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Volumn 29, Issue 8, 2009, Pages 3195-3205

Keratinocyte growth factor (KGF) regulates estrogen receptor-α (ER-α) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells

Author keywords

Apoptosis; Bcl 2 family; Breast cancer; ER ; Estrogen; KGF; PI3 Akt; Tamoxifen

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 HYDROXYTAMOXIFEN; CASPASE 9; ESTROGEN RECEPTOR ALPHA; GENOMIC DNA; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN BAD; PROTEIN BCL 2; PROTEIN BCL X; RECOMBINANT KERATINOCYTE GROWTH FACTOR;

EID: 68549136607     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (21)

References (52)
  • 2
    • 0035945656 scopus 로고    scopus 로고
    • Estrogen and the risk of breast cancer
    • Clemons M and Goss P: Estrogen and the risk of breast cancer. N Engl J Med 344: 276-285, 2001.
    • (2001) N Engl J Med , vol.344 , pp. 276-285
    • Clemons, M.1    Goss, P.2
  • 3
    • 0028331871 scopus 로고
    • Steroid hormone receptor phosphorylation: Is there a physiological role?
    • Kuiper GG and Brinkmann AO: Steroid hormone receptor phosphorylation: is there a physiological role? Mol Cell Endocrinol 100: 103-107, 1994.
    • (1994) Mol Cell Endocrinol , vol.100 , pp. 103-107
    • Kuiper, G.G.1    Brinkmann, A.O.2
  • 5
    • 0024312674 scopus 로고
    • Tamoxifen therapy in primary breast cancer: Biology, efficacy, and side effects
    • Love RR: Tamoxifen therapy in primary breast cancer: biology, efficacy, and side-effects. J Clin Oncol 7: 803-815, 1989. (Pubitemid 19145604)
    • (1989) Journal of Clinical Oncology , vol.7 , Issue.6 , pp. 803-815
    • Love, R.R.1
  • 7
    • 0032502451 scopus 로고    scopus 로고
    • Tamoxifen. A 'big deal' but a complex hand to play
    • Marshall E: Tamoxifen. A 'big deal' but a complex hand to play. Science 280: 196, 1998.
    • (1998) Science , vol.280 , pp. 196
    • Marshall, E.1
  • 8
    • 0029303048 scopus 로고
    • Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells
    • Perry RR, Kang Y and Greaves B: Effects of tamoxifen on growth and apoptosis of estrogen-dependent and -independent human breast cancer cells. Ann Surg Oncol 2: 238-245, 1995.
    • (1995) Ann Surg Oncol , vol.2 , pp. 238-245
    • Perry, R.R.1    Kang, Y.2    Greaves, B.3
  • 9
    • 0032575750 scopus 로고    scopus 로고
    • Caspases: Enemies within
    • Thornberry NA and Lazebnik Y: Caspases: enemies within. Science 281: 1312-1316, 1998.
    • (1998) Science , vol.281 , pp. 1312-1316
    • Thornberry, N.A.1    Lazebnik, Y.2
  • 10
    • 0034326818 scopus 로고    scopus 로고
    • 2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells
    • Mandlekar S, Yu R, Tan TH and Kong AN: Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells. Cancer Res 60: 5995-6000, 2000. (Pubitemid 30839629)
    • (2000) Cancer Research , vol.60 , Issue.21 , pp. 5995-6000
    • Mandlekar, S.1    Yu, R.2    Tan, T.-H.3    Kong, A.-N.T.4
  • 11
    • 0034690750 scopus 로고    scopus 로고
    • UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years
    • Peto R, Boreham J, Clarke M, Davies C and Beral V: UK and USA breast cancer deaths down 25% in year 2000 at ages 20-69 years. Lancet 355: 1822, 2000.
    • (2000) Lancet , vol.355 , pp. 1822
    • Peto, R.1    Boreham, J.2    Clarke, M.3    Davies, C.4    Beral, V.5
  • 12
    • 0036900628 scopus 로고    scopus 로고
    • Insulin-like growth factor-I and estrogen interactions in breast cancer
    • Martin MB and Stoica A: Insulin-like growth factor-I and estrogen interactions in breast cancer. J Nutr 132: 3799S-3801S, 2002.
    • (2002) J Nutr , vol.132
    • Martin, M.B.1    Stoica, A.2
  • 13
    • 0038636495 scopus 로고    scopus 로고
    • Heregulin-β1 regulates the estrogen receptor-α gene expression and activity via the ErbB2/PI 3-K/Akt pathway
    • DOI 10.1038/sj.onc.1206311
    • Stoica GE, Franke TF, Wellstein A, Morgan E, Czubayko F, List HJ, Reiter R, Martin MB and Stoica A: Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. Oncogene 22: 2073-2087, 2003. (Pubitemid 36539558)
    • (2003) Oncogene , vol.22 , Issue.14 , pp. 2073-2087
    • Stoica, G.E.1    Franke, T.F.2    Wellstein, A.3    Morgan, E.4    Czubayko, F.5    List, H.-J.6    Reiter, R.7    Martin, M.B.8    Stoica, A.9
  • 15
    • 0032887942 scopus 로고    scopus 로고
    • Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer
    • Nicholson RI, McClelland RA, Robertson JF and Gee JM: Involvement of steroid hormone and growth factor cross-talk in endocrine response in breast cancer. Endocr Relat Cancer 6: 373-387, 1999.
    • (1999) Endocr Relat Cancer , vol.6 , pp. 373-387
    • Nicholson, R.I.1    McClelland, R.A.2    Robertson, J.F.3    Gee, J.M.4
  • 17
    • 0037462733 scopus 로고    scopus 로고
    • Proximal events in signaling by plasma membrane estrogen receptors
    • DOI 10.1074/jbc.M205692200
    • Razandi M, Pedram A, Park ST and Levin ER: Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem 278: 2701-2712, 2003. (Pubitemid 36801351)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.4 , pp. 2701-2712
    • Razandi, M.1    Pedram, A.2    Park, S.T.3    Levin, E.R.4
  • 19
    • 0029436347 scopus 로고
    • Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction
    • Rubin JS, Bottaro DP, Chedid M, Miki T, Ron D, Cunha GR and Finch PW: Keratinocyte growth factor as a cytokine that mediates mesenchymal-epithelial interaction. EXS 74: 191-214, 1995.
    • (1995) EXS , vol.74 , pp. 191-214
    • Rubin, J.S.1    Bottaro, D.P.2    Chedid, M.3    Miki, T.4    Ron, D.5    Cunha, G.R.6    Finch, P.W.7
  • 20
    • 0031970538 scopus 로고    scopus 로고
    • Estrogen-induced keratinocyte growth factor mRNA expression in normal and cancerous human breast cells
    • Zhang Y, Sugimoto Y, Kulp SK, Farrar WB, Brueggemeier RW and Lin YC: Estrogen-induced keratinocyte growth factor mRNA expression in normal and cancerous human breast cells. Oncol Rep 5: 577-583, 1998. (Pubitemid 28189307)
    • (1998) Oncology Reports , vol.5 , Issue.3 , pp. 577-583
    • Zhang, Y.1    Sugimoto, Y.2    Kulp, S.K.3    Farrar, W.B.4    Brueggemeier, R.W.5    Lin, Y.C.6
  • 21
    • 0028104947 scopus 로고
    • Keratinocyte growth factor and acidic fibroblast growth factor are mitogens for primary cultures of mammary epithelium
    • DOI 10.1006/bbrc.1994.2585
    • Imagawa W, Cunha GR, Young P and Nandi S: Keratinocyte growth factor and acidic fibroblast growth factor are mitogens for primary cultures of mammary epithelium. Biochem Biophys Res Commun 204: 1165-1169, 1994. (Pubitemid 24367174)
    • (1994) Biochemical and Biophysical Research Communications , vol.204 , Issue.3 , pp. 1165-1169
    • Imagawa, W.1    Cunha, G.R.2    Young, P.3    Nandi, S.4
  • 22
    • 0027302012 scopus 로고
    • Differential expression of keratinocyte growth factor and its receptor in the human uterus
    • Pekonen F, Nyman T and Rutanen EM: Differential expression of keratinocyte growth factor and its receptor in the human uterus. Mol Cell Endocrinol 95: 43-49, 1993. (Pubitemid 23267194)
    • (1993) Molecular and Cellular Endocrinology , vol.95 , Issue.1-2 , pp. 43-49
    • Pekonen, F.1    Nyman, T.2    Rutanen, E.-M.3
  • 23
    • 0028198774 scopus 로고
    • Keratinocyte growth factor is a growth factor for mammary epithelium in vivo: The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor
    • Ulich TR, Yi ES, Cardiff R, Yin S, Bikhazi N, Biltz R, Morris CF and Pierce GF: Keratinocyte growth factor is a growth factor for mammary epithelium in vivo. The mammary epithelium of lactating rats is resistant to the proliferative action of keratinocyte growth factor. Am J Pathol 144: 862-868, 1994. (Pubitemid 24160626)
    • (1994) American Journal of Pathology , vol.144 , Issue.5 , pp. 862-868
    • Ulich, T.R.1    Yi, E.S.2    Cardiff, R.3    Yin, S.4    Bikhazi, N.5    Biltz, R.6    Morris, C.F.7    Pierce, G.F.8
  • 24
  • 25
    • 0036417339 scopus 로고    scopus 로고
    • Keratinocyte growth factor stimulates the migration and proliferation of breast cancer cells in a culture wounding model
    • Nguyen TN, Zang XP and Pento JT: Keratinocyte growth factor stimulates the migration and proliferation of breast cancer cells in a culture wounding model. Pharmacol Res 46: 179-183, 2002.
    • (2002) Pharmacol Res , vol.46 , pp. 179-183
    • Nguyen, T.N.1    Zang, X.P.2    Pento, J.T.3
  • 26
    • 0842333182 scopus 로고    scopus 로고
    • Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells
    • Zang XP, Lerner MR, Dunn ST, Brackett DJ and Pento JT: Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells. Anticancer Res 23: 4913-4919, 2003.
    • (2003) Anticancer Res , vol.23 , pp. 4913-4919
    • Zang, X.P.1    Lerner, M.R.2    Dunn, S.T.3    Brackett, D.J.4    Pento, J.T.5
  • 27
    • 4744372082 scopus 로고    scopus 로고
    • Evolution of the Fgf and Fgfr gene families
    • DOI 10.1016/j.tig.2004.08.007, PII S0168952504002410
    • Itoh N and Ornitz DM: Evolution of the Fgf and Fgfr gene families. Trends Genet 20: 563-569, 2004. (Pubitemid 39314564)
    • (2004) Trends in Genetics , vol.20 , Issue.11 , pp. 563-569
    • Itoh, N.1    Ornitz, D.M.2
  • 28
    • 0027199056 scopus 로고
    • Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2)
    • DOI 10.1006/dbio.1993.1205
    • Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D and Lonai P: Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol 158: 475-486, 1993. (Pubitemid 23243904)
    • (1993) Developmental Biology , vol.158 , Issue.2 , pp. 475-486
    • Orr-Urtreger, A.1    Bedford, M.T.2    Burakova, T.3    Arman, E.4    Zimmer, Y.5    Yayon, A.6    Givol, D.7    Lonai, P.8
  • 31
    • 0031749349 scopus 로고    scopus 로고
    • Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways
    • Liang Q, Mohan RR, Chen L and Wilson SE: Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways. Invest Ophthalmol Vis Sci 39: 1329-1338, 1998. (Pubitemid 28307357)
    • (1998) Investigative Ophthalmology and Visual Science , vol.39 , Issue.8 , pp. 1329-1338
    • Liang, Q.1    Mohan, R.R.2    Chen, L.3    Wilson, S.E.4
  • 32
    • 2942574599 scopus 로고    scopus 로고
    • Keratinocyte growth factor stimulates alveolar type II cell proliferation through the extracellular signal-regulated kinase and phosphatidylinositol 3-OH kinase pathways
    • DOI 10.1165/rcmb.2003-0406OC
    • Portnoy J, Curran-Everett D and Mason RJ: Keratinocyte growth factor stimulates alveolar type II cell proliferation through the extracellular signal-regulated kinase and phosphatidylinositol 3-OH kinase pathways. Am J Respir Cell Mol Biol 30: 901-907, 2004. (Pubitemid 38736916)
    • (2004) American Journal of Respiratory Cell and Molecular Biology , vol.30 , Issue.6 , pp. 901-907
    • Portnoy, J.1    Curran-Everett, D.2    Mason, R.J.3
  • 33
    • 0037821639 scopus 로고    scopus 로고
    • P38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing. Evidence of cross-talk activation between map kinase cascades
    • DOI 10.1074/jbc.M302650200
    • Sharma GD, He J and Bazan HE: p38 and ERK1/2 coordinate cellular migration and proliferation in epithelial wound healing: evidence of cross-talk activation between MAP kinase cascades. J Biol Chem 278: 21989-21997, 2003. (Pubitemid 36792607)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.24 , pp. 21989-21997
    • Sharma, G.-D.1    He, J.2    Bazan, H.E.P.3
  • 34
    • 0037323441 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells
    • DOI 10.1210/jc.2002-021062
    • Taniguchi F, Harada T, Sakamoto Y, Yamauchi N, Yoshida S, Iwabe T and Terakawa N: Activation of mitogen-activated protein kinase pathway by keratinocyte growth factor or fibroblast growth factor-10 promotes cell proliferation in human endometrial carcinoma cells. J Clin Endocrinol Metab 88: 773-780, 2003. (Pubitemid 36207821)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.2 , pp. 773-780
    • Taniguchi, F.1    Harada, T.2    Sakamoto, Y.3    Yamauchi, N.4    Yoshida, S.5    Iwabe, T.6    Terakawa, N.7
  • 35
    • 17144395975 scopus 로고    scopus 로고
    • The activation of Akt/PKB signaling pathway and cell survival
    • Song G, Ouyang G and Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9: 59-71, 2005.
    • (2005) J Cell Mol Med , vol.9 , pp. 59-71
    • Song, G.1    Ouyang, G.2    Bao, S.3
  • 36
    • 0028799420 scopus 로고
    • Molecular cloning and characterization of a new member of the RAC protein kinase family: Association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins
    • Konishi H, Kuroda S, Tanaka M, Matsuzaki H, Ono Y, Kameyama K, Haga T and Kikkawa U: Molecular cloning and characterization of a new member of the RAC protein kinase family: association of the pleckstrin homology domain of three types of RAC protein kinase with protein kinase C subspecies and beta gamma subunits of G proteins. Biochem Biophys Res Commun 216: 526-534, 1995.
    • (1995) Biochem Biophys Res Commun , vol.216 , pp. 526-534
    • Konishi, H.1    Kuroda, S.2    Tanaka, M.3    Matsuzaki, H.4    Ono, Y.5    Kameyama, K.6    Haga, T.7    Kikkawa, U.8
  • 37
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA and Williams LT: Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 16: 4117-4127, 1996. (Pubitemid 26251211)
    • (1996) Molecular and Cellular Biology , vol.16 , Issue.8 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.-A.5    Williams, L.T.6
  • 38
    • 0036550053 scopus 로고    scopus 로고
    • 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling
    • Storz P and Toker A. 3′-Phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling. Front Biosci 7: d886-902, 2002.
    • (2002) Front Biosci , vol.7
    • Storz, P.1    Toker, A.2
  • 39
    • 0033951059 scopus 로고    scopus 로고
    • Role of insulin-like growth factor-I in regulating estrogen receptor-α gene expression
    • DOI 10.1002/(SICI)1097-4644(20000315)76:4<605::AID-JCB9>3.0.CO;2-T
    • Stoica A, Saceda M, Fakhro A, Joyner M and Martin MB: Role of insulin-like growth factor-I in regulating estrogen receptor-alpha gene expression. J Cell Biochem 76: 605-614, 2000. (Pubitemid 30083143)
    • (2000) Journal of Cellular Biochemistry , vol.76 , Issue.4 , pp. 605-614
    • Stoica, A.1    Saceda, M.2    Fakhro, A.3    Joyner, M.4    Martin, M.B.5
  • 41
    • 33745605543 scopus 로고    scopus 로고
    • Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells
    • Chang HL, Sugimoto Y, Liu S, Ye W, Wang LS, Huang YW and Lin YC: Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. Anticancer Res 26: 1773-1784, 2006. (Pubitemid 43989431)
    • (2006) Anticancer Research , vol.26 , Issue.3 A , pp. 1773-1784
    • Chang, H.-L.1    Sugimoto, Y.2    Liu, S.3    Ye, W.4    Wang, L.-S.5    Huang, Y.-W.6    Lin, Y.C.7
  • 42
    • 0037237481 scopus 로고    scopus 로고
    • Breast cancer endocrine resistance: How growth factor signaling and estrogen receptor coregulators modulate response
    • Schiff R, Massarweh S, Shou J and Osborne CK: Breast cancer endocrine resistance: how growth factor signaling and estrogen receptor coregulators modulate response. Clin Cancer Res 9: 447S-454S, 2003. (Pubitemid 36105786)
    • (2003) Clinical Cancer Research , vol.9 , Issue.1
    • Schiff, R.1    Massarweh, S.2    Shou, J.3    Osborne, C.K.4
  • 44
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death
    • DOI 10.1016/0092-8674(93)90509-O
    • Oltvai ZN, Milliman CL and Korsmeyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74: 609-619, 1993. (Pubitemid 23259742)
    • (1993) Cell , vol.74 , Issue.4 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 45
    • 40249102092 scopus 로고    scopus 로고
    • Additive effects of a prolactin receptor antagonist, G129R, and herceptin on inhibition of HER2-overexpressing breast cancer cells
    • Scotti ML, Langenheim JF, Tomblyn S, Springs AE and Chen WY: Additive effects of a prolactin receptor antagonist, G129R, and herceptin on inhibition of HER2-overexpressing breast cancer cells. Breast Cancer Res Treat 111: 241-250, 2008.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 241-250
    • Scotti, M.L.1    Langenheim, J.F.2    Tomblyn, S.3    Springs, A.E.4    Chen, W.Y.5
  • 48
    • 39149108820 scopus 로고    scopus 로고
    • The functional implications of Akt activity and TGF-beta signaling in tamoxifen-resistant breast cancer
    • Yoo YA, Kim YH, Kim JS and Seo JH: The functional implications of Akt activity and TGF-beta signaling in tamoxifen-resistant breast cancer. Biochim Biophys Acta 1783: 438-447, 2008.
    • (2008) Biochim Biophys Acta , vol.1783 , pp. 438-447
    • Yoo, Y.A.1    Kim, Y.H.2    Kim, J.S.3    Seo, J.H.4
  • 49
    • 22544470606 scopus 로고    scopus 로고
    • HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: An unexpected effect on TRAIL-induced apoptosis
    • DOI 10.1016/j.febslet.2005.06.047, PII S001457930500788X
    • Dubska L, Andera L and Sheard MA: HER2 signaling down-regulation by trastuzumab and suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis. FEBS Lett 579: 4149-4158, 2005. (Pubitemid 41021805)
    • (2005) FEBS Letters , vol.579 , Issue.19 , pp. 4149-4158
    • Dubska, L.1    Andera, L.2    Sheard, M.A.3
  • 50
    • 22544470606 scopus 로고    scopus 로고
    • HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: An unexpected effect on TRAIL-induced apoptosis
    • DOI 10.1016/j.febslet.2005.06.047, PII S001457930500788X
    • Dubska L, Andera L and Sheard MA: HER2 signaling downregulation by trastuzumab and suppression of the PI3K/Akt pathway: an unexpected effect on TRAIL-induced apoptosis. FEBS Lett 579: 4149-4158, 2005. (Pubitemid 41021805)
    • (2005) FEBS Letters , vol.579 , Issue.19 , pp. 4149-4158
    • Dubska, L.1    Andera, L.2    Sheard, M.A.3
  • 51
    • 0036731976 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells
    • Kandasamy K and Srivastava RK: Role of the phosphatidylinositol 3′-kinase/PTEN/Akt kinase pathway in tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in non-small cell lung cancer cells. Cancer Res 62: 4929-4937, 2002. (Pubitemid 34984416)
    • (2002) Cancer Research , vol.62 , Issue.17 , pp. 4929-4937
    • Kandasamy, K.1    Srivastava, R.K.2
  • 52
    • 0036064773 scopus 로고    scopus 로고
    • Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis
    • Park SY and Seol DW: Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis. Biochem Biophys Res Commun 295: 515-518, 2002.
    • (2002) Biochem Biophys Res Commun , vol.295 , pp. 515-518
    • Park, S.Y.1    Seol, D.W.2


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