Synthesis and biological evaluation of novel (-)-cercosporamide derivatives as potent selective PPARγ modulators

European Journal of Medicinal Chemistry

Volumn 54, Issue , 2012, Pages 522-533

  Furukawa, Akihiro ^a   Arita, Tsuyoshi ^a   Fukuzaki, Takehiro ^a   Mori, Makoto ^a   Honda, Takeshi ^a   Satoh, Susumu ^a   Matsui, Yumi ^a   Wakabayashi, Kenji ^a   Hayashi, Shinko ^a   Nakamura, Kouichi ^a   Araki, Kazushi ^a   Kuroha, Masanori ^a   Tanaka, Jun ^a   Wakimoto, Satoko ^a   Suzuki, Osamu ^a   Ohsumi, Jun ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

( ) Cercosporamide; Diabetes; PPAR ; SPPARM; Type 2 diabetes

Indexed keywords

(9AS) 8 ACETYL 1,7 DIHYDROXY 3 METHOXY 9A METHYL N (NAPHTHALEN 1 YLMETHYL) 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL 1,7 DIHYDROXY 3 METHOXY 9A METHYL N [(2 ETHYLNAPHTHALEN 1 YL)METHYL] 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL 1,7 DIHYDROXY 3 METHOXY 9A METHYL N [(2 METHYLNAPHTHALEN 1 YL)METHYL] 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL 1,7 DIHYDROXY 3 METHOXY 9A METHYL N [(2 PROPYLNAPHTHALEN 1 YL)METHYL] 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(2 BUTYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(2 ETHYL 4 FLUORONAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(4 CHLORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(4 FLUORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(5 CHLORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(5 FLUORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(6 CHLORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(6 FLUORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(7 CHLORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; (9AS) 8 ACETYL N [(7 FLUORO 2 METHYLNAPHTHALEN 1 YL)METHYL] 1,7 DIHYDROXY 3 METHOXY 9A METHYL 9 OXO 9,9A DIHYDRODIBENZO[B,D]FURAN 4 CARBOXAMIDE; AMIDE; ANTIDIABETIC AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; POTASSIUM (9BS) 2 ACETYL 6 [[(2 ETHYL 4 FLUORONAPHTHALEN1 YL)METHYL]CARBAMOYL] 9 HYDROXY 7 METHOXY 9B METHYL 1 OXO 1,9B DIHYDRODIBENZO[B,D]FURAN 3 OLATE; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; CARDIOMEGALY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PLASMA VOLUME; RAT; SUBSTITUTION REACTION;

ANIMALS; BENZOFURANS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DIABETES MELLITUS, TYPE 2; FEMALE; GENES, REPORTER; HUMANS; HYPOGLYCEMIC AGENTS; MODELS, MOLECULAR; PPAR GAMMA; PROTEIN CONFORMATION; RATS;

EID: 84864397782     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.05.040     Document Type: Article

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