메뉴 건너뛰기




Volumn 126, Issue 2, 2003, Pages 165-172

Antiprotozoal activities of phospholipid analogues

Author keywords

Miltefosine; Phospholipid analogues; Protozoa

Indexed keywords

MILTEFOSINE; PHOSPHOLIPID DERIVATIVE; PHOSPHORYLCHOLINE;

EID: 0037325060     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(02)00283-9     Document Type: Review
Times cited : (159)

References (62)
  • 2
    • 0018186318 scopus 로고
    • Selective destruction of human leukemic cells by alkyl-lysophospholipids
    • Andreesen R., Modolell M., Weltzien H.U.et al. Selective destruction of human leukemic cells by alkyl-lysophospholipids. Cancer Res. 38:1978;3894-3899.
    • (1978) Cancer Res. , vol.38 , pp. 3894-3899
    • Andreesen, R.1    Modolell, M.2    Weltzien, H.U.3
  • 4
    • 0023521342 scopus 로고
    • Cytostatic activity of synthetic O-alkylglycerolipids
    • Brachwitz H., Arndt D., Fichtner I., Langen P. Cytostatic activity of synthetic O-alkylglycerolipids. Lipids. 22:1987;897-903.
    • (1987) Lipids , vol.22 , pp. 897-903
    • Brachwitz, H.1    Arndt, D.2    Fichtner, I.3    Langen, P.4
  • 6
    • 0013524781 scopus 로고
    • Phospholipid synthesis. Oxazaphospholanes and dioxaphospholanes as intermediates
    • Eibl H. Phospholipid synthesis. Oxazaphospholanes and dioxaphospholanes as intermediates. Proc. Natl. Acad. Sci. USA. 75:1978;4074-4077.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 4074-4077
    • Eibl, H.1
  • 7
    • 0025679466 scopus 로고
    • Hexadecylphosphocholine: A new and selective antitumor drug
    • Eibl H., Unger C. Hexadecylphosphocholine: a new and selective antitumor drug. Cancer Treat. Rev. 17:1990;233-242.
    • (1990) Cancer Treat. Rev. , vol.17 , pp. 233-242
    • Eibl, H.1    Unger, C.2
  • 8
    • 0018802260 scopus 로고
    • Semi-synthesis and proposed structure of platelet-activating factor (PAF): PAF-acether an alkyl ether analog of lysophosphatidylcholine
    • Benveniste J., Tence M., Varenne P., Bidault J., Boullet C., Polonsky J. Semi-synthesis and proposed structure of platelet-activating factor (PAF): PAF-acether an alkyl ether analog of lysophosphatidylcholine. C R Seances Acad. Sci. D. 289:1979;1037-1040.
    • (1979) C R Seances Acad. Sci. D , vol.289 , pp. 1037-1040
    • Benveniste, J.1    Tence, M.2    Varenne, P.3    Bidault, J.4    Boullet, C.5    Polonsky, J.6
  • 9
    • 0018691869 scopus 로고
    • Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators)
    • Demopoulos C.A., Pinckard R.N., Hanahan D.J. Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators). J. Biol. Chem. 254:1979;9355-9358.
    • (1979) J. Biol. Chem. , vol.254 , pp. 9355-9358
    • Demopoulos, C.A.1    Pinckard, R.N.2    Hanahan, D.J.3
  • 11
    • 0023122228 scopus 로고
    • Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotes
    • Achterberg V., Gercken G. Cytotoxicity of ester and ether lysophospholipids on Leishmania donovani promastigotes. Mol. Biochem. Parasitol. 23:1987;117-122.
    • (1987) Mol. Biochem. Parasitol. , vol.23 , pp. 117-122
    • Achterberg, V.1    Gercken, G.2
  • 12
    • 0023506917 scopus 로고
    • Metabolism of ether lysophospholipids in Leishmania donovani promastigotes
    • Achterberg V., Gercken G. Metabolism of ether lysophospholipids in Leishmania donovani promastigotes. Mol. Biochem. Parasitol. 26:1987;277-287.
    • (1987) Mol. Biochem. Parasitol. , vol.26 , pp. 277-287
    • Achterberg, V.1    Gercken, G.2
  • 13
    • 0023186694 scopus 로고
    • The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani
    • Croft S.L., Neal R.A., Pendergast W., Chan J.H. The activity of alkyl phosphorylcholines and related derivatives against Leishmania donovani. Biochem. Pharmacol. 36:1987;2633-2636.
    • (1987) Biochem. Pharmacol. , vol.36 , pp. 2633-2636
    • Croft, S.L.1    Neal, R.A.2    Pendergast, W.3    Chan, J.H.4
  • 14
    • 0020097110 scopus 로고
    • Metabolism of 1-O-[1′-14C]octadecyl-sn-glycerol in Leishmania donovani promastigotes. Ether-lipid synthesis and degradation of the ether bond
    • Herrmann H.O., Gercken G. Metabolism of 1-O-[1′-14C]octadecyl-sn-glycerol in Leishmania donovani promastigotes. Ether-lipid synthesis and degradation of the ether bond. Mol. Biochem. Parasitol. 5:1982;65-76.
    • (1982) Mol. Biochem. Parasitol. , vol.5 , pp. 65-76
    • Herrmann, H.O.1    Gercken, G.2
  • 15
    • 0025861450 scopus 로고
    • Membrane-interactive lipids as experimental anticancer drugs
    • Berdel W.E. Membrane-interactive lipids as experimental anticancer drugs. Br. J. Cancer. 64:1991;208-211.
    • (1991) Br. J. Cancer , vol.64 , pp. 208-211
    • Berdel, W.E.1
  • 17
    • 0030481123 scopus 로고    scopus 로고
    • The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei
    • Croft S.L., Snowdon D., Yardley V. The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei. J. Antimicrob. Chemother. 38:1996;1041-1047.
    • (1996) J. Antimicrob. Chemother. , vol.38 , pp. 1041-1047
    • Croft, S.L.1    Snowdon, D.2    Yardley, V.3
  • 19
    • 0030995115 scopus 로고    scopus 로고
    • Ether-lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmanial alkylphospholipid analogues
    • Lux H., Hart D.T., Parker P.J., Klenner T. Ether-lipid metabolism, GPI anchor biosynthesis, and signal transduction are putative targets for anti-leishmanial alkylphospholipid analogues. Adv. Exp. Med. Biol. 416:1996;201-211.
    • (1996) Adv. Exp. Med. Biol. , vol.416 , pp. 201-211
    • Lux, H.1    Hart, D.T.2    Parker, P.J.3    Klenner, T.4
  • 20
    • 0029856575 scopus 로고    scopus 로고
    • Antileishmanial activity of rac-1-dodecyl-2-octanamido-2-deoxy-glycerophosphocholine, a new dialkylglycerophosphocholine, in vitro
    • Bourass J., Loiseau P.M., Bories C., Letourneux Y. Antileishmanial activity of rac-1-dodecyl-2-octanamido-2-deoxy-glycerophosphocholine, a new dialkylglycerophosphocholine, in vitro. Ann. Trop. Med. Parasitol. 90:1996;559-561.
    • (1996) Ann. Trop. Med. Parasitol. , vol.90 , pp. 559-561
    • Bourass, J.1    Loiseau, P.M.2    Bories, C.3    Letourneux, Y.4
  • 23
    • 0032418802 scopus 로고    scopus 로고
    • In vivo antileishmanial activity of hexadecylphosphocholine and other alkylphosphocholines
    • Unger C., Maniera T., Kaufmann-Kolle P., Eibl H. In vivo antileishmanial activity of hexadecylphosphocholine and other alkylphosphocholines. Drugs of Today. 34(suppl. F):1998;133-140.
    • (1998) Drugs of Today , vol.34 , Issue.SUPPL. F , pp. 133-140
    • Unger, C.1    Maniera, T.2    Kaufmann-Kolle, P.3    Eibl, H.4
  • 24
    • 0028924499 scopus 로고
    • Analogs of alkyllysophospholipids: Chemistry, effects on the molecular level and their consequences for normal and malignant cells
    • Brachwitz H., Vollgraf C. Analogs of alkyllysophospholipids: chemistry, effects on the molecular level and their consequences for normal and malignant cells. Pharmac. Ther. 66:1995;39-82.
    • (1995) Pharmac. Ther. , vol.66 , pp. 39-82
    • Brachwitz, H.1    Vollgraf, C.2
  • 25
    • 0035885286 scopus 로고    scopus 로고
    • Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities
    • Rybczynska M., Spitaler M., Knebel N.G., Boeck G., Grunicke H., Hofmann J. Effects of miltefosine on various biochemical parameters in a panel of tumor cell lines with different sensitivities. Biochem. Pharmacol. 62:2001;765-772.
    • (2001) Biochem. Pharmacol. , vol.62 , pp. 765-772
    • Rybczynska, M.1    Spitaler, M.2    Knebel, N.G.3    Boeck, G.4    Grunicke, H.5    Hofmann, J.6
  • 26
    • 0034771454 scopus 로고    scopus 로고
    • Monitoring drug resistance in leishmaniasis
    • Croft S.L. Monitoring drug resistance in leishmaniasis. Trop. Med. Int. Health. 6:2001;899-905.
    • (2001) Trop. Med. Int. Health , vol.6 , pp. 899-905
    • Croft, S.L.1
  • 27
    • 0034712428 scopus 로고    scopus 로고
    • Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi
    • Santa-Rita R.M., Santos Barbosa H.S., Meirelles M.N.S.L., de Castro S.L. Effect of the alkyl-lysophospholipids on the proliferation and differentiation of Trypanosoma cruzi. Acta Trop. 75:2000;219-228.
    • (2000) Acta Trop. , vol.75 , pp. 219-228
    • Santa-Rita, R.M.1    Santos Barbosa, H.S.2    Meirelles, M.N.S.L.3    De Castro, S.L.4
  • 28
    • 0035025017 scopus 로고    scopus 로고
    • Mechanism of action of anti-proliferative lysophospholipid analogues against the protozoan parasite Trypanosoma cruzi: Potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole
    • Lira R., Contreras L.M., Santa-Rita R.M., Urbina J.A. Mechanism of action of anti-proliferative lysophospholipid analogues against the protozoan parasite Trypanosoma cruzi: potentiation of in vitro activity by the sterol biosynthesis inhibitor ketoconazole. J. Antimicrob. Chemother. 47:2001;537-546.
    • (2001) J. Antimicrob. Chemother. , vol.47 , pp. 537-546
    • Lira, R.1    Contreras, L.M.2    Santa-Rita, R.M.3    Urbina, J.A.4
  • 29
    • 0030893937 scopus 로고    scopus 로고
    • Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies
    • Konstantinov S.M., Kaminsky R., Brun R., Berger M.R., Zillmann U. Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. Acta Trop. 64:1997;145-154.
    • (1997) Acta Trop. , vol.64 , pp. 145-154
    • Konstantinov, S.M.1    Kaminsky, R.2    Brun, R.3    Berger, M.R.4    Zillmann, U.5
  • 30
    • 0026450907 scopus 로고
    • Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment
    • Marschner M., Kötting J., Eibl H., Unger C. Distribution of hexadecylphosphocholine and octadecyl-methyl-glycero-3-phosphocholine in rat tissues during steady-state treatment. Cancer Chemother. Pharmacol. 31:1992;18-22.
    • (1992) Cancer Chemother. Pharmacol. , vol.31 , pp. 18-22
    • Marschner, M.1    Kötting, J.2    Eibl, H.3    Unger, C.4
  • 31
    • 0026625517 scopus 로고
    • Hexadecylphosphocholine: Oral treatment of visceral leishmaniasis in mice
    • Kuhlencord A., Maniera T., Eibl H., Unger C. Hexadecylphosphocholine: oral treatment of visceral leishmaniasis in mice. Antimicrob. Agents Chemother. 36:1992;1630-1634.
    • (1992) Antimicrob. Agents Chemother. , vol.36 , pp. 1630-1634
    • Kuhlencord, A.1    Maniera, T.2    Eibl, H.3    Unger, C.4
  • 32
    • 0031895279 scopus 로고    scopus 로고
    • Short- and long-term efficacy of hexadecylphosphocholine against established Leishmania infantum infection in BALB/c mice
    • Le Fichoux Y., Rousseau D., Ferrua B.et al. Short- and long-term efficacy of hexadecylphosphocholine against established Leishmania infantum infection in BALB/c mice. Antimicrob. Agents Chemother. 42:1998;654-658.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 654-658
    • Le Fichoux, Y.1    Rousseau, D.2    Ferrua, B.3
  • 33
    • 0033752823 scopus 로고    scopus 로고
    • Suppression of posttreatment recurrence of experimental visceral Leishmaniasis in T-cell-deficient mice by oral miltefosine
    • Murray H.W. Suppression of posttreatment recurrence of experimental visceral Leishmaniasis in T-cell-deficient mice by oral miltefosine. Antimicrob. Agents Chemother. 44:2000;3235-3236.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 3235-3236
    • Murray, H.W.1
  • 34
    • 0034048702 scopus 로고    scopus 로고
    • Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms
    • Murray H.W., Delph-Etienne S. Visceral leishmanicidal activity of hexadecylphosphocholine (miltefosine) in mice deficient in T cells and activated macrophage microbicidal mechanisms. J. Infect. Dis. 181:2000;795-799.
    • (2000) J. Infect. Dis. , vol.181 , pp. 795-799
    • Murray, H.W.1    Delph-Etienne, S.2
  • 35
    • 0035024396 scopus 로고    scopus 로고
    • Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice
    • Escobar P., Yardley V., Croft S.L. Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice. Antimicrob. Agents Chemother. 45:2001;1872-1875.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1872-1875
    • Escobar, P.1    Yardley, V.2    Croft, S.L.3
  • 37
    • 0032488285 scopus 로고    scopus 로고
    • Trial of oral miltefosine for visceral leishmaniasis
    • Sundar S., Rosenkaimer F., Makharia M.K.et al. Trial of oral miltefosine for visceral leishmaniasis. Lancet. 352:1998;1821-1823.
    • (1998) Lancet , vol.352 , pp. 1821-1823
    • Sundar, S.1    Rosenkaimer, F.2    Makharia, M.K.3
  • 39
    • 0033540005 scopus 로고    scopus 로고
    • Miltefosine, an oral agent, for the treatment of Indian visceral Leishmaniasis
    • Jha T.K., Sundar S., Thakur C.P.et al. Miltefosine, an oral agent, for the treatment of Indian visceral Leishmaniasis. New Engl. J. Med. 341:1999;1795-1800.
    • (1999) New Engl. J. Med. , vol.341 , pp. 1795-1800
    • Jha, T.K.1    Sundar, S.2    Thakur, C.P.3
  • 40
    • 0034450717 scopus 로고    scopus 로고
    • Short-course of oral miltefosine for treatment of visceral leishmaniasis
    • Sundar S., Makharia A., More D.K.et al. Short-course of oral miltefosine for treatment of visceral leishmaniasis. Clin. Infect. Dis. 31:2000;1110-1113.
    • (2000) Clin. Infect. Dis. , vol.31 , pp. 1110-1113
    • Sundar, S.1    Makharia, A.2    More, D.K.3
  • 41
    • 1342308517 scopus 로고    scopus 로고
    • Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent
    • Soto J., Toledo J., Gutierrez P.et al. Treatment of American cutaneous leishmaniasis with miltefosine, an oral agent. Clin. Infect. Dis. 33:2001;57-61.
    • (2001) Clin. Infect. Dis. , vol.33 , pp. 57-61
    • Soto, J.1    Toledo, J.2    Gutierrez, P.3
  • 42
    • 0032484959 scopus 로고    scopus 로고
    • The inhibition of cell signaling pathways by antitumor ether-lipids
    • Arthur G., Bittman R. The inhibition of cell signaling pathways by antitumor ether-lipids. Biochim. Biophys. Acta. 1390:1998;85-102.
    • (1998) Biochim. Biophys. Acta , vol.1390 , pp. 85-102
    • Arthur, G.1    Bittman, R.2
  • 43
    • 0032813920 scopus 로고    scopus 로고
    • Mechanism of action of phospholipid analogs as anticancer compounds
    • Wieder T., Reutter W., Orfanos C.E., Geilen C.C. Mechanism of action of phospholipid analogs as anticancer compounds. Prog. Lipid Res. 38:1999;249-259.
    • (1999) Prog. Lipid Res. , vol.38 , pp. 249-259
    • Wieder, T.1    Reutter, W.2    Orfanos, C.E.3    Geilen, C.C.4
  • 44
    • 0025963780 scopus 로고
    • Hexadecylphosphocholine inhibits inositol phosphate formation and protein kinase C activity
    • Überall F., Oberhuber H., Maly K., Zaknun J., Demuth L., Grunicke H.H. Hexadecylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res. 51:1991;807-812.
    • (1991) Cancer Res. , vol.51 , pp. 807-812
    • Überall, F.1    Oberhuber, H.2    Maly, K.3    Zaknun, J.4    Demuth, L.5    Grunicke, H.H.6
  • 45
    • 0028246103 scopus 로고
    • Protein kinase C is not involved in the cytotoxic action of 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine in HL-60 and K562 cells
    • Heesbeen E.C., Verdonck L.F., Staal G.E., Rijksen G. Protein kinase C is not involved in the cytotoxic action of 1-octadecyl-2-O-methyl-sn-glycerol-3-phosphocholine in HL-60 and K562 cells. Biochem. Pharmacol. 47:1994;1481-1488.
    • (1994) Biochem. Pharmacol. , vol.47 , pp. 1481-1488
    • Heesbeen, E.C.1    Verdonck, L.F.2    Staal, G.E.3    Rijksen, G.4
  • 46
    • 0025769543 scopus 로고
    • The phospholipid analogue hexadecylphosphocholine inhibits phosphoatidylcholine biosynthesis in Madin-Darby canine kidney cells
    • Haase R., Wieder T., Geilen C.C., Reutter W. The phospholipid analogue hexadecylphosphocholine inhibits phosphoatidylcholine biosynthesis in Madin-Darby canine kidney cells. FEBS Lett. 288:1991;129-132.
    • (1991) FEBS Lett. , vol.288 , pp. 129-132
    • Haase, R.1    Wieder, T.2    Geilen, C.C.3    Reutter, W.4
  • 47
    • 0032079477 scopus 로고    scopus 로고
    • Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog hexadecylphosphocholine
    • Wieder T., Orfanos C.E., Geilen C.C. Induction of ceramide-mediated apoptosis by the anticancer phospholipid analog hexadecylphosphocholine. J. Biol. Chem. 273:1998;11025-11031.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11025-11031
    • Wieder, T.1    Orfanos, C.E.2    Geilen, C.C.3
  • 48
    • 0031904988 scopus 로고    scopus 로고
    • Alkylphosphocholines induce apoptosis in HL-60 and U-937 leukemic cells
    • Konstantinov S.M., Eibl H., Berger M.R. Alkylphosphocholines induce apoptosis in HL-60 and U-937 leukemic cells. Cancer Chemother. Pharmacol. 41:1998;210-216.
    • (1998) Cancer Chemother. Pharmacol. , vol.41 , pp. 210-216
    • Konstantinov, S.M.1    Eibl, H.2    Berger, M.R.3
  • 49
    • 1842290345 scopus 로고    scopus 로고
    • 3 (Edelfosine): Molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L)
    • 3 (Edelfosine): molecular structure requirements, cellular uptake, and protection by Bcl-2 and Bcl-X(L). Cancer Res. 57:1997;1320-1328.
    • (1997) Cancer Res. , vol.57 , pp. 1320-1328
    • Mollinedo, F.1    Fernandez-Luna, J.L.2    Gajate, C.3
  • 50
    • 0033758270 scopus 로고    scopus 로고
    • Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania
    • Lux H., Heise N., Klenner T., Hart D., Opperdoes F.R. Ether-lipid (alkyl-phospholipid) metabolism and the mechanism of action of ether-lipid analogues in Leishmania. Mol. Biochem. Parasitol. 111:2000;1-14.
    • (2000) Mol. Biochem. Parasitol. , vol.111 , pp. 1-14
    • Lux, H.1    Heise, N.2    Klenner, T.3    Hart, D.4    Opperdoes, F.R.5
  • 51
    • 0032799784 scopus 로고    scopus 로고
    • Phospholipid signalling pathways in Trypanosoma cruzi growth control
    • Malaquias A.T., Oliveira M.M. Phospholipid signalling pathways in Trypanosoma cruzi growth control. Acta Trop. 73:1999;93-108.
    • (1999) Acta Trop. , vol.73 , pp. 93-108
    • Malaquias, A.T.1    Oliveira, M.M.2
  • 52
    • 0034141210 scopus 로고    scopus 로고
    • Pathways involved in environmental sensing in trypanosomatids
    • Parsons M., Ruben L. Pathways involved in environmental sensing in trypanosomatids. Parasitol. Today. 16:2000;56-62.
    • (2000) Parasitol. Today , vol.16 , pp. 56-62
    • Parsons, M.1    Ruben, L.2
  • 53
    • 0035912807 scopus 로고    scopus 로고
    • L-Arginine-dependent suppression of apoptosis in Trypanosoma cruzi: Contribution of the nitric oxide and polyamine pathways
    • Piacenza L., Peluffo G., Radi R. L-Arginine-dependent suppression of apoptosis in Trypanosoma cruzi: contribution of the nitric oxide and polyamine pathways. Proc. Natl. Acad. Sci. USA. 98:2001;7301-7306.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7301-7306
    • Piacenza, L.1    Peluffo, G.2    Radi, R.3
  • 54
    • 0027176383 scopus 로고
    • Investigations on the cellular uptake of hexadecylphosphocholine
    • Fleer E.A., Berkovic D., Eibl H., Unger C. Investigations on the cellular uptake of hexadecylphosphocholine. Lipids. 28:1993;731-736.
    • (1993) Lipids , vol.28 , pp. 731-736
    • Fleer, E.A.1    Berkovic, D.2    Eibl, H.3    Unger, C.4
  • 55
    • 0030037465 scopus 로고    scopus 로고
    • Early stage monitoring of miltefosine induced apoptosis in KB cells by multinuclear NMR spectroscopy
    • Engelmann J., Henke J., Willker W.et al. Early stage monitoring of miltefosine induced apoptosis in KB cells by multinuclear NMR spectroscopy. Anticancer Res. 16:1996;1429-1440.
    • (1996) Anticancer Res. , vol.16 , pp. 1429-1440
    • Engelmann, J.1    Henke, J.2    Willker, W.3
  • 56
    • 0026676293 scopus 로고
    • Effects of hexadecylphosphocholine on cellular function
    • Eibl H, Hilgard P, Unger C, editors. Prog Exp Tumor Res Basel: Karger
    • Berkovic D, Fleer EAM, Eibl H, Unger C. Effects of hexadecylphosphocholine on cellular function. In: Eibl H, Hilgard P, Unger C, editors. New drugs in cancer therapy. Prog Exp Tumor Res Basel: Karger, 1992;34:59-68.
    • (1992) New Drugs in Cancer Therapy , vol.34 , pp. 59-68
    • Berkovic, D.1    Fleer, E.A.M.2    Eibl, H.3    Unger, C.4
  • 57
    • 0034863516 scopus 로고    scopus 로고
    • Alkyl-lysophospholipid resistance in multidrug resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator
    • Perez-Victoria J.M., Perez-Victoria F.J., Parodi-Talice A.et al. Alkyl-lysophospholipid resistance in multidrug resistant Leishmania tropica and chemosensitization by a novel P-glycoprotein-like transporter modulator. Antimicrob. Agents Chemother. 45:2001;2468-2474.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 2468-2474
    • Perez-Victoria, J.M.1    Perez-Victoria, F.J.2    Parodi-Talice, A.3
  • 58
    • 0035035188 scopus 로고    scopus 로고
    • Effects of miltefosine and other alkylphosphocholines on human intestinal parasite Entamoeba histolytica
    • Seifert K., Duchêne M., Wernsdorfer W.H.et al. Effects of miltefosine and other alkylphosphocholines on human intestinal parasite Entamoeba histolytica. Antimicrob. Agents Chemother. 45:2001;1505-1510.
    • (2001) Antimicrob. Agents Chemother. , vol.45 , pp. 1505-1510
    • Seifert, K.1    Duchêne, M.2    Wernsdorfer, W.H.3
  • 59
    • 0026506456 scopus 로고
    • Alkylphosphocholines: Influence of structural variation on biodistribution at antineoplastically active concentrations
    • Kötting J., Berger M.R., Unger C., Eibl H. Alkylphosphocholines: influence of structural variation on biodistribution at antineoplastically active concentrations. Cancer Chemother. Pharmacol. 30:1992;105-112.
    • (1992) Cancer Chemother. Pharmacol. , vol.30 , pp. 105-112
    • Kötting, J.1    Berger, M.R.2    Unger, C.3    Eibl, H.4
  • 60
    • 0023031853 scopus 로고
    • Acanthamoeba - The ultimate opportunist?
    • Jones D.B. Acanthamoeba - the ultimate opportunist? Am. J. Ophthalmol. 102:1986;527.
    • (1986) Am. J. Ophthalmol. , vol.102 , pp. 527
    • Jones, D.B.1
  • 61
    • 0036167747 scopus 로고    scopus 로고
    • Cytotoxic activity of alkylphosphocholines against clinical isolates of Acanthamoeba spp
    • Walochnik J., Duchêne M., Seifert K.et al. Cytotoxic activity of alkylphosphocholines against clinical isolates of Acanthamoeba spp. Antimicrob. Agents Chemother. 46:2002;695-701.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 695-701
    • Walochnik, J.1    Duchêne, M.2    Seifert, K.3
  • 62
    • 0033540012 scopus 로고    scopus 로고
    • Miltefosine - The long-awaited therapy for visceral leishmaniasis?
    • Herwaldt B.L. Miltefosine - the long-awaited therapy for visceral leishmaniasis? N Engl. J. Med. 341:1999;1840-1842.
    • (1999) N Engl. J. Med. , vol.341 , pp. 1840-1842
    • Herwaldt, B.L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.