Circulating testosterone and SHBG concentrations are heritable in women: The Framingham Heart Study

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 9, 2011, Pages

  Coviello, Andrea D ^a   Zhuang, W V ^b   Lunetta, K L ^b,d   Bhasin, S ^a   Ulloor, J ^a   Zhang, A ^a   Karasik, D ^c   Kiel, D P ^c   Vasan, R S ^a,d   Murabito, J M ^a,d  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d FRAMINGHAM HEART STUDY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULATING TOTAL TESTOSTERONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DAUGHTER; DIABETES MELLITUS; ENVIRONMENTAL FACTOR; FEMALE; FLUOROMETRY; FRAMINGHAM RISK SCORE; HERITABILITY; HUMAN; LINKAGE ANALYSIS; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MENOPAUSE; MOTHER; OVARIECTOMY; PHENOTYPE; PREMENOPAUSE; PRIORITY JOURNAL; SISTER GROUP; SMOKING; TANDEM MASS SPECTROMETRY;

ADULT; AGED; FEMALE; HUMANS; MIDDLE AGED; SEX HORMONE-BINDING GLOBULIN; TESTOSTERONE;

EID: 80052519148     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-0050     Document Type: Article

References (25)

1. Lee J.S., LaCroix A.Z., Wu L., Cauley J.A., Jackson R.D., Kooperberg C., Leboff M.S., Robbins J., Lewis C.E., Bauer D.C., Cummings S.R. 2008 Associations of serum sex hormone-binding globulin and sex hormone concentrations with hip fracture risk in postmenopausal women. J Clin Endocrinol Metab 93:1796-1803 (Pubitemid 351656520)
2. Patel S.M., Ratcliffe S.J., Reilly M.P., Weinstein R., Bhasin S., Blackman M.R., Cauley J.A., Sutton-Tyrrell K., Robbins J., Fried L.P., Cappola A.R. 2009 Higher serum testosterone concentration in older women is associated with insulin resistance, metabolic syndrome, and cardiovascular disease. J Clin Endocrinol Metab 94:4776-4784
3. Shakir Y.A., Samsioe G., Nyberg P., Lidfeldt J., Nerbrand C., Agardh C.D. 2007 Do sex hormones influence features of the metabolic syndrome in middle-aged women? A population-based study of Swedish women: The Women's Health in the Lund Area (WHILA) Study. Fertil Steril 88:163-171 (Pubitemid 47001398)
4. Ding E.L., Song Y., Manson J.E., Rifai N., Buring J.E., Liu S. 2007 Plasma sex steroid hormones and risk of developing type 2 diabetes in women: A prospective study. Diabetologia 50:2076-2084 (Pubitemid 47373864)
5. Kalyani R.R., Franco M., Dobs A.S., Ouyang P., Vaidya D., Bertoni A., Gapstur S.M., Golden S.H. 2009 The association of endogenous sex hormones, adiposity, and insulin resistance with incident diabetes in postmenopausal women. J Clin Endocrinol Metab 94:4127-4135
6. Shahar E., Burke G.L., Cushman M., Heckbert S.R., Ouyang P., Szklo M. 2008 Post menopausal hormones and measures of subclinical atherosclerosis: The multi-ethnic study of atherosclerosis. Prev Med 47: 38-45
7. Rossouw J.E., Anderson G.L., Prentice R.L., LaCroix A.Z., Kooperberg C., Stefanick M.L., Jackson R.D., Beresford S.A., Howard B.V., Johnson K.C., Kotchen J.M., Ockene J. 2002 Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results From the Women's Health Initiative randomized controlled trial. JAMA 288:321-333 (Pubitemid 34761611)
8. Laughlin G.A., Goodell V., Barrett-Connor E. 2010 Extremes of endogenous testosterone are associated with increased risk of incident coronary events in older women. J Clin Endocrinol Metab 95:740-747
9. Ding E.L., Song Y., Manson J.E., Hunter D.J., Lee C.C., Rifai N., Buring J.E., Gaziano J.M., Liu S. 2009 Sex hormone-binding globulin and risk of type 2 diabetes in women and men.NEngl JMed361:1152-1163
10. Perry J.R., Weedon M.N., Langenberg C., Jackson A.U., Lyssenko V., Sparsø T., Thorleifsson G., Grallert H., Ferrucci L., Maggio M., Paolisso G., Walker M., Palmer C.N., Payne F., Young E., Herder C., Narisu N., Morken M.A., Bonnycastle L.L., Owen K.R., Shields B., Knight B., Bennett A., Groves C.J., Ruokonen A., et al. 2010 Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes. Hum Mol Genet 19:535-544
11. Maggio M., Lauretani F., Basaria S., Ceda G.P., Bandinelli S., Metter E.J., Bos A.J., Ruggiero C., Ceresini G., Paolisso G., Artoni A., Valenti G., Guralnik J.M., Ferrucci L. 2008 Sex hormone binding globulin levels across the adult lifespan in women: The role of body mass index and fasting insulin. J Endocrinol Invest 31:597-601
12. Jaquish C.E., Blangero J., Haffner S.M., Stern M.P., MacCluer J.W. 1997 Quantitative genetics of serum sex hormone-binding globulin levels in participants in the San Antonio Family Heart Study. Metabolism 46:988-991 (Pubitemid 27371812)
13. Meikle A.W., Bishop D.T., Stringham J.D., West D.W. 1986 Quantitating genetic and nongenetic factors that determine plasma sex steroid variation in normal male twins. Metabolism 35:1090-1095 (Pubitemid 17214171)
14. Ring H.Z., Lessov C.N., Reed T., Marcus R., Holloway L., Swan G.E., Carmelli D. 2005 Heritability of plasma sex hormones and hormone binding globulin in adult male twins. J Clin Endocrinol Metab 90: 3653-3658 (Pubitemid 41014339)
15. Stone J., Folkerd E., Doody D., Schroen C., Treloar S.A., Giles G.G., Pike M.C., English D.R., Southey M.C., Hopper J.L., Dowsett M. 2009 Familial correlations in postmenopausal serum concentrations of sex steroid hormones and other mitogens: A twins and sisters study. J Clin Endocrinol Metab 94:4793-4800
16. Splansky G.L., Corey D., Yang Q., Atwood L.D., Cupples L.A., Benjamin E.J., D'Agostino Sr R.B., Fox C.S., Larson M.G., Murabito J.M., O'Donnell C.J., Vasan R.S., Wolf P.A., Levy D. 2007 The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, recruitment, and initial examination. Am J Epidemiol 165:1328-1335 (Pubitemid 47234329)
17. Sir-Petermann T., Codner E., Pérez V., Echiburú B., Maliqueo M., Ladrón de Guevara A., Preisler J., Crisosto N., Sánchez F., Cassorla F., Bhasin S. 2009 Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome. J Clin Endocrinol Metab 94:1923-1930
18. Mazer N.A. 2009 A novel spreadsheet method for calculating the free serum concentrations of testosterone, dihydrotestosterone, estradiol, estrone and cortisol: With illustrative examples from male and female populations. Steroids 74:512-519
19. Almasy L., Blangero J. 1998 Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211 (Pubitemid 28199022)
20. Davison S.L., Bell R., Donath S., Montalto J.G., Davis S.R. 2005 Androgen levels in adult females: Changes with age, menopause, and oophorectomy. J Clin Endocrinol Metab 90:3847-3853 (Pubitemid 41058142)
21. Agrinier N., Cournot M., Dallongeville J., Arveiler D., Ducimetière P., Ruidavets J.B., Ferrières J. 2010 Menopause and modifiable coronary heart disease risk factors: A population based study. Maturitas 65: 237-243
22. Coviello A.D., Vasan R.S., Pencina M., D'Agostino R., Zhang A., Ulloor J., Bhasin S. 2007 Free testosterone is positively associated with diabetes, metabolic syndrome, and dyslipidemia in women: The Framingham Offspring Study. J Womens Health 16:1113
23. Shaw L.J., Bairey Merz C.N., Azziz R., Stanczyk F.Z., Sopko G., Braunstein G.D., Kelsey S.F., Kip K.E., Cooper-Dehoff R.M., Johnson B.D., Vaccarino V., Reis S.E., Bittner V., Hodgson T.K., Rogers W., Pepine C.J. 2008 Postmenopausalwomenwith a history of irregular menses and elevated androgen measurements at high risk for worsening cardiovascular event-free survival: Results from the National Institutes of Health-National Heart, Lung, and Blood Institute sponsored Women's Ischemia Syndrome Evaluation. J Clin Endocrinol Metab 93:1276-1284 (Pubitemid 351519721)
24. Hryb D.J., Khan M.S., Romas N.A., Rosner W. 1990 The control of the interaction of sex hormone-binding globulin with its receptor by steroid hormones. J Biol Chem 265:6048-6054
25. Hammes A., Andreassen T.K., Spoelgen R., Raila J., Hubner N., Schulz H., Metzger J., Schweigert F.J., Luppa P.B., Nykjaer A., Willnow T.E. 2005 Role of endocytosis in cellular uptake of sex steroids. Cell 122:751-762 (Pubitemid 41242639)