메뉴 건너뛰기




Volumn 26, Issue 8, 2012, Pages 1394-1405

Secretin receptor promotes the proliferation of endocrine tumor cells via the PI3K/AKT pathway

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P27; SECRETIN; SMALL INTERFERING RNA;

EID: 84864435955     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2012-1055     Document Type: Article
Times cited : (13)

References (43)
  • 1
    • 0027745212 scopus 로고
    • Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-proteinlinked receptor family
    • Segre GV, Goldring SR 1993 Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related peptide, vasoactive intestinal peptide, glucagonlike peptide 1, growth hormone-releasing hormone, and glucagon belong to a newly discovered G-proteinlinked receptor family. Trends Endocrinol Metab 4:309-314
    • (1993) Trends Endocrinol Metab , vol.4 , pp. 309-314
    • Segre, G.V.1    Goldring, S.R.2
  • 2
    • 0348143339 scopus 로고    scopus 로고
    • Secretin, 100 years later
    • Chey WY, Chang TM 2003 Secretin, 100 years later. J Gastroenterol 38:1025-1035
    • (2003) J Gastroenterol , vol.38 , pp. 1025-1035
    • Chey, W.Y.1    Chang, T.M.2
  • 5
    • 0026710665 scopus 로고
    • Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism
    • Kato A, Gores GJ, LaRusso NF 1992 Secretin stimulates exocytosis in isolated bile duct epithelial cells by a cyclic AMP-mediated mechanism. J Biol Chem 267:15523-15529
    • (1992) J Biol Chem , vol.267 , pp. 15523-15529
    • Kato, A.1    Gores, G.J.2    Larusso, N.F.3
  • 6
    • 0026787649 scopus 로고
    • Secretin stimulates bile ductular secretory activity through the cAMP system
    • Lenzen R, Alpini G, Tavoloni N 1992 Secretin stimulates bile ductular secretory activity through the cAMP system. Am J Physiol 263:G527-G532
    • (1992) Am J Physiol , vol.263
    • Lenzen, R.1    Alpini, G.2    Tavoloni, N.3
  • 9
    • 26244457664 scopus 로고    scopus 로고
    • Secretin receptors in normal and diseased human pancreas: Marked reduction of receptor binding in ductal neoplasia
    • Körner M, Hayes GM, Rehmann R, Zimmermann A, Friess H, Miller LJ, Reubi JC 2005 Secretin receptors in normal and diseased human pancreas: marked reduction of receptor binding in ductal neoplasia. Am J Pathol 167:959-968
    • (2005) Am J Pathol , vol.167 , pp. 959-968
    • Körner, M.1    Hayes, G.M.2    Rehmann, R.3    Zimmermann, A.4    Friess, H.5    Miller, L.J.6    Reubi, J.C.7
  • 10
    • 33750442885 scopus 로고    scopus 로고
    • Secretin receptors in the human liver: Expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma
    • Körner M, Hayes GM, Rehmann R, Zimmermann A, Scholz A, Wiedenmann B, Miller LJ, Reubi JC 2006 Secretin receptors in the human liver: expression in biliary tract and cholangiocarcinoma, but not in hepatocytes or hepatocellular carcinoma. J Hepatol 45:825-835
    • (2006) J Hepatol , vol.45 , pp. 825-835
    • Körner, M.1    Hayes, G.M.2    Rehmann, R.3    Zimmermann, A.4    Scholz, A.5    Wiedenmann, B.6    Miller, L.J.7    Reubi, J.C.8
  • 12
    • 0036158930 scopus 로고    scopus 로고
    • Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma
    • Ding WQ, Kuntz S, Böhmig M, Wiedenmann B, Miller LJ 2002 Dominant negative action of an abnormal secretin receptor arising from mRNA missplicing in a gastrinoma. Gastroenterology 122: 500-511
    • (2002) Gastroenterology , vol.122 , pp. 500-511
    • Ding, W.Q.1    Kuntz, S.2    Böhmig, M.3    Wiedenmann, B.4    Miller, L.J.5
  • 13
    • 41149111070 scopus 로고    scopus 로고
    • Wild-type and splice-variant secretin receptors in lung cancer: Overexpression in carcinoid tumors and peritumoral lung tissue
    • Körner MU, Hayes GM, Carrigan PE, Rehmann R, Miller LJ, Reubi JC 2008 Wild-type and splice-variant secretin receptors in lung cancer: overexpression in carcinoid tumors and peritumoral lung tissue. Mod Pathol 21:387-395
    • (2008) Mod Pathol , vol.21 , pp. 387-395
    • Körner, M.U.1    Hayes, G.M.2    Carrigan, P.E.3    Rehmann, R.4    Miller, L.J.5    Reubi, J.C.6
  • 15
    • 77956634043 scopus 로고    scopus 로고
    • The MENX syndrome and p27: Relationships with multiple endocrine neoplasia
    • Molatore S, Pellegata NS 2010 The MENX syndrome and p27: relationships with multiple endocrine neoplasia. Prog Brain Res 182:295-320
    • (2010) Prog Brain Res , vol.182 , pp. 295-320
    • Molatore, S.1    Pellegata, N.S.2
  • 23
    • 35948949052 scopus 로고    scopus 로고
    • Secretin-receptor and secretin-receptorvariant expression in gastrinomas: Correlation with clinical and tumoral features and secretin and calcium provocative test results
    • Long SH, Berna MJ, Thill M, Pace A, Pradhan TK, Hoffmann KM, Serrano J, Jensen RT 2007 Secretin-receptor and secretin-receptorvariant expression in gastrinomas: correlation with clinical and tumoral features and secretin and calcium provocative test results. J Clin Endocrinol Metab 92:4394-4402
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 4394-4402
    • Long, S.H.1    Berna, M.J.2    Thill, M.3    Pace, A.4    Pradhan, T.K.5    Hoffmann, K.M.6    Serrano, J.7    Jensen, R.T.8
  • 24
    • 0031936197 scopus 로고    scopus 로고
    • Secretin and vasoactive intestinal peptide receptors: Members of a unique family of G protein-coupled receptors
    • Ulrich 2nd CD, Holtmann M, Miller LJ 1998 Secretin and vasoactive intestinal peptide receptors: members of a unique family of G protein-coupled receptors. Gastroenterology 114:382-397
    • (1998) Gastroenterology , vol.114 , pp. 382-397
    • Ulrich, C.D.1    Holtmann, M.2    Miller, L.J.3
  • 25
    • 0022391393 scopus 로고
    • Regulation of the concenmend.endojournals.org 1405 tration of adenosine 3,5-cyclic monophosphate and the activity of tyrosine hydroxylase in the rat superior cervical ganglion by three neuropeptides of the secretin family
    • Ip NY, Baldwin C, Zigmond RE 1985 Regulation of the concenmend.endojournals.org 1405 tration of adenosine 3,5-cyclic monophosphate and the activity of tyrosine hydroxylase in the rat superior cervical ganglion by three neuropeptides of the secretin family. J Neurosci 5:1947-1954
    • (1985) J Neurosci , vol.5 , pp. 1947-1954
    • Ip, N.Y.1    Baldwin, C.2    Zigmond, R.E.3
  • 26
    • 33644808833 scopus 로고    scopus 로고
    • Secretin induces neurite outgrowth of PC12 through cAMPmitogen-activated protein kinase pathway
    • Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG 2006 Secretin induces neurite outgrowth of PC12 through cAMPmitogen-activated protein kinase pathway. Exp Mol Med 38:85-93
    • (2006) Exp Mol Med , vol.38 , pp. 85-93
    • Kim, H.S.1    Yumkham, S.2    Kim, S.H.3    Yea, K.4    Shin, Y.C.5    Ryu, S.H.6    Suh, P.G.7
  • 28
    • 0028000952 scopus 로고
    • Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons
    • Takeda S, Okabe S, Funakoshi T, Hirokawa N 1994 Differential dynamics of neurofilament-H protein and neurofilament-L protein in neurons. J Cell Biol 127:173-185
    • (1994) J Cell Biol , vol.127 , pp. 173-185
    • Takeda, S.1    Okabe, S.2    Funakoshi, T.3    Hirokawa, N.4
  • 30
    • 0024832414 scopus 로고
    • Regulation of tyrosine hydroxylase activity in rat PC12 cells by neuropeptides of the secretin family
    • Roskoski Jr R, White L, Knowlton R, Roskoski LM 1989 Regulation of tyrosine hydroxylase activity in rat PC12 cells by neuropeptides of the secretin family. Mol Pharmacol 36:925-931
    • (1989) Mol Pharmacol , vol.36 , pp. 925-931
    • Roskoski, R.1    White, L.2    Knowlton, R.3    Roskoski, L.M.4
  • 31
    • 0345704610 scopus 로고
    • Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor
    • Greene LA, Tischler AS 1976 Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc Natl Acad Sci USA 73:2424-2428
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 2424-2428
    • Greene, L.A.1    Tischler, A.S.2
  • 33
    • 0038165488 scopus 로고    scopus 로고
    • Secretin activation of chromogranin A gene transcription. Identification of the signaling pathways in cis and in trans
    • Mahapatra NR, Mahata M, O'Connor DT, Mahata SK 2003 Secretin activation of chromogranin A gene transcription. Identification of the signaling pathways in cis and in trans. J Biol Chem 278:19986-19994
    • (2003) J Biol Chem , vol.278 , pp. 19986-19994
    • Mahapatra, N.R.1    Mahata, M.2    O'Connor, D.T.3    Mahata, S.K.4
  • 34
    • 0036799377 scopus 로고    scopus 로고
    • PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
    • Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL 2002 PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8:1145-1152
    • (2002) Nat Med , vol.8 , pp. 1145-1152
    • Shin, I.1    Yakes, F.M.2    Rojo, F.3    Shin, N.Y.4    Bakin, A.V.5    Baselga, J.6    Arteaga, C.L.7
  • 35
    • 77951980124 scopus 로고    scopus 로고
    • Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels
    • Anderson P, Gonzalez-Rey E 2010 Vasoactive intestinal peptide induces cell cycle arrest and regulatory functions in human T cells at multiple levels. Mol Cell Biol 30:2537-2551
    • (2010) Mol Cell Biol , vol.30 , pp. 2537-2551
    • Anderson, P.1    Gonzalez-Rey, E.2
  • 36
    • 0032768616 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in (INS-1)-cells
    • Buteau J, Roduit R, Susini S, Prentki M 1999 Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in (INS-1)-cells. Diabetologia 42:856-864
    • (1999) Diabetologia , vol.42 , pp. 856-864
    • Buteau, J.1    Roduit, R.2    Susini, S.3    Prentki, M.4
  • 37
    • 0037386156 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5-adenosine monophosphate-dependent protein kinase Aand a phosphatidylinositol 3-kinase-dependent pathway
    • Hui H, Nourparvar A, Zhao X, Perfetti R 2003 Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5-adenosine monophosphate-dependent protein kinase Aand a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 144:1444-1455
    • (2003) Endocrinology , vol.144 , pp. 1444-1455
    • Hui, H.1    Nourparvar, A.2    Zhao, X.3    Perfetti, R.4
  • 38
    • 77951223899 scopus 로고    scopus 로고
    • Pituitary adenylate cyclase-activating polypeptide (PACAP)/ PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase and vesicle endocytosis for neuronal survival
    • May V, Lutz E, MacKenzie C, Schutz KC, Dozark K, Braas KM 2010 Pituitary adenylate cyclase-activating polypeptide (PACAP)/ PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase and vesicle endocytosis for neuronal survival. J Biol Chem 285:9749-9761
    • (2010) J Biol Chem , vol.285 , pp. 9749-9761
    • May, V.1    Lutz, E.2    Mackenzie, C.3    Schutz, K.C.4    Dozark, K.5    Braas, K.M.6
  • 39
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: Opportunities, challenges and limitations
    • Engelman JA 2009 Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9:550-562
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 40
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM 2007 Defining the role of mTOR in cancer. Cancer Cell 12:9-22
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 41
    • 70350033524 scopus 로고    scopus 로고
    • Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells
    • Adler JT, Hottinger DG, Kunnimalaiyaan M, Chen H 2009 Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells. World J Surg 33:2452-2457
    • (2009) World J Surg , vol.33 , pp. 2452-2457
    • Adler, J.T.1    Hottinger, D.G.2    Kunnimalaiyaan, M.3    Chen, H.4
  • 42
    • 84857579424 scopus 로고    scopus 로고
    • The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer
    • Awasthi N, Yen PL, Schwarz MA, Schwarz RE 2012 The efficacy of a novel, dual PI3K/mTOR inhibitor NVP-BEZ235 to enhance chemotherapy and antiangiogenic response in pancreatic cancer. J Cell Biochem 113:784-791
    • (2012) J Cell Biochem , vol.113 , pp. 784-791
    • Awasthi, N.1    Yen, P.L.2    Schwarz, M.A.3    Schwarz, R.E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.