Identification of furo[3', 2':3,4]naphtho[1,2-d]imidazole derivatives as orally active and selective inhibitors of microsomal prostaglandin E 2 synthase-1 (mPGES-1)

Molecular Diversity

Volumn 16, Issue 2, 2012, Pages 215-229

  Tseng, Chih Hua ^a   Tzeng, Cherng Chyi ^a   Shih, Pin Keng ^a   Yang, Chia Ning ^b   Chuang, You Chung ^b   Peng, Shin I ^a   Lin, Chang Sheng ^a   Wang, Jih Pyang ^c   Cheng, Chih Mei ^a   Chen, Yeh Long ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL UNIVERSITY OF KAOHSIUNG   (Taiwan)

^c TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Furo 3',2':3,4 naphtho 1,2 d imidazole derivatives; MPGES 1 inhibitor; Oral anti inflammatory drug

Indexed keywords

2 (4 METHOXYPHENYL)FURO[3',2':3,4]NAPHTHO[1,2 D]IMIDAZOLE; 2 (4 METHYLSULFINYLPHENYL)FURO[3',2':3,4]NAPHTHO[1,2 D]IMIDAZOLE; 2 (4 METHYLSULFONYLPHENYL)FURO[3',2':3,4]NAPHTHO[1,2 D]IMIDAZOLE; CYCLOOXYGENASE 2; FURO[3',2':3,4]NAPHTHO[1,2 C][1,2,5]OXADIAZOLE; IMIDAZOLE DERIVATIVE; ISOMERASE; NAPHTHO[1,2 B]FURAN 4,5 DIONE DIOXIME; PROSTAGLANDIN E2 SYNTHASE 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEPSIS; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION;

ADMINISTRATION, ORAL; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL DEGRANULATION; CELL LINE; DINOPROSTONE; ENZYME INHIBITORS; IMIDAZOLES; INTRAMOLECULAR OXIDOREDUCTASES; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, INBRED BALB C; NEUTROPHILS; NITRIC OXIDE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS; SUPEROXIDES;

EID: 84864698432     PISSN: 13811991     EISSN: 1573501X     Source Type: Journal    
DOI: 10.1007/s11030-011-9347-9     Document Type: Article

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