analysis of its efficacy. N Z Med J 2009;122:47-60
12. Blair S, Cokcetin NN, Harry EJ, et al: The unusual antibacterial activity of medical-grade leptospermum honey: antibacterial spectrum, resistance and transcriptome analysis. Europ J Clin Microbiol Infect Dis 2009;1199-1208.
13. Lusby PE, Coombes AL, Wilkinson JM: Bactericidal activity of different honeys against pathogenic bacteria. Arch Med Res 2005;36:464-467
14. Cooper RA, Halas E, Molan PC: The efficacy of honey in inhibiting strains of Pseudomonas aeruginosa from infected burns. J Burn Care Rehab 2002;23:366-370
15. Majtan J, Kumar P, Majtar T, et al: Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Derm 2010; 19:e73-79
16. Henriques A, Jackson S, Cooper R, et al: Free radical production and quenching in honeys with wound healing potential. J Antimicrobial Chemother 2006;58:773-777
17. Moore OA, Smith LA, Campbell F, et al: Systematic review of the use of honey as a wound dressing. BMC Complement Altern Med 2001;1:2-3
18. Bang LM, Buntting C, Molan P: The effect of dilution on the rate of hydrogen peroxide production in honey and its implications for wound healing. J Altern Complement Med 2003;9:267-273
19. Allen KL, Molan PC, Reid GM: A survey of the antibacterial activity of some New Zealand honeys. J Pharm Pharmacol 1991;43:817-822
20. Mavric E, Wittmann S, Barth G, et al: Identification and quantification of methylglyoxal as the dominant antibacterial constituent of Manuka (Leptospermum scoparium) honeys from New Zealand. Molec Nutrit Food Res 2008;52:483-489
21. Adams CJ, Manley-Harris M, Molan PC: The origin of methylglyoxal in New Zealand manuka (Leptospermum scoparium) honey. Carbohydrate Res 2009;344:1050-1053
22. Snow MJ, Manley-Harris M: On the nature of non-peroxide antibacterial activity in New Zealand manuka honey. Food Chem 2004;84:145-147
23. Tonks A, Cooper RA, Price AJ, et al: Stimulation of TNF-alpha release in monocytes by honey. Cytokine 2001;14:240-242
24. Tonks AJ, Cooper RA, Jones KP, et al: Honey stimulates inflammatory cytokine production from monocytes. Cytokine 2003;21:242-247
25. Tonks AJ, Dudley E, Porter NG, et al: A 5.8-kDa component of manuka honey stimulates immune cells via TLR4. J Leukocyte Biol 2007;82:1147-1155
26. Benjamini, Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Royal Stat Soc 1995;57:289-300
27. Dart AJ, Cries L, Jeffcott LB, et al: Effect of recombinant equine growth hormone on second intention wound healing in horses. Vet Surg 2002;31:314-319
28. Dart AJ, Cries L, Jeffcott LB, et al: Effects of 25% propylene glycol hydrogel (Solugel) on second intention wound healing in horses. Vet Surg 2002;31:309-313
29. Theoret CL: Update on wound repair. Clin Tech Equine Pract 2004;3:110-122.
30. Theoret CL: The pathophysiology of wound repair. Vet Clin North Am Equine Pract 2005;21:1-13
31. Swaim SF, Hinkle SH, Bradley DM: Wound contraction: basic and clinical factors. Compend Contin Educ Pract Vet 2001;23:20-33