A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple loci implicated in sex steroid hormone regulation

PLoS Genetics

Volumn 8, Issue 7, 2012, Pages

  Coviello, Andrea D ^a,b   Haring, Robin ^c   Wellons, Melissa ^d   Vaidya, Dhananjay ^e   Lehtimäki, Terho ^f   Keildson, Sarah ^g   Lunetta, Kathryn L ^h   He, Chunyan ^i,j   Fornage, Myriam ^k   Lagou, Vasiliki ^g,l   Mangino, Massimo ^m   Onland Moret, N Charlotte ⁿ   Chen, Brian ^o   Eriksson, Joel ^p   Garcia, Melissa ^q   Liu, Yong Mei ^r,s   Koster, Annemarie ^q   Lohman, Kurt ^r   Lyytikäinen, Leo Pekka ^f   Petersen, Ann Kristin ^q   Prescott, Jennifer ^t,v   Stolk, Lisette ^v,x   Vandenput, Liesbeth ^p   Wood, Andrew R ^x   Zhuang, Wei Vivian ^h   Ruokonen, Aimo ^y   Hartikainen, Anna Liisa ^z   Pouta, Anneli ^aa   Bandinelli, Stefania ^z   Biffar, Reiner ^ab   Brabant, Georg ^c   Cox, David G ^ac,ae   Chen, Yuhui ^g   Cummings, Steven ^af   Ferrucci, Luigi ^q   Gunter, Marc J ^ad   Hankinson, Susan E ^u,ag   Martikainen, Hannu ^z   Hofman, Albert ^w   Homuth, Georg ^c   Illig, Thomas ^t,ah   Jansson, John Olov ^p   Johnson, Andrew D ^b   Karasik, David ^ai   Karlsson, Magnus ^aj   Kettunen, Johannes ^ak,al   Kiel, Douglas P ^ah   Kraft, Peter ^t   Liu, Jingmin ^al   Ljunggren, Östen ^u   Lorentzon, Mattias ^p   Maggio, Marcello ^am   Markus, Marcello R P ^an   Mellström, Dan ^p   Miljkovic, Iva ^ao   Mirel, Daniel ^c   Nelson, Sarah ^ap   Morin Papunen, Laure ^z   Peeters, Petra H M ⁿ   Prokopenko, Inga ^g,l   Raffel, Leslie ^aq   Reincke, Martin ^at   Reiner, Alex P ^as   Rexrode, Kathryn ^v   Rivadeneira, Fernando ^v,x   Schwartz, Stephen M ^au   Siscovick, David ^am   Soranzo, Nicole ^m,av   Stöckl, Doris ^t,at   Tworoger, Shelley ^u   Uitterlinden, André G ^v,w,x   van Gils, Carla H ⁿ   Vasan, Ramachandran S ^a,b   Wichmann, H Erich ^t,at,aw   Zhai, Guangju ^m,ax   Bhasin, Shalender ^a   Bidlingmaier, Martin ^ar   Chanock, Stephen J ^ay   de Vivo, Immaculata ^t,v   Harris, Tamara B ^q   Hunter, David J ^t,v   Kähönen, Mika ^az   Liu, Simin ^ba   Ouyang, Pamela ^bb   Spector, Tim D ^m   van der Schouw, Yvonne T ⁿ   Viikari, Jorma ^bc   Wallaschofski, Henri ^c   McCarthy, Mark I ^g,l,bd   Frayling, Timothy M ^x   Murray, Anna ^x   Franks, Steve ^ae   Järvelin, Marjo Riitta ^z,ae   de Jong, Frank H ^v   Raitakari, Olli ^be   Teumer, Alexander ^w   Ohlsson, Claes ^p   Murabito, Joanne M ^a,b   Perry, John R B ^g,m,y   more..

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

^c UNIVERSITY OF GREIFSWALD   (Germany)

^d University of Alabama at Birmingham   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f TAMPERE UNIVERSITY HOSPITAL   (Finland)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

ⁱ INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^j INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k UNIVERSITY OF TEXAS   (United States)

^l UNIVERSITY OF OXFORD   (United Kingdom)

^m KING'S COLLEGE LONDON   (United Kingdom)

ⁿ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^o UNIVERSITY OF CALIFORNIA   (United States)

^p UNIVERSITY OF GOTHENBURG   (Sweden)

^q NATIONAL INSTITUTE ON AGING   (United States)

^r WAKE FOREST SCHOOL OF MEDICINE   (United States)

^s WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

^t INSTITUTE OF EPIDEMIOLOGY   (Germany)

^u HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^v BRIGHAM AND WOMEN S HOSPITAL   (United States)

^w ERASMUS MEDICAL CENTER   (Netherlands)

^x Netherlands Consortium of Healthy Aging   (Netherlands)

^y UNIVERSITY OF EXETER   (United Kingdom)

^z UNIVERSITY OF OULU   (Finland)

^aa OULU UNIVERSITY HOSPITAL   (Finland)

^ab Geriatric Unit   (Italy)

^ac UNIVERSITY OF LÜBECK   (Germany)

^ad CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^ae IMPERIAL COLLEGE LONDON   (United Kingdom)

^af CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^ag UNIVERSITY OF MASSACHUSETTS   (United States)

^ah HANNOVER MEDICAL SCHOOL   (Germany)

^ai HARVARD MEDICAL SCHOOL   (United States)

^aj LUND UNIVERSITY   (Sweden)

^ak UNIVERSITY OF HELSINKI   (Finland)

^al NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^am Fred Hutchinson Cancer Research Center   (United States)

^an UPPSALA UNIVERSITY   (Sweden)

^ao UNIVERSITY OF PARMA   (Italy)

^ap UNIVERSITY OF PITTSBURGH   (United States)

^aq BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^ar UNIVERSITY OF WASHINGTON   (United States)

^as CEDARS SINAI MEDICAL CENTER   (United States)

^at UNIVERSITY OF MUNICH   (Germany)

^au UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^av WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^aw LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^ax MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

^ay NATIONAL CANCER INSTITUTE   (United States)

^az TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^ba UNIVERSITY OF CALIFORNIA   (United States)

^bb JOHNS HOPKINS BAYVIEW MEDICAL CENTER   (United States)

^bc TURKU UNIVERSITY HOSPITAL   (Finland)

^bd CHURCHILL HOSPITAL   (United Kingdom)

^be UNIVERSITY OF TURKU   (Finland)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR; ORGANIC ANION TRANSPORTER 2; SEX HORMONE BINDING GLOBULIN; SEX HORMONE;

ARTICLE; BAIAP2L1 GENE; BREAST CANCER; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; EPIGENETICS; FEMALE; GCKR GENE; GENE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC IDENTIFICATION; GENETIC VARIABILITY; HORMONAL REGULATION; HUMAN; JMJD1C GENE; LHCGR GENE; LIPID METABOLISM; LIVER FUNCTION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NR2F2 GENE; PRMT6 GENE; PROSTATE CANCER; PROTEIN ANALYSIS; SEX DIFFERENCE; SEX HORMONE BINDING GLOBULIN GENE; SEX HORMONE DETERMINATION; SINGLE NUCLEOTIDE POLYMORPHISM; SLCO1B1 GENE; TDGF3 GENE; UGT2B15 GENE; ZBTB10 GENE; ZNF652 GENE; ALLELE; GENETICS; META ANALYSIS; METABOLISM; SEXUAL DEVELOPMENT;

ALLELES; FEMALE; GENETIC HETEROGENEITY; GENOME-WIDE ASSOCIATION STUDY; GONADAL STEROID HORMONES; HUMANS; MALE; METABOLIC NETWORKS AND PATHWAYS; POLYMORPHISM, SINGLE NUCLEOTIDE; SEX CHARACTERISTICS; SEX HORMONE-BINDING GLOBULIN;

EID: 84864619335     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1002805     Document Type: Article

References (78)

1. Hammond GL, (2011) Diverse roles for sex hormone-binding globulin in reproduction. Biol Reprod 85: 431-441.
2. Hammes A, Andreassen TK, Spoelgen R, Raila J, Hubner N, et al. (2005) Role of endocytosis in cellular uptake of sex steroids. Cell 122: 751-762.
3. Thompson DJ, Healey CS, Baynes C, Kalmyrzaev B, Ahmed S, et al. (2008) Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women. Cancer Epidemiol Biomarkers Prev 17: 3490-3498.
4. Wassell J, Michail M, Soliman N, Wardle PG, (2011) The value of sex hormone binding globulin (SHBG) in predicting treatment response in polycystic ovary syndrome (PCOS). Clin Lab 57: 95-98.
5. Xita N, Tsatsoulis A, Chatzikyriakidou A, Georgiou I, (2003) Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels. J Clin Endocrinol Metab 88: 5976-5980.
6. Ding EL, Song Y, Manson JE, Hunter DJ, Lee CC, et al. (2009) Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med 361: 1152-1163.
7. Perry JR, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, et al. (2010) Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 19: 535-544.
8. Coviello AD, Zhuang WV, Lunetta KL, Bhasin S, Ulloor J, et al. (2011) Circulating testosterone and SHBG concentrations are heritable in women: the Framingham Heart Study. J Clin Endocrinol Metab 96: E1491-1495.
9. Melzer D, Perry JR, Hernandez D, Corsi AM, Stevens K, et al. (2008) A genome-wide association study identifies protein quantitative trait loci (pQTLs). PLoS Genet 4: e1000072 doi:10.1371/journal.pgen.1000072.
10. Ohlsson C, Wallaschofski H, Lunetta KL, Stolk L, Perry JR, et al. (2011) Genetic determinants of serum testosterone concentrations in men. PLoS Genet 7: e1002313 doi:10.1371/journal.pgen.1002313.
11. Chasman DI, Pare G, Mora S, Hopewell JC, Peloso G, et al. (2009) Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis. PLoS Genet 5: e1000730 doi:10.1371/journal.pgen.1000730.
12. Han SY, Zhou L, Upadhyaya A, Lee SH, Parker KL, et al. (2001) TFIIAalpha/beta-like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors during spermatogenesis in the mouse. Biol Reprod 64: 507-517.
13. Kudo M, Osuga Y, Kobilka BK, Hsueh AJ, (1996) Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. J Biol Chem 271: 22470-22478.
14. Hogeveen KN, Talikka M, Hammond GL, (2001) Human sex hormone-binding globulin promoter activity is influenced by a (TAAAA)n repeat element within an Alu sequence. J Biol Chem 276: 36383-36390.
15. Martin LJ, Tremblay JJ, (2010) Nuclear receptors in Leydig cell gene expression and function. Biol Reprod 83: 3-14.
16. Hu Z, Xia Y, Guo X, Dai J, Li H, et al. (2011) A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia. Nat Genet 44: 183-186.
17. Li X, Mertens-Talcott SU, Zhang S, Kim K, Ball J, et al. (2010) MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology 151: 2462-2473.
18. Harrison MJ, Tang YH, Dowhan DH, (2010) Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. Nucleic Acids Res 38: 2201-2216.
19. Franks S, Gharani N, McCarthy M, (2001) Candidate genes in polycystic ovary syndrome. Hum Reprod Update 7: 405-410.
20. Chen ZJ, Zhao H, He L, Shi Y, Qin Y, et al. (2011) Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet 43: 55-59.
21. Cousin P, Calemard-Michel L, Lejeune H, Raverot G, Yessaad N, et al. (2004) Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women. J Clin Endocrinol Metab 89: 917-924.
22. Ehrmann DA, (2005) Polycystic ovary syndrome. N Engl J Med 352: 1223-1236.
23. Franks S, (1995) Polycystic ovary syndrome. N Engl J Med 333: 853-861.
24. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, et al. (1999) Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 274: 17159-17163.
25. Lee JW, Choi HS, Gyuris J, Brent R, Moore DD, (1995) Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol 9: 243-254.
26. Selva DM, Hammond GL, (2009) Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4alpha. J Mol Endocrinol 43: 19-27.
27. Janne M, Hammond GL, (1998) Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter. J Biol Chem 273: 34105-34114.
28. Reiling E, van 't Riet E, Groenewoud MJ, Welschen LM, van Hove EC, et al. (2009) Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk. Diabetologia 52: 1866-1870.
29. Qi Q, Wu Y, Li H, Loos RJ, Hu FB, et al. (2009) Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population. Diabetologia 52: 834-843.
30. Ling Y, Li X, Gu Q, Chen H, Lu D, et al. (2011) Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study. BMC Med Genet 12: 66.
31. Tanaka D, Nagashima K, Sasaki M, Yamada C, Funakoshi S, et al. (2011) GCKR mutations in Japanese families with clustered type 2 diabetes. Mol Genet Metab 102: 453-460.
32. Varbo A, Benn M, Tybjaerg-Hansen A, Grande P, Nordestgaard BG, (2011) TRIB1 and GCKR polymorphisms, lipid levels, and risk of ischemic heart disease in the general population. Arterioscler Thromb Vasc Biol 31: 451-457.
33. Takeuchi F, Katsuya T, Chakrewarthy S, Yamamoto K, Fujioka A, et al. (2010) Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. Diabetologia 53: 299-308.
34. Onuma H, Tabara Y, Kawamoto R, Shimizu I, Kawamura R, et al. (2010) The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. J Hum Genet 55: 600-604.
35. Hadarits F, Kisfali P, Mohas M, Maasz A, Duga B, et al. (2011) Common functional variants of APOA5 and GCKR accumulate gradually in association with triglyceride increase in metabolic syndrome patients. Mol Biol Rep.
36. Hu C, Zhang R, Wang C, Yu W, Lu J, et al. (2010) Effects of GCK, GCKR, G6PC2 and MTNR1B variants on glucose metabolism and insulin secretion. PLoS ONE 5: e11761 doi:10.1371/journal.pone.0011761.
37. Kozian DH, Barthel A, Cousin E, Brunnhofer R, Anderka O, et al. (2010) Glucokinase-activating GCKR polymorphisms increase plasma levels of triglycerides and free fatty acids, but do not elevate cardiovascular risk in the Ludwigshafen Risk and Cardiovascular Health Study. Horm Metab Res 42: 502-506.
38. Mohas M, Kisfali P, Jaromi L, Maasz A, Feher E, et al. (2010) GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? Cardiovasc Diabetol 9: 79.
39. Orho-Melander M, Melander O, Guiducci C, Perez-Martinez P, Corella D, et al. (2008) Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations. Diabetes 57: 3112-3121.
40. Perez-Martinez P, Delgado-Lista J, Garcia-Rios A, Mc Monagle J, Gulseth HL, et al. (2011) Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome. PLoS ONE 6: e20555 doi:10.1371/journal.pone.0020555.
41. Tam CH, Ma RC, So WY, Wang Y, Lam VK, et al. (2009) Interaction effect of genetic polymorphisms in glucokinase (GCK) and glucokinase regulatory protein (GCKR) on metabolic traits in healthy Chinese adults and adolescents. Diabetes 58: 765-769.
42. Yang Z, Wen J, Tao X, Lu B, Du Y, et al. (2011) Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people. Mol Biol Rep 38: 1145-1150.
43. Seithel A, Klein K, Zanger UM, Fromm MF, Konig J, (2008) Non-synonymous polymorphisms in the human SLCO1B1 gene: an in vitro analysis of SNP c.1929A>C. Mol Genet Genomics 279: 149-157.
44. Buch S, Schafmayer C, Volzke H, Seeger M, Miquel JF, et al. (2010) Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition. Gastroenterology 139: 1942-1951 e1942.
45. Miyahara A, Okamura-Oho Y, Miyashita T, Hoshika A, Yamada M, (2003) Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. J Hum Genet 48: 410-414.
46. Galligan CL, Baig E, Bykerk V, Keystone EC, Fish EN, (2007) Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity. Genes Immun 8: 480-491.
47. Millard TH, Dawson J, Machesky LM, (2007) Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties. J Cell Sci 120: 1663-1672.
48. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, et al. (2010) New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 42: 105-116.
49. Wang L, Muromoto N, Hayashi H, Mitani Y, Uehara H, et al. (1997) Hyperinsulinemia but no diabetes in transgenic mice homozygously expressing the tyrosine kinase-deficient human insulin receptor. Biochem Biophys Res Commun 240: 446-451.
50. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM, (1994) Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 94: 1543-1549.
51. Kusari J, Takata Y, Hatada E, Freidenberg G, Kolterman O, et al. (1991) Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles. J Biol Chem 266: 5260-5267.
52. Block NE, Komori K, Robinson KA, Dutton SL, Lam CF, et al. (1991) Diabetes-associated impairment of hepatic insulin receptor tyrosine kinase activity: a study of mechanisms. Endocrinology 128: 312-322.
53. Odawara M, Kadowaki T, Yamamoto R, Shibasaki Y, Tobe K, et al. (1989) Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor. Science 245: 66-68.
54. Arner P, Pollare T, Lithell H, Livingston JN, (1987) Defective insulin receptor tyrosine kinase in human skeletal muscle in obesity and type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 30: 437-440.
55. Selva DM, Hammond GL, (2009) Peroxisome-proliferator receptor gamma represses hepatic sex hormone-binding globulin expression. Endocrinology 150: 2183-2189.
56. Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, et al. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26: 76-80.
57. Hakonarson H, Grant SF, (2011) GWAS and its impact on elucidating the etiology of diabetes. Diabetes Metab Res Rev.
58. Selva DM, Hogeveen KN, Innis SM, Hammond GL, (2007) Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest 117: 3979-3987.
59. Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, et al. (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet 27: 375-382.
60. Yin L, Ma H, Ge X, Edwards PA, Zhang Y, (2011) Hepatic hepatocyte nuclear factor 4alpha is essential for maintaining triglyceride and cholesterol homeostasis. Arterioscler Thromb Vasc Biol 31: 328-336.
61. Wilson W 3rd, Pardo-Manuel de Villena F, Lyn-Cook BD, Chatterjee PK, Bell TA, et al. (2004) Characterization of a common deletion polymorphism of the UGT2B17 gene linked to UGT2B15. Genomics 84: 707-714.
62. Turgeon D, Carrier JS, Levesque E, Hum DW, Belanger A, (2001) Relative enzymatic activity, protein stability, and tissue distribution of human steroid-metabolizing UGT2B subfamily members. Endocrinology 142: 778-787.
63. Menard V, Eap O, Harvey M, Guillemette C, Levesque E, (2009) Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism. Hum Mutat 30: 1310-1319.
64. Levesque E, Beaulieu M, Green MD, Tephly TR, Belanger A, et al. (1997) Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 7: 317-325.
65. Swanson C, Mellstrom D, Lorentzon M, Vandenput L, Jakobsson J, et al. (2007) The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17 deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men. J Clin Endocrinol Metab 92: 4878-4882.
66. Chouinard S, Barbier O, Belanger A, (2007) UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells. J Biol Chem 282: 33466-33474.
67. Chouinard S, Pelletier G, Belanger A, Barbier O, (2004) Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium. Endocr Res 30: 717-725.
68. Pathi SS, Jutooru I, Chadalapaka G, Sreevalsan S, Anand S, et al. (2011) GT-094, a NO-NSAID, inhibits colon cancer cell growth by activation of a reactive oxygen species-microRNA-27a: ZBTB10-specificity protein pathway. Mol Cancer Res 9: 195-202.
69. Kumar R, Manning J, Spendlove HE, Kremmidiotis G, McKirdy R, et al. (2006) ZNF652, a novel zinc finger protein, interacts with the putative breast tumor suppressor CBFA2T3 to repress transcription. Mol Cancer Res 4: 655-665.
70. Kumar R, Selth L, Schulz RB, Tay BS, Neilsen PM, et al. (2011) Genome-wide mapping of ZNF652 promoter binding sites in breast cancer cells. J Cell Biochem.
71. Kumar R, Cheney KM, Neilsen PM, Schulz RB, Callen DF, (2010) CBFA2T3-ZNF651, like CBFA2T3-ZNF652, functions as a transcriptional corepressor complex. FEBS Lett 584: 859-864.
72. Callen DF, Ricciardelli C, Butler M, Stapleton A, Stahl J, et al. (2010) Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome. Oncol Rep 23: 1045-1052.
73. Baldassarre G, Romano A, Armenante F, Rambaldi M, Paoletti I, et al. (1997) Expression of teratocarcinoma-derived growth factor-1 (TDGF-1) in testis germ cell tumors and its effects on growth and differentiation of embryonal carcinoma cell line NTERA2/D1. Oncogene 15: 927-936.
74. Burger HG, Dudley EC, Cui J, Dennerstein L, Hopper JL, (2000) A prospective longitudinal study of serum testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin levels through the menopause transition. J Clin Endocrinol Metab 85: 2832-2838.
75. Schijf CP, van der Mooren MJ, Doesburg WH, Thomas CM, Rolland R, (1993) Differences in serum lipids, lipoproteins, sex hormone binding globulin and testosterone between the follicular and the luteal phase of the menstrual cycle. Acta Endocrinol (Copenh) 129: 130-133.
76. Link E, Parish S, Armitage J, Bowman L, Heath S, et al. (2008) SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med 359: 789-799.
77. Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, et al. (2011) Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet 43: 1131-1138.
78. Lee DK, Kurihara I, Jeong JW, Lydon JP, DeMayo FJ, et al. (2010) Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization. Mol Endocrinol 24: 930-940.