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Volumn 37, Issue 5, 2010, Pages 440-449

Ipilimumab: Unleashing the power of the immune system through CTLA-4 blockade

Author keywords

[No Author keywords available]

Indexed keywords

BUDESONIDE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DACARBAZINE; GLYCOPROTEIN GP 100; INDOLEAMINE 2,3 DIOXYGENASE; INFLIXIMAB; IPILIMUMAB; LOPERAMIDE; MESSENGER RNA; METHYLPREDNISOLONE; TRANSCRIPTION FACTOR FOXP3;

EID: 78449249018     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2010.09.004     Document Type: Article
Times cited : (63)

References (70)
  • 1
    • 0028266553 scopus 로고
    • Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose interleukin 2
    • S.A. Rosenberg, J.C. Yang, S.L. Topalian, D.J. Schwartzentruber, J.S. Weber, and D.R. Parkinson Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose interleukin 2 JAMA 271 1994 907 913
    • (1994) JAMA , vol.271 , pp. 907-913
    • Rosenberg, S.A.1    Yang, J.C.2    Topalian, S.L.3    Schwartzentruber, D.J.4    Weber, J.S.5    Parkinson, D.R.6
  • 2
    • 45549103395 scopus 로고    scopus 로고
    • Functions of anti-MAGE T-cells induced in melanoma patients under different vaccination modalities
    • T. Connerotte, A. Van Pel, and D. Godelaine Functions of anti-MAGE T-cells induced in melanoma patients under different vaccination modalities Cancer Res 68 2008 3931 3940
    • (2008) Cancer Res , vol.68 , pp. 3931-3940
    • Connerotte, T.1    Van Pel, A.2    Godelaine, D.3
  • 3
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • M.E. Dudley, J.R. Wunderlich, and J.C. Yang Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma J Clin Oncol 23 2005 2346 2357
    • (2005) J Clin Oncol , vol.23 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3
  • 4
    • 0026802163 scopus 로고
    • Prolongation of survival in metastatic melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine
    • D.L. Morton, L.J. Foshag, and D.S. Hoon Prolongation of survival in metastatic melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine Ann Surg 216 1992 463 482
    • (1992) Ann Surg , vol.216 , pp. 463-482
    • Morton, D.L.1    Foshag, L.J.2    Hoon, D.S.3
  • 5
    • 77957766128 scopus 로고    scopus 로고
    • A phase III, randomized, double-blind, multicenter study comparing monotherapy with ipilimumab or gp100 peptide vaccine and the combination in patients with previously treated, unresectable stage III or IV melanoma
    • S. O'Day, F.S. Hodi, and D. McDermott A phase III, randomized, double-blind, multicenter study comparing monotherapy with ipilimumab or gp100 peptide vaccine and the combination in patients with previously treated, unresectable stage III or IV melanoma J Clin Oncol (Meeting Abstracts) 28 2010 4
    • (2010) J Clin Oncol (Meeting Abstracts) , vol.28 , pp. 4
    • O'Day, S.1    Hodi, F.S.2    McDermott, D.3
  • 6
    • 77954801079 scopus 로고    scopus 로고
    • Ipilimumab immunotherapy alone or in combination with a peptide vaccine for pretreated, metastatic melanoma
    • F.S. Hodi, S. O'Day, and D. McDermott Ipilimumab immunotherapy alone or in combination with a peptide vaccine for pretreated, metastatic melanoma N Engl J Med 363 2010 711 723
    • (2010) N Engl J Med , vol.363 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.2    McDermott, D.3
  • 7
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • G.Q. Phan, J.C. Yang, and R.M. Sherry Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma Proc Natl Acad Sci U S A 100; 2003 8372 8377
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3
  • 8
    • 0026649765 scopus 로고
    • Identification and distribution of the costimulatory receptor CD28 in the mouse
    • J.A. Gross, E. Callas, and J.P. Allison Identification and distribution of the costimulatory receptor CD28 in the mouse J Immunol 149 1992 380 388
    • (1992) J Immunol , vol.149 , pp. 380-388
    • Gross, J.A.1    Callas, E.2    Allison, J.P.3
  • 9
    • 0025963594 scopus 로고
    • Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation
    • P.S. Linsley, W. Brady, L. Grosmaire, A. Aruffo, N.K. Damle, and J.A. Ledbetter Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation J Exp Med 173 1991 721 730
    • (1991) J Exp Med , vol.173 , pp. 721-730
    • Linsley, P.S.1    Brady, W.2    Grosmaire, L.3    Aruffo, A.4    Damle, N.K.5    Ledbetter, J.A.6
  • 11
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • R.H. Schwartz A cell culture model for T lymphocyte clonal anergy Science 248 1990 1349 1356
    • (1990) Science , vol.248 , pp. 1349-1356
    • Schwartz, R.H.1
  • 12
    • 0027282960 scopus 로고
    • Characterization of CTLA-4 structure and expression on human T cells
    • T. Lindsten, K.P. Lee, and E.S. Harris Characterization of CTLA-4 structure and expression on human T cells J Immunol 151 1993 3489 3499
    • (1993) J Immunol , vol.151 , pp. 3489-3499
    • Lindsten, T.1    Lee, K.P.2    Harris, E.S.3
  • 13
    • 0028484545 scopus 로고
    • CTLA-4 can function as a negative regulator of T cell activation
    • T.L. Walunas, D.J. Lenschow, and C.Y. Bakker CTLA-4 can function as a negative regulator of T cell activation Immunity 1 1994 405 413
    • (1994) Immunity , vol.1 , pp. 405-413
    • Walunas, T.L.1    Lenschow, D.J.2    Bakker, C.Y.3
  • 14
    • 55949083407 scopus 로고    scopus 로고
    • Anticytotoxic T-lymphocyte antigen-4 antibody: The first in an emerging class of immunomodulatory antibodies for cancer treatment
    • L. Fong, and E.J. Small Anticytotoxic T-lymphocyte antigen-4 antibody: the first in an emerging class of immunomodulatory antibodies for cancer treatment J Clin Oncol 26 2008 5275 5283
    • (2008) J Clin Oncol , vol.26 , pp. 5275-5283
    • Fong, L.1    Small, E.J.2
  • 15
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • T.L. Walunas, C.Y. Bakker, and J.A. Bluestone CTLA-4 ligation blocks CD28-dependent T cell activation J Exp Med 183 1996 2541 2550
    • (1996) J Exp Med , vol.183 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.Y.2    Bluestone, J.A.3
  • 16
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • M.F. Krummel, and J.P. Allison CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells J Exp Med 183 1996 2533 2540
    • (1996) J Exp Med , vol.183 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 18
    • 0036180686 scopus 로고    scopus 로고
    • CTLA-4 regulates cell cycle progression during a primary immune response
    • R.J. Greenwald, M.A. Oosterwegel, and D. van der Woude CTLA-4 regulates cell cycle progression during a primary immune response Eur J Immunol 32 2002 366 373
    • (2002) Eur J Immunol , vol.32 , pp. 366-373
    • Greenwald, R.J.1    Oosterwegel, M.A.2    Van Der Woude, D.3
  • 19
    • 28244492012 scopus 로고    scopus 로고
    • Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
    • A.V. Maker, P. Attia, and S.A. Rosenberg Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade J Immunol 175 2005 7746 7754
    • (2005) J Immunol , vol.175 , pp. 7746-7754
    • Maker, A.V.1    Attia, P.2    Rosenberg, S.A.3
  • 20
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • D.R. Leach, M.F. Krummel, and J.P. Allison Enhancement of antitumor immunity by CTLA-4 blockade Science 271 1996 1734 1736
    • (1996) Science , vol.271 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 21
    • 0033613173 scopus 로고    scopus 로고
    • In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
    • E.M. Sotomayor, I. Borrello, E. Tubb, J.P. Allison, and H.I. Levitsky In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance Proc Natl Acad Sci U S A 96 1999 11476 11481
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 11476-11481
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3    Allison, J.P.4    Levitsky, H.I.5
  • 22
    • 17944364189 scopus 로고    scopus 로고
    • Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: Comparison of prophylaxis and therapy
    • A. van Elsas, R.P. Sutmuller, and A.A. Hurwitz Elucidating the autoimmune and antitumor effector mechanisms of a treatment based on cytotoxic T lymphocyte antigen-4 blockade in combination with a B16 melanoma vaccine: comparison of prophylaxis and therapy J Exp Med 194 2001 481 489
    • (2001) J Exp Med , vol.194 , pp. 481-489
    • Van Elsas, A.1    Sutmuller, R.P.2    Hurwitz, A.A.3
  • 23
    • 0033592924 scopus 로고    scopus 로고
    • Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
    • E.D. Kwon, B.A. Foster, and A.A. Hurwitz Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy Proc Natl Acad Sci U S A 96 1999 15074 15079
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 15074-15079
    • Kwon, E.D.1    Foster, B.A.2    Hurwitz, A.A.3
  • 24
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing bacines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • A. van Elsas, A.A. Hurwitz, and J.P. Allison Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing bacines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation J Exp Med 190 1999 355 366
    • (1999) J Exp Med , vol.190 , pp. 355-366
    • Van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 25
    • 0034194329 scopus 로고    scopus 로고
    • Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade
    • A.A. Hurwitz, B.A. Foster, and E.D. Kwon Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade Cancer Res 60 2000 2444 2448
    • (2000) Cancer Res , vol.60 , pp. 2444-2448
    • Hurwitz, A.A.1    Foster, B.A.2    Kwon, E.D.3
  • 26
    • 0035903324 scopus 로고    scopus 로고
    • Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses
    • R.P. Sutmuller, L.M. van Duivenvoorde, and A. van Elsas Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses J Exp Med 194 2001 823 832
    • (2001) J Exp Med , vol.194 , pp. 823-832
    • Sutmuller, R.P.1    Van Duivenvoorde, L.M.2    Van Elsas, A.3
  • 27
    • 25844517914 scopus 로고    scopus 로고
    • Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells
    • K. Ko, S. Yamazaki, and K. Nakamura Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells J Exp Med 202 2005 885 891
    • (2005) J Exp Med , vol.202 , pp. 885-891
    • Ko, K.1    Yamazaki, S.2    Nakamura, K.3
  • 28
    • 33749038866 scopus 로고    scopus 로고
    • Reversal of the TCR stop signal by CTLA-4
    • H. Schneider, J. Downey, and A. Smith Reversal of the TCR stop signal by CTLA-4 Science 29 2006 1972 1975
    • (2006) Science , vol.29 , pp. 1972-1975
    • Schneider, H.1    Downey, J.2    Smith, A.3
  • 30
    • 37049008206 scopus 로고    scopus 로고
    • Kinetics of response to ipilimumab (MDX-010) in patients with stage III/IV melanoma
    • O. Hamid, W.J. Urba, and M. Yellin Kinetics of response to ipilimumab (MDX-010) in patients with stage III/IV melanoma J Clin Oncol (Meeting Abstracts) 25 2007 8525
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 8525
    • Hamid, O.1    Urba, W.J.2    Yellin, M.3
  • 31
    • 41149164223 scopus 로고    scopus 로고
    • The efficacy and safety of ipilimumab (MDX-010) in patients with unresectable stage III or stage IV malignant melanoma
    • J.S. Weber, E.M. Hersh, and M. Yellin The efficacy and safety of ipilimumab (MDX-010) in patients with unresectable stage III or stage IV malignant melanoma J Clin Oncol (Meeting Abstracts) 25 2007 8523
    • (2007) J Clin Oncol (Meeting Abstracts) , vol.25 , pp. 8523
    • Weber, J.S.1    Hersh, E.M.2    Yellin, M.3
  • 32
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • P. Attia, G.Q. Phan, and A.V. Maker Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4 J Clin Oncol 23 2005 6043 6053
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1    Phan, G.Q.2    Maker, A.V.3
  • 33
    • 58049202334 scopus 로고    scopus 로고
    • Phase I/II study of ipilimumab for patients with metastatic melanoma
    • J.S. Weber, S. O'Day, and W. Urba Phase I/II study of ipilimumab for patients with metastatic melanoma J Clin Oncol 26 2008 5950 5956
    • (2008) J Clin Oncol , vol.26 , pp. 5950-5956
    • Weber, J.S.1    O'Day, S.2    Urba, W.3
  • 34
    • 69949095926 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma
    • J. Weber, J.A. Thompson, and O. Hamid A randomized, double-blind, placebo-controlled, phase II study comparing the tolerability and efficacy of ipilimumab administered with or without prophylactic budesonide in patients with unresectable stage III or IV melanoma Clin Cancer Res 15 2009 5591 5598
    • (2009) Clin Cancer Res , vol.15 , pp. 5591-5598
    • Weber, J.1    Thompson, J.A.2    Hamid, O.3
  • 35
    • 75249100054 scopus 로고    scopus 로고
    • Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
    • J.D. Wolchok, B. Neyns, and G. Linette Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study Lancet Oncol 11 2010 155 164
    • (2010) Lancet Oncol , vol.11 , pp. 155-164
    • Wolchok, J.D.1    Neyns, B.2    Linette, G.3
  • 36
    • 77955256254 scopus 로고    scopus 로고
    • Efficacy and safety of ipilimumab in patients with pretreated advanced melanoma: A multicenter single-arm phase II study
    • S.J. O'Day, M. Maio, and V. Chiarion-Sileni Efficacy and safety of ipilimumab in patients with pretreated advanced melanoma: a multicenter single-arm phase II study Ann Oncol 21 2010 1712 1717
    • (2010) Ann Oncol , vol.21 , pp. 1712-1717
    • O'Day, S.J.1    Maio, M.2    Chiarion-Sileni, V.3
  • 37
    • 39149104690 scopus 로고    scopus 로고
    • Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials
    • E.L. Korn, P.Y. Liu, and S.J. Lee Meta-analysis of phase II cooperative group trials in metastatic stage IV melanoma to determine progression-free and overall survival benchmarks for future phase II trials J Clin Oncol 26 2008 527 534
    • (2008) J Clin Oncol , vol.26 , pp. 527-534
    • Korn, E.L.1    Liu, P.Y.2    Lee, S.J.3
  • 38
    • 78449248613 scopus 로고    scopus 로고
    • The effect of HLA-A2 subtype on the efficacy and safety of ipilimumab in previously treated patients with advanced melanoma
    • Lebbe C, O'Day S, Hamid O, et al. The effect of HLA-A2 subtype on the efficacy and safety of ipilimumab in previously treated patients with advanced melanoma. Perepectives in Melanoma XIV, 2010, #0016.
    • (2010) Perepectives in Melanoma , vol.16 , pp. 0016
    • Lebbe, C.1    O'Day, S.2    Hamid, O.3
  • 39
    • 78449252619 scopus 로고    scopus 로고
    • A multi-center, randomized, double-blind, two-arm, phase III study in patients with untreated stage III (unresectable) or IV melanoma receiving dacarbazine plus 10 mg/kg ipilimumab (MDX-010) vs. dacarbazine with placebo. ClinicalTrials.govIdentifier: NCT00324155.Bristol-MeyersSquibb
    • A multi-center, randomized, double-blind, two-arm, phase III study in patients with untreated stage III (unresectable) or IV melanoma receiving dacarbazine plus 10 mg/kg ipilimumab (MDX-010) vs. dacarbazine with placebo. ClinicalTrials.gov Identifier: NCT00324155. Bristol-Meyers Squibb.
  • 40
    • 78449236060 scopus 로고    scopus 로고
    • Re-induction with ipilimumab, gp100 peptide vaccine, or a combination of both from a phase III, randomized, double-blind, multicenter study of previously treated patients with unresectable stage III or IV melanoma
    • F.S. Hodi, S. O'Day, and D.F. McDermott Re-induction with ipilimumab, gp100 peptide vaccine, or a combination of both from a phase III, randomized, double-blind, multicenter study of previously treated patients with unresectable stage III or IV melanoma J Clin Oncol (Meeting Abstracts) 28 2010 8509
    • (2010) J Clin Oncol (Meeting Abstracts) , vol.28 , pp. 8509
    • Hodi, F.S.1    O'Day, S.2    McDermott, D.F.3
  • 41
    • 55949101240 scopus 로고    scopus 로고
    • Disease control and long-term survival in chemotherapy-naive patients with advanced melanoma treated with ipilimumab (MDX- 010) with or without dacarbazine
    • E.M. Hersh, J.S. Weber, and J.D. Powderly Disease control and long-term survival in chemotherapy-naive patients with advanced melanoma treated with ipilimumab (MDX- 010) with or without dacarbazine J Clin Oncol (Meeting Abstracts) 26 2008 9022
    • (2008) J Clin Oncol (Meeting Abstracts) , vol.26 , pp. 9022
    • Hersh, E.M.1    Weber, J.S.2    Powderly, J.D.3
  • 42
    • 79955574161 scopus 로고    scopus 로고
    • A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-nave patients with advanced melanoma
    • E.M. Hersh, S.J. O'Day, and J. Powderly A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-nave patients with advanced melanoma Invest New Drugs 2010 Jan 15
    • (2010) Invest New Drugs
    • Hersh, E.M.1    O'Day, S.J.2    Powderly, J.3
  • 43
    • 75749139984 scopus 로고    scopus 로고
    • Long-term survival of patients (pts) with advanced melanoma treated with ipilimumab with or without dacarbazine
    • E. Hersh, J. Weber, and J. Powderly Long-term survival of patients (pts) with advanced melanoma treated with ipilimumab with or without dacarbazine J Clin Oncol (Meeting Abstracts) 27 2009 9038
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 9038
    • Hersh, E.1    Weber, J.2    Powderly, J.3
  • 44
    • 0037010054 scopus 로고    scopus 로고
    • The treatment of brain metastases from malignant melanoma
    • J.G. Douglas, and K. Margolin The treatment of brain metastases from malignant melanoma Semin Oncol 29 2002 518 524
    • (2002) Semin Oncol , vol.29 , pp. 518-524
    • Douglas, J.G.1    Margolin, K.2
  • 45
    • 0036208833 scopus 로고    scopus 로고
    • Temozolomide and whole brain irradiation in melanoma metastatic to the brain: A phase II trial of the Cytokine Working Group
    • K. Margolin, B. Atkins, and A. Thompson Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group J Cancer Res Clin Oncol 128 2002 214 218
    • (2002) J Cancer Res Clin Oncol , vol.128 , pp. 214-218
    • Margolin, K.1    Atkins, B.2    Thompson, A.3
  • 46
    • 77957587190 scopus 로고    scopus 로고
    • Phase II trial of ipilimumab monotherapy in melanoma patients with brain metastases
    • D.P. Lawrence, O. Hamid, and D.F. McDermott Phase II trial of ipilimumab monotherapy in melanoma patients with brain metastases J Clin Oncol (Meeting Abstracts) 28 2010 8523
    • (2010) J Clin Oncol (Meeting Abstracts) , vol.28 , pp. 8523
    • Lawrence, D.P.1    Hamid, O.2    McDermott, D.F.3
  • 47
    • 77952238391 scopus 로고    scopus 로고
    • Complete regression of a previously untreated melanoma brain metastasis with ipilimumab
    • N.E. Schartz, C. Farges, and I. Madelaine Complete regression of a previously untreated melanoma brain metastasis with ipilimumab Melanoma Res 20 2010 247 250
    • (2010) Melanoma Res , vol.20 , pp. 247-250
    • Schartz, N.E.1    Farges, C.2    Madelaine, I.3
  • 48
    • 77953452829 scopus 로고    scopus 로고
    • Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multipeptide vaccine for resected stages IIIC and IV melanoma
    • J.S. Weber, A. Sarnaik, and S. Targan Phase II trial of extended dose anti-CTLA-4 antibody ipilimumab (formerly MDX-010) with a multipeptide vaccine for resected stages IIIC and IV melanoma J Clin Oncol (Meeting Abstracts) 27 2009 9023
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 9023
    • Weber, J.S.1    Sarnaik, A.2    Targan, S.3
  • 49
    • 77950285080 scopus 로고    scopus 로고
    • Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab
    • D.M. Berman, J. Wolchok, J. Weber, O. Hamid, S. O'Day, and S.D. Chasalow Association of peripheral blood absolute lymphocyte count (ALC) and clinical activity in patients (pts) with advanced melanoma treated with ipilimumab J Clin Oncol (Meeting Abstracts) 27 2009 3020
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 3020
    • Berman, D.M.1    Wolchok, J.2    Weber, J.3    Hamid, O.4    O'Day, S.5    Chasalow, S.D.6
  • 50
    • 77950258677 scopus 로고    scopus 로고
    • Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: Lymphocyte count after 2 doses correlates with survival
    • G.Y. Ku, J. Yuan, and D.B. Page Single-institution experience with ipilimumab in advanced melanoma patients in the compassionate use setting: lymphocyte count after 2 doses correlates with survival Cancer 116 2010 1767 1775
    • (2010) Cancer , vol.116 , pp. 1767-1775
    • Ku, G.Y.1    Yuan, J.2    Page, D.B.3
  • 51
    • 77953635401 scopus 로고    scopus 로고
    • Refractory colitis following anti-CTLA4 antibody therapy: Analysis of mucosal FOXP3+ T cells
    • J.D. Lord, R.C. Hackman, and A. Moklebust Refractory colitis following anti-CTLA4 antibody therapy: analysis of mucosal FOXP3+ T cells Dig Dis Sci 55 2010 1396 1405
    • (2010) Dig Dis Sci , vol.55 , pp. 1396-1405
    • Lord, J.D.1    Hackman, R.C.2    Moklebust, A.3
  • 52
    • 77955253357 scopus 로고    scopus 로고
    • Association of baseline and on-study tumor biopsy markers with clinical activity in patients (pts) with advanced melanoma treated with ipilimumab
    • O. Hamid, S.D. Chasalow, and Z. Tsuchihashi Association of baseline and on-study tumor biopsy markers with clinical activity in patients (pts) with advanced melanoma treated with ipilimumab J Clin Oncol (Meeting Abstracts) 27 2009 9008
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 9008
    • Hamid, O.1    Chasalow, S.D.2    Tsuchihashi, Z.3
  • 53
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • J.D. Wolchok, A. Hoos, and S. O'Day Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria Clin Cancer Res 15 2009 7412 7420
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 54
    • 33745081884 scopus 로고    scopus 로고
    • Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma
    • R.F. Little, J.M. Pluda, and K.M. Wyvill Activity of subcutaneous interleukin-12 in AIDS-related Kaposi sarcoma Blood 107 2006 4650 4657
    • (2006) Blood , vol.107 , pp. 4650-4657
    • Little, R.F.1    Pluda, J.M.2    Wyvill, K.M.3
  • 55
    • 28844471692 scopus 로고    scopus 로고
    • Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells
    • N. van Baren, M.C. Bonnet, and B. Drno Tumoral and immunologic response after vaccination of melanoma patients with an ALVAC virus encoding MAGE antigens recognized by T cells J Clin Oncol 23 2005 9008 9021
    • (2005) J Clin Oncol , vol.23 , pp. 9008-9021
    • Van Baren, N.1    Bonnet, M.C.2    Drno, B.3
  • 56
    • 27144514758 scopus 로고    scopus 로고
    • Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma
    • W.H. Kruit, H.H. van Ojik, and V.G. Brichard Phase 1/2 study of subcutaneous and intradermal immunization with a recombinant MAGE-3 protein in patients with detectable metastatic melanoma Int J Cancer 117 2005 596 604
    • (2005) Int J Cancer , vol.117 , pp. 596-604
    • Kruit, W.H.1    Van Ojik, H.H.2    Brichard, V.G.3
  • 57
    • 67349182592 scopus 로고    scopus 로고
    • Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: Clinical and immunological evidence from three patient cases
    • A.M. Di Giacomo, R. Danielli, and M. Guidoboni Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases Cancer Immunol Immunother 58 2009 1297 1306
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1297-1306
    • Di Giacomo, A.M.1    Danielli, R.2    Guidoboni, M.3
  • 58
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • J.D. Wolchok, A. Hoos, and S. O'Day Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria Clin Cancer Res 15 2009 7412 7420
    • (2009) Clin Cancer Res , vol.15 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 59
    • 67650491041 scopus 로고    scopus 로고
    • Anti-CTLA4 antibodyinduced lupus nephritis
    • F. Fadel, K.E. Karoui, and B. Knebelmann Anti-CTLA4 antibodyinduced lupus nephritis N Engl J Med 361 2009 211
    • (2009) N Engl J Med , vol.361 , pp. 211
    • Fadel, F.1    Karoui, K.E.2    Knebelmann, B.3
  • 60
    • 68349092608 scopus 로고    scopus 로고
    • Autoimmune inflammatory myopathy after treatment with ipilimumab
    • G. Hunter, C. Voll, and C.A. Robinson Autoimmune inflammatory myopathy after treatment with ipilimumab Can J Neurol Sci 36 2009 518 520
    • (2009) Can J Neurol Sci , vol.36 , pp. 518-520
    • Hunter, G.1    Voll, C.2    Robinson, C.A.3
  • 61
    • 69949088914 scopus 로고    scopus 로고
    • An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: Prevention of gastrointestinal perforation and/or colectomy
    • R. Lin, M.J. Yellin, I. Lowy, A. Safferman, K. Chin, and R. Ibrahim An analysis of the effectiveness of specific guidelines for the management of ipilimumab-mediated diarrhea/colitis: prevention of gastrointestinal perforation and/or colectomy J Clin Oncol (Meeting Abstracts) 26 2008 9063
    • (2008) J Clin Oncol (Meeting Abstracts) , vol.26 , pp. 9063
    • Lin, R.1    Yellin, M.J.2    Lowy, I.3    Safferman, A.4    Chin, K.5    Ibrahim, R.6
  • 62
    • 33744792341 scopus 로고    scopus 로고
    • Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4
    • K.E. Beck, J.A. Blansfield, and K.Q. Tran Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte-associated antigen 4 J Clin Oncol 24 2006 2283 2289
    • (2006) J Clin Oncol , vol.24 , pp. 2283-2289
    • Beck, K.E.1    Blansfield, J.A.2    Tran, K.Q.3
  • 63
    • 67650848410 scopus 로고    scopus 로고
    • Infliximab in the treatment of anti-CTLA4 (ipilimumab) induced immune-related colitis
    • D.R. Minor, K. Chin, and M. Kashani-Sabat Infliximab in the treatment of anti-CTLA4 (ipilimumab) induced immune-related colitis Cancer Biother Radiopharm 24 2008 321 325
    • (2008) Cancer Biother Radiopharm , vol.24 , pp. 321-325
    • Minor, D.R.1    Chin, K.2    Kashani-Sabat, M.3
  • 64
    • 78449237338 scopus 로고    scopus 로고
    • Evaluation of the effect of systemic corticosteroids for the treatment of immune-related adverse events (irAEs) on the development or maintenance of ipilimumab clinical activity
    • A. Amin, V. DePril, and O. Hamid Evaluation of the effect of systemic corticosteroids for the treatment of immune-related adverse events (irAEs) on the development or maintenance of ipilimumab clinical activity J Clin Oncol (Meeting Abstracts) 27 2009 9037
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 9037
    • Amin, A.1    Depril, V.2    Hamid, O.3
  • 65
    • 27444444916 scopus 로고    scopus 로고
    • Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells
    • C.S. Hinrichs, D.C. Palmer, S.A. Rosenberg, and N.P. Restifo Glucocorticoids do not inhibit antitumor activity of activated CD8+ T cells J Immunother 28 2005 517 524
    • (2005) J Immunother , vol.28 , pp. 517-524
    • Hinrichs, C.S.1    Palmer, D.C.2    Rosenberg, S.A.3    Restifo, N.P.4
  • 66
    • 33846012904 scopus 로고    scopus 로고
    • Risk of bowel perforation in patients receiving interleukin-2 after therapy with anti-CTLA 4 monoclonal antibody
    • F.O. Smith, S.L. Goff, and J.A. Klapper Risk of bowel perforation in patients receiving interleukin-2 after therapy with anti-CTLA 4 monoclonal antibody J Immunother 30 2007 130
    • (2007) J Immunother , vol.30 , pp. 130
    • Smith, F.O.1    Goff, S.L.2    Klapper, J.A.3
  • 67
    • 27444440093 scopus 로고    scopus 로고
    • Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer
    • J.A. Blansfield, K.E. Beck, and K. Tran Cytotoxic T-lymphocyte-associated antigen-4 blockage can induce autoimmune hypophysitis in patients with metastatic melanoma and renal cancer J Immunother 28 2005 593 598
    • (2005) J Immunother , vol.28 , pp. 593-598
    • Blansfield, J.A.1    Beck, K.E.2    Tran, K.3
  • 68
    • 70449881133 scopus 로고    scopus 로고
    • Anti-CTLA-4 therapy-related autoimmune hypophysitis in a melanoma patient
    • K.C. Kaehler, F. Egberts, P. Lorigan, and A. Hauschild Anti-CTLA-4 therapy-related autoimmune hypophysitis in a melanoma patient Melanoma Res 19 2009 333 334
    • (2009) Melanoma Res , vol.19 , pp. 333-334
    • Kaehler, K.C.1    Egberts, F.2    Lorigan, P.3    Hauschild, A.4
  • 69
    • 77951443592 scopus 로고    scopus 로고
    • Initial phase II experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration-resistant prostate cancer (mCRPC)
    • S.F. Slovin, T.M. Beer, and C.S. Higano Initial phase II experience of ipilimumab (IPI) alone and in combination with radiotherapy (XRT) in patients with metastatic castration-resistant prostate cancer (mCRPC) J Clin Oncol (Meeting Abstracts) 27 2009 5138
    • (2009) J Clin Oncol (Meeting Abstracts) , vol.27 , pp. 5138
    • Slovin, S.F.1    Beer, T.M.2    Higano, C.S.3
  • 70
    • 78449264515 scopus 로고    scopus 로고
    • Phase II trial of ipilimumab (IPI) and paclitaxel/carboplatin (P/C) in first-line stage IIIb/IV non-small cell lung cancer (NSCLC)
    • T.J. Lynch, I.N. Bondarenko, and A. Luft Phase II trial of ipilimumab (IPI) and paclitaxel/carboplatin (P/C) in first-line stage IIIb/IV non-small cell lung cancer (NSCLC) J Clin Oncol (Meeting Abstracts) 28 2010 7531
    • (2010) J Clin Oncol (Meeting Abstracts) , vol.28 , pp. 7531
    • Lynch, T.J.1    Bondarenko, I.N.2    Luft, A.3


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