-
1
-
-
3242883729
-
The p53 response to DNA damage
-
Meek DW, (2004) The p53 response to DNA damage. DNA Repair (Amst) 3(8-9): 1049-1056.
-
(2004)
DNA Repair (Amst)
, vol.3
, Issue.8-9
, pp. 1049-1056
-
-
Meek, D.W.1
-
2
-
-
0030905284
-
Mdm2 promotes the rapid degradation of p53
-
Haupt Y, Maya R, Kazaz A, Oren M, (1997) Mdm2 promotes the rapid degradation of p53. Nature 387(6630): 296-299.
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 296-299
-
-
Haupt, Y.1
Maya, R.2
Kazaz, A.3
Oren, M.4
-
3
-
-
0030965946
-
Regulation of p53 stability by Mdm2
-
Kubbutat MH, Jones SN, Vousden KH, (1997) Regulation of p53 stability by Mdm2. Nature 387(6630): 299-303.
-
(1997)
Nature
, vol.387
, Issue.6630
, pp. 299-303
-
-
Kubbutat, M.H.1
Jones, S.N.2
Vousden, K.H.3
-
4
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
Banin S, Moyal L, Shieh S, Taya Y, Anderson CW, et al. (1998) Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 281(5383): 1674-1677.
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1674-1677
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.W.5
-
5
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, et al. (1998) Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 281(5383): 1677-1679.
-
(1998)
Science
, vol.281
, Issue.5383
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
-
6
-
-
0034629072
-
DNA damage-induced activation of p53 by the checkpoint kinase Chk2
-
Hirao A, Kong YY, Matsuoka S, Wakeham A, Ruland J, et al. (2000) DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science 287(5459): 1824-1827.
-
(2000)
Science
, vol.287
, Issue.5459
, pp. 1824-1827
-
-
Hirao, A.1
Kong, Y.Y.2
Matsuoka, S.3
Wakeham, A.4
Ruland, J.5
-
7
-
-
0034142034
-
The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
-
Shieh SY, Ahn J, Tamai K, Taya Y, Prives C, (2000) The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. Genes Dev 14(3): 289-300.
-
(2000)
Genes Dev
, vol.14
, Issue.3
, pp. 289-300
-
-
Shieh, S.Y.1
Ahn, J.2
Tamai, K.3
Taya, Y.4
Prives, C.5
-
8
-
-
0035810054
-
Regulation of the G2/M transition by p53
-
Taylor WR, Stark GR, (2001) Regulation of the G2/M transition by p53. Oncogene 20(15): 1803-1815.
-
(2001)
Oncogene
, vol.20
, Issue.15
, pp. 1803-1815
-
-
Taylor, W.R.1
Stark, G.R.2
-
9
-
-
0038751837
-
Transcriptional repression mediated by the p53 tumour suppressor
-
Ho J, Benchimol S, (2003) Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 10(4): 404-408.
-
(2003)
Cell Death Differ
, vol.10
, Issue.4
, pp. 404-408
-
-
Ho, J.1
Benchimol, S.2
-
10
-
-
18144416611
-
The transcriptional targets of p53 in apoptosis control
-
Yu J, Zhang L, (2005) The transcriptional targets of p53 in apoptosis control. Biochem Biophys Res Commun 331(3): 851-858.
-
(2005)
Biochem Biophys Res Commun
, vol.331
, Issue.3
, pp. 851-858
-
-
Yu, J.1
Zhang, L.2
-
11
-
-
0027244853
-
The p53-mdm-2 autoregulatory feedback loop
-
Wu X, Bayle JH, Olson D, Levine AJ, (1993) The p53-mdm-2 autoregulatory feedback loop. Genes Dev 7(7A): 1126-1132.
-
(1993)
Genes Dev
, vol.7
, Issue.7 A
, pp. 1126-1132
-
-
Wu, X.1
Bayle, J.H.2
Olson, D.3
Levine, A.J.4
-
12
-
-
0345435117
-
Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle
-
Hengstschlager M, Braun K, Soucek T, Miloloza A, Hengstschlager-Ottnad E, (1999) Cyclin-dependent kinases at the G1-S transition of the mammalian cell cycle. Mutat Res 436(1): 1-9.
-
(1999)
Mutat Res
, vol.436
, Issue.1
, pp. 1-9
-
-
Hengstschlager, M.1
Braun, K.2
Soucek, T.3
Miloloza, A.4
Hengstschlager-Ottnad, E.5
-
13
-
-
0033533612
-
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
-
Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B, (1999) 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 401(6753): 616-620.
-
(1999)
Nature
, vol.401
, Issue.6753
, pp. 616-620
-
-
Chan, T.A.1
Hermeking, H.2
Lengauer, C.3
Kinzler, K.W.4
Vogelstein, B.5
-
14
-
-
0034725698
-
Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression
-
Laronga C, Yang HY, Neal C, Lee MH, (2000) Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275(30): 23106-23112.
-
(2000)
J Biol Chem
, vol.275
, Issue.30
, pp. 23106-23112
-
-
Laronga, C.1
Yang, H.Y.2
Neal, C.3
Lee, M.H.4
-
15
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
-
Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, et al. (1992) A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71(4): 587-597.
-
(1992)
Cell
, vol.71
, Issue.4
, pp. 587-597
-
-
Kastan, M.B.1
Zhan, Q.2
el-Deiry, W.S.3
Carrier, F.4
Jacks, T.5
-
16
-
-
0033529121
-
Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
-
Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, et al. (1999) Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18(18): 2892-2900.
-
(1999)
Oncogene
, vol.18
, Issue.18
, pp. 2892-2900
-
-
Zhan, Q.1
Antinore, M.J.2
Wang, X.W.3
Carrier, F.4
Smith, M.L.5
-
17
-
-
0032743748
-
Mechanisms of G2 arrest in response to overexpression of p53
-
Taylor WR, DePrimo SE, Agarwal A, Agarwal ML, Schonthal AH, et al. (1999) Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell 10(11): 3607-3622.
-
(1999)
Mol Biol Cell
, vol.10
, Issue.11
, pp. 3607-3622
-
-
Taylor, W.R.1
DePrimo, S.E.2
Agarwal, A.3
Agarwal, M.L.4
Schonthal, A.H.5
-
18
-
-
13844280115
-
p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription
-
Innocente SA, Lee JM, (2005) p53 is a NF-Y- and p21-independent, Sp1-dependent repressor of cyclin B1 transcription. FEBS Lett 579(5): 1001-1007.
-
(2005)
FEBS Lett
, vol.579
, Issue.5
, pp. 1001-1007
-
-
Innocente, S.A.1
Lee, J.M.2
-
19
-
-
0026849821
-
Definition of a consensus binding site for p53
-
el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B, (1992) Definition of a consensus binding site for p53. Nat Genet 1(1): 45-49.
-
(1992)
Nat Genet
, vol.1
, Issue.1
, pp. 45-49
-
-
el-Deiry, W.S.1
Kern, S.E.2
Pietenpol, J.A.3
Kinzler, K.W.4
Vogelstein, B.5
-
20
-
-
0032526426
-
How p53 binds DNA as a tetramer
-
McLure KG, Lee PW, (1998) How p53 binds DNA as a tetramer. EMBO J 17(12): 3342-3350.
-
(1998)
EMBO J
, vol.17
, Issue.12
, pp. 3342-3350
-
-
McLure, K.G.1
Lee, P.W.2
-
21
-
-
0030794423
-
In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation
-
Chin PL, Momand J, Pfeifer GP, (1997) In vivo evidence for binding of p53 to consensus binding sites in the p21 and GADD45 genes in response to ionizing radiation. Oncogene 15(1): 87-99.
-
(1997)
Oncogene
, vol.15
, Issue.1
, pp. 87-99
-
-
Chin, P.L.1
Momand, J.2
Pfeifer, G.P.3
-
22
-
-
0027717617
-
P21 is a universal inhibitor of cyclin kinases
-
Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, et al. (1993) P21 is a universal inhibitor of cyclin kinases. Nature 366(6456): 701-704.
-
(1993)
Nature
, vol.366
, Issue.6456
, pp. 701-704
-
-
Xiong, Y.1
Hannon, G.J.2
Zhang, H.3
Casso, D.4
Kobayashi, R.5
-
23
-
-
0028294605
-
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis
-
el-Deiry WS, Harper JW, O'Connor PM, Velculescu VE, Canman CE, et al. (1994) WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res 54(5): 1169-1174.
-
(1994)
Cancer Res
, vol.54
, Issue.5
, pp. 1169-1174
-
-
el-Deiry, W.S.1
Harper, J.W.2
O'Connor, P.M.3
Velculescu, V.E.4
Canman, C.E.5
-
24
-
-
0035920197
-
Transcriptional repression by p53 through direct binding to a novel DNA element
-
Johnson RA, Ince TA, Scotto KW, (2001) Transcriptional repression by p53 through direct binding to a novel DNA element. J Biol Chem 276(29): 27716-27720.
-
(2001)
J Biol Chem
, vol.276
, Issue.29
, pp. 27716-27720
-
-
Johnson, R.A.1
Ince, T.A.2
Scotto, K.W.3
-
25
-
-
19844373994
-
Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints
-
Levesque AA, Kohn EA, Bresnick E, Eastman A, (2005) Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints. Oncogene 24(23): 3786-3796.
-
(2005)
Oncogene
, vol.24
, Issue.23
, pp. 3786-3796
-
-
Levesque, A.A.1
Kohn, E.A.2
Bresnick, E.3
Eastman, A.4
-
26
-
-
0029840667
-
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains
-
Ossovskaya VS, Mazo IA, Chernov MV, Chernova OB, Strezoska Z, et al. (1996) Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc Natl Acad Sci U S A 93(19): 10309-10314.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.19
, pp. 10309-10314
-
-
Ossovskaya, V.S.1
Mazo, I.A.2
Chernov, M.V.3
Chernova, O.B.4
Strezoska, Z.5
-
27
-
-
0037135554
-
Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation
-
Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A, (2002) Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation. J Biol Chem 277(29): 26553-26564.
-
(2002)
J Biol Chem
, vol.277
, Issue.29
, pp. 26553-26564
-
-
Kohn, E.A.1
Ruth, N.D.2
Brown, M.K.3
Livingstone, M.4
Eastman, A.5
-
28
-
-
0026560995
-
Formation of stable p53 homotetramers and multiples of tetramers
-
Stenger JE, Mayr GA, Mann K, Tegtmeyer P, (1992) Formation of stable p53 homotetramers and multiples of tetramers. Mol Carcinog 5(2): 102-106.
-
(1992)
Mol Carcinog
, vol.5
, Issue.2
, pp. 102-106
-
-
Stenger, J.E.1
Mayr, G.A.2
Mann, K.3
Tegtmeyer, P.4
-
29
-
-
64149108150
-
p53 oligomerization is essential for its C-terminal lysine acetylation
-
Itahana Y, Ke H, Zhang Y, (2009) p53 oligomerization is essential for its C-terminal lysine acetylation. J Biol Chem 284(8): 5158-5164.
-
(2009)
J Biol Chem
, vol.284
, Issue.8
, pp. 5158-5164
-
-
Itahana, Y.1
Ke, H.2
Zhang, Y.3
-
30
-
-
33745209412
-
Structural basis of DNA recognition by p53 tetramers
-
Kitayner M, Rozenberg H, Kessler N, Rabinovich D, Shaulov L, et al. (2006) Structural basis of DNA recognition by p53 tetramers. Mol Cell 22(6): 741-753.
-
(2006)
Mol Cell
, vol.22
, Issue.6
, pp. 741-753
-
-
Kitayner, M.1
Rozenberg, H.2
Kessler, N.3
Rabinovich, D.4
Shaulov, L.5
-
31
-
-
14944378159
-
Redox factor 1 (ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization
-
10.1038/sj.onc.1208351
-
Hanson S, Kim E, Deppert W, (2005) Redox factor 1 (ref-1) enhances specific DNA binding of p53 by promoting p53 tetramerization. Oncogene 24(9) 1641-1647: 10.1038/sj.onc.1208351.
-
(2005)
Oncogene
, vol.24
, Issue.9
, pp. 1641-1647
-
-
Hanson, S.1
Kim, E.2
Deppert, W.3
-
32
-
-
0033514511
-
p53 regulates a G2 checkpoint through cyclin B1
-
Innocente SA, Abrahamson JL, Cogswell JP, Lee JM, (1999) p53 regulates a G2 checkpoint through cyclin B1. Proc Natl Acad Sci U S A 96(5): 2147-2152.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.5
, pp. 2147-2152
-
-
Innocente, S.A.1
Abrahamson, J.L.2
Cogswell, J.P.3
Lee, J.M.4
-
33
-
-
0028786616
-
Premature expression of cyclin B sensitizes human HT1080 cells to caffeine-induced premature mitosis
-
Tam SW, Belinsky GS, Schlegel R, (1995) Premature expression of cyclin B sensitizes human HT1080 cells to caffeine-induced premature mitosis. J Cell Biochem 59(3): 339-349.
-
(1995)
J Cell Biochem
, vol.59
, Issue.3
, pp. 339-349
-
-
Tam, S.W.1
Belinsky, G.S.2
Schlegel, R.3
-
34
-
-
80054771419
-
Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck
-
Hoffmann TK, Trellakis S, Okulicz K, Schuler P, Greve J, et al. (2011) Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck. Anticancer Res 31(10): 3151-3157.
-
(2011)
Anticancer Res
, vol.31
, Issue.10
, pp. 3151-3157
-
-
Hoffmann, T.K.1
Trellakis, S.2
Okulicz, K.3
Schuler, P.4
Greve, J.5
-
35
-
-
0035418188
-
Inverse regulation of cyclin B1 by c-myc and p53 and induction of tetraploidy by cyclin B1 overexpression
-
Yin XY, Grove L, Datta NS, Katula K, Long MW, et al. (2001) Inverse regulation of cyclin B1 by c-myc and p53 and induction of tetraploidy by cyclin B1 overexpression. Cancer Res 61(17): 6487-6493.
-
(2001)
Cancer Res
, vol.61
, Issue.17
, pp. 6487-6493
-
-
Yin, X.Y.1
Grove, L.2
Datta, N.S.3
Katula, K.4
Long, M.W.5
-
36
-
-
0035937118
-
NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest
-
Manni I, Mazzaro G, Gurtner A, Mantovani R, Haugwitz U, et al. (2001) NF-Y mediates the transcriptional inhibition of the cyclin B1, cyclin B2, and cdc25C promoters upon induced G2 arrest. J Biol Chem 276(8): 5570-5576.
-
(2001)
J Biol Chem
, vol.276
, Issue.8
, pp. 5570-5576
-
-
Manni, I.1
Mazzaro, G.2
Gurtner, A.3
Mantovani, R.4
Haugwitz, U.5
-
37
-
-
20244390478
-
Direct p53 transcriptional repression: In vivo analysis of CCAAT-containing G2/M promoters
-
Imbriano C, Gurtner A, Cocchiarella F, Di Agostino S, Basile V, et al. (2005) Direct p53 transcriptional repression: In vivo analysis of CCAAT-containing G2/M promoters. Mol Cell Biol 25(9): 3737-3751.
-
(2005)
Mol Cell Biol
, vol.25
, Issue.9
, pp. 3737-3751
-
-
Imbriano, C.1
Gurtner, A.2
Cocchiarella, F.3
Di Agostino, S.4
Basile, V.5
-
38
-
-
39749185974
-
Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest
-
Levesque AA, Fanous AA, Poh A, Eastman A, (2008) Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest. Mol Cancer Ther 7(2): 252-262.
-
(2008)
Mol Cancer Ther
, vol.7
, Issue.2
, pp. 252-262
-
-
Levesque, A.A.1
Fanous, A.A.2
Poh, A.3
Eastman, A.4
-
39
-
-
70349438905
-
The expanding universe of p53 targets
-
Menendez D, Inga A, Resnick MA, (2009) The expanding universe of p53 targets. Nat Rev Cancer 9(10): 724-737.
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.10
, pp. 724-737
-
-
Menendez, D.1
Inga, A.2
Resnick, M.A.3
-
40
-
-
33746002633
-
Structure of the p53 core domain dimer bound to DNA
-
Ho WC, Fitzgerald MX, Marmorstein R, (2006) Structure of the p53 core domain dimer bound to DNA. J Biol Chem 281(29): 20494-20502.
-
(2006)
J Biol Chem
, vol.281
, Issue.29
, pp. 20494-20502
-
-
Ho, W.C.1
Fitzgerald, M.X.2
Marmorstein, R.3
-
41
-
-
4143154293
-
Cooperative binding of tetrameric p53 to DNA
-
Weinberg RL, Veprintsev DB, Fersht AR, (2004) Cooperative binding of tetrameric p53 to DNA. J Mol Biol 341(5): 1145-1159.
-
(2004)
J Mol Biol
, vol.341
, Issue.5
, pp. 1145-1159
-
-
Weinberg, R.L.1
Veprintsev, D.B.2
Fersht, A.R.3
-
42
-
-
31944448886
-
A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network
-
Menendez D, Krysiak O, Inga A, Krysiak B, Resnick MA, et al. (2006) A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network. Proc Natl Acad Sci U S A 103(5): 1406-1411.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.5
, pp. 1406-1411
-
-
Menendez, D.1
Krysiak, O.2
Inga, A.3
Krysiak, B.4
Resnick, M.A.5
-
43
-
-
34147204571
-
A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1
-
Menendez D, Inga A, Snipe J, Krysiak O, Schonfelder G, et al. (2007) A single-nucleotide polymorphism in a half-binding site creates p53 and estrogen receptor control of vascular endothelial growth factor receptor 1. Mol Cell Biol 27(7): 2590-2600.
-
(2007)
Mol Cell Biol
, vol.27
, Issue.7
, pp. 2590-2600
-
-
Menendez, D.1
Inga, A.2
Snipe, J.3
Krysiak, O.4
Schonfelder, G.5
-
44
-
-
67749131153
-
A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage
-
Yan J, Menendez D, Yang XP, Resnick MA, Jetten AM, (2009) A regulatory loop composed of RAP80-HDM2-p53 provides RAP80-enhanced p53 degradation by HDM2 in response to DNA damage. J Biol Chem 284(29): 19280-19289.
-
(2009)
J Biol Chem
, vol.284
, Issue.29
, pp. 19280-19289
-
-
Yan, J.1
Menendez, D.2
Yang, X.P.3
Resnick, M.A.4
Jetten, A.M.5
-
45
-
-
0033973807
-
Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus
-
Atz J, Wagner P, Roemer K, (2000) Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus. J Cell Biochem 76(4): 572-584.
-
(2000)
J Cell Biochem
, vol.76
, Issue.4
, pp. 572-584
-
-
Atz, J.1
Wagner, P.2
Roemer, K.3
-
46
-
-
0034669312
-
The tumour suppressor protein p53 can repress transcription of cyclin B
-
Krause K, Wasner M, Reinhard W, Haugwitz U, Dohna CL, et al. (2000) The tumour suppressor protein p53 can repress transcription of cyclin B. Nucleic Acids Res. 28(22): 4410-4418.
-
(2000)
Nucleic Acids Res
, vol.28
, Issue.22
, pp. 4410-4418
-
-
Krause, K.1
Wasner, M.2
Reinhard, W.3
Haugwitz, U.4
Dohna, C.L.5
|