Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in parkinson's disease

Human Molecular Genetics

Volumn 21, Issue 15, 2012, Pages 3317-3332

  Goswami, Arvind Vittal ^a   Samaddar, Madhuja ^a   Sinha, Devanjan ^a   Purushotham, Jaya ^a   D'Silva, Patrick ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; HEAT SHOCK PROTEIN 70; J PROTEIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; PROTEIN P486S; PROTEIN P509S; PROTEIN R103W; PROTEIN R126W; PROTEIN VARIANT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; GENETIC SCREENING; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MUTATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TRANSPORT; REGULATORY MECHANISM; YEAST;

BINDING SITES; DNA, MITOCHONDRIAL; DOPAMINERGIC NEURONS; GENETIC VARIATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MITOCHONDRIA; MOLECULAR CHAPERONES; MUTATION; PARKINSON DISEASE; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE; TRANSFECTION;

EID: 84864517463     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/dds162     Document Type: Article

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