메뉴 건너뛰기




Volumn 29, Issue 41, 2010, Pages 5545-5555

Analysis of the genome to personalize therapy for melanoma

Author keywords

BRAF; C KIT; ERBB4; GN Q; melanoma; NRAS

Indexed keywords

5 (4 BROMO 2 CHLOROANILINO) 4 FLUORO 1 METHYL 1H BENZIMIDAZOLE 6 CARBOHYDROXAMIC ACID 2 HYDROXYETHYL ESTER; ALPHA2B INTERFERON; AZ 628; B RAF KINASE; BRAF INHIBITOR; DACARBAZINE; EPIDERMAL GROWTH FACTOR RECEPTOR 4; G PROTEIN COUPLED RECEPTOR; IMATINIB; INTERLEUKIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PACLITAXEL; PERIFOSINE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PLX 4032; PROTEIN INHIBITOR; RAS PROTEIN; SORAFENIB; TEMSIROLIMUS; UNCLASSIFIED DRUG;

EID: 77957982878     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.323     Document Type: Review
Times cited : (114)

References (118)
  • 1
    • 42449147592 scopus 로고    scopus 로고
    • Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma
    • Akslen LA, Puntervoll H, Bachmann IM, Straume O, Vuhahula E, Kumar R et al. (2008). Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma. Melanoma Res 18: 29-35.
    • (2008) Melanoma Res , vol.18 , pp. 29-35
    • Akslen, L.A.1    Puntervoll, H.2    Bachmann, I.M.3    Straume, O.4    Vuhahula, E.5    Kumar, R.6
  • 2
    • 0024292722 scopus 로고
    • Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
    • Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. (1988). Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53: 549-554.
    • (1988) Cell , vol.53 , pp. 549-554
    • Almoguera, C.1    Shibata, D.2    Forrester, K.3    Martin, J.4    Arnheim, N.5    Perucho, M.6
  • 3
    • 34250335270 scopus 로고    scopus 로고
    • L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition
    • Antonescu CR, Busam KJ, Francone TD, Wong GC, Guo T, Agaram NP et al. (2007). L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. Int J Cancer 121: 257-264.
    • (2007) Int J Cancer , vol.121 , pp. 257-264
    • Antonescu, C.R.1    Busam, K.J.2    Francone, T.D.3    Wong, G.C.4    Guo, T.5    Agaram, N.P.6
  • 4
    • 58149461573 scopus 로고    scopus 로고
    • Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
    • Ashida A, Takata M, Murata H, Kido K, Saida T. (2009). Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas. Int J Cancer 124: 862-868.
    • (2009) Int J Cancer , vol.124 , pp. 862-868
    • Ashida, A.1    Takata, M.2    Murata, H.3    Kido, K.4    Saida, T.5
  • 5
    • 0033848628 scopus 로고    scopus 로고
    • High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: Long-term survival update
    • Atkins MB, Kunkel L, Sznol M, Rosenberg SA. (2000). High-dose recombinant interleukin-2 therapy in patients with metastatic melanoma: long-term survival update. Cancer J Sci Am 6(Suppl 1): S11-S14.
    • (2000) Cancer J Sci Am , vol.6 , Issue.SUPPL. 1
    • Atkins, M.B.1    Kunkel, L.2    Sznol, M.3    Rosenberg, S.A.4
  • 6
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K et al. (1999). High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 17: 2105-2116.
    • (1999) J Clin Oncol , vol.17 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3    Fisher, R.I.4    Weiss, G.5    Margolin, K.6
  • 7
    • 73949102380 scopus 로고    scopus 로고
    • Multidrug resistance in cancer
    • Baguley BC. (2010). Multidrug resistance in cancer. Methods Mol Biol 596: 1-14.
    • (2010) Methods Mol Biol , vol.596 , pp. 1-14
    • Baguley, B.C.1
  • 8
    • 57349121073 scopus 로고    scopus 로고
    • Melanoma in mice casts doubt on scarcity of cancer stem cells
    • Baker M. (2008). Melanoma in mice casts doubt on scarcity of cancer stem cells. Nature 456: 553.
    • (2008) Nature , vol.456 , pp. 553
    • Baker, M.1
  • 9
    • 0032523833 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
    • Bastian BC, LeBoit PE, Hamm H, Brocker EB, Pinkel D. (1998). Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 58: 2170-2175.
    • (1998) Cancer Res , vol.58 , pp. 2170-2175
    • Bastian, B.C.1    Leboit, P.E.2    Hamm, H.3    Brocker, E.B.4    Pinkel, D.5
  • 11
    • 0034086867 scopus 로고    scopus 로고
    • Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies
    • Birck A, Ahrenkiel V, Zeuthen J, Hou-Jensen K, Guldberg P. (2000). Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies. J Invest Dermatol 114: 277-280.
    • (2000) J Invest Dermatol , vol.114 , pp. 277-280
    • Birck, A.1    Ahrenkiel, V.2    Zeuthen, J.3    Hou-Jensen, K.4    Guldberg, P.5
  • 12
    • 0030789242 scopus 로고    scopus 로고
    • Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hemato-poietic cell
    • Bonnet D, Dick JE. (1997). Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hemato-poietic cell. Nat Med 3: 730-737.
    • (1997) Nat Med , vol.3 , pp. 730-737
    • Bonnet, D.1    Dick, J.E.2
  • 13
    • 0024376173 scopus 로고
    • Ras oncogenes in human cancer: A review
    • Bos JL. (1989). ras oncogenes in human cancer: a review. Cancer Res 49: 4682-4689.
    • (1989) Cancer Res , vol.49 , pp. 4682-4689
    • Bos, J.L.1
  • 16
    • 0036849331 scopus 로고    scopus 로고
    • PKB binding proteins. Getting in on the Akt
    • Brazil DP, Park J, Hemmings BA. (2002). PKB binding proteins. Getting in on the Akt. Cell 111: 293-303.
    • (2002) Cell , vol.111 , pp. 293-303
    • Brazil, D.P.1    Park, J.2    Hemmings, B.A.3
  • 18
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. (2002). The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 19
    • 34547172596 scopus 로고    scopus 로고
    • A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
    • Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM et al. (2007). A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448: 439-444.
    • (2007) Nature , vol.448 , pp. 439-444
    • Carpten, J.D.1    Faber, A.L.2    Horn, C.3    Donoho, G.P.4    Briggs, S.L.5    Robbins, C.M.6
  • 20
    • 16844385347 scopus 로고    scopus 로고
    • Melanoma genetics and the development of rational therapeutics
    • Chudnovsky Y, Khavari PA, Adams AE. (2005). Melanoma genetics and the development of rational therapeutics. J Clin Invest 115: 813-824.
    • (2005) J Clin Invest , vol.115 , pp. 813-824
    • Chudnovsky, Y.1    Khavari, P.A.2    Adams, A.E.3
  • 22
  • 24
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin JA, Busam K, Pinkel D, Bastian BC. (2006). Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24: 4340-4346.
    • (2006) J Clin Oncol , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 28
    • 34248546062 scopus 로고    scopus 로고
    • Point mutations of protein kinases and individualised cancer therapy
    • Davies M, Hennessy B, Mills GB. (2006). Point mutations of protein kinases and individualised cancer therapy. Expert Opin Pharmacother 7: 2243-2261.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 2243-2261
    • Davies, M.1    Hennessy, B.2    Mills, G.B.3
  • 29
    • 73349128709 scopus 로고    scopus 로고
    • Integrated molecular and clinical analysis of AKT activation in metastatic melanoma
    • Davies MA, Stemke-Hale K, Lin E, Tellez C, Deng W, Gopal YN et al. (2009). Integrated molecular and clinical analysis of AKT activation in metastatic melanoma. Clin Cancer Res 15: 7538-7546.
    • (2009) Clin Cancer Res , vol.15 , pp. 7538-7546
    • Davies, M.A.1    Stemke-Hale, K.2    Lin, E.3    Tellez, C.4    Deng, W.5    Gopal, Y.N.6
  • 30
    • 0037264633 scopus 로고    scopus 로고
    • Targeting RAS signalling pathways in cancer therapy
    • Downward J. (2003). Targeting RAS signalling pathways in cancer therapy. Nat Rev Cancer 3: 11-22.
    • (2003) Nat Rev Cancer , vol.3 , pp. 11-22
    • Downward, J.1
  • 31
    • 77950261074 scopus 로고    scopus 로고
    • Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)
    • Dry JR, Pavey S, Pratilas CA, Harbron C, Runswick S, Hodgson D et al. (2010). Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244). Cancer Res 70: 2264-2273.
    • (2010) Cancer Res , vol.70 , pp. 2264-2273
    • Dry, J.R.1    Pavey, S.2    Pratilas, C.A.3    Harbron, C.4    Runswick, S.5    Hodgson, D.6
  • 32
    • 57349126306 scopus 로고    scopus 로고
    • Cancer stem cells: Here, there, everywhere?
    • Eaves CJ. (2008). Cancer stem cells: here, there, everywhere? Nature 456: 581-582.
    • (2008) Nature , vol.456 , pp. 581-582
    • Eaves, C.J.1
  • 33
    • 33748325763 scopus 로고    scopus 로고
    • Sorafenib in advanced melanoma: A phase II randomized discontinuation trial analysis
    • Eisen T, Ahmad T, Flaherty KT, Gore M, Kaye S, Marais R et al. (2006). Sorafenib in advanced melanoma: a phase II randomized discontinuation trial analysis. Br J Cancer 95: 581-586.
    • (2006) Br J Cancer , vol.95 , pp. 581-586
    • Eisen, T.1    Ahmad, T.2    Flaherty, K.T.3    Gore, M.4    Kaye, S.5    Marais, R.6
  • 35
    • 57349194139 scopus 로고    scopus 로고
    • Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
    • Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R et al. (2008). Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 14: 1351-1356.
    • (2008) Nat Med , vol.14 , pp. 1351-1356
    • Engelman, J.A.1    Chen, L.2    Tan, X.3    Crosby, K.4    Guimaraes, A.R.5    Upadhyay, R.6
  • 36
    • 31544448600 scopus 로고    scopus 로고
    • Phase II study of perifosine in previously untreated patients with metastatic melanoma
    • Ernst DS, Eisenhauer E, Wainman N, Davis M, Lohmann R, Baetz T et al. (2005). Phase II study of perifosine in previously untreated patients with metastatic melanoma. Invest New Drugs 23: 569-575.
    • (2005) Invest New Drugs , vol.23 , pp. 569-575
    • Ernst, D.S.1    Eisenhauer, E.2    Wainman, N.3    Davis, M.4    Lohmann, R.5    Baetz, T.6
  • 38
    • 51049095131 scopus 로고    scopus 로고
    • A phase i trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel
    • Flaherty KT, Schiller J, Schuchter LM, Liu G, Tuveson DA, Redlinger M et al. (2008). A phase I trial of the oral, multikinase inhibitor sorafenib in combination with carboplatin and paclitaxel. Clin Cancer Res 14: 4836-4842.
    • (2008) Clin Cancer Res , vol.14 , pp. 4836-4842
    • Flaherty, K.T.1    Schiller, J.2    Schuchter, L.M.3    Liu, G.4    Tuveson, D.A.5    Redlinger, M.6
  • 39
    • 0023262990 scopus 로고
    • Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
    • Forrester K, Almoguera C, Han K, Grizzle WE, Perucho M. (1987). Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature 327: 298-303.
    • (1987) Nature , vol.327 , pp. 298-303
    • Forrester, K.1    Almoguera, C.2    Han, K.3    Grizzle, W.E.4    Perucho, M.5
  • 41
    • 33847220364 scopus 로고    scopus 로고
    • Melanoma biology and new targeted therapy
    • Gray-Schopfer V, Wellbrock C, Marais R. (2007). Melanoma biology and new targeted therapy. Nature 445: 851-857.
    • (2007) Nature , vol.445 , pp. 851-857
    • Gray-Schopfer, V.1    Wellbrock, C.2    Marais, R.3
  • 42
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg P, Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. (1997). Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 57: 3660-3663.
    • (1997) Cancer Res , vol.57 , pp. 3660-3663
    • Guldberg, P.1    Straten, P.2    Birck, A.3    Ahrenkiel, V.4    Kirkin, A.F.5    Zeuthen, J.6
  • 45
    • 77949406203 scopus 로고    scopus 로고
    • Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure
    • Handolias D, Salemi R, Murray W, Tan A, Liu W, Viros A et al. (2010). Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. Pigment Cell Melanoma Res 23: 210-215.
    • (2010) Pigment Cell Melanoma Res , vol.23 , pp. 210-215
    • Handolias, D.1    Salemi, R.2    Murray, W.3    Tan, A.4    Liu, W.5    Viros, A.6
  • 46
  • 47
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, Hersey P et al. (2009). Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 27: 2823-2830.
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3    Hogg, D.4    Robert, C.5    Hersey, P.6
  • 48
    • 39749104201 scopus 로고    scopus 로고
    • Practical guidelines for the management of interferon-alpha-2b side effects in patients receiving adjuvant treatment for melanoma
    • Hauschild A, Gogas H, Tarhini A, Middleton MR, Testori A, Dreno B et al. (2008). Practical guidelines for the management of interferon-alpha-2b side effects in patients receiving adjuvant treatment for melanoma. Cancer 112: 982-994.
    • (2008) Cancer , vol.112 , pp. 982-994
    • Hauschild, A.1    Gogas, H.2    Tarhini, A.3    Middleton, M.R.4    Testori, A.5    Dreno, B.6
  • 49
    • 74849109743 scopus 로고    scopus 로고
    • Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
    • Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N et al. (2010). Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell 140: 209-221.
    • (2010) Cell , vol.140 , pp. 209-221
    • Heidorn, S.J.1    Milagre, C.2    Whittaker, S.3    Nourry, A.4    Niculescu-Duvas, I.5    Dhomen, N.6
  • 52
    • 34248375532 scopus 로고    scopus 로고
    • Ultraviolet radiation and melanoma: A systematic review and analysis of reported sequence variants
    • Hocker T, Tsao H. (2007). Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants. Hum Mutat 28: 578-588.
    • (2007) Hum Mutat , vol.28 , pp. 578-588
    • Hocker, T.1    Tsao, H.2
  • 54
    • 0030459095 scopus 로고    scopus 로고
    • Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
    • Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD et al. (1996). Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 13: 2339-2347.
    • (1996) Oncogene , vol.13 , pp. 2339-2347
    • Huang, S.1    Luca, M.2    Gutman, M.3    McConkey, D.J.4    Langley, K.E.5    Lyman, S.D.6
  • 57
    • 66349098469 scopus 로고    scopus 로고
    • Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors
    • Jaiswal BS, Janakiraman V, Kljavin NM, Eastham-Anderson J, Cupp JE, Liang Y et al. (2009b). Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors. PLoS One 4: e5717.
    • (2009) PLoS One , vol.4
    • Jaiswal, B.S.1    Janakiraman, V.2    Kljavin, N.M.3    Eastham-Anderson, J.4    Cupp, J.E.5    Liang, Y.6
  • 61
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. (2001). Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 17: 615-675.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3    White, S.4    Timms, J.5    Waterfield, M.D.6
  • 63
    • 0030030347 scopus 로고    scopus 로고
    • Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group Trial EST 1684
    • Kirkwood J, Strawderman M, Ernstoff M, Smith T, Borden E, Blum R. (1996). Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. J Clin Oncol 14: 7-17.
    • (1996) J Clin Oncol , vol.14 , pp. 7-17
    • Kirkwood, J.1    Strawderman, M.2    Ernstoff, M.3    Smith, T.4    Borden, E.5    Blum, R.6
  • 64
    • 1842533233 scopus 로고    scopus 로고
    • A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma
    • Kirkwood JM, Manola J, Ibrahim J, Sondak V, Ernstoff MS, Rao U. (2004). A pooled analysis of eastern cooperative oncology group and intergroup trials of adjuvant high-dose interferon for melanoma. Clin Cancer Res 10: 1670-1677.
    • (2004) Clin Cancer Res , vol.10 , pp. 1670-1677
    • Kirkwood, J.M.1    Manola, J.2    Ibrahim, J.3    Sondak, V.4    Ernstoff, M.S.5    Rao, U.6
  • 65
    • 34347369084 scopus 로고    scopus 로고
    • Post-translational modifications and regulation of the RAS super-family of GTPases as anticancer targets
    • Konstantinopoulos PA, Karamouzis MV, Papavassiliou AG. (2007). Post-translational modifications and regulation of the RAS super-family of GTPases as anticancer targets. Nat Rev Drug Discov 6: 541-555.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 541-555
    • Konstantinopoulos, P.A.1    Karamouzis, M.V.2    Papavassiliou, A.G.3
  • 66
    • 0026518279 scopus 로고
    • Loss of c-kit expression in cultured melanoma cells
    • Lassam N, Bickford S. (1992). Loss of c-kit expression in cultured melanoma cells. Oncogene 7: 51-56.
    • (1992) Oncogene , vol.7 , pp. 51-56
    • Lassam, N.1    Bickford, S.2
  • 67
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI et al. (1997). PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275: 1943-1947.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3    Podsypanina, K.4    Bose, S.5    Wang, S.I.6
  • 69
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phospha-tidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE. (1998). The tumor suppressor, PTEN/ MMAC1, dephosphorylates the lipid second messenger, phospha-tidylinositol 3,4,5-trisphosphate. J Biol Chem 273: 13375-13378.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 70
    • 23844476134 scopus 로고    scopus 로고
    • CCI-779 in metastatic melanoma: A phase II trial of the California Cancer Consortium
    • Margolin K, Longmate J, Baratta T, Synold T, Christensen S, Weber J et al. (2005). CCI-779 in metastatic melanoma: a phase II trial of the California Cancer Consortium. Cancer 104: 1045-1048.
    • (2005) Cancer , vol.104 , pp. 1045-1048
    • Margolin, K.1    Longmate, J.2    Baratta, T.3    Synold, T.4    Christensen, S.5    Weber, J.6
  • 72
    • 49649118852 scopus 로고    scopus 로고
    • Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
    • Montagut C, Sharma SV, Shioda T, McDermott U, Ulman M, Ulkus LE et al. (2008). Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma. Cancer Res 68: 4853-4861.
    • (2008) Cancer Res , vol.68 , pp. 4853-4861
    • Montagut, C.1    Sharma, S.V.2    Shioda, T.3    McDermott, U.4    Ulman, M.5    Ulkus, L.E.6
  • 75
    • 32944457518 scopus 로고    scopus 로고
    • MTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly KE, Rojo F, She QB, Solit D, Mills GB, Smith D et al. (2006). mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res 66: 1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.B.3    Solit, D.4    Mills, G.B.5    Smith, D.6
  • 76
    • 33745888704 scopus 로고    scopus 로고
    • Mutations of PIK3CA are rare in cutaneous melanoma
    • Omholt K, Krockel D, Ringborg U, Hansson J. (2006). Mutations of PIK3CA are rare in cutaneous melanoma. Melanoma Res 16: 197-200.
    • (2006) Melanoma Res , vol.16 , pp. 197-200
    • Omholt, K.1    Krockel, D.2    Ringborg, U.3    Hansson, J.4
  • 78
    • 0021990041 scopus 로고
    • Activation of N-ras in a human melanoma cell line
    • Padua RA, Barrass NC, Currie GA. (1985). Activation of N-ras in a human melanoma cell line. Mol Cell Biol 5: 582-585.
    • (1985) Mol Cell Biol , vol.5 , pp. 582-585
    • Padua, R.A.1    Barrass, N.C.2    Currie, G.A.3
  • 79
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD et al. (2005). BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 15: 249-254.
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3    Kopani, K.R.4    Amatruda, J.F.5    Murphey, R.D.6
  • 80
    • 0035425425 scopus 로고    scopus 로고
    • Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma
    • Phan GQ, Attia P, Steinberg SM, White DE, Rosenberg SA. (2001). Factors associated with response to high-dose interleukin-2 in patients with metastatic melanoma. J Clin Oncol 19: 3477-3482.
    • (2001) J Clin Oncol , vol.19 , pp. 3477-3482
    • Phan, G.Q.1    Attia, P.2    Steinberg, S.M.3    White, D.E.4    Rosenberg, S.A.5
  • 84
    • 70349556805 scopus 로고    scopus 로고
    • Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
    • Prickett TD, Agrawal NS, Wei X, Yates KE, Lin JC, Wunderlich JR et al. (2009). Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4. Nat Genet 41: 1127-1132.
    • (2009) Nat Genet , vol.41 , pp. 1127-1132
    • Prickett, T.D.1    Agrawal, N.S.2    Wei, X.3    Yates, K.E.4    Lin, J.C.5    Wunderlich, J.R.6
  • 86
    • 57049109807 scopus 로고    scopus 로고
    • Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib
    • Quintas-Cardama A, Lazar AJ, Woodman SE, Kim K, Ross M, Hwu P. (2008). Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib. Nat Clin Pract Oncol 5: 737-740.
    • (2008) Nat Clin Pract Oncol , vol.5 , pp. 737-740
    • Quintas-Cardama, A.1    Lazar, A.J.2    Woodman, S.E.3    Kim, K.4    Ross, M.5    Hwu, P.6
  • 88
    • 37549021543 scopus 로고    scopus 로고
    • C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma
    • Rivera RS, Nagatsuka H, Gunduz M, Cengiz B, Gunduz E, Siar CH et al. (2008). C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 452: 27-32.
    • (2008) Virchows Arch , vol.452 , pp. 27-32
    • Rivera, R.S.1    Nagatsuka, H.2    Gunduz, M.3    Cengiz, B.4    Gunduz, E.5    Siar, C.H.6
  • 90
    • 0023271954 scopus 로고
    • Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung
    • Rodenhuis S, van de Wetering ML, Mooi WJ, Evers SG, van Zandwijk N, Bos JL. (1987). Mutational activation of the K-ras oncogene. A possible pathogenetic factor in adenocarcinoma of the lung. N Engl J Med 317: 929-935.
    • (1987) N Engl J Med , vol.317 , pp. 929-935
    • Rodenhuis, S.1    Van De Wetering, M.L.2    Mooi, W.J.3    Evers, S.G.4    Van Zandwijk, N.5    Bos, J.L.6
  • 91
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A et al. (2010). A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 141: 583-594.
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3    Zabierowski, S.E.4    Brafford, P.A.5    Vultur, A.6
  • 94
    • 33749993417 scopus 로고    scopus 로고
    • The consensus coding sequences of human breast and colorectal cancers
    • Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD et al. (2006). The consensus coding sequences of human breast and colorectal cancers. Science 314: 268-274.
    • (2006) Science , vol.314 , pp. 268-274
    • Sjoblom, T.1    Jones, S.2    Wood, L.D.3    Parsons, D.W.4    Lin, J.5    Barber, T.D.6
  • 97
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH et al. (1997). Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 15: 356-362.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3    Yung, W.K.4    Lin, H.5    Ligon, A.H.6
  • 98
    • 33644684217 scopus 로고    scopus 로고
    • Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
    • Strumberg D. (2005). Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc) 41: 773-784.
    • (2005) Drugs Today (Barc) , vol.41 , pp. 773-784
    • Strumberg, D.1
  • 100
    • 4444240325 scopus 로고    scopus 로고
    • Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference
    • Sumimoto H, Miyagishi M, Miyoshi H, Yamagata S, Shimizu A, Taira K et al. (2004). Inhibition of growth and invasive ability of melanoma by inactivation of mutated BRAF with lentivirus-mediated RNA interference. Oncogene 23: 6031-6039.
    • (2004) Oncogene , vol.23 , pp. 6031-6039
    • Sumimoto, H.1    Miyagishi, M.2    Miyoshi, H.3    Yamagata, S.4    Shimizu, A.5    Taira, K.6
  • 101
    • 43249131245 scopus 로고    scopus 로고
    • Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: A phase i tumor pharmacodynamic study in patients with advanced solid tumors
    • Tabernero J, Rojo F, Calvo E, Burris H, Judson I, Hazell K et al. (2008). Dose-and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J Clin Oncol 26: 1603-1610.
    • (2008) J Clin Oncol , vol.26 , pp. 1603-1610
    • Tabernero, J.1    Rojo, F.2    Calvo, E.3    Burris, H.4    Judson, I.5    Hazell, K.6
  • 102
    • 0029148164 scopus 로고
    • Cytogenetics of 158 patients with regional or disseminated melanoma. Subset analysis of near-diploid and simple karyotypes
    • Thompson FH, Emerson J, Olson S, Weinstein R, Leavitt SA, Leong SP et al. (1995). Cytogenetics of 158 patients with regional or disseminated melanoma. Subset analysis of near-diploid and simple karyotypes. Cancer Genet Cytogenet 83: 93-104.
    • (1995) Cancer Genet Cytogenet , vol.83 , pp. 93-104
    • Thompson, F.H.1    Emerson, J.2    Olson, S.3    Weinstein, R.4    Leavitt, S.A.5    Leong, S.P.6
  • 103
    • 70350668375 scopus 로고    scopus 로고
    • Correlation between KIT expression and KIT mutation in melanoma: A study of 173 cases with emphasis on the acral-lentiginous/mucosal type
    • Torres-Cabala CA, Wang WL, Trent J, Yang D, Chen S, Galbincea J et al. (2009). Correlation between KIT expression and KIT mutation in melanoma: a study of 173 cases with emphasis on the acral-lentiginous/mucosal type. Mod Pathol 22: 1446-1456.
    • (2009) Mod Pathol , vol.22 , pp. 1446-1456
    • Torres-Cabala, C.A.1    Wang, W.L.2    Trent, J.3    Yang, D.4    Chen, S.5    Galbincea, J.6
  • 104
    • 42949149240 scopus 로고    scopus 로고
    • Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
    • Tsai J, Lee JT, Wang W, Zhang J, Cho H, Mamo S et al. (2008). Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA 105: 3041-3046.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3041-3046
    • Tsai, J.1    Lee, J.T.2    Wang, W.3    Zhang, J.4    Cho, H.5    Mamo, S.6
  • 105
    • 4344656396 scopus 로고    scopus 로고
    • Management of cutaneous melanoma
    • Tsao H, Atkins MB, Sober AJ. (2004a). Management of cutaneous melanoma. N Engl J Med 351: 998-1012.
    • (2004) N Engl J Med , vol.351 , pp. 998-1012
    • Tsao, H.1    Atkins, M.B.2    Sober, A.J.3
  • 106
    • 1442274619 scopus 로고    scopus 로고
    • Genetic interaction between NRAS and BRAF mutations and PTEN// MMAC1 inactivation in melanoma
    • Tsao H, Goel V, Wu H, Yang G, Haluska FG. (2004b). Genetic interaction between NRAS and BRAF mutations and PTEN// MMAC1 inactivation in melanoma. J Invest Dermatol 122: 337-341.
    • (2004) J Invest Dermatol , vol.122 , pp. 337-341
    • Tsao, H.1    Goel, V.2    Wu, H.3    Yang, G.4    Haluska, F.G.5
  • 107
    • 0032474749 scopus 로고    scopus 로고
    • Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
    • Tsao H, Zhang X, Benoit E, Haluska FG. (1998). Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene 16: 3397-3402.
    • (1998) Oncogene , vol.16 , pp. 3397-3402
    • Tsao, H.1    Zhang, X.2    Benoit, E.3    Haluska, F.G.4
  • 108
    • 67349179787 scopus 로고    scopus 로고
    • Massively parallel exon capture and library-free resequencing across 16 genomes
    • Turner EH, Lee C, Ng SB, Nickerson DA, Shendure J. (2009). Massively parallel exon capture and library-free resequencing across 16 genomes. Nat Methods 6: 315-316.
    • (2009) Nat Methods , vol.6 , pp. 315-316
    • Turner, E.H.1    Lee, C.2    Ng, S.B.3    Nickerson, D.A.4    Shendure, J.5
  • 111
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. (2002). The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 112
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PTC, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM et al. (2004). Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116: 855-867.
    • (2004) Cell , vol.116 , pp. 855-867
    • Ptc, W.1    Garnett, M.J.2    Roe, S.M.3    Lee, S.4    Niculescu-Duvaz, D.5    Good, V.M.6
  • 113
    • 68849093078 scopus 로고    scopus 로고
    • Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
    • Woodman SE, Trent JC, Stemke-Hale K, Lazar AJ, Pricl S, Pavan GM et al. (2009). Activity of dasatinib against L576P KIT mutant melanoma: molecular, cellular, and clinical correlates. Mol Cancer Ther 8: 2079-2085.
    • (2009) Mol Cancer Ther , vol.8 , pp. 2079-2085
    • Woodman, S.E.1    Trent, J.C.2    Stemke-Hale, K.3    Lazar, A.J.4    Pricl, S.5    Pavan, G.M.6
  • 114
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Significant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V, Eton O, McDermott DF, Hubbard F et al. (2006). Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy. Cancer 106: 2005-2011.
    • (2006) Cancer , vol.106 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3    Eton, O.4    McDermott, D.F.5    Hubbard, F.6
  • 116
    • 0030943198 scopus 로고    scopus 로고
    • Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type i
    • Zhang FL, Kirschmeier P, Carr D, James L, Bond RW, Wang L et al. (1997). Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I. J Biol Chem 272: 10232-10239.
    • (1997) J Biol Chem , vol.272 , pp. 10232-10239
    • Zhang, F.L.1    Kirschmeier, P.2    Carr, D.3    James, L.4    Bond, R.W.5    Wang, L.6
  • 117
    • 51849128358 scopus 로고    scopus 로고
    • Class i PI3K in oncogenic cellular transformation
    • Zhao L, Vogt PK. (2008). Class I PI3K in oncogenic cellular transformation. Oncogene 27: 5486-5496.
    • (2008) Oncogene , vol.27 , pp. 5486-5496
    • Zhao, L.1    Vogt, P.K.2
  • 118
    • 0033819340 scopus 로고    scopus 로고
    • Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
    • Zhou XP, Gimm O, Hampel H, Niemann T, Walker MJ, Eng C. (2000). Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol 157: 1123-1128.
    • (2000) Am J Pathol , vol.157 , pp. 1123-1128
    • Zhou, X.P.1    Gimm, O.2    Hampel, H.3    Niemann, T.4    Walker, M.J.5    Eng, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.