Genetic changes in sporadic keratocystic odontogenic tumors (Odontogenic Keratocysts)

Journal of Dental Research

Volumn 86, Issue 6, 2007, Pages 544-549

  Heikinheimo, K ^a,b   Jee, K J ^c   Morgan, P R ^d   Nagy, B ^e   Knuutila, S ^c   Leivo, I ^c  

^a UNIVERSITY OF TURKU   (Finland)

^b TURKU UNIVERSITY HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d KING'S COLLEGE LONDON   (United Kingdom)

^e SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

Gene expression; Genomic aberrations; Keratocystic odontogenic tumor; Odontogenic keratocyst

Indexed keywords

ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; CADHERIN; CDH18 PROTEIN, HUMAN; CYTOKERATIN 6; DNA; GLI PROTEIN, HUMAN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 12; CHROMOSOME ABERRATION; COMPARATIVE STUDY; CYTOLOGY; DNA MICROARRAY; GENE DELETION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; NUCLEIC ACID HYBRIDIZATION; ODONTOGENIC CYST; PROTO ONCOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOOTH FLORA;

ACTIVATED-LEUKOCYTE CELL ADHESION MOLECULE; CADHERINS; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 12; DNA; GENE DELETION; GENE EXPRESSION REGULATION; GENES, ERBB-1; HUMANS; IMMUNOHISTOCHEMISTRY; KERATIN-6; NUCLEIC ACID HYBRIDIZATION; ODONTOGENIC CYSTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TOOTH GERM; TRANSCRIPTION FACTORS;

EID: 34347205193     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910708600611     Document Type: Article

References (34)

1. Albertson DG, Pinkel D (2003). Genomic microarrays in human genetic disease and cancer. Hum Mol Genet 12(Spec No 2):R145-R152.
2. Arheden K. Ronne M. Mandahl N. Heim S, Kinzler KW, Vogelstein B. et al. (1989). In situ hybridization localizes the human putative oncogene GLI to chromosome subbands 12q13.3-14.1. Hum Genet 82:1-2.
3. Barreto DC. Gomez RS, Bale AE, Boson WL, De Marco L (2000). PTCH gene mutations in odontogenic keratocysts. J Dent Res 79:1418-1422.
4. Chalmers IJ, Hofler H, Atkison MJ (1999). Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent alloue loss in carcinoma. Genomics 57:160-163.
5. Chen W, Song M-S, Napoli JL (2002). SDR-O: an orphan short-chain dehydrogenase/reductase localized at mouse chromosome 10/human chromosome 12. Gene 294:141-146.
6. Cobourne MT, Sharpe PT (2005). Sonic hedgehog signaling and the developing tooth. Curr Top Dev Biol 65:255-287.
7. Di Palma S. Lambros MB, Savage K, Jones C, Mackay A, Dexter T, et al (2006). Oncocytic change in pleomorphic adenoma: molecular evidence in support of an origin in neoplastic cells. J Clin Pathol Feb 7 (Epub ahead of print).
8. Eisen MB, Spellman PT. Brown PO, Botstein D (1998). Cluster analysis and display of genome-wide expression patterns. Proc Natl Acad Sci USA 95:14863-14868.
9. +-dependent dehydrogenase that oxidizes all-trans-retinol 3alpha-hydroxysteroids. J Biol Chem 273:19778-19785.
10. Heikinheimo KA, Laine MA. Ritvos OV, Voutilainen RJ, Hogan BL, Leivo IV (1999). Bone morphogenetic protein-6 is a marker of serous acinar cell differentiation in normal and neoplastic human salivary gland. Cancer Res 59:5815-5821.
11. Heikinheimo K, Jee KJ, Niini T, Aalto Y, Happonen RP, Leivo I, et al. (2002). Gene expression profiling of ameloblastoma and human tooth germ by means of a cDNA microarray. J Dent Res 81:525-530.
12. Knuutila S (2004). Cytogenetics and molecular pathology in cancer diagnostics. Ann Med 36:162-171.
13. Kominc M. Rao LS, Kaneko T, Tomic-Canic M, Tamaki K, Freedberg IM, et al. (2000). Inflammatory versus proliferative processes in epidermis. Tumor necrosis factor alpha induces K6b keratin synthesis through a transcriptional complex containing NFkappaB and C/EBPbeta. J Biol Chem 275:32077-32088.
14. Kubota Y. Ninomiya T, Oka S, Takenoshita Y, Shirasuna K (2000). Interleukin-1 alpha-dependent regulation of matrix metallo-proteinase-9 (MMP-9) secretion and activation in the epithelial cells of odontogenic jaw cysts. J Dent Res 79:1423-1430.
15. Lappin TR, Grier DG. Thompson A, Halliday HL (2006). HOX genes: seductive science, mysterious mechanisms. Ulster Med J 75(1):23-31.
16. Lench NJ, High AS, Markham AF, Hume WJ, Robinson PA (1996). Investigation on chromosome 9q22.3-q31 DNA marker loss in odontogenic keratocysts. Eur J Cancer B Oral Oncol 32(B):202-206.
17. Li TJ, Browne RM, Matthews JB (1995). Epithelial cell proliferation in odontogenic keratocysts: a comparative immunocytochemical study of Ki67 in simple, recurrent and basal cell naevus syndrome (BCNS)-associated lesions. J Oral Pathol Med 24:221-226.
18. Lunter PC, van Kilsdonk JW, van Beek H, Cornelissen IM, Bergers M, Willems PH, et al. (2005). Activated leucocyte cell adhesion molecule (ALCAM/CD166/MEMD), a novel actor in invasive growth, controls matrix metalloproteinase activity. Cancer Res 65:8801-8808.
19. Mazzocchi G, Malendowicz LK, Ziolkowska A, Spinazzi R, Rebuffat P, Aragona F, et al. (2004). Adrenomedullin (AM) and AM receptor type 2 expression is up-regulated in prostate carcinomas (PC), and AM stimulates in vitro growth of a PC-derived cell line by enhancing proliferation and decreasing apoptosis rates. Int J Oncol 25:1781-1787.
20. Navarrro JM, Casatorres J, Jorcano JL (1995). Elements controlling the expression and induction of the skin hyperproliferation-associated keratin K6.J Biol Chem 270:21362-21367.
21. Oostlander AE, Meijer GA, Ylstra B (2004). Microarray-based comparative genomic hybridization and its applications in human genetics. Clin Genet 66:488-495.
22. Or YY, Hui AB. Tam KY, Huang DP, Lo KW (2005). Characterization of chromosome 3q and 12q amplicons in nasopharyngeal carcinoma cell lines. Int J Oncol 26:49-56.
23. Philipsen HP (2005). Keratocystic odontogenic tumor. In: World Health Organization classification of tumors. Pathology and genetics of the head and ceck tumors. Barnes L, Eveson JW, Reichart P, Sidransky D, editors. Lyon, France: IARC Press, pp. 306-307.
24. Rogers MA, Edler L, Winter H, Langbein L, Beckmann I, Schweizer J (2005). Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromososme 12q13.13. J Invest Dermatol 124:536-544.
25. Sesterhenn AM, Mandic R, Dunne AA, Werner JA (2005). Cytokeratins 6 and 16 are frequently expressed in head and neck squamous cell carcinoma cell lines and fresh biopsies. Anticancer Res 25:2675-2680.
26. Shear M (2002a). The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 1. Clinical and early experimental evidence of aggressive behaviour. Oral Oncol 38:219-226.
27. Shear M (2002b). The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 2. Proliferation and genetic studies. Oral Oncol 38:323-331.
28. Shear M (2002e). The aggressive nature of the odontogenic keratocyst: is it a benign cystic neoplasm? Part 3. Immunocytochemistry of cytokeratin and other epithelial cell markers. Oral Oncol 38:407-415.
29. Shibata T, Shimoyama Y, Gotoh M, Hirohashi S (1997). Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning. J Biol Chem 272:5236-5240.
30. Simon R, Struckmann K, Schraml P, Wagner U, Forster T, Moch H, et al. (2002). Amplification pattern of 12q13-q15 genes (MDM2, CDK4, GLI) in urinary bladder cancer. Oncogene 21:2476-2483.
31. Su WT, Alaminos M, More J, Cheung N-K, La Quaglia MP, Gerald WL (2004). Positional gene expression analysis identifies 12q over-expression and amplification in a subset of neuroblastomas. Cancer Genet Cytogenet 154:131-137.
32. Todd R, Wong DT (2002). DNA hybridization arrays for gene expression analysis of human oral cancer. J Dent Res 81:89-97.
33. Villavicencio EH, Walterhouse DO, lannaccone PM (2000). The sonic hedgehog-patched-gli pathway in human development and disease. Am J Hum Genet 67:1047-1054.
34. Vivekanand P, Rebay I (2006). Intersection of signal transduction pathways and development. Annu Rev Genet 40:139-157.