Effective attenuation of acute lung injury in vivo and the formyl peptide-induced neutrophil activation in vitro by CYL-26z through the phosphoinositide 3-kinase γ pathway

Biochemical Pharmacology

Volumn 72, Issue 6, 2006, Pages 749-760

  Kuan, Yu Hsiang ^a   Lin, Ruey Hseng ^b   Chen, Yeh Long ^c   Tsao, Lo Ti ^a   Tzeng, Cherng Chyi ^c   Wang, Jih Pyang ^a,d  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Acute lung injury; Chemotaxis; CYL 26z; Neutrophils; PI3K ; Ras; Respiratory burst

Indexed keywords

5 (4 ACRIDIN 9 YLAMINOPHENYL) 5 METHYL 3 METHYLENEDIHYDROFURAN 2 ONE; ACRIDINE DERIVATIVE; ARACHIDONIC ACID; CHEMOATTRACTANT; DIHYDROXYFUMARIC ACID; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; OXIDOREDUCTASE; PHORBOL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN P110; RAS PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; AUTOOXIDATION; CELL FREE SYSTEM; CHEMOTAXIS; CONTROLLED STUDY; DNA FLANKING REGION; FLOW CYTOMETRY; IC 50; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; LEUKOCYTE ACTIVATION; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RESPIRATORY BURST;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACRIDINES; ANIMALS; FURANS; MICE; NEUTROPHIL ACTIVATION; NEUTROPHILS; RESPIRATORY DISTRESS SYNDROME, ADULT; SIGNAL TRANSDUCTION;

EID: 33747170332     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2006.06.025     Document Type: Article

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