Chronic treatment with anabolic steroids induces ventricular repolarization disturbances: Cellular, ionic and molecular mechanism

Journal of Molecular and Cellular Cardiology

Volumn 49, Issue 2, 2010, Pages 165-175

  Medei, Emiliano ^a   Marocolo, Moacir ^a   Rodrigues, Deivid de Carvalho ^a   Arantes, Paulo Cesar ^a   Takiya, Christina Maeda ^a   Silva, Juliana ^a   Rondinelli, Edson ^a   Goldenberg, Regina Coeli dos Santos ^a   de Carvalho, Antonio Carlos Campos ^a,b   Nascimento, José Hamilton Matheus ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO NACIONAL DE CARDIOLOGIA   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANABOLIC AGENT; COLLAGEN TYPE 1; COLLAGEN TYPE 3; EOSIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEMATOXYLIN; KV CHANNEL INTERACTING PROTEIN; NANDROLONE DECANOATE; POTASSIUM CHANNEL KV1.4; POTASSIUM CHANNEL KV4.2; POTASSIUM CHANNEL KV4.3; POTASSIUM ION; SHAL POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; ELECTRIC POTENTIAL; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART LEFT VENTRICLE; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; HEART RIGHT VENTRICLE; HEART VENTRICLE REMODELING; HISTOPATHOLOGY; MALE; MOLECULAR MECHANICS; MORPHOLOGY; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; QT INTERVAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; TIME; TREATMENT DURATION;

ACTION POTENTIALS; ANIMALS; BODY WEIGHT; ELECTROCARDIOGRAPHY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEART VENTRICLES; ION CHANNEL GATING; KV CHANNEL-INTERACTING PROTEINS; MALE; NANDROLONE; ORGAN SIZE; POTASSIUM CHANNELS; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RNA, MESSENGER; STEROIDS; VENTRICULAR FUNCTION;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 77953728025     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2010.04.014     Document Type: Article

References (54)

1. Sullivan M.L., Martinez C.M., Gennis P., Gallagher E.J. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis 1998, 41:1-15.
2. Payne J.R., Kotwinski P.J., Montgomery H.E. Cardiac effects of anabolic steroids. Heart 2004, 90:473-475.
3. Kennedy M.C., Lawrence C. Anabolic steroid abuse and cardiac death. Med J Aust 1993, 158(5):346-348. 1.
4. Maron B.J. Sudden death in young athletes. N Engl J Med 2003, 349(11):1064-1075. 11.
5. Sullivan M.L., Martinez C.M., Gallagher E.J. Atrial Fibrillation and anabolic steroids. J Emerg Med 1999, 17:851-857.
6. Nieminen M.S., Ramo M.P., Viitasalo M., Heikkila P., Karjalainen J., Mantysaari M., et al. Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters. Eur Heart J 1996, 17:1576-1583.
7. Stolt A., Karila T., Viitasalo M., Mäntysaari M., Kujala U.M., Karjalainen J. QT interval and QT dispersion in endurance athletes and in power athletes using large doses of anabolic steroids. Am J Cardiol Aug 1 1999, 84(3):364-366. A9.
8. Kleiger R.E., Miller J.P., Bigger J.T., Moss A.J. The Multicenter Post-Infarction Research Group. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol 1987, 59:256-262.
9. Schwartz P.J., La Rovere M.T., Vanoli E. Autonomic nervous system and sudden cardiac death. Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation 1992, 85(1 Suppl):I77-I91.
10. Pereira-Junior P.P., Chaves E.A., Costa-E-Sousa R.H., Masuda M.O., de Carvalho A.C., Nascimento J.H. Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid. Eur J Appl Physiol 2006, 96(5):487-494.
11. Aronson R.S. Characteristics of action potentials of hypertrophied myocardium from rats with renal hypertension. Circ Res 1980, 47:443-454.
12. Tomita F.A., Basset L., Myerbug R., Kimura S. Diminished transient outward current in rat hypertrophied ventricular myocytes. Circulation 1994, 75:296-303.
13. Sah R., Ramirez R.J., Oudit G.Y., Gidrewicz D., Trivieri M.G., Zobel C., et al. Regulation of cardiac excitation-contraction coupling by action potential repolarization: role of the transient outward potassium current (Ito). J Physiol 2003, 546:5-18.
14. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ Res 1996, 79:659-668.
15. Kobayashi T., Yamada Y., Nagashima M., Seki S., Tsutsuura M., Ito Y., et al. Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes. J Mol Cell Cardiol Sep 2003, 35(9):1073-1082.
16. Trifunovic B., Norton G.R., Duffield M.J., Avraam P., Woodiwiss A.J. An androgenic steroid decreases left ventricular compliance in rats. Am J Physiol 1995, 268:H1096-H1105.
17. Woodiwiss A.J., Trifunovic B., Philippides M., Norton G.R. Effects of an androgenic steroid on exercise-induced cardiac remodeling in rats. J Appl Physiol 2000, 88:409-415.
18. Pope H.G., Katz D.L. Affective and psychotic symptoms associated with anabolic steroid use. Am J Psychiatry 1988, 145(4):487-490.
19. Medei E.H., Nascimento J.H., Pedrosa R.C., Barcellos L., Masuda M.O., Sicouri S., et al. Antibodies with beta-adrenergic activity from chronic chagasic patients modulate the QT interval and M cell action potential duration. Europace Jul 2008, 10(7):868-876.
20. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative CT method. Nat Protoc 2008, 3(6):1101-1108.
21. Dolber P.C., Spach M.S. Conventional and confocal fluorescence microscopy of collagen fibers in the heart. J Histochem Cytochem 1993, 41:461-469.
22. Koda M., Takemura G., Okada H., Kanoh M., Maruyama R., Esaki M., et al. Nuclear hypertrophy reflects increased biosynthetic activities in myocytes of human hypertrophic hearts. Circ J 2006, 70(6):710-718.
23. Cunningham K.S., Veinot J.P., Butany J. An approach to endomyocardial biopsy interpretation. J Clin Pathol 2006, 59(2):121-129.
24. Assad R.S., Cardarelli M., Abduch M.C., Aiello V.D., Maizato M., Barbero-Marcial M., et al. Reversible pulmonary trunk banding with a balloon catheter: assessment of rapid pulmonary ventricular hypertrophy. J Thorac Cardiovasc Surg 2000, 120(1):66-72.
25. Rocha F.L., Carmo E.C., Roque F.R., Hashimoto N.Y., Rossoni L.V., Frimm C., et al. Anabolic steroids induce cardiac renin-angiotensin system and impair the beneficial effects of aerobic training in rats. Am J Physiol Heart Circ Physiol 2007, 293(6):H3575-H3583.
26. Andrade T.U., Santos M.C., Busato V.C., Medeiros A.R., Abreu G.R., Moysés M.R., et al. Higher physiological doses of nandrolone decanoate do not influence the Bezold-Jarish reflex control of bradycardia. Arch Med Res 2008, 39(1):27-32.
27. Fanton L., Belhani D., Vaillant F., Tabib A., Gomez L., Descotes J., et al. Heart lesions associated with anabolic steroid abuse: comparison of post-mortem findings in athletes and norethandrolone-induced lesions in rabbits. Exp Toxicol Pathol 2009, 61(4):317-323.
28. Zaugg M., Jamali N.Z., Lucchinetti E., Xu W., Alam M., Shafiq S.A., et al. Anabolic-androgenic steroids induce apoptotic cell death in adult rat ventricular myocytes. J Cell Physiol 2001, 187(1):90-95.
29. Lyon A.R., MacLeod K.T., Zhang Y., Garcia E., Kanda G.K., Lab M.J., et al. Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci U S A 2009, 106(16):6854-6859. 21.
30. He J., Conklin M.W., Foell J.D., Wolff M.R., Haworth R.A., Coronado R., et al. Reduction in density of transverse tubules and L-type Ca(2+) channels in canine tachycardia-induced heart failure. Cardiovasc Res Feb 1 2001, 49(2):298-307.
31. Bispo M., Valente A., Maldonado R., Palma R., Glória H., Nóbrega J., et al. Anabolic steroid-induced cardiomyopathy underlying acute liver failure in a young bodybuilder. World J Gastroenterol Jun 21 2009, 15(23):2920-2922.
32. Nieminen M.S., Rämö M.P., Viitasalo M., Heikkilä P., Karjalainen J., Mäntysaari M., et al. Serious cardiovascular side effects of large doses of anabolic steroids in weight lifters. Eur Heart J Oct 1996, 17(10):1576-1583.
33. Wickenden A.D., Jegla T.J., Kaprielian R., Backx P.H. Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle. Am J Physiol 1999, 276(5 Pt 2):H1599-H1607.
34. Casis O., Iriarte M., Gallego M., Sanchez-Chapula J.A. Differences in regional distribution of K_ current densities in rat ventricle. Life Sci 1998, 63:391-400.
35. Knollmann B.C., Knollmann-Ritschel B.E., Weissman N.J., Jones L.R., Morad M. Remodelling of ionic currents in hypertrophied and failing hearts of transgenic mice overexpressing calsequestrin. J Physiol Jun 1 2000, 525(Pt 2):483-498.
36. Gidh-Jain M., Huang B., Jain P., El-Sherif N. Differential expression of voltage-gated K+ channel genes in left ventricular remodeled myocardium after experimental myocardial infarction. Circ Res Oct 1996, 79(4):669-675.
37. Kaprielian R., Wickenden A.D., Kassiri Z., Parker T.G., Liu P.P., Backx P.H. Relationship between K+ channel down-regulation and [Ca2+]i in rat ventricular myocytes following myocardial infarction. J Physiol 1999; May 15, 517(Pt 1):229-245.
38. Deschenes I., Tomaselli G.F. Modulation of Kv4.3 current by accessory subunits. FEBS Lett 2002, 528:183-188.
39. An W.F., Bowlby M.R., Betty M., Cao J., Ling H.P., Mendoza G., et al. Modulation of A-type potassium channels by a family of calcium sensors. Nature 2000, 403:553-556.
40. Rosati B., Grau F., Rodriguez S., Li H., Nerbonne J.M., McKinnon D. Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle. J Physiol 2003, 548:815-822.
41. Deschenes I., DiSilvestre D., Juang G.J., Wu R.C., An W.F., Tomaselli G.F. Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)?. Circulation 2002, 106:423-429.
42. Soltysinska E., Olesen S.P., Christ T., Wettwer E., Varró A., Grunnet M., et al. Transmural expression of ion channels and transporters in human non-diseased and end-stage failing hearts. Pflugers Arch 2009; Nov, 459(1):11-23.
43. Radicke S., Cotella D., Graf E.M., Banse U., Jost N., Varró A., et al. Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts. Cardiovasc Res 2006; Sep 1, 71(4):695-703.
44. Kuo H.C., Cheng C.F., Clark R.B., Lin J.J., Lin J.L., Hoshijima M., et al. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell 2001; Dec 14, 107(6):801-813.
45. Jin H., Hadri L., Palomeque J., Morel C., Karakikes I., Kaprielian R., et al. KChIP2 attenuates cardiac hypertrophy through regulation of I(to) and intracellular calcium signaling. J Mol Cell Cardiol 2010 Jan 4, Electronic publication ahead of print.
46. Jia Y., Takimoto K. Mitogen-activated protein kinases control cardiac KChIP2 gene expression. Circ Res 2006; Feb 17, 98(3):386-393.
47. Abe A., Yamamoto T., Isome M., Ma M., Yaoita E., Kawasaki K., et al. Thyroid hormone regulates expression of shaker-related potassium channel mRNA in rat heart. Biochem Biophys Res Commun 1998; Apr 7, 245(1):226-230.
48. Gassanov N., Er F., Michels G., Zagidullin N., Brandt M.C., Hoppe U.C. Divergent regulation of cardiac KCND3 potassium channel expression by the thyroid hormone receptors alpha1 and beta1. J Physiol 2009; Mar 15, 587(Pt 6):1319-1329.
49. Fortunato R.S., Marassi M.P., Chaves E.A., Nascimento J.H., Rosenthal D., Carvalho D.P. Chronic administration of anabolic androgenic steroid alters murine thyroid function. Med Sci Sports Exerc 2006; Feb, 38(2):256-261.
50. Luke J.L., Farb A., Virmani R., Sample R.H. Sudden cardiac death during exercise in a weight lifter using anabolic androgenic steroids: pathological and toxicological findings. J Forensic Sci 1990, 35:1441-1447.
51. Hausmann R., Hammer S., Betz P. Performance enhancing drugs (doping agents) and sudden death - a case report and review of the literature. Int J Leg Med 1998, 111(5):261-264.
52. Di Paolo M., Agozzino M., Toni C., Luciani A.B., Molendini L., Scaglione M., et al. Sudden anabolic steroid abuse-related death in athletes. Int J Cardiol 2007, 114(1):114-117. 2.
53. Kääb S., Nuss H.B., Chiamvimonvat N., O'Rourke B., Pak P.H., Kass D.A., et al. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res 1996, 78(2):262-273.
54. Kaprielian R., Sah R., Nguyen T., Wickenden A.D., Backx P.H. Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I(to) K(+) currents, and [Ca(2+)](i) transients. Am J Physiol Heart Circ Physiol 2002, 283(3):H1157-H1168.