Down-regulation of iASPP in human hepatocellular carcinoma cells inhibits cell proliferation and tumor growth

Neoplasma

Volumn 58, Issue 3, 2011, Pages 205-210

  Lin, B L ^a   Xie, D Y ^a   Xie, S B ^a   Xie, J Q ^a   Zhang, X H ^a   Zhang, Y F ^a   Gao, Z L ^a  

^a THE THIRD AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; iASPP; Proliferation

Indexed keywords

IASPP PROTEIN; ONCOPROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; PPP1R13L PROTEIN, HUMAN; REPRESSOR PROTEIN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; ANIMAL; BAGG ALBINO MOUSE; DISEASE COURSE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; REPRESSOR PROTEINS; RNA, SMALL INTERFERING; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79961118984     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: 10.4149/neo_2011_03_205     Document Type: Article

References (20)

1. DI BA, LYRA AC, SCHWARTZ M, REDDZ RK, NARTIN P et al. Hepatitis C-related hepatocellular carcinoma in the United States: influence of ethnic status. Am J Gastroenterol 2003; 98: 2060-2063.
2. CHEN XP, QIU FZ, WU ZD, ZHANG ZW, HUANG ZY et al. Long-term outcome of resection of large hepatocellular carcinoma. Br J Surg 2006; 93: 600-606. doi:10.1002/ bjs.5335
3. KERN MA, BREUHAHN K, SCHIMACHER P. Molecular pathogenesis of human hepatocellular carcinoma. Adv Cancer Res 2002; 86: 67-112. doi:10.1016/S0065-230X(02)86003-1
4. CHEN Y, HUANG L. Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy. Expert Opin Drug Deliv 2008; 12: 1301-1311. doi:10.1517/ 17425240802568505
5. IWABUCHI K, BARTEL PL, LI B, MARRACINO R, FIELDS S. Two cellular proteins that bind to wild-type but not mutant p53. Proc Natl Acad Sci USA 1994; 91: 6098-6102.doi:10.1073/pnas.91.13.6098
6. N AGASE T, ISHIKAWA K, SUYAMA M, KIKUNO R, HIROSAWA M et al. Prediction of the Coding Sequences of Unidentified Human Genes. XII. The Complete Sequences of 100 New cDNA Clones from Brain Which Code for Large Proteins in vitro. DNA Res 1998; 5: 355-364. doi:10.1093/ dnares/5.6.355
7. SAMUELS. LY, O'CONNOR DJ, BERGAMASHI D, TRI-GIANTE G, HSIEH JK et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001; 8: 781-794. doi:10.1016/S1097-2765(01)00367-7
8. BERGAMASHI D, SAMUELS Y, JIN B, DURAISINGHAM S, CROOK T et al. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol 2004; 24: 1341-1350.doi:10.1128/MCB.24.3.1341-1350.2004
9. SLEE EA, GILLOTIN S, BERGAMASCHI D, ROYER C, LLAMOS S, ALI S, et al. The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization. Oncogene 2004; 23: 9007-9016. doi:10.1038/sj.onc.1208088
10. BERGAMASCHI D, SAMUELS Y, O,NAILl NJ, TRIGIANTE G, CROOK T, HSIEH J, et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 2003; 33: 162-167. doi:10.1038/ng1070
11. LIU ZJ, ZHANG Y, ZHANG XB, YANG X. Abnormal mRNA expression of ASPP members in leukemia cell lines. Leukemia 2004; 18: 880. doi:10.1038/sj.leu.2403300
12. ZHANG X, WANG M, ZHOU C, CHEN S, WANG J. The expression of iASPP in acute leukemias. Leuk Res 2005; 29: 179-183. doi:10.1016/j.leukres.2004.07.001
13. AGIRRE X. ASPP1, a common activator of TP53, is inactivated by aberrant methylation of its promotor in acute lymphoblastic leukemia. Oncogene 2006; 25: 1862-1870.doi:10.1038/sj.onc.1209236
14. LOSSOS IS, NATKUNAM Y, LEVY R, LOPEZ CD. Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome. Leuk. Lymphoma 2002; 43: 2309-2317.doi:10.1080/1042819021000040017
15. LIU Z, CAI Y, HOU L, GAO X, XIN H et al. Effect of RNA interference of iASPP on the Apoptosis in MCF-7 breast cancer cells. Cancer Invest 2008; 26: 878-882. doi:10.1080/ 07357900801965042
16. SULLIVAN A, LU X. ASPP: a new family of oncogenes and tumour suppressor genes. Br J Cancer 2007; 96: 196-200.doi:10.1038/sj.bjc.6603525
17. TRIGIANTE G, LU X. ASPP and cancer. Nat Rev Cancer 2006; 6: 217-226. doi:10.1038/nrc1818
18. p53 mutation database. Available from: www.p53.curic.fr.
19. VOGELSTEiN B, LANE D, LEVINE AJ. Surfing the p53 network. Nature 2000; 408: 307-310. doi:10.1038/35042675
20. YANG JP, HORI M, SANDA T, OKAMOTO T. Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor. J Biol Chem 1999; 274: 15662-15670. doi:10.1074/ jbc.274.22.15662