메뉴 건너뛰기




Volumn 103, Issue 7, 2012, Pages 579-590

New therapeutic targets in melanoma;Nuevas dianas terapéuticas en el melanoma

Author keywords

Anti CTLA 4; BRAF; C kit; Melanoma; Molecular targets; Therapeutic targets

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR;

EID: 84864701199     PISSN: 00017310     EISSN: 15782190     Source Type: Journal    
DOI: 10.1016/j.adengl.2012.08.005     Document Type: Short Survey
Times cited : (13)

References (112)
  • 1
    • 66149090765 scopus 로고    scopus 로고
    • Molecular pathogenesis of cutaneous melanocytic neoplasms
    • N. Ibrahim, and F.G. Haluska Molecular pathogenesis of cutaneous melanocytic neoplasms Annu Rev Pathol 4 2009 551 579
    • (2009) Annu Rev Pathol , vol.4 , pp. 551-579
    • Ibrahim, N.1    Haluska, F.G.2
  • 2
    • 79251514285 scopus 로고    scopus 로고
    • New therapeutic options in the medical management of advanced melanoma
    • J. Lutzky New therapeutic options in the medical management of advanced melanoma Semin Cutan Med Surg 29 2010 249 257
    • (2010) Semin Cutan Med Surg , vol.29 , pp. 249-257
    • Lutzky, J.1
  • 3
    • 77951494873 scopus 로고    scopus 로고
    • Targeted cancer therapies in the twenty-first century: Lessons from imatinib
    • F. Stegmeier, M. Warmuth, W.R. Sellers, and M. Dorsch Targeted cancer therapies in the twenty-first century: lessons from imatinib Clin Pharmacol Ther 87 2010 543 552
    • (2010) Clin Pharmacol Ther , vol.87 , pp. 543-552
    • Stegmeier, F.1    Warmuth, M.2    Sellers, W.R.3    Dorsch, M.4
  • 4
    • 73349085919 scopus 로고    scopus 로고
    • Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer
    • N.L. Spector, and K.L. Blackwell Understanding the mechanisms behind trastuzumab therapy for human epidermal growth factor receptor 2-positive breast cancer J Clin Oncol 27 2009 5838 5847
    • (2009) J Clin Oncol , vol.27 , pp. 5838-5847
    • Spector, N.L.1    Blackwell, K.L.2
  • 6
    • 1642569629 scopus 로고    scopus 로고
    • New molecular targets in melanoma
    • DOI 10.1097/00001622-200403000-00012
    • K.T. Flaherty New molecular targets in melanoma Curr Opin Oncol 16 2004 150 154 (Pubitemid 38402529)
    • (2004) Current Opinion in Oncology , vol.16 , Issue.2 , pp. 150-154
    • Flaherty, K.T.1    Brose, M.S.2
  • 7
    • 79551645339 scopus 로고    scopus 로고
    • Targeted therapies in metastatic melanoma: Toward a clinical breakthrough
    • F. Julia, L. Thomas, C. Dumontet, and S. Dalle Targeted therapies in metastatic melanoma: toward a clinical breakthrough Anticancer Agents Med Chem 10 2010 661 665
    • (2010) Anticancer Agents Med Chem , vol.10 , pp. 661-665
    • Julia, F.1    Thomas, L.2    Dumontet, C.3    Dalle, S.4
  • 8
    • 78650015822 scopus 로고    scopus 로고
    • A new era: Melanoma genetics and therapeutics
    • J.M. Ko, and D.E. Fisher A new era: melanoma genetics and therapeutics J Pathol 223 2011 241 250
    • (2011) J Pathol , vol.223 , pp. 241-250
    • Ko, J.M.1    Fisher, D.E.2
  • 10
    • 68749110795 scopus 로고    scopus 로고
    • Molecular markers of tumor progression in melanoma
    • J. Rother, and D. Jones Molecular markers of tumor progression in melanoma Current Genomics 10 2009 231 239
    • (2009) Current Genomics , vol.10 , pp. 231-239
    • Rother, J.1    Jones, D.2
  • 11
    • 77954145777 scopus 로고    scopus 로고
    • Using genetics and genomics strategies to personalize therapy for cancer: Focus on melanoma
    • K.L. Nathanson Using genetics and genomics strategies to personalize therapy for cancer: focus on melanoma Biochem Pharmacol 80 2010 755 761
    • (2010) Biochem Pharmacol , vol.80 , pp. 755-761
    • Nathanson, K.L.1
  • 13
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • DOI 10.1200/JCO.2006.06.2984
    • J.A. Curtin, K. Busam, D. Pinkel, and B.C. Bastian Somatic activation of KIT in distinct subtypes of melanoma J Clin Oncol 24 2006 4340 4346 (Pubitemid 46630793)
    • (2006) Journal of Clinical Oncology , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 14
    • 77957982878 scopus 로고    scopus 로고
    • Analysis of the genome to personalize therapy for melanoma
    • M.A. Davies, and Y. Samuels Analysis of the genome to personalize therapy for melanoma Oncogene 29 2010 5545 5555
    • (2010) Oncogene , vol.29 , pp. 5545-5555
    • Davies, M.A.1    Samuels, Y.2
  • 15
    • 77957337442 scopus 로고    scopus 로고
    • Diferentes alteraciones genéticas causan diferentes melanomas y nuevas posibilidades terapéuticas
    • R. Botella-Estrada, and O. Sanmartín Jiménez Diferentes alteraciones genéticas causan diferentes melanomas y nuevas posibilidades terapéuticas Actas Dermosifiliogr 101 2010 394 400
    • (2010) Actas Dermosifiliogr , vol.101 , pp. 394-400
    • Botella-Estrada, R.1    Sanmartín Jiménez, O.2
  • 17
    • 77956596327 scopus 로고    scopus 로고
    • Molecular targeted therapy for patients with melanoma: The promise of MAPK pathway inhibition and beyond
    • R.J. Sullivan, and M.B. Atkins Molecular targeted therapy for patients with melanoma: the promise of MAPK pathway inhibition and beyond Expert Opin Investig Drugs 19 2010 1205 1216
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 1205-1216
    • Sullivan, R.J.1    Atkins, M.B.2
  • 18
    • 77954218212 scopus 로고    scopus 로고
    • BRAF as therapeutic target in melanoma
    • C. Wellbrock, and A. Hurlstone BRAF as therapeutic target in melanoma Biochem Pharmacol 80 2010 561 567
    • (2010) Biochem Pharmacol , vol.80 , pp. 561-567
    • Wellbrock, C.1    Hurlstone, A.2
  • 19
    • 77954216113 scopus 로고    scopus 로고
    • Targeting the MAPK pathway in melanoma: Why some approaches succeed and other fail
    • G.S. Inamdar, S.V. Madhunapantula, and G.P. Robertson Targeting the MAPK pathway in melanoma: why some approaches succeed and other fail Biochem Pharmacol 80 2010 624 637
    • (2010) Biochem Pharmacol , vol.80 , pp. 624-637
    • Inamdar, G.S.1    Madhunapantula, S.V.2    Robertson, G.P.3
  • 20
    • 77952236279 scopus 로고    scopus 로고
    • B-RAF inhibitors: An evolving role in the therapy of malignant melanoma
    • C. Shepherd, I. Puzanov, and J.A. Sosman B-RAF inhibitors: an evolving role in the therapy of malignant melanoma Curr Oncol Rep 12 2010 146 152
    • (2010) Curr Oncol Rep , vol.12 , pp. 146-152
    • Shepherd, C.1    Puzanov, I.2    Sosman, J.A.3
  • 22
    • 46349084183 scopus 로고    scopus 로고
    • Improving melanoma classification by integrating genetic and morphologic features
    • A. Viros, J. Fridlyand, J. Bauer, K. Lasithiotakis, C. Garbe, and D. Pinkel Improving melanoma classification by integrating genetic and morphologic features PLoS Med 5 2008 e120
    • (2008) PLoS Med , vol.5 , pp. 120
    • Viros, A.1    Fridlyand, J.2    Bauer, J.3    Lasithiotakis, K.4    Garbe, C.5    Pinkel, D.6
  • 23
    • 80051873884 scopus 로고    scopus 로고
    • Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma
    • B. Devitt, W. Liu, R. Salemi, R. Wolfe, J. Kelly, and C.Y. Tzen Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma Pigment Cell Melanoma Res 24 2011 666 672
    • (2011) Pigment Cell Melanoma Res , vol.24 , pp. 666-672
    • Devitt, B.1    Liu, W.2    Salemi, R.3    Wolfe, R.4    Kelly, J.5    Tzen, C.Y.6
  • 27
    • 78650373172 scopus 로고    scopus 로고
    • Drug discovery: How melanomas bypass new therapy
    • D. Solit, and C.L. Sawyers Drug discovery: how melanomas bypass new therapy Nature 468 2010 902 903
    • (2010) Nature , vol.468 , pp. 902-903
    • Solit, D.1    Sawyers, C.L.2
  • 28
    • 78049497378 scopus 로고    scopus 로고
    • Targeted molecular therapy in melanoma
    • I. Puzanov, and K.T. Flaherty Targeted molecular therapy in melanoma Semin Cutan Med Surg 29 2010 196 201
    • (2010) Semin Cutan Med Surg , vol.29 , pp. 196-201
    • Puzanov, I.1    Flaherty, K.T.2
  • 29
    • 78650303507 scopus 로고    scopus 로고
    • Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
    • R. Nazarian, H. Shi, Q. Wang, X. Kong, R.C. Koya, and H. Lee Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation Nature 468 2010 973 977
    • (2010) Nature , vol.468 , pp. 973-977
    • Nazarian, R.1    Shi, H.2    Wang, Q.3    Kong, X.4    Koya, R.C.5    Lee, H.6
  • 31
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • S.J. Heidorn, C. Milagre, S. Whittaker, A. Nourry, I. Niculescu-Duvas, and N. Dhomen Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF Cell 140 2010 209 221
    • (2010) Cell , vol.140 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3    Nourry, A.4    Niculescu-Duvas, I.5    Dhomen, N.6
  • 32
    • 74549180398 scopus 로고    scopus 로고
    • The brothers RAF
    • L.N. Kwong, and L. Chin The brothers RAF Cell 140 2010 180 182
    • (2010) Cell , vol.140 , pp. 180-182
    • Kwong, L.N.1    Chin, L.2
  • 33
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
    • P.I. Poulikakos, C. Zhang, G. Bollag, K.M. Shokat, and N. Rosen RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF Nature 464 2010 427 430
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 34
  • 35
    • 77949678177 scopus 로고    scopus 로고
    • Drug discovery: Inhibitors that activate
    • K. Cichowski, and P.A. Jänne Drug discovery: inhibitors that activate Nature 464 2010 358 359
    • (2010) Nature , vol.464 , pp. 358-359
    • Cichowski, K.1    Jänne, P.A.2
  • 36
    • 79952003197 scopus 로고    scopus 로고
    • RAF inhibition and induction of cutaneous squamous cell carcinoma
    • C. Robert, J.P. Arnault, and C. Mateus RAF inhibition and induction of cutaneous squamous cell carcinoma Curr Opin Oncol 23 2011 177 182
    • (2011) Curr Opin Oncol , vol.23 , pp. 177-182
    • Robert, C.1    Arnault, J.P.2    Mateus, C.3
  • 37
    • 29244482591 scopus 로고    scopus 로고
    • Review: Melanocyte migration and survival controlled by SCF/c-kit expression
    • H. Yoshida, T. Kunisada, T. Grimm, E.K. Nishimura, E. Nishioka, and S.I. Nishikawa Review: melanocyte migration and survival controlled by SCF/c-kit expression J Investig Dermatol Symp Proc 6 2001 1 5 (Pubitemid 33758596)
    • (2001) Journal of Investigative Dermatology Symposium Proceedings , vol.6 , Issue.1 , pp. 1-5
    • Kunisada, T.1
  • 38
    • 0026793058 scopus 로고
    • Progression of human cutaneous melanoma is associated with loss of expression of c-Kit proto-oncogene receptor
    • P.G. Natali, M.R. Nicotra, A.B. Winkler, R. Cavaliere, A. Bigotti, and A. Ullrich Progression of human cutaneous melanoma is associated with loss of expression of c-Kit proto-oncogene receptor Int J Cancer 52 1992 197 201
    • (1992) Int J Cancer , vol.52 , pp. 197-201
    • Natali, P.G.1    Nicotra, M.R.2    Winkler, A.B.3    Cavaliere, R.4    Bigotti, A.5    Ullrich, A.6
  • 39
    • 0141958794 scopus 로고    scopus 로고
    • Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array
    • DOI 10.1034/j.1600-0560.2003.00090.x
    • S.S. Shen, P.S. Zhang, O. Eton, and V.G. Prieto Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array J Cutan Pathol 30 2003 539 547 (Pubitemid 37255550)
    • (2003) Journal of Cutaneous Pathology , vol.30 , Issue.9 , pp. 539-547
    • Shen, S.S.1    Zhang, P.S.2    Eton, O.3    Prieto, V.G.4
  • 40
    • 0027197555 scopus 로고
    • KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells
    • R. Zakut, R. Perlis, S. Eliyahu, Y. Yarden, D. Givol, and S.D. Lyman KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells Oncogene 8 1993 2221 2229 (Pubitemid 23226956)
    • (1993) Oncogene , vol.8 , Issue.8 , pp. 2221-2229
    • Zakut, R.1    Perlis, R.2    Eliyahu, S.3    Yarden, Y.4    Givol, D.5    Lyman, S.D.6    Halaban, R.7
  • 41
    • 0030459095 scopus 로고    scopus 로고
    • Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
    • S. Huang, M. Luca, M. Gutman, D.J. McConkey, K.E. Langley, and S.D. Lyman AQ9 Enforced c-Kit expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential Oncogene 13 1996 2339 2347 (Pubitemid 27026017)
    • (1996) Oncogene , vol.13 , Issue.11 , pp. 2339-2347
    • Huang, S.1    Luca, M.2    Gutman, M.3    McConkey, D.J.4    Langley, K.E.5    Lyman, S.D.6    Bar-Eli, M.7
  • 43
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • DOI 10.1002/cncr.21834
    • K. Wyman, M.B. Atkins, V. Prieto, O. Eton, D.F. McDermott, and F. Hubbard Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy Cancer 106 2006 2005 2011 (Pubitemid 43673217)
    • (2006) Cancer , vol.106 , Issue.9 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3    Eton, O.4    McDermott, D.F.5    Hubbard, F.6    Byrnes, C.7    Sanders, K.8    Sosman, J.A.9
  • 46
    • 33646227320 scopus 로고    scopus 로고
    • Bedikian phase II trial of imatinib mesylate (STI-571) in metastatic melanoma (MM)
    • O. Eton, L. Billings, K. Kim, M.L. Frazier, D.J. McConkey, and A.H. Diwan Bedikian phase II trial of imatinib mesylate (STI-571) in metastatic melanoma (MM) J Clin Oncol 22 14S 2004 S7528
    • (2004) J Clin Oncol , vol.22 , Issue.14 , pp. 7528
    • Eton, O.1    Billings, L.2    Kim, K.3    Frazier, M.L.4    McConkey, D.J.5    Diwan, A.H.6
  • 48
    • 20144378490 scopus 로고    scopus 로고
    • Human malignant melanoma: Detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis
    • DOI 10.1016/j.humpath.2005.03.015, PII S0046817705001668
    • C. Willmore-Payne, J.A. Holden, S. Tripp, and L.J. Layfield Human malignant melanoma: detection of BRAF and KIT activating mutations by high-resolution amplicon melting analysis Hum Pathol 36 2005 486 493 (Pubitemid 40776001)
    • (2005) Human Pathology , vol.36 , Issue.5 , pp. 486-493
    • Willmore-Payne, C.1    Holden, J.A.2    Tripp, S.3    Layfield, L.J.4
  • 49
    • 33947515933 scopus 로고    scopus 로고
    • Imatinib in melanoma: A selective treatment option based on KIT mutation status?
    • J.C. Becker, E.B. Bröcker, D. Schadendorf, and S. Ugurel Imatinib in melanoma: a selective treatment option based on KIT mutation status? J Clin Oncol 25 2007 e9
    • (2007) J Clin Oncol , vol.25 , pp. 9
    • Becker, J.C.1    Bröcker, E.B.2    Schadendorf, D.3    Ugurel, S.4
  • 51
    • 77950866918 scopus 로고    scopus 로고
    • Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT
    • D. Handolias, A.L. Hamilton, R. Salemi, A. Tan, K. Moodie, and L. Kerr Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT Br J Cancer 102 2010 1219 1223
    • (2010) Br J Cancer , vol.102 , pp. 1219-1223
    • Handolias, D.1    Hamilton, A.L.2    Salemi, R.3    Tan, A.4    Moodie, K.5    Kerr, L.6
  • 52
    • 72049115498 scopus 로고    scopus 로고
    • KIT as a therapeutic target in melanoma
    • M.C. Garrido, and B.C. Bastian KIT as a therapeutic target in melanoma J Invest Dermatol 130 2010 20 27
    • (2010) J Invest Dermatol , vol.130 , pp. 20-27
    • Garrido, M.C.1    Bastian, B.C.2
  • 53
    • 77954216079 scopus 로고    scopus 로고
    • Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics
    • S.E. Woodman, and M.A. Davies Targeting KIT in melanoma: a paradigm of molecular medicine and targeted therapeutics Biochem Pharmacol 80 2010 568 574
    • (2010) Biochem Pharmacol , vol.80 , pp. 568-574
    • Woodman, S.E.1    Davies, M.A.2
  • 54
    • 79251567650 scopus 로고    scopus 로고
    • Advances in targeted therapy for melanoma
    • P. Friedlander, and F.S. Hodi Advances in targeted therapy for melanoma Clin Adv Hematol Oncol 8 2010 619 635
    • (2010) Clin Adv Hematol Oncol , vol.8 , pp. 619-635
    • Friedlander, P.1    Hodi, F.S.2
  • 56
    • 47249099056 scopus 로고    scopus 로고
    • Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
    • DOI 10.1111/j.1755-148X.2008.00475.x
    • J. Lutzky, J. Bauer, and B.C. Bastian Dose-dependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation Pigment Cell Melanoma Res 21 2008 492 493 (Pubitemid 351990966)
    • (2008) Pigment Cell and Melanoma Research , vol.21 , Issue.4 , pp. 492-493
    • Lutzky, J.1    Bauer, J.2    Bastian, B.C.3
  • 57
    • 57049109807 scopus 로고    scopus 로고
    • Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib
    • A. Quintás-Cardama, A.J. Lazar, S.E. Woodman, K. Kim, M. Ross, and P. Hwu Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib Nat Clin Pract Oncol 5 2008 737 740
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 737-740
    • Quintás-Cardama, A.1    Lazar, A.J.2    Woodman, S.E.3    Kim, K.4    Ross, M.5    Hwu, P.6
  • 58
    • 68849093078 scopus 로고    scopus 로고
    • Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
    • S.E. Woodman, J.C. Trent, K. Stemke-Hale, A.J. Lazar, S. Pricl, and G.M. Pavan Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates Mol Cancer Ther 8 2009 2079 2085
    • (2009) Mol Cancer Ther , vol.8 , pp. 2079-2085
    • Woodman, S.E.1    Trent, J.C.2    Stemke-Hale, K.3    Lazar, A.J.4    Pricl, S.5    Pavan, G.M.6
  • 60
  • 61
    • 77957767675 scopus 로고    scopus 로고
    • Targeted therapy in melanoma
    • H. Tawbi, and N. Nimmagadda Targeted therapy in melanoma Biologics 3 2009 475 484
    • (2009) Biologics , vol.3 , pp. 475-484
    • Tawbi, H.1    Nimmagadda, N.2
  • 62
    • 77949881462 scopus 로고    scopus 로고
    • The PI3K pathway as drug target in human cancer
    • K.D. Courtney, R.B. Corcoran, and J.A. Engelman The PI3K pathway as drug target in human cancer J Clin Oncol 28 2010 1075 1083
    • (2010) J Clin Oncol , vol.28 , pp. 1075-1083
    • Courtney, K.D.1    Corcoran, R.B.2    Engelman, J.A.3
  • 63
    • 78651388423 scopus 로고    scopus 로고
    • Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo
    • J. Werzowa, S. Koehrer, S. Strommer, D. Cejka, T. Fuereder, and E. Zebedin Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic effects against melanoma in vitro and in vivo J Invest Dermatol 131 2011 495 503
    • (2011) J Invest Dermatol , vol.131 , pp. 495-503
    • Werzowa, J.1    Koehrer, S.2    Strommer, S.3    Cejka, D.4    Fuereder, T.5    Zebedin, E.6
  • 64
    • 77449135697 scopus 로고    scopus 로고
    • The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells
    • M. López-Fauqued, R. Gil, J. Grueso, J. Hernández-Losa, A. Pujol, and T. Moliné The dual PI3K/mTOR inhibitor PI-103 promotes immunosuppression, in vivo tumor growth and increases survival of sorafenib-treated melanoma cells Int J Cancer 126 2010 1549 1561
    • (2010) Int J Cancer , vol.126 , pp. 1549-1561
    • López-Fauqued, M.1    Gil, R.2    Grueso, J.3    Hernández-Losa, J.4    Pujol, A.5    Moliné, T.6
  • 65
    • 27244460815 scopus 로고    scopus 로고
    • Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies
    • DOI 10.1002/cncr.21414
    • H. Ludwig, D. Khayat, G. Giaccone, and T. Facon Proteasome inhibition and its clinical prospects in the treatment of hematologic and solid malignancies Cancer 104 2005 1794 1807 (Pubitemid 41513161)
    • (2005) Cancer , vol.104 , Issue.9 , pp. 1794-1807
    • Ludwig, H.1    Khayat, D.2    Giaccone, G.3    Facon, T.4
  • 66
    • 22244454745 scopus 로고    scopus 로고
    • Differential regulation of Noxa in normal melanocytes and melanoma cells by proteasome inhibition: Therapeutic implications
    • DOI 10.1158/0008-5472.CAN-05-0686
    • Y. Fernández, M. Verhaegen, T.P. Miller, J.L. Rush, P. Steiner, and A.W Opipari Jr. Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications Cancer Res 65 2005 6294 6304 (Pubitemid 40994415)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 6294-6304
    • Fernandez, Y.1    Verhaegen, M.2    Miller, T.P.3    Rush, J.L.4    Steiner, P.5    Opipari Jr., A.W.6    Lowe, S.W.7    Soengas, M.S.8
  • 70
    • 74949096197 scopus 로고    scopus 로고
    • A phase i trial of bortezomib with temozolomide in patients with advanced melanoma: Toxicities, antitumor effects, and modulation of therapeutic targets
    • Y. Su, K.I. Amiri, L.W. Horton, Y. Yu, G.D. Ayers, and E. Koehler A phase I trial of bortezomib with temozolomide in patients with advanced melanoma: toxicities, antitumor effects, and modulation of therapeutic targets Clin Cancer Res 16 2010 348 357
    • (2010) Clin Cancer Res , vol.16 , pp. 348-357
    • Su, Y.1    Amiri, K.I.2    Horton, L.W.3    Yu, Y.4    Ayers, G.D.5    Koehler, E.6
  • 73
    • 33645776929 scopus 로고    scopus 로고
    • Immunosensitization of tumour cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade)
    • L.Y. Schumacher, D.D. Vo, H.J. Garban, B. Comin-Anduix, S.K. Owens, and V.B. Dissette Immunosensitization of tumour cells to dendritic cell-activated immune responses with the proteasome inhibitor bortezomib (PS-341, Velcade) J Immunol 176 2006 4757 4765
    • (2006) J Immunol , vol.176 , pp. 4757-4765
    • Schumacher, L.Y.1    Vo, D.D.2    Garban, H.J.3    Comin-Anduix, B.4    Owens, S.K.5    Dissette, V.B.6
  • 74
    • 33847624711 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib augments anti-proliferative effects of mistletoe lectin-I and the PPAR-gamma agonist rosiglitazone in human melanoma cells
    • C. Freudlsperger, A. Thies, U. Pfuller, and U. Schumacher The proteasome inhibitor bortezomib augments anti-proliferative effects of mistletoe lectin-I and the PPAR-gamma agonist rosiglitazone in human melanoma cells Anticancer Res 27 2007 207 213
    • (2007) Anticancer Res , vol.27 , pp. 207-213
    • Freudlsperger, C.1    Thies, A.2    Pfuller, U.3    Schumacher, U.4
  • 76
    • 77949541721 scopus 로고    scopus 로고
    • NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways
    • K. Amschler, M.P. Schön, N. Pletz, K. Wallbrecht, L. Erpenbeck, and M. Schön NF-kappaB inhibition through proteasome inhibition or IKKbeta blockade increases the susceptibility of melanoma cells to cytostatic treatment through distinct pathways J Invest Dermatol 30 2010 1073 1086
    • (2010) J Invest Dermatol , vol.30 , pp. 1073-1086
    • Amschler, K.1    Schön, M.P.2    Pletz, N.3    Wallbrecht, K.4    Erpenbeck, L.5    Schön, M.6
  • 77
    • 77950205394 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack
    • J.M. Seeger, P. Schmidt, K. Brinkmann, A.A. Hombach, O. Coutelle, and P. Zigrino The proteasome inhibitor bortezomib sensitizes melanoma cells toward adoptive CTL attack Cancer Res 70 2010 1825 1834
    • (2010) Cancer Res , vol.70 , pp. 1825-1834
    • Seeger, J.M.1    Schmidt, P.2    Brinkmann, K.3    Hombach, A.A.4    Coutelle, O.5    Zigrino, P.6
  • 78
    • 77649178970 scopus 로고    scopus 로고
    • Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition
    • C. Wang, S. Li, and M.W. Wang Evodiamine-induced human melanoma A375-S2 cell death was mediated by PI3K/Akt/caspase and Fas-L/NF-kappaB signaling pathways and augmented by ubiquitin-proteasome inhibition Toxicol In Vitro 24 2010 898 904
    • (2010) Toxicol in Vitro , vol.24 , pp. 898-904
    • Wang, C.1    Li, S.2    Wang, M.W.3
  • 79
    • 83955161761 scopus 로고    scopus 로고
    • Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitises melanoma cells to Bortezomib by blocking Akt pathway
    • A. Yeramian, A. Sorolla, A. Velasco, M. Santacana, X. Dolcet, and J. Valls Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitises melanoma cells to Bortezomib by blocking Akt pathway Int J Cancer 2011 10.1002/ijc.26096 Epub ahead of print
    • (2011) Int J Cancer
    • Yeramian, A.1    Sorolla, A.2    Velasco, A.3    Santacana, M.4    Dolcet, X.5    Valls, J.6
  • 80
    • 77649237033 scopus 로고    scopus 로고
    • Building on bortezomib: Second-generation proteasome inhibitors as anti-cancer therapy
    • L.R. Dick, and P.E. Fleming Building on bortezomib: second-generation proteasome inhibitors as anti-cancer therapy Drug Discov Today 15 2010 243 249
    • (2010) Drug Discov Today , vol.15 , pp. 243-249
    • Dick, L.R.1    Fleming, P.E.2
  • 81
    • 73949128107 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in cancer therapy
    • A.A. Lane, and B.A. Chabner Histone deacetylase inhibitors in cancer therapy J Clin Oncol 27 2009 5459 5468
    • (2009) J Clin Oncol , vol.27 , pp. 5459-5468
    • Lane, A.A.1    Chabner, B.A.2
  • 82
    • 77956413585 scopus 로고    scopus 로고
    • Regulation of apoptosis-associated genes by histone deacetylase inhibitors: Implications in cancer therapy
    • A.R. Jazirehi Regulation of apoptosis-associated genes by histone deacetylase inhibitors: implications in cancer therapy Anticancer Drugs 21 2010 805 813
    • (2010) Anticancer Drugs , vol.21 , pp. 805-813
    • Jazirehi, A.R.1
  • 83
    • 4344716951 scopus 로고    scopus 로고
    • Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors
    • DOI 10.1023/B:APPT.0000038036.31271.50
    • F. Facchetti, S. Previdi, M. Ballarini, S. Minucci, P. Perego, and C.A. La Porta Modulation of pro- and anti-apoptotic factors in human melanoma cells exposed to histone deacetylase inhibitors Apoptosis 9 2004 573 582 (Pubitemid 39158633)
    • (2004) Apoptosis , vol.9 , Issue.5 , pp. 573-582
    • Facchetti, F.1    Previdi, S.2    Ballarini, M.3    Minucci, S.4    Perego, P.5    Porta, C.A.M.L.6
  • 84
    • 70349126890 scopus 로고    scopus 로고
    • A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways
    • J.J. Hwang, Y.S. Kim, M.J. Kim, S. Jang, J.H. Lee, and J. Choi A novel histone deacetylase inhibitor, CG0006, induces cell death through both extrinsic and intrinsic apoptotic pathways Anticancer Drugs 20 2009 815 821
    • (2009) Anticancer Drugs , vol.20 , pp. 815-821
    • Hwang, J.J.1    Kim, Y.S.2    Kim, M.J.3    Jang, S.4    Lee, J.H.5    Choi, J.6
  • 85
    • 78650794154 scopus 로고    scopus 로고
    • Preparation and evaluation of tributyrin emulsion as a potent anti-cancer agent against melanoma
    • S.N. Kang, E. Lee, M.K. Lee, and S.J. Lim Preparation and evaluation of tributyrin emulsion as a potent anti-cancer agent against melanoma Drug Deliv 18 2011 143 149
    • (2011) Drug Deliv , vol.18 , pp. 143-149
    • Kang, S.N.1    Lee, E.2    Lee, M.K.3    Lim, S.J.4
  • 86
    • 70349309607 scopus 로고    scopus 로고
    • Systemic cell-cycle suppression by apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells
    • J.H. Noh, J.H. Song, J.W. Eun, J.K. Kim, K.H. Jung, and H.J. Bae Systemic cell-cycle suppression by apicidin, a histone deacetylase inhibitor, in MDA-MB-435 cells Int J Mol Med 24 2009 205 226
    • (2009) Int J Mol Med , vol.24 , pp. 205-226
    • Noh, J.H.1    Song, J.H.2    Eun, J.W.3    Kim, J.K.4    Jung, K.H.5    Bae, H.J.6
  • 87
    • 77950543254 scopus 로고    scopus 로고
    • Epigenetic modifiers as anticancer drugs: Effectiveness of valproic acid in neural crest-derived tumor cells
    • A. Papi, A.M. Ferreri, P. Rocchi, F. Guerra, and M. Orlandi Epigenetic modifiers as anticancer drugs: effectiveness of valproic acid in neural crest-derived tumor cells Anticancer Res 30 2010 535 540
    • (2010) Anticancer Res , vol.30 , pp. 535-540
    • Papi, A.1    Ferreri, A.M.2    Rocchi, P.3    Guerra, F.4    Orlandi, M.5
  • 88
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of γ-H2AX foci
    • DOI 10.1158/1535-7163.MCT-06-0022
    • A. Munshi, T. Tanaka, M.L. Hobbs, S.L. Tucker, V.M. Richon, and R.E. Meyn Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci Mol Cancer Ther 5 2006 1967 1974 (Pubitemid 44336568)
    • (2006) Molecular Cancer Therapeutics , vol.5 , Issue.8 , pp. 1967-1974
    • Munshi, A.1    Tanaka, T.2    Hobbs, M.L.3    Tucker, S.L.4    Richon, V.M.5    Meyn, R.E.6
  • 89
    • 34347226747 scopus 로고    scopus 로고
    • Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines
    • DOI 10.1002/jgm.1036
    • T. Lillehammer, B.O. Engesaeter, L. Prasmickaite, G.M. Maelandsmo, O. Fodstad, and O. Engebraaten Combined treatment with Ad-hTRAIL and DTIC or SAHA is associated with increased mitochondrial-mediated apoptosis in human melanoma cell lines J Gene Med 9 2007 440 451 (Pubitemid 46994573)
    • (2007) Journal of Gene Medicine , vol.9 , Issue.6 , pp. 440-451
    • Lillehammer, T.1    Engesaeter, B.O.2    Prasmickaite, L.3    Maelandsmo, G.M.4    Fodstad, O.5    Engebraaten, O.6
  • 91
    • 72249084921 scopus 로고    scopus 로고
    • Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
    • D.D. Vo, R.M. Prins, J.L. Begley, T.R. Donahue, L.F. Morris, and K.W. Bruhn Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824 Cancer Res 69 2009 8693 8699
    • (2009) Cancer Res , vol.69 , pp. 8693-8699
    • Vo, D.D.1    Prins, R.M.2    Begley, J.L.3    Donahue, T.R.4    Morris, L.F.5    Bruhn, K.W.6
  • 92
    • 77953232497 scopus 로고    scopus 로고
    • Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (-)-epigallocatechin-3-gallate (EGCG)
    • M. Nihal, C.T. Roelke, and G.S. Wood Anti-melanoma effects of vorinostat in combination with polyphenolic antioxidant (-)-epigallocatechin-3-gallate (EGCG) Pharm Res 27 2010 1103 1104
    • (2010) Pharm Res , vol.27 , pp. 1103-1104
    • Nihal, M.1    Roelke, C.T.2    Wood, G.S.3
  • 93
    • 58149377828 scopus 로고    scopus 로고
    • Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma
    • A. Hauschild, U. Trefzer, C. Garbe, K.C. Kaehler, S. Ugurel, and F. Kiecker Multicenter phase II trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2-aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma Melanoma Res 18 2008 274 278
    • (2008) Melanoma Res , vol.18 , pp. 274-278
    • Hauschild, A.1    Trefzer, U.2    Garbe, C.3    Kaehler, K.C.4    Ugurel, S.5    Kiecker, F.6
  • 94
    • 65249131145 scopus 로고    scopus 로고
    • Potentiation of a topoisomerase i inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: Translational and phase I/II clinical trial
    • A.I. Daud, J. Dawson, R.C. DeConti, E. Bicaku, D. Marchion, and S. Bastien Potentiation of a topoisomerase I inhibitor, karenitecin, by the histone deacetylase inhibitor valproic acid in melanoma: translational and phase I/II clinical trial Clin Cancer Res 15 2009 2479 2487
    • (2009) Clin Cancer Res , vol.15 , pp. 2479-2487
    • Daud, A.I.1    Dawson, J.2    Deconti, R.C.3    Bicaku, E.4    Marchion, D.5    Bastien, S.6
  • 95
    • 70349682188 scopus 로고    scopus 로고
    • Phase i trial of vorinostat and doxorubicin in solid tumours: Histone deacetylase 2 expression as a predictive marker
    • P.N. Munster, D. Marchion, S. Thomas, M. Egorin, S. Minton, and G. Springett Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker Br J Cancer 101 2009 1044 1050
    • (2009) Br J Cancer , vol.101 , pp. 1044-1050
    • Munster, P.N.1    Marchion, D.2    Thomas, S.3    Egorin, M.4    Minton, S.5    Springett, G.6
  • 96
    • 58149263278 scopus 로고    scopus 로고
    • A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma
    • A. Rocca, S. Minucci, G. Tosti, D. Croci, F. Contegno, and M. Ballarini A phase I-II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma Br J Cancer 100 2009 28 36
    • (2009) Br J Cancer , vol.100 , pp. 28-36
    • Rocca, A.1    Minucci, S.2    Tosti, G.3    Croci, D.4    Contegno, F.5    Ballarini, M.6
  • 97
    • 77955455211 scopus 로고    scopus 로고
    • Molecular therapy for melanoma. Useful and not useful targets
    • C. Abdullah, X. Xiaolei Wang, and D. Becker Molecular therapy for melanoma. Useful and not useful targets Cancer Biology & Therapy 10 2010 113 118
    • (2010) Cancer Biology & Therapy , vol.10 , pp. 113-118
    • Abdullah, C.1    Xiaolei Wang, X.2    Becker, D.3
  • 98
    • 79952072157 scopus 로고    scopus 로고
    • Transcriptional control of melanoma metastasis: The importance of the tumor microenvironment
    • R.R. Braeuer, M. Zigler, G.J. Villares, A.S. Dobroff, and M. Bar-Eli Transcriptional control of melanoma metastasis: the importance of the tumor microenvironment Semin Cancer Biol 21 2011 83 88
    • (2011) Semin Cancer Biol , vol.21 , pp. 83-88
    • Braeuer, R.R.1    Zigler, M.2    Villares, G.J.3    Dobroff, A.S.4    Bar-Eli, M.5
  • 99
    • 21544479745 scopus 로고    scopus 로고
    • Integrin signaling in malignant melanoma
    • DOI 10.1007/s10555-005-1572-1
    • S. Kuphal, R. Bauer, and A-K. Bosserhoff Integrin signaling in malignant melanoma Cancer Metastasis Rev 24 2005 195 222 (Pubitemid 40922795)
    • (2005) Cancer and Metastasis Reviews , vol.24 , Issue.2 , pp. 195-222
    • Kuphal, S.1    Bauer, R.2    Bosserhoff, A.-K.3
  • 101
    • 33751088793 scopus 로고    scopus 로고
    • 3 integrin in melanoma progression, proliferation, migration and invasion
    • K. Watson-Hurst, and D. Becker The role of N-cadherin, MCAM and beta3 integrin in melanoma progression, proliferation, migration and invasion Cancer Biol Ther 5 2006 1375 1382 (Pubitemid 44772267)
    • (2006) Cancer Biology and Therapy , vol.5 , Issue.10 , pp. 1375-1382
    • Watson-Hurst, K.1    Becker, D.2
  • 102
    • 77949394260 scopus 로고    scopus 로고
    • A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + - Dacarbazine in patients with stage IV metastatic melanoma
    • P. Hersey, J. Sosman, S. O'Day, J. Richards, A. Bedikian, and R. González A randomized phase 2 study of etaracizumab, a monoclonal antibody against integrin alpha(v)beta(3), + - dacarbazine in patients with stage IV metastatic melanoma Cancer 116 2010 1526 1534
    • (2010) Cancer , vol.116 , pp. 1526-1534
    • Hersey, P.1    Sosman, J.2    O'Day, S.3    Richards, J.4    Bedikian, A.5    González, R.6
  • 103
    • 79952781372 scopus 로고    scopus 로고
    • Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma
    • G.M. Beasley, J.C. Riboh, C.K. Augustine, J.S. Zager, S.N. Hochwald, and S.R. Grobmyer Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma J Clin Oncol 29 2011 1210 1215
    • (2011) J Clin Oncol , vol.29 , pp. 1210-1215
    • Beasley, G.M.1    Riboh, J.C.2    Augustine, C.K.3    Zager, J.S.4    Hochwald, S.N.5    Grobmyer, S.R.6
  • 104
    • 71949095641 scopus 로고    scopus 로고
    • Angiogenesis in cutaneous malignant melanoma and potential therapeutic strategies
    • B. Basu, S. Biswas, J. Wrigley, B. Sirohi, and P. Corrie Angiogenesis in cutaneous malignant melanoma and potential therapeutic strategies Expert Rev Anticancer Ther 9 2009 1583 1598
    • (2009) Expert Rev Anticancer Ther , vol.9 , pp. 1583-1598
    • Basu, B.1    Biswas, S.2    Wrigley, J.3    Sirohi, B.4    Corrie, P.5
  • 105
    • 77950537144 scopus 로고    scopus 로고
    • BEAM: A randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untrated advanced melanoma
    • S.J. O'Day, K.B. Kim, J.A. Sosman, A.C. Peterson, S. Feng, and D.R. Minor BEAM: a randomized phase II study evaluating the activity of bevacizumab in combination with carboplatin plus paclitaxel in patients with previously untrated advanced melanoma Eur J Cancer Suppl 7 2009 13
    • (2009) Eur J Cancer Suppl , vol.7 , pp. 13
    • O'Day, S.J.1    Kim, K.B.2    Sosman, J.A.3    Peterson, A.C.4    Feng, S.5    Minor, D.R.6
  • 107
    • 78449249018 scopus 로고    scopus 로고
    • Ipilimumab: Unleashing the power of the immune system through CTLA-4 blockade
    • P. Boasberg, O. Hamid, and S. O'Day Ipilimumab: unleashing the power of the immune system through CTLA-4 blockade Semin Oncol 37 2010 440 449
    • (2010) Semin Oncol , vol.37 , pp. 440-449
    • Boasberg, P.1    Hamid, O.2    O'Day, S.3
  • 108
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • J.D. Wolchok, A. Hoos, S. O'Day, J.S. Weber, O. Hamid, and C. Lebbé Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria Clin Cancer Res 15 2009 7412 7420
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3    Weber, J.S.4    Hamid, O.5    Lebbé, C.6
  • 110
    • 77951679822 scopus 로고    scopus 로고
    • Advanced malignant melanoma: Immunologic and multimodal therapeutic strategies
    • N. Halama, I. Zoernig, and D. Jaeger Advanced malignant melanoma: immunologic and multimodal therapeutic strategies J Oncol 2010 2010 1 8
    • (2010) J Oncol , vol.2010 , pp. 1-8
    • Halama, N.1    Zoernig, I.2    Jaeger, D.3
  • 111
    • 74949091875 scopus 로고    scopus 로고
    • Expression of somatostatin receptors in human melanoma cell lines: Effect of two different somatostatin analogues, octreotide and SOM230, on cell proliferation
    • M. Martínez-Alonso, N. Llecha, M.E. Mayorga, A. Sorolla, X. Dolcet, and V. Sanmartín Expression of somatostatin receptors in human melanoma cell lines: effect of two different somatostatin analogues, octreotide and SOM230, on cell proliferation J Int Med Res 37 2009 1813 1822
    • (2009) J Int Med Res , vol.37 , pp. 1813-1822
    • Martínez-Alonso, M.1    Llecha, N.2    Mayorga, M.E.3    Sorolla, A.4    Dolcet, X.5    Sanmartín, V.6
  • 112
    • 53949103143 scopus 로고    scopus 로고
    • Melanoma genetics and therapeutic approaches in the 21st century: Moving from the benchside to the bedside
    • T.L. Hocker, M.K. Singh, and H. Tsao Melanoma genetics and therapeutic approaches in the 21st century: moving from the benchside to the bedside J Invest Dermatol 128 2008 2575 2595
    • (2008) J Invest Dermatol , vol.128 , pp. 2575-2595
    • Hocker, T.L.1    Singh, M.K.2    Tsao, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.