IASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes

Biochemical and Biophysical Research Communications

Volumn 424, Issue 3, 2012, Pages 414-420

  Wang, Lin ^a   Xing, Haiyan ^a   Tian, Zheng ^a   Peng, Leiwen ^a   Li, Yan ^a   Tang, Kejing ^a   Rao, Qing ^a   Wang, Min ^a   Wang, Jianxiang ^a  

^a INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

Author keywords

Apoptosis; Chemotherapeutic agents; IASPP; IASPPsv; P53

Indexed keywords

ANTIINFECTIVE AGENT; DEXAMETHASONE; DOUBLE STRANDED DNA; ETOPOSIDE; INHIBITORY MEMBER OF ASPP PROTEIN; LENTIVIRUS VECTOR; PROTEIN BAX; PROTEIN INHIBITOR; PROTEIN NOXA; PUMA PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CELL PROTECTION; CELL STRAIN MCF 7; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMOCYTE; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DEXAMETHASONE; DNA BREAKS, DOUBLE-STRANDED; ETOPOSIDE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, TRANSGENIC; NEOPLASMS; REPRESSOR PROTEINS; T-LYMPHOCYTES;

LENTIVIRUS; MUS MUSCULUS;

EID: 84864743192     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.124     Document Type: Article

References (37)

1. Riley T., Sontag E., Chen P., Levine A. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 2008, 9:402-412.
2. Helton E.S., Chen X. P53 modulation of the DNA damage response. J. Cell. Biochem. 2007, 100:883-896.
3. Vousden K.H. Outcomes of p53 activation-spoilt for choice. J. Cell Sci. 2006, 119:5015-5020.
4. Wang W., El-Deiry W.S. Restoration of p53 to limit tumor growth. Curr. Opin. Oncol. 2008, 20:90-96.
5. Schittek B., Psenner K., Sauer B., Meier F., Iftner T., Garbe C. The increased expression of Y box-binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance. Int. J. Cancer 2007, 120:2110-2118.
6. Matoba S., Kang J.G., Patino W.D., Wragg A., Boehm M., Gavrilova O., Hurley P.J., Bunz F., Hwang P.M. P53 regulates mitochondrial respiration. Science 2006, 312:1650-1653.
7. Vousden K.H., Prives C. Blinded by the Light: The Growing Complexity of p53. Cell 2009, 137:413-431.
8. Soussi T., Kato S., Levy P.P., Ishioka C. Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations. Hum. Mutat. 2005, 25:6-17.
9. Coutts A.S., La Thangue N.B. The p53 response: emerging levels of co-factor complexity. Biochem. Biophys. Res. Commun. 2005, 331:778-785.
10. Sugimoto M., Gromley A., Sherr C.J. Hzf, a p53-responsive gene, regulates maintenance of the G2 phase checkpoint induced by DNA damage. Mol. Cell. Biol. 2006, 26:502-512.
11. Das S., Raj L., Zhao B., Kimura Y., Bernstein A., Aaronson S.A., Lee S.W. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. Cell 2007, 130:624-637.
12. Budhram-Mahadeo V.S., Bowen S., Lee S., Perez-Sanchez C., Ensor E., Morris P.J., Latchman D.S. Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 2006, 34:6640-6652.
13. Samuels-Lev Y., O'Connor D.J., Bergamaschi D., Trigiante G., Hsieh J.K., Zhong S., Campargue I., Naumovski L., Crook T., Lu X. ASPP proteins specifically stimulate the apoptotic function of p53. Mol. Cell 2001, 8:781-794.
14. Tidow H., Andreeva A., Rutherford T.J., Fersht A.R. Solution structure of ASPP2 N-terminal domain (N-ASPP2) reveals a ubiquitin-like fold. J. Mol. Biol. 2007, 371:948-958.
15. Sun W.T., Hsieh P.C., Chiang M.L., Wang M.C., Wang F.F. P53 target DDA3 binds ASPP2 and inhibits its stimulation on p53-mediated BAX activation. Biochem. Biophys. Res. Commun. 2008, 376:395-398.
16. Kobayashi S., Kajino S., Takahashi N., Kanazawa S., Imai K., Hibi Y., Ohara H., Itoh M., Okamoto T. 53BP2 induces apoptosis through the mitochondrial death pathway. Genes Cells 2005, 10:253-260.
17. Vives V., Su J., Zhong S., Ratnayaka I., Slee E., Goldin R., Lu X. ASPP2 is a haploinsufficient tumor suppressor that cooperates with p53 to suppress tumor growth. Gene Dev. 2006, 20:1262-1267.
18. Bergamaschi D., Samuels Y., O'Neil N.J., Trigiante G., Crook T., Hsieh J.K., O'Connor D.J., Zhong S., Campargue I., Tomlinson M.L., Kuwabara P.E., Lu X. IASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat. Genet. 2003, 33:162-167.
19. Slee E.A., Gillotin S., Bergamaschi D., Royer C., Llanos S., Ali S., Jin B., Trigiante G., Lu X. The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. Oncogene 2004, 23:9007-9016.
20. Zhang X., Diao S., Rao Q., Xing H., Liu H., Liao X., Wang M., Wang J. Identification of a novel isoform of iASPP and its interaction with p53. J. Mol. Biol. 2007, 368:1162-1171.
21. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
22. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
23. Liu Z.J., Zhang Y., Zhang X.B., Yang X. Abnormal mRNA expression of ASPP members in leukemia cell lines. Leukemia 2004, 18:880.
24. Zhang X., Wang M., Zhou C., Chen S., Wang J. The expression of iASPP in acute leukemias. Leuk. Res. 2005, 29:179-183.
25. Liu Z.J., Xin H.M., Chen J., Lu X., Zhong S., Gu S.Z., Wang G., Liu L., Cai Y., Hou L. A new strategy to resume the apoptosis activity of p53 in leukemia cell lines retaining wild-type p53. Leuk. Res. 2007, 31:1156-1158.
26. Liu H., Wang M., Diao S., Rao Q., Zhang X., Xing H., Wang J. SiRNA-mediated down-regulation of iASPP promotes apoptosis induced by etoposide and daunorubicin in leukemia cells expressing wild-type p53. Leuk. Res. 2009, 33:1243-1248.
27. Liu T., Li L., Yang W., Jia H., Xu M., Bi J., Li Z., Liu X., Li Z., Jing H., Kong C. IASPP is important for bladder cancer cell proliferation. Oncol. Res. 2011, 19:125-130.
28. Lin B.L., Xie D.Y., Xie S.B., Xie J.Q., Zhang X.H., Zhang Y.F., Gao Z.L. Down-regulation of iASPP in human hepatocellular carcinoma cells inhibits cell proliferation and tumor growth. Neoplasma 2011, 58:205-210.
29. Trigiante G., Lu X. ASPP [corrected] and cancer. Nat. Rev. Cancer 2006, 6:217-226.
30. Ghiotto F., Fais F., Bruno S. BH3-only proteins: the death-puppeteer's wires. Cytometry A 2010, 77:11-21.
31. Giam M., Huang D.C., Bouillet P. BH3-only proteins and their roles in programmed cell death. Oncogene 2008, 27(Suppl 1):S128-S136.
32. Bonner W.M., Redon C.E., Dickey J.S., Nakamura A.J., Sedelnikova O.A., Solier S., Pommier Y. GammaH2AX and cancer. Nat. Rev. Cancer 2008, 8:957-967.
33. Xiao B., Guo J., Lou Y., Meng D., Zhao W., Zhang L., Yan C., Wang D. Inhibition of growth and increase of alkaline phosphatase activity in cultured human oral cancer cells by all-trans retinoic acid. Int. J. Oral Maxillofac. Surg. 2006, 35:643-648.
34. Markova E., Schultz N., Belyaev I.Y. Kinetics and dose-response of residual 53BP1/gamma-H2AX foci: co-localization, relationship with DSB repair and clonogenic survival. Int. J. Radiat. Biol. 2007, 83:319-329.
35. Wood J.L., Singh N., Mer G., Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J. Biol. Chem. 2007, 282:35416-35423.
36. Lyakhovich A., Surralles J. New roads to FA/BRCA pathway: H2AX. Cell Cycle 2007, 6:1019-1023.
37. Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.