Targeting the sonic hedgehog pathway in keratocystic odontogenic tumor

Journal of Biological Chemistry

Volumn 287, Issue 32, 2012, Pages 27117-27125

  Ren, Changchun ^a   Amm, Hope M ^a   DeVilliers, Patricia ^b   Wu, Yixin ^a   Deatherage, Joseph R ^a   Liu, Zhongyu ^a   MacDougall, Mary ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMELOGENIN; BASAL CELL CARCINOMA; CELL POPULATIONS; DOSE-DEPENDENT MANNER; DOWN-REGULATION; GENE EXPRESSION PROFILES; HIGH RATE; IMMUNOHISTOCHEMISTRY; MATRIX PROTEINS; NOTCH SIGNALING PATHWAYS; ODONTOGENIC; PROTEIN EXPRESSIONS; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; SIGNALING PATHWAYS; SONIC HEDGEHOGS; TUMOR CELLS;

CELL PROLIFERATION; CELLS; GENE EXPRESSION; PROTEINS; SIGNALING; TOOTH ENAMEL; TUMORS;

CELL CULTURE;

AMELOBLASTIN; AMELOGENIN; AMELOTIN; CYCLOPAMINE; CYTOKERATIN 14; DELTA LIKE 1 PROTEIN; ENAMEL MATRIX PROTEIN; ENAMELIN; JAGGED2; KALLIKREIN; KALLIKREIN 4; MATRIX METALLOPROTEINASE 20; MEMBRANE PROTEIN; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; ODONTOGENIC AMELOBLAST ASSOCIATED PROTEIN; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1; TRANSCRIPTION FACTOR GLI2; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG TARGETING; GENE EXPRESSION PROFILING; GROWTH INHIBITION; GROWTH RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; ODONTOGENIC KERATOCYST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ADULT; CELL LINE, TUMOR; GENE EXPRESSION PROFILING; HEDGEHOG PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; ODONTOGENIC TUMORS; VERATRUM ALKALOIDS;

ERINACEIDAE;

EID: 84864543099     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.367680     Document Type: Article

References (42)

1. Barnes, L., Eveson, J., Reichart, P., Sidransky, D., and editors. (2005) World Health Organization Classification of Tumors, Pathology, and Genetics of Head and Neck Tumors, pp. 306-307, IARC Press, Lyons, France
2. Meiselman, F. (1994) Surgical management of the odontogenic keratocyst: conservative approach. J. Oral Maxillofac. Surg. 52, 960-963
3. Shear, M. (2002) The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1. Clinical and early experimental evidence of aggressive behavior. Oral Oncol. 38, 219-226
4. Shear, M. (2002) The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol. 38, 323-331
5. Shear, M. (2002) The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 3. Immunocytochemistry of cytokeratin and other epithelial cell markers. Oral Oncol. 38, 407-415
6. Farndon, P. A., Del Mastro, R. G., Evans, D. G., and Kilpatrick, M. W. (1992) Location of gene for Gorlin syndrome. Lancet 339, 581-582
7. Barreto, D. C., Gomez, R. S., Bale, A. E., Boson, W. L., and De Marco, L. (2000) PTCH gene mutations in odontogenic keratocysts. J. Dent. Res. 79, 1418-1422 (Pubitemid 32489450)
8. Lench, N. J., High, A. S., Markham, A. F., Hume, W. J., and Robinson, P. A. (1996) Investigation of chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts. Eur. J. Cancer B Oral. Oncol. 32B, 202-206
9. Diniz, M. G., Borges, E. R., Guimarães, A. L., Moreira, P. R., Brito, J. A., Gomez, M. V., De Marco, L., and Gomez, R. S. (2009) PTCH1 isoforms in odontogenic keratocysts. Oral. Oncol. 45, 291-295
10. Hopyan, S., Gokgoz, N., Poon, R., Gensure, R. C., Yu, C., Cole, W. G., Bell, R. S., Jüppner, H., Andrulis, I. L., Wunder, J. S., and Alman, B. A. (2002) A mutant PTH/PTHrP type I receptor in enchondromatosis. Nat. Genet. 30, 306-310
11. Nishimaki, H., Kasai, K., Kozaki, K., Takeo, T., Ikeda, H., Saga, S., Nitta, M., and Itoh, G. (2004) A role of activated sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem. Biophys. Res. Commun. 314, 313-320 (Pubitemid 38084719)
12. Lam, C. W., Xie, J., To, K. F., Ng, H. K., Lee, K. C., Yuen, N. W., Lim, P. L., Chan, L. Y., Tong, S. F., and McCormick, F. (1999) A frequent activated smoothened mutation in sporadic basal cell carcinomas. Oncogene 18, 833-836 (Pubitemid 29080343)
13. Mimeault, M., Johansson, S. L., Vankatraman, G., Moore, E., Henichart, J. P., Depreux, P., Lin, M. F., and Batra, S. K. (2007) Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells. Mol. Cancer Ther. 6, 967-978 (Pubitemid 46554566)
14. Buchtová, M., Handrigan, G. R., Tucker, A. S., Lozanoff, S., Town, L., Fu, K., Diewert, V. M., Wicking, C., and Richman, J. M. (2008) Initiation and patterning of the snake dentition are dependent on sonic hedgehog signaling. Dev. Biol. 319, 132-145
15. Miyazaki, K., Saika, S., Yamanaka, O., Okada, Y., and Ohnishi, Y. (2006) Treatment of eyelid epithelial neoplasm by targeting sonic hedgehog signaling: an experimental study. Jpn. J. Ophthalmol. 50, 305-311 (Pubitemid 44172634)
16. Mukherjee, S., Frolova, N., Sadlonova, A., Novak, Z., Steg, A., Page, G. P., Welch, D. R., Lobo-Ruppert, S. M., Ruppert, J. M., Johnson, M. R., and Frost, A. R. (2006) Hedgehog signaling and response to cyclopamine differ in epithelial and stromal cells in benign breast and breast cancer. Cancer Biol. Ther. 5, 674-683 (Pubitemid 44024723)
17. Ren, C., Diniz, M. G., Piazza, C., Amm, H. M., Rollins, D. L., Rivera, H., Devilliers, P., Kestler, D. P., Waite, P. D., Mamaeva, O. A., and Macdougall, M. (2011) Differential enamel and osteogenic gene expression profiles in odontogenic tumors. Cells Tissues Organs 194, 296-301
18. MacDougall, M., Thiemann, F., Ta, H., Hsu, P., Chen, L. S., and Snead, M. L. (1995) Temperature-sensitive simian virus 40 large T antigen immortalization of murine odontoblast cell cultures: establishment of clonal odontoblast cell line. Connect Tissue Res. 33, 97-103
19. Rohatgi, R., Milenkovic, L., and Scott, M. P. (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317, 372-376 (Pubitemid 47106377)
20. Zavros, Y., Waghray, M., Tessier, A., Bai, L., Todisco, A., L Gumucio, D., Samuelson, L. C., Dlugosz, A., and Merchant, J. L. (2007) Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J. Biol. Chem. 282, 33265-33274
21. Mitsiadis, T. A., Regaudiat, L., and Gridley, T. (2005) Role of the Notch signaling pathway in tooth morphogenesis. Arch. Oral. Biol. 50, 137-140 (Pubitemid 40252929)
22. Mitsiadis, T. A., Hirsinger, E., Lendahl, U., and Goridis, C. (1998) Delta-Notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation. Dev. Biol. 204, 420-431 (Pubitemid 29024489)
23. Heikinheimo, K., Jee, K. J., Morgan, P. R., Nagy, B., Knuutila, S., and Leivo, I. (2007) Genetic changes in sporadic keratocystic odontogenic tumors (odontogenic keratocysts). J. Dent. Res. 86, 544-549
24. Sire, J. Y., Davit-Béal, T., Delgado, S., and Gu, X. (2007) The origin and evolution of enamel mineralization genes. Cells Tissues Organs 186, 25-48 (Pubitemid 47026715)
25. Kolár, Z., Geierová, M., Bouchal, J., Pazdera, J., Zboril, V., and Tvrdý, P. (2006) Immunohistochemical analysis of the biological potential of odontogenic keratocysts. J. Oral. Pathol. Med. 35, 75-80
26. Katase, N., Nagatsuka, H., Tsujigiwa, H., Gunduz, M., Tamamura, R., Pwint, H. P., Rivera, R. S., Nakajima, M., Naomoto, Y., and Nagai, N. (2007) Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor. J. Oral. Pathol. Med. 36, 550-554 (Pubitemid 47390150)
27. Park, J. C., Park, J. T., Son, H. H., Kim, H. J., Jeong, M. J., Lee, C. S., Dey, R., and Cho, M. I. (2007) The amyloid protein APin is highly expressed during enamel mineralization and maturation in rat incisors. Eur. J. Oral Sci. 115, 153-160
28. Moffatt, P., Smith, C. E., St-Arnaud, R., and Nanci, A. (2008) Characterization of Apin, a secreted protein highly expressed in tooth-associated epithelia. J. Cell Biochem. 103, 941-956 (Pubitemid 351240629)
29. Murphy, C. L., Kestler, D. P., Foster, J. S., Wang, S., Macy, S. D., Kennel, S. J., Carlson, E. R., Hudson, J., Weiss, D. T., and Solomon, A. (2008) Odontogenic ameloblast-associated protein nature of the amyloid found in calcifying epithelial odontogenic tumors and unerupted tooth follicles. Amyloid 15, 89-95 (Pubitemid 351883254)
30. Kestler, D. P., Foster, J. S., Macy, S. D., Murphy, C. L., Weiss, D. T., and Solomon, A. (2008) Expression of odontogenic ameloblast-associated protein (ODAM) in dental and other epithelial neoplasms. Mol. Med. 14, 318-326 (Pubitemid 351785705)
31. Hardcastle, Z., Mo, R., Hui, C. C., and Sharpe, P. T. (1998) The Shh signaling pathway in tooth development: defects in Gli2 and Gli3 mutants. Development 125, 2803-2811 (Pubitemid 28410205)
32. Sun, L. S., Li, X. F., and Li, T. J. (2008) PTCH1 and SMO gene alterations in keratocystic odontogenic tumors. J. Dent. Res. 87, 575-579
33. Li, T. J., Yuan, J. W., Gu, X. M., Sun, L. S., and Zhao, H. S. (2008) PTCH germline mutations in Chinese nevoid basal cell carcinoma syndrome patients. Oral Dis. 14, 174-179
34. Zhang, L., Sun, Z. J., Zhao, Y. F., Bian, Z., Fan, M. W., and Chen, Z. (2006) Inhibition of SHH signaling pathway: molecular treatment strategy of odontogenic keratocyst. Med. Hypotheses 67, 1242-1244 (Pubitemid 44302262)
35. Taipale, J., Chen, J. K., Cooper, M. K., Wang, B., Mann, R. K., Milenkovic, L., Scott, M. P., and Beachy, P. A. (2000) Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature 406, 1005-1009
36. Heretsch, P., Tzagkaroulaki, L., and Giannis, A. (2010) Modulators of the hedgehog signaling pathway. Bioorg. Med. Chem. 18, 6613-6624
37. Karhadkar, S. S., Bova, G. S., Abdallah, N., Dhara, S., Gardner, D., Maitra, A., Isaacs, J. T., Berman, D. M., and Beachy, P. A. (2004) Hedgehog signaling in prostate regeneration, neoplasia, and metastasis. Nature 431, 707-712 (Pubitemid 39382619)
38. Chen, J. K., Taipale, J., Cooper, M. K., and Beachy, P. A. (2002) Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 16, 2743-2748 (Pubitemid 35253140)
39. Lee, K. R., Kozukue, N., Han, J. S., Park, J. H., Chang, E. Y., Baek, E. J., Chang, J. S., and Friedman, M. (2004) Glycoalkaloids and metabolites inhibit the growth of human colon (HT29) and liver (HepG2) cancer cells. J. Agric. Food Chem. 52, 2832-2839
40. Williams, J. A., Guicherit, O. M., Zaharian, B. I., Xu, Y., Chai, L., Wichterle, H., Kon, C., Gatchalian, C., Porter, J. A., Rubin, L. L., and Wang, F. Y. (2003) Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc. Natl. Acad. Sci. U.S.A. 100, 4616-4621 (Pubitemid 36457779)
41. Sacedón, R., Díez, B., Nuñez, V., Hernández-López, C., Gutierrez-Frías, C., Cejalvo, T., Outram, S. V., Crompton, T., Zapata, A. G., Vicente, A., and Varas, A. (2005) Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis. J. Immunol. 174, 1456-1461
42. Katoh, Y., and Katoh, M. (2006) Hedgehog signaling pathway and gastrointestinal stem cell signaling network (review). Int. J. Mol. Med. 18, 1019-1023