Concentration response to the coenzyme Q10 supplement Q-Gel in human volunteers

Nutrition Research

Volumn 27, Issue 6, 2007, Pages 307-312

  Molyneux, Sarah ^a,b   Florkowski, Christopher ^a   McGrane, Yasmin ^a   Lever, Michael ^a,b   George, Peter ^a  

^a CANTERBURY HEALTH LABORATORIES   (New Zealand)

^b UNIVERSITY OF CANTERBURY   (New Zealand)

Author keywords

Absorption; Coenzyme Q10; Concentration response; Human; Supplementation; Ubiquinone

Indexed keywords

ALPHA TOCOPHEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UBIDECARENONE;

ADULT; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; BLOOD ANALYSIS; CHOLESTEROL BLOOD LEVEL; CLINICAL TRIAL; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET RESTRICTION; DOSE RESPONSE; DRUG ABSORPTION; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG EFFICACY; GEL; HUMAN; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; SUPPLEMENTATION; TRIACYLGLYCEROL BLOOD LEVEL; VOLUNTEER;

EID: 34250720560     PISSN: 02715317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nutres.2007.04.011     Document Type: Article

References (26)

1. 10 in humans. FEBS Lett 443 (1999) 163-166
2. Rötig A., Appelkvist E.-L., Geromel V., Chretein D., Kadhom N., Edery P., et al. Quinone-responsive multiple respiratory-chain dysfunction due to widespread coenzyme Q10 deficiency. Lancet 356 (2000) 391-395
3. Folkers K., Langsjoen P., Willis R., Richardson P., Xia L.-J., Ye C.-Q., et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci U S A 87 (1990) 8931-8934
4. Päivä H., Thelen K.M., Van Coster R., Smet J., De Paepe B., Mattila K.M., et al. High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial. Clin Pharmacol Ther 78 (2005) 60-68
5. 10. Proc Natl Acad Sci U S A 82 (1985) 901-904
6. Lockwood K., Moesgaard S., Yamamoto T., and Folkers K. Progress on therapy of breast cancer with vitamin Q10 and the regression of metastases. Biochem Biophys Res Commun 212 (1995) 172-177
7. 10 illuminated by meta-analyses of clinical trials. Mol Aspects Med 18 (1997) s159-s168
8. Ogasahara S., Engel A.G., Frens D., and Mack D. Muscle coenzyme Q deficiency in familial mitochondrial encephalomyopathy. Proc Natl Acad Sci U S A 86 (1989) 2379-2382
9. 10 preparations. Ann Nutr Metab 47 (2003) 16-21
10. 10 formulations in healthy volunteers. Mol Aspects Med 15 (1994) s273-s280
11. Kaikkonen J., Nyyssönen K., Porkkala-Sarataho E., Poulsen H.E., Metsä-Ketelä T., Hayn M., et al. Effect of oral coenzyme Q10 supplementation on the oxidation resistance of human VLDL + LDL fraction: absorption and antioxidative properties of oil and granule-based preparations. Free Radic Biol Med 22 (1997) 1195-1202
12. Chopra R.K., Goldman R., Sinatra S.T., and Bhagavan H.N. Relative bioavailability of coenzyme Q10 formulations in human subjects. Int J Vitam Nutr Res 68 (1998) 109-113
13. 10 in healthy subjects. Asia Pac J Clin Nutr 7 (1998) 37-40
14. Miles M.V., Horn P., Miles L., Tang P., Steele P., and DeGrauw T. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res 22 (2002) 919-929
15. Molyneux S., Florkowski C., Lever M., and George P. The bioavailability of coenzyme Q10 supplements available in New Zealand differs markedly. N Z Med J 117 (2004)
16. Weber C., Bysted A., and Hølmer G. The coenzyme Q10 content of the average Danish diet. Int J Vitam Nutr Res 67 (1997) 123-129
17. 10: contents in foods and dietary intake. J Food Compos Anal 14 (2001) 409-417
18. Tang P.H., Miles M.V., DeGrauw A., Hershey A., and Pesce A. HPLC analysis of reduced and oxidised coenzyme Q10 in human plasma. Clin Chem 47 (2001) 256-265
19. Matthews J.N.S., Altman D.G., Campbell M.J., and Royston P. Analysis of serial measurements in medical research. BMJ 300 (1990) 230-235
20. Kirkwood B.R. Essentials of medical statistics (1999), Blackwell Science Ltd, Oxford
21. 10 for two months in a randomised controlled study. Biofactors 18 (2003) 185-193
22. Ullmann U., Metzner J., Schulz C., Perkins J., and Leuenberger B. A new coenzyme Q10 tablet-grade formulation (all-Q) is bioequivalent to Q-Gel and both have better bioavailability properties than Q-SorB. J Med Food 8 (2005) 397-399
23. Wolters M., and Hahn A. Plasma ubiquinone status and response to 6-month supplementation combined with multivitamins in healthy elderly women-results of a randomized, double blind, placebo-controlled study. Int J Vitam Nutr Res 73 (2003) 207-214
24. Singh R.B., Niaz M.A., Kumar A., Sindberg C.D., Moesgaard S., and Littarru G.P. Effect on absorption and oxidative stress of different oral coenzyme Q10 dosages and intake strategy in healthy men. Biofactors 25 (2005) 219-224
25. Kaikkonen J., Tuomainen T.P., Nyyssönen K., and Salonen J.T. Coenzyme Q10: Absorption, antioxidative properties, determinants, and plasma levels. Free Radic Res 36 (2002) 389-397
26. Kaikkonen J., Nyyssonen K., Tomasi A., Iannone A., Tuomainen T.P., Porkkala-Sarataho E., et al. Antioxidant efficacy of parallel and combined supplementation with coenzyme Q10 and d-α-tocopherol in mildly hypercholesterolemic subjects: a randomised placebo-controlled clinical study. Free Radic Res 33 (2000) 329-340