Design, synthesis, and preliminary evaluation of 4-(6-(3-nitroguanidino)hexanamido)pyrrolidine derivatives as potential iNOS inhibitors

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 578-585

  Liu, Feng Zhi ^a   Fang, Hao ^a   Zhu, Hua Wei ^a   Wang, Qiang ^a   Yang, Yue ^a   Xu, Wen Fang ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

4 (6 (3 Nitroguanidino)hexanamido)pyrrolidine derivatives; iNOS inhibitor; Synthesis

Indexed keywords

4 [6 (3 NITROGUANIDINO)HEXANAMIDO] N PHENYLPYRROLIDINE 2 CARBOXAMIDE; 4 [6 (3 NITROGUANIDINO)HEXANAMIDO]PYRROLIDINE DERIVATIVE; HYDROXYPROLINE; INDUCIBLE NITRIC OXIDE SYNTHASE; N (3 CHLORO 4 METHYLPHENYL) 4 [6 (3 NITROGUANIDINO)HEXANAMIDO]PYRROLIDINE 2 CARBOXAMIDE; N (3,4 DIFLUOROPHENYL) 4 [6 (3 NITROGUANIDINO)HEXANAMIDO]PYRROLIDINE 2 CARBOXAMIDE; N(G) NITROARGININE; NITRIC OXIDE SYNTHASE INHIBITOR; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; EVALUATION; IC 50; INFRARED SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; NITRIC OXIDE SYNTHASE TYPE II; PYRROLIDINES;

EID: 38049025783     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.04.030     Document Type: Article

References (13)

1. Kerwin J.F., Lancaster J.R., and Feldman P.L. J. Med. Chem. 38 (1995) 4343
2. Marletta M.A. J. Med. Chem. 37 (1994) 1899
3. Timothy J.H., Arija A.B., Steven A.K., et al. J. Med. Chem. 41 (1998) 3675
4. William M.M.R., Keith W., Kam F.F., et al. J. Med. Chem. 39 (1996) 669
5. José A., Gómez V., Pavel M., et al. J. Med. Chem. 47 (2004) 703
6. Haitao J., José A., Gómez V., et al. J. Med. Chem. 49 (2006) 6254
7. Li Y.L., and Xu W.F. Bioorg. Med. Chem. 12 (2004) 5171
8. Zhang Li., Zhang J., Fang H., et al. Bioorg. Med. Chem. 14 (2006) 8286
9. Hallinan E.A., Kramer S.W., Houdek S.C., Moore W.M., Jerome G.M., Spangler D.P., Stevens A.M., Shieh H.S., Manning P.T., and Pitzele B.S. Org. Biomol. Chem. 20 (2003) 3527
10. Jordis U., Sauter F., and Siddiqi S.M. Indian J. Chem. Sect. B 28 (1989) 294
11. Terry R., Daniel T.W.C., Isabella M.L., et al. J. Med. Chem. 31 (1988) 1598
12. Yoshihisa U., Makoto M., Hiroyuki K., et al. J. Antibiotics 38 (1985) 886-897
13. Sadao, H., Katsushi, O., Setsuro, F., United States Patent [11] 3, 799, 988 Mar. 26, 1974.