Cardiac two-pore-domain potassium channels (K2P): Physiology, pharmacology, and therapeutic potential;Kardiale Zwei-Porendomänen-Kaliumkanäle (K2P): Physiologie, Pharmakologie und therapeutisches Potenzial

Deutsche Medizinische Wochenschrift

Volumn 137, Issue 33, 2012, Pages 1654-1658

  Schmidt, C ^a   Wiedmann, F ^a   Schweizer, P A ^a   Katus, H A ^a   Thomas, D ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

antiarrhythmic drugs; atrial fibrillation; cardiac action potential; cardiac arrhythmia; two pore domain potassium (K2P) channels

Indexed keywords

POTASSIUM CHANNEL; TWO PORE DOMAIN POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

HEART; REVIEW;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIAS, CARDIAC; ATRIAL FIBRILLATION; ELECTROCARDIOGRAPHY; GENE SILENCING; HEART ATRIA; HEART CONDUCTION SYSTEM; HEART VENTRICLES; HUMANS; MICE; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; RATS;

EID: 84864646807     PISSN: 00120472     EISSN: 14394413     Source Type: Journal    
DOI: 10.1055/s-0032-1305216     Document Type: Review

References (42)

1. Baker JG. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol: 2005; 144 317 322 (Pubitemid 40313677)
2. Barel O, Shalev SA, Ofir R et al. Maternally inherited Birk Barel mental retardation dysmorphism syndrome caused by a mutation in the genomically imprinted potassium channel KCNK9. Am J Hum Genet 83 193 199
3. Chatelain P, Meysmans L, Mattéazzi JR et al. Interaction of the antiarrhythmic agents SR 33589 and amiodarone with the beta-adrenoceptor and adenylate cyclase in rat heart. Br J Pharmacol: 1995; 116 1949 1956
4. Coburn CA, Luo Y, Cui M et al. Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3). Chem Med Chem: 2012; 7 123 133
5. Cooper BY, Johnson RD, Rau KK. Characterization and function of TWIK-related acid sensing K+ channels in a rat nociceptive cell. Neuroscience: 2004; 129 209 224 (Pubitemid 39360956)
6. Decher N, Wemhöner K, Rinné S et al. Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex. Cell Physiol Biochem: 2011; 28 77 86
7. Donner BC, Schullenberg M, Geduldig N et al. Functional role of TASK-1 in the heart: studies in TASK-1 deficient mice show prolonged cardiac repolarization and reduced heart variability. Basic Res Cardiol: 2011; 106 75 87
8. Friedrich C, Rinné S, Zumhagen S et al. K2P-Kaliumkanalgen KCNK17 (TASK-4): Erste Identifizierung einer Gain-of-function-Mutation bei einer angeborenen Überleitungsstörung. Clin Res Cardiol: 2012; 101 01 P984
9. Gierten J, Ficker E, Bloehs R et al. Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. Br J Pharmacol: 2008; 154 1680 1690
10. Gierten J, Ficker E, Bloehs R et al. The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone. Naunyn Schmiedebergs Arch Pharmacol: 2010; 381 261 270
11. Gierten J, Hassel D, Schweizer PA et al. Identification and functional characterization of zebrafish K2P10.1 (TREK2) two-pore-domain K+ channels. Biochim Biophys Acta: 2012; 1818 33 41
12. Goldstein SAN, Bayliss DA, Kim D et al. International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev: 2005; 57 527 540 (Pubitemid 43036439)
13. Gurney A, Manoury B. Two-pore potassium channels in the cardiovascular system. Eur Biophys J: 2009; 38 305 318
14. Gurney AM, Osipenko ON, MacMillan D et al. Two-pore domain K channel, TASK-1, in pulmonary artery smooth muscle cells. Circ Res: 2003; 93 957 964 (Pubitemid 37433233)
15. Hancox JC. Amiodarone blocks L-type calcium current in single myocytes isolated from the rabbit atrioventricular node. Gen Pharmacol: 1997; 29 429 435 (Pubitemid 27412468)
16. Heurteaux C, Guy N, Laigle C et al. TREK-1, a K(+) channel involved in neuroprotection and general anesthesia. Embo J: 2004; 23 2684 2695 (Pubitemid 38988239)
17. Hirota M, Ohtani H, Hanada E et al. Influence of extracellular K+ concentrations on quinidine-induced K+ current inhibition in rat ventricular myocytes. J Pharm Pharmacol: 2000; 52 99 105 (Pubitemid 30125290)
18. Honoré E. The neuronal background K2P channels: focus on TREK1. Nat Rev Neurosci: 2007; 8 251 261 (Pubitemid 46452327)
19. Kamiya K, Nishiyama A, Yasui K et al. Short- and long-term effects of amiodarone on the two components of cardiac delayed rectifier K(+) current. Circulation: 2001; 103 1317 1324 (Pubitemid 32221358)
20. Kang D, Choe C, Kim D. Thermosensitivity of the two-pore domain K+ channels TREK-2 and TRAAK. J Physiol: 2005; 564 103 116 (Pubitemid 40542191)
21. Koumi S, Sato R, Hayakawa H et al. Quinidine blocks cardiac sodium current after removal of the fast inactivation process with chloramine-T. J Mol Cell Cardiol: 1991; 23 427 438
22. Lafrenière RG, Cader MZ, Poulin JF et al. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nat Med: 2010; 16 1157 1160
23. Lalevée N, Nargeot J, Barrére-Lemaire S et al. Effects of amiodarone and dronedarone on voltage-dependent sodium current in human cardiomyocytes. J Cardiovasc Electrophysiol: 2003; 14 885 890 (Pubitemid 37006354)
24. Leonoudakis D, Gray AT, Winegar BD et al. An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci: 1998; 18 868 877 (Pubitemid 28112909)
25. Lesage F, Lazdunski M. Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol: 2000; 279 F793 F801
26. Lesage F, Maingret F, Lazdunski M. Cloning and expression of human TRAAK, a polyunsatured fatty acids-activated and mechano-sensitive K(+) channel. FEBS Lett: 2000; 471 137 140 (Pubitemid 30190052)
27. Lesage F, Terrenoire C, Romey G et al. Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem: 2000; 275 28398 28405
28. Limberg SH, Netter MF, Rolfes C et al. TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes. Cell Physiol Biochem: 2011; 28 613 624
29. Maingret F, Patel AJ, Lesage F et al. Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK. J Biol Chem: 2000; 275 10128 10133 (Pubitemid 30202065)
30. Patel AJ, Honore E. Anesthetic-sensitive 2P domain K+ channels. Anesthesiology: 2001; 95 1013 1021
31. Putzke C, Wemhöner K, Sachse FB et al. The acid-sensitive potassium channel TASK-1 in rat cardiac muscle. Cardiovasc Res: 2007; 75 59 68 (Pubitemid 46873507)
32. Rahm AK, Gierten J, Kisselbach J et al. Protein kinase C-dependent activation of human K2P18.1 K+ channels. Br J Pharmacol: 2012; 166 764 773
33. Schmidt C, Wiedmann F, Schweizer PA et al. Novel electrophysiological properties of dronedarone: Inhibition of human cardiac two-pore-domain potassium (K2P) channels. Naunyn Schmiedebergs Arch Pharmacol: 2012; doi 10.1007/s00210 012-0780-9
34. Seyler C, Duthil-Straub E, Zitron E et al. TASK1 (K2P3.1) K+ current inhibition by endothelin-1 is mediated by Rho kinase-dependent channel phosphorylation. Br J Pharmacol: 2012; 165 1467 1475
35. Staudacher K, Baldea I, Kisselbach J et al. Alternative splicing determines mRNA translation initiation and function of human K2P10.1 K+ channels. J Physiol: 2011; 589 3709 3720
36. Staudacher K, Staudacher I, Ficker E et al. Carvedilol targets human K2P3.1 (TASK1) K+ leak channels. Br J Pharmacol: 2011; 163 1099 1110
37. Streit AK, Netter MF, Kempf F et al. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem: 2011; 286 13977 13984
38. Thomas D, Goldstein SAN. Two-P-domain (K2P) potassium channels: leak conductance regulators of excitability. Academic Press In: Squire LR. editor. Encyclopedia of Neuroscience. Oxford: 2009; 1207 1220
39. Thomas D, Plant LD, Wilkens CM et al. Alternative translation initiation in rat brain yields K2P2.1 potassium channels permeable to sodium. Neuron: 2008; 58 859 870 (Pubitemid 351842748)
40. Watanabe Y, Hara Y, Tamagawa M et al. Inhibitory effect of amiodarone on the muscarinic acetylcholine receptor-operated potassium current in guinea pig atrial cells. J Pharmacol Exp Ther: 1996; 279 617 624 (Pubitemid 27166832)
41. Xian Tao L, Dyachenko V, Zuzarte M et al. The stretch-activated potassium channel TREK-1 in rat cardiac ventricular muscle. Cardiovasc Res: 2006; 69 86 97 (Pubitemid 41814814)
42. Yang T, Snyders DJ, Roden DM. Rapid inactivation determines the rectification and [K+]o dependence of the rapid component of the delayed rectifier K+ current in cardiac cells. Circ Res: 1997; 80 782 789 (Pubitemid 27230052)