Defeating Leishmania resistance to Miltefosine (hexadecylphosphocholine) by peptide-mediated drug smuggling: A proof of mechanism for trypanosomatid chemotherapy

Journal of Controlled Release

Volumn 161, Issue 3, 2012, Pages 835-842

  Luque Ortega, Juan Román ^a   De La Torre, Beatriz G ^b   Hornillos, Valentín ^c,d   Bart, Jean Mathieu ^e   Rueda, Cristina ^a   Navarro, Miguel ^e   Amat Guerri, Francisco ^c   Acuña, A Ulises ^d   Andreu, David ^b   Rivas, Luis ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^d INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

^e INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

Cell penetrating peptide; Leishmania; Miltefosine; Resistance reversion; Tat; Trypanosoma

Indexed keywords

CELL-PENETRATING PEPTIDE; LEISHMANIA; MILTEFOSINE; TAT; TRYPANOSOMA;

CHEMOTHERAPY; SULFUR COMPOUNDS;

PEPTIDES;

CELL PENETRATING PEPTIDE; DISULFIDE; MILTEFOSINE; MILTEFOSINE DERIVATIVE; SULFIDE; TAT[48-60] PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA BRUCEI;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL MEMBRANE; CELL-PENETRATING PEPTIDES; DRUG RESISTANCE, MICROBIAL; LEISHMANIA DONOVANI; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; PHOSPHORYLCHOLINE; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84864626959     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.05.023     Document Type: Article

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