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Volumn 51, Issue 1-2, 2012, Pages 12-21

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS

Author keywords

ALS; Diaphragm; Nandrolone; Neuromuscular junction; SOD1G93A mice; Ultrastructure

Indexed keywords

NANDROLON VETRANAL; NANDROLONE; UNCLASSIFIED DRUG;

EID: 84864777689     PISSN: 10447431     EISSN: 10959327     Source Type: Journal    
DOI: 10.1016/j.mcn.2012.07.003     Document Type: Article
Times cited : (32)

References (60)
  • 1
    • 58149170620 scopus 로고    scopus 로고
    • Effect of anabolic steroids on osteoporosis
    • Adachi M., Takayanagi R. Effect of anabolic steroids on osteoporosis. Clin. Calcium 2008, 18(10):1451-1459.
    • (2008) Clin. Calcium , vol.18 , Issue.10 , pp. 1451-1459
    • Adachi, M.1    Takayanagi, R.2
  • 2
    • 0035886428 scopus 로고    scopus 로고
    • Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity
    • Bendotti C., Calvaresi N., Chiveri L., Prelle A., Moggio M., Braga M., Silani V., De Biasi S. Early vacuolization and mitochondrial damage in motor neurons of FALS mice are not associated with apoptosis or with changes in cytochrome oxidase histochemical reactivity. J. Neurol. Sci. 2001, 191(1-2):25-33.
    • (2001) J. Neurol. Sci. , vol.191 , Issue.1-2 , pp. 25-33
    • Bendotti, C.1    Calvaresi, N.2    Chiveri, L.3    Prelle, A.4    Moggio, M.5    Braga, M.6    Silani, V.7    De Biasi, S.8
  • 3
    • 84860683749 scopus 로고    scopus 로고
    • Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: implication for protein aggregation and immune response
    • Bendotti C., Marino M., Cheroni C., Fontana E., Crippa V., Poletti A., De Biasi S. Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: implication for protein aggregation and immune response. Prog. Neurobiol. 2012, 97(2):101-126.
    • (2012) Prog. Neurobiol. , vol.97 , Issue.2 , pp. 101-126
    • Bendotti, C.1    Marino, M.2    Cheroni, C.3    Fontana, E.4    Crippa, V.5    Poletti, A.6    De Biasi, S.7
  • 4
    • 33646452761 scopus 로고    scopus 로고
    • Overload of stable and exclusion of unstable human superoxide dismutase-1 variants in mitochondria of murine amyotrophic lateral sclerosis models
    • Bergemalm D., Jonsson P.A., Graffmo K.S., Andersen P.M., Brannstorm T., Rehnmark A., Marklund S.L. Overload of stable and exclusion of unstable human superoxide dismutase-1 variants in mitochondria of murine amyotrophic lateral sclerosis models. J. Neurosci. 2006, 26(16):4147-4154.
    • (2006) J. Neurosci. , vol.26 , Issue.16 , pp. 4147-4154
    • Bergemalm, D.1    Jonsson, P.A.2    Graffmo, K.S.3    Andersen, P.M.4    Brannstorm, T.5    Rehnmark, A.6    Marklund, S.L.7
  • 6
    • 0035106272 scopus 로고    scopus 로고
    • Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats
    • Blanco C.E., Zhan W.Z., Fang Y.H., Sieck G.C. Exogenous testosterone treatment decreases diaphragm neuromuscular transmission failure in male rats. J. Appl. Physio. 2001, 90:850-856.
    • (2001) J. Appl. Physio. , vol.90 , pp. 850-856
    • Blanco, C.E.1    Zhan, W.Z.2    Fang, Y.H.3    Sieck, G.C.4
  • 7
    • 0036261301 scopus 로고    scopus 로고
    • Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis
    • Chung M.J., Suh Y.L. Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis. Ultrastruct. Pathol. 2002, 26(1):3-7.
    • (2002) Ultrastruct. Pathol. , vol.26 , Issue.1 , pp. 3-7
    • Chung, M.J.1    Suh, Y.L.2
  • 8
    • 79955824241 scopus 로고    scopus 로고
    • The "dying-back" phenomenon of motor neurons in ALS
    • Dadon-Nachum M., Melamed E., Offen D. The "dying-back" phenomenon of motor neurons in ALS. J. Mol. Neurosci. 2011, 43(3):470-477.
    • (2011) J. Mol. Neurosci. , vol.43 , Issue.3 , pp. 470-477
    • Dadon-Nachum, M.1    Melamed, E.2    Offen, D.3
  • 12
    • 79959462293 scopus 로고    scopus 로고
    • Review: the role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis
    • Duffy L.M., Chapman A.L., Shaw P.J., Grierson A.J. Review: the role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol. 2011, 37(4):336-352.
    • (2011) Neuropathol. Appl. Neurobiol. , vol.37 , Issue.4 , pp. 336-352
    • Duffy, L.M.1    Chapman, A.L.2    Shaw, P.J.3    Grierson, A.J.4
  • 13
    • 65949094823 scopus 로고    scopus 로고
    • Neuromuscular junction destruction during amyotrophic lateral sclerosis: insight from transgenic models
    • Dupuis L., Loeffler J.P. Neuromuscular junction destruction during amyotrophic lateral sclerosis: insight from transgenic models. Curr Op Pharmacol. 2009, 9:341-348.
    • (2009) Curr Op Pharmacol. , vol.9 , pp. 341-348
    • Dupuis, L.1    Loeffler, J.P.2
  • 14
    • 80755163102 scopus 로고    scopus 로고
    • Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
    • Ferraiuolo L., Kirby J., Grierson A.J., Sendtner M., Shaw P.J. Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat Rev Neurol. 2011, 7(11):616-630.
    • (2011) Nat Rev Neurol. , vol.7 , Issue.11 , pp. 616-630
    • Ferraiuolo, L.1    Kirby, J.2    Grierson, A.J.3    Sendtner, M.4    Shaw, P.J.5
  • 18
    • 0034175513 scopus 로고    scopus 로고
    • Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases
    • Frey D., Schneider C., Xu L., Borg J., Spooren W., Caroni P. Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases. J. Neurosci. 2000, 20(7):2534-2542.
    • (2000) J. Neurosci. , vol.20 , Issue.7 , pp. 2534-2542
    • Frey, D.1    Schneider, C.2    Xu, L.3    Borg, J.4    Spooren, W.5    Caroni, P.6
  • 22
    • 35349025311 scopus 로고    scopus 로고
    • Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis
    • Hegedus J., Putman C.T., Gordon T. Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis. Neurobiol. Dis. 2007, 28(2):154-164.
    • (2007) Neurobiol. Dis. , vol.28 , Issue.2 , pp. 154-164
    • Hegedus, J.1    Putman, C.T.2    Gordon, T.3
  • 23
    • 48949120504 scopus 로고    scopus 로고
    • Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis
    • Hegedus J., Putman C.T., Tyreman N., Gordon T. Preferential motor unit loss in the SOD1 G93A transgenic mouse model of amyotrophic lateral sclerosis. J. Physiol. 2008, 586(14):3337-3351.
    • (2008) J. Physiol. , vol.586 , Issue.14 , pp. 3337-3351
    • Hegedus, J.1    Putman, C.T.2    Tyreman, N.3    Gordon, T.4
  • 24
    • 77449157694 scopus 로고    scopus 로고
    • Nandrolone: a multi-faceted doping agent
    • Hemmersbach P., Grosse J. Nandrolone: a multi-faceted doping agent. Handb. Exp. Pharmacol. 2010, 195:127-154.
    • (2010) Handb. Exp. Pharmacol. , vol.195 , pp. 127-154
    • Hemmersbach, P.1    Grosse, J.2
  • 26
    • 74049164709 scopus 로고    scopus 로고
    • Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    • Ilieva H., Polymenidou M., Cleveland D.W. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell. Biol. 2009, 187(6):761-772.
    • (2009) J. Cell. Biol. , vol.187 , Issue.6 , pp. 761-772
    • Ilieva, H.1    Polymenidou, M.2    Cleveland, D.W.3
  • 27
    • 39849103473 scopus 로고    scopus 로고
    • Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    • Jaarsma D., Teuling E., Haasdijk E.D., De Zeeuw C.I., Hoogenraad C.C. Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice. J. Neurosci. 2008, 28(9):2075-2088.
    • (2008) J. Neurosci. , vol.28 , Issue.9 , pp. 2075-2088
    • Jaarsma, D.1    Teuling, E.2    Haasdijk, E.D.3    De Zeeuw, C.I.4    Hoogenraad, C.C.5
  • 28
    • 18244390714 scopus 로고    scopus 로고
    • Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis
    • Kaspar B.K., Frost L.M., Christian L., Umapathi P., Gage F.H. Synergy of insulin-like growth factor-1 and exercise in amyotrophic lateral sclerosis. Ann. Neurol. 2005, 57(5):649-655.
    • (2005) Ann. Neurol. , vol.57 , Issue.5 , pp. 649-655
    • Kaspar, B.K.1    Frost, L.M.2    Christian, L.3    Umapathi, P.4    Gage, F.H.5
  • 29
    • 64049091552 scopus 로고    scopus 로고
    • Gene, cell, and axon changes in the familial amyotrophic lateral sclerosis mouse sensorimotor cortex
    • Kassa R.M., Mariotti R., Bonaconsa M., Bertini G., Bentivoglio M. Gene, cell, and axon changes in the familial amyotrophic lateral sclerosis mouse sensorimotor cortex. J. Neuropathol. Exp. Neurol. 2009, 68(1):59-72.
    • (2009) J. Neuropathol. Exp. Neurol. , vol.68 , Issue.1 , pp. 59-72
    • Kassa, R.M.1    Mariotti, R.2    Bonaconsa, M.3    Bertini, G.4    Bentivoglio, M.5
  • 30
    • 0032079517 scopus 로고    scopus 로고
    • Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1
    • Kong J., Xu Z. Massive mitochondrial degeneration in motor neurons triggers the onset of amyotrophic lateral sclerosis in mice expressing a mutant SOD1. J. Neurosci. 1998, 18(9):3241-3250.
    • (1998) J. Neurosci. , vol.18 , Issue.9 , pp. 3241-3250
    • Kong, J.1    Xu, Z.2
  • 33
    • 0032983064 scopus 로고    scopus 로고
    • Alterations in diaphragm contractility after nandrolone administration: an analysis of potential mechanisms
    • Lewis M.I., Fournier M., Yeh A.Y., Micevych P.E., Sieck G.C. Alterations in diaphragm contractility after nandrolone administration: an analysis of potential mechanisms. J. Appl. Physiol. 1999, 86(3):985-992.
    • (1999) J. Appl. Physiol. , vol.86 , Issue.3 , pp. 985-992
    • Lewis, M.I.1    Fournier, M.2    Yeh, A.Y.3    Micevych, P.E.4    Sieck, G.C.5
  • 34
    • 0036087346 scopus 로고    scopus 로고
    • Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone
    • Lewis M.I., Horvitz G.D., Clemmons D.R., Fournier M. Role of IGF-I and IGF-binding proteins within diaphragm muscle in modulating the effects of nandrolone. Am. J. Physiol. Endocrinol. Metab. 2002, 282(2):E483-E490.
    • (2002) Am. J. Physiol. Endocrinol. Metab. , vol.282 , Issue.2
    • Lewis, M.I.1    Horvitz, G.D.2    Clemmons, D.R.3    Fournier, M.4
  • 37
    • 34347355361 scopus 로고    scopus 로고
    • Nandrolone decanoate as anabolic therapy in chronic kidney disease: a randomized phase II dose-finding study
    • Macdonald J.H., Marcora S.M., Jibani M.M., Kumwenda M.J., Ahmed W., Lemmey A.B. Nandrolone decanoate as anabolic therapy in chronic kidney disease: a randomized phase II dose-finding study. Nephron. Clin. Pract. 2007, 106(3):c125-c135.
    • (2007) Nephron. Clin. Pract. , vol.106 , Issue.3
    • Macdonald, J.H.1    Marcora, S.M.2    Jibani, M.M.3    Kumwenda, M.J.4    Ahmed, W.5    Lemmey, A.B.6
  • 38
    • 23044480160 scopus 로고    scopus 로고
    • Adverse effects of anabolic steroid in athletes. A constant threat
    • Maravelias C., Dona A., Stefanidou M., Spiliopoulou C. Adverse effects of anabolic steroid in athletes. A constant threat. Toxicol. Lett. 2005, 158(3):167-175.
    • (2005) Toxicol. Lett. , vol.158 , Issue.3 , pp. 167-175
    • Maravelias, C.1    Dona, A.2    Stefanidou, M.3    Spiliopoulou, C.4
  • 39
    • 0037119407 scopus 로고    scopus 로고
    • Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice
    • Mattiazzi M., D'Aurelio M., Gajewski C.D., Martushova K., Kiaei M., Beal M.F., Manfredi G. Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice. J. Biol. Chem. 2002, 277(33):29626-29633.
    • (2002) J. Biol. Chem. , vol.277 , Issue.33 , pp. 29626-29633
    • Mattiazzi, M.1    D'Aurelio, M.2    Gajewski, C.D.3    Martushova, K.4    Kiaei, M.5    Beal, M.F.6    Manfredi, G.7
  • 41
    • 0036176613 scopus 로고    scopus 로고
    • Mitochondrial involvement in amyotrophic lateral sclerosis
    • Menzies F.M., Ince P.G., Shaw P.J. Mitochondrial involvement in amyotrophic lateral sclerosis. Neurochem. Int. 2002, 40(6):543-551.
    • (2002) Neurochem. Int. , vol.40 , Issue.6 , pp. 543-551
    • Menzies, F.M.1    Ince, P.G.2    Shaw, P.J.3
  • 43
    • 1942452872 scopus 로고    scopus 로고
    • Androgen receptor immunoreactivity in skeletal muscle: enrichment at the neuromuscular junction
    • Monks D.A., O'Bryant E.L., Jordan C.L. Androgen receptor immunoreactivity in skeletal muscle: enrichment at the neuromuscular junction. J. Comp. Neurol. 2004, 473(1):59-72.
    • (2004) J. Comp. Neurol. , vol.473 , Issue.1 , pp. 59-72
    • Monks, D.A.1    O'Bryant, E.L.2    Jordan, C.L.3
  • 45
    • 3242703300 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
    • Pasinelli P., Belford M.E., Lennon N., Bacskai B.J., Hyman B.T., Trotti D., Brown R.H. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 2004, 43(1):19-30.
    • (2004) Neuron , vol.43 , Issue.1 , pp. 19-30
    • Pasinelli, P.1    Belford, M.E.2    Lennon, N.3    Bacskai, B.J.4    Hyman, B.T.5    Trotti, D.6    Brown, R.H.7
  • 46
    • 70449726493 scopus 로고    scopus 로고
    • Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis: longitudinal study
    • Pinto S., Geraldes R., Vaz N., Pinto A., de Carvalho M. Changes of the phrenic nerve motor response in amyotrophic lateral sclerosis: longitudinal study. Clin. Neurophysiol. 2009, 120(12):2082-2085.
    • (2009) Clin. Neurophysiol. , vol.120 , Issue.12 , pp. 2082-2085
    • Pinto, S.1    Geraldes, R.2    Vaz, N.3    Pinto, A.4    de Carvalho, M.5
  • 47
    • 33344462702 scopus 로고    scopus 로고
    • Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
    • Pun S., Santos A.F., Saxena S., Xu L., Caroni P. Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF. Nat. Neurosci. 2006, 9(3):408-419.
    • (2006) Nat. Neurosci. , vol.9 , Issue.3 , pp. 408-419
    • Pun, S.1    Santos, A.F.2    Saxena, S.3    Xu, L.4    Caroni, P.5
  • 48
    • 77958062579 scopus 로고    scopus 로고
    • Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy
    • Qin W., Pan J., Bauman W.A., Cardozo C.P. Differential alterations in gene expression profiles contribute to time-dependent effects of nandrolone to prevent denervation atrophy. BMC Genomics 2010, 11:596-612.
    • (2010) BMC Genomics , vol.11 , pp. 596-612
    • Qin, W.1    Pan, J.2    Bauman, W.A.3    Cardozo, C.P.4
  • 51
    • 69349094901 scopus 로고    scopus 로고
    • A computational approach to compare microvessel distributions in tumors following antiangiogenic treatments
    • Righi M., Giacomini A., Lavazza C., Sia D., Carlo-Stella C., Gianni A.M. A computational approach to compare microvessel distributions in tumors following antiangiogenic treatments. Lab. Invest. 2009, 89(9):1063-1070.
    • (2009) Lab. Invest. , vol.89 , Issue.9 , pp. 1063-1070
    • Righi, M.1    Giacomini, A.2    Lavazza, C.3    Sia, D.4    Carlo-Stella, C.5    Gianni, A.M.6
  • 53
    • 78049425043 scopus 로고    scopus 로고
    • Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial
    • Sardar P., Jha A., Roy D., Majumdar U., Guha P., Roy S., Banerjee R., Banerjee A.K., Bandyopadhyay D. Therapeutic effects of nandrolone and testosterone in adult male HIV patients with AIDS wasting syndrome (AWS): a randomized, double-blind, placebo-controlled trial. HIV. Clin. Trials. 2010, 11(4):220-229.
    • (2010) HIV. Clin. Trials. , vol.11 , Issue.4 , pp. 220-229
    • Sardar, P.1    Jha, A.2    Roy, D.3    Majumdar, U.4    Guha, P.5    Roy, S.6    Banerjee, R.7    Banerjee, A.K.8    Bandyopadhyay, D.9
  • 54
    • 0028278119 scopus 로고
    • A comparison of the morphology of denervated with aneurally regenerated soleus muscle of rat
    • Schmalbruch H., Lewis D.M. A comparison of the morphology of denervated with aneurally regenerated soleus muscle of rat. J. Muscle. Res. Cell Motil. 1994, 15(3):256-266.
    • (1994) J. Muscle. Res. Cell Motil. , vol.15 , Issue.3 , pp. 256-266
    • Schmalbruch, H.1    Lewis, D.M.2
  • 56
    • 0030026832 scopus 로고    scopus 로고
    • Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis
    • Siklos L., Engelhardt J., Harati Y., Smith R.G., Joo F., Appel S.H. Ultrastructural evidence for altered calcium in motor nerve terminals in amyotrophic lateral sclerosis. Ann. Neurol. 1996, 39(2):203-216.
    • (1996) Ann. Neurol. , vol.39 , Issue.2 , pp. 203-216
    • Siklos, L.1    Engelhardt, J.2    Harati, Y.3    Smith, R.G.4    Joo, F.5    Appel, S.H.6
  • 58
    • 42249102078 scopus 로고    scopus 로고
    • Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
    • Turner B.J., Talbot K. Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Prog. Neurobiol. 2008, 85(1):94-134.
    • (2008) Prog. Neurobiol. , vol.85 , Issue.1 , pp. 94-134
    • Turner, B.J.1    Talbot, K.2
  • 59
    • 77953530958 scopus 로고    scopus 로고
    • Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice
    • Wong M., Martin L.J. Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice. Hum. Mol. Genet. 2010, 19(11):2284-2302.
    • (2010) Hum. Mol. Genet. , vol.19 , Issue.11 , pp. 2284-2302
    • Wong, M.1    Martin, L.J.2
  • 60
    • 37749030886 scopus 로고    scopus 로고
    • Effects of nandrolone on denervation atrophy depend upon time after nerve transection
    • Zhao J., Zhang Y., Zhao W., Wu Y., Pan J., Bauman W.A., Cardozo C. Effects of nandrolone on denervation atrophy depend upon time after nerve transection. Muscle Nerve 2008, 37(1):42-49.
    • (2008) Muscle Nerve , vol.37 , Issue.1 , pp. 42-49
    • Zhao, J.1    Zhang, Y.2    Zhao, W.3    Wu, Y.4    Pan, J.5    Bauman, W.A.6    Cardozo, C.7


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