Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthase

Applied and Environmental Microbiology

Volumn 77, Issue 4, 2011, Pages 1501-1507

  Wesener, Shane R ^a   Potharla, Vishwakanth Y ^a   Cheng, Yi Qiang ^a,b  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANAEROBIC CULTIVATION; BACTERIAL STRAINS; BIO-AGENTS; BIOSYNTHETIC ENZYMES; BIOSYNTHETIC PATHWAY; CHAIN ELONGATION; CHROMOBACTERIUM VIOLACEUM; COENZYME A; COMPLEMENTATION; E. COLI; ENCODING GENES; ESCHERICHIA COLI CELLS; ESSENTIAL GENE; FATTY ACID BIOSYNTHESIS; FATTY ACID SYNTHASE; GENE CLUSTERS; GENE PRODUCTS; NATURAL PRODUCTS; NONRIBOSOMAL PEPTIDE SYNTHETASES; POLYKETIDE SYNTHASES; POLYKETIDES; SECONDARY METABOLISM;

BIOCHEMISTRY; CROSSTALK; CULTIVATION; ENCODING (SYMBOLS); ENZYMES; ESCHERICHIA COLI; FATTY ACIDS; GENE ENCODING; METABOLISM; PLANTS (BOTANY);

BIOSYNTHESIS;

ACYL CARRIER PROTEIN MALONYLTRANSFERASE; ANTINEOPLASTIC ANTIBIOTIC; BACTERIAL PROTEIN; DEPSIPEPTIDE; ESCHERICHIA COLI PROTEIN; FABD PROTEIN, E COLI; FATTY ACID SYNTHASE; PHOSPHOPANTETHEINYL TRANSFERASE; PHOSPHOTRANSFERASE; POLYKETIDE SYNTHASE; ROMIDEPSIN;

ANOXIC CONDITIONS; BACTERIUM; ENZYME ACTIVITY; FATTY ACID; METABOLISM; TUMOR;

ANAEROBIC GROWTH; ARTICLE; BIOSYNTHESIS; CHROMOBACTERIUM; ESCHERICHIA COLI; FERMENTATION; GENE DELETION; GENE EXPRESSION; GENETIC ENGINEERING; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; NONRIBOSOMAL PEPTIDE SYNTHESIS; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION;

ACYL-CARRIER PROTEIN S-MALONYLTRANSFERASE; ANAEROBIOSIS; ANTIBIOTICS, ANTINEOPLASTIC; BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CHROMOBACTERIUM; DEPSIPEPTIDES; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACID SYNTHETASE COMPLEX, TYPE II; FERMENTATION; GENE EXPRESSION; GENETIC ENGINEERING; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT; POLYKETIDE SYNTHASES; POLYMERASE CHAIN REACTION; SEQUENCE DELETION; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

BACTERIA (MICROORGANISMS); CHROMOBACTERIUM VIOLACEUM; ESCHERICHIA COLI;

EID: 79953208066     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.01513-10     Document Type: Article

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