Isolation and characterization of therapeutic antibody charge variants using cation exchange displacement chromatography

Journal of Chromatography A

Volumn 1218, Issue 31, 2011, Pages 5079-5086

  Zhang, Taylor ^a   Bourret, Justin ^a   Cano, Tony ^a  

^a GENENTECH INC   (United States)

Author keywords

Antibody charge variants; Displacement chromatography; Ion exchange chromatography; Monoclonal antibody; Quality by design

Indexed keywords

CATION EXCHANGES; DISPLACEMENT CHROMATOGRAPHY; DISPLACERS; DISTRIBUTION PATTERNS; ION-EXCHANGE CHROMATOGRAPHY; ISOLATION AND CHARACTERIZATION; LOW-MOLECULAR-WEIGHT SPECIES; MOLECULAR CHARACTERIZATION; QUALITY BY DESIGN; STABILITY TESTS; STATIONARY PHASE; THERAPEUTIC ANTIBODIES; WIDE SPECTRUM;

AMINO ACIDS; CHARACTERIZATION; ION CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; POSITIVE IONS; SURFACE PLASMON RESONANCE; TRACE ANALYSIS;

CHROMATOGRAPHY;

GLYCAN; METHIONINE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CHARGE VARIANT; MONOCLONAL ANTIBODY IMMUNOGLOBULIN G1; UNCLASSIFIED DRUG;

ARTICLE; CARBOHYDRATE SYNTHESIS; CATION EXCHANGE DISPLACEMENT CHROMATOGRAPHY; CHEMICAL ANALYSIS; CHROMATOGRAPHY; CONTROLLED STUDY; DRUG POTENCY; DRUG PURITY; DRUG STABILITY; GEL PERMEATION CHROMATOGRAPHY; ION DISPLACEMENT; ISOLATION PROCEDURE; MOLECULAR WEIGHT; PRIORITY JOURNAL; SURFACE CHARGE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CHROMATOGRAPHY, ION EXCHANGE; CRICETINAE; CRICETULUS; DRUG THERAPY; HUMANS; IMMUNOGLOBULIN G;

EID: 79960137705     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.05.061     Document Type: Article

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