-
1
-
-
9244222261
-
Targeted cancer therapy
-
Sawyers, C. Targeted cancer therapy. Nature 2004, 432, 294-297.
-
(2004)
Nature
, vol.432
, pp. 294-297
-
-
Sawyers, C.1
-
2
-
-
11444269801
-
Novel anticancer targets and drug discovery in post genomic age
-
Li, Q.; Xu, W. Novel anticancer targets and drug discovery in post genomic age. Curr. Med. Chem. Anticancer Agents 2005, 5, 53-55.
-
(2005)
Curr. Med. Chem. Anticancer Agents
, vol.5
, pp. 53-55
-
-
Li, Q.1
Xu, W.2
-
3
-
-
27544446579
-
Promiscuous drugs compared to selective drugs (promiscuity can be a virtue)
-
Mencher, S.K.; Wang, L.G. Promiscuous drugs compared to selective drugs (promiscuity can be a virtue). BMC Clin. Pharmacol. 2005, 5, 3-7.
-
(2005)
BMC Clin. Pharmacol
, vol.5
, pp. 3-7
-
-
Mencher, S.K.1
Wang, L.G.2
-
4
-
-
33746232407
-
Multitargeted therapy: Can promiscuity be praised in an era of political correctness
-
Jimeno, A.; Hidalgo, M. Multitargeted therapy: Can promiscuity be praised in an era of political correctness? Crit. Rev. Oncol. Hematol. 2006, 59, 150-158.
-
(2006)
Crit. Rev. Oncol. Hematol
, vol.59
, pp. 150-158
-
-
Jimeno, A.1
Hidalgo, M.2
-
5
-
-
17744400080
-
Synthesis of 2-substituted piperazines via direct α-lithiation
-
Berkheij, M.; van der Sluis, L.; Sewing, C.J.; den Boer, D.; Terpstra, J.W.; Hiemstra, H.; Bakker, W.I.I.; van den Hoogenband, A.; van Haarseveen, J.H. Synthesis of 2-substituted piperazines via direct α-lithiation. Tetrahedron Lett. 2005, 46, 2369-2371.
-
(2005)
Tetrahedron Lett
, vol.46
, pp. 2369-2371
-
-
Berkheij, M.1
van der Sluis, L.2
Sewing, C.J.3
den Boer, D.4
Terpstra, J.W.5
Hiemstra, H.6
Bakker, W.I.I.7
van den Hoogenband, A.8
van Haarseveen, J.H.9
-
6
-
-
1842817632
-
Chloroalkyl piperazine and nitrogen mustard porphyrins: Synthesis and anticancer activity
-
Guo, C.C.; Tong, R.B.; Li, K.L. Chloroalkyl piperazine and nitrogen mustard porphyrins: Synthesis and anticancer activity. Bioorg. Med. Chem. 2004, 12, 2469-2475.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 2469-2475
-
-
Guo, C.C.1
Tong, R.B.2
Li, K.L.3
-
7
-
-
0031929859
-
Piperazine derivatives of butyric acid as differentiating agents in human leukemic cells
-
Gillet, R.; Jeannesson, P.; Sefraoui, H.; Arnould-GueArin, M.; Kirkiacharian, L.S.; Jardillier, J.C.; Pieri, F. Piperazine derivatives of butyric acid as differentiating agents in human leukemic cells. Cancer Chemother. Pharmaco. 1998, 41, 252-255.
-
(1998)
Cancer Chemother. Pharmaco
, vol.41
, pp. 252-255
-
-
Gillet, R.1
Jeannesson, P.2
Sefraoui, H.3
Arnould-Guearin, M.4
Kirkiacharian, L.S.5
Jardillier, J.C.6
Pieri, F.7
-
8
-
-
0033981477
-
Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents
-
Gabriel, F.E.; Gu, J.; Slater, L.M.; Hara, K.; Jacobs, J.W. Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents. Cancer Chemother. Pharmacol. 2000, 45, 183-191.
-
(2000)
Cancer Chemother. Pharmacol
, vol.45
, pp. 183-191
-
-
Gabriel, F.E.1
Gu, J.2
Slater, L.M.3
Hara, K.4
Jacobs, J.W.5
-
9
-
-
0033575465
-
Novel applications of ethyl glyoxalate with the Ugi MCR
-
Hulme, C.; Ma, L.; Romano, J.; Morisette, M. Novel applications of ethyl glyoxalate with the Ugi MCR. Tetrahedron Lett. 1999, 40, 5295-5299.
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 5295-5299
-
-
Hulme, C.1
Ma, L.2
Romano, J.3
Morisette, M.4
-
10
-
-
1842787547
-
Optically active antifungal azoles: Synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-1-yl]-ethyl]-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol
-
Upadhayaya, R.S.; Sinha, N.; Jain, S.; Kishore, N.; Chandra, R. Arora, S.K. Optically active antifungal azoles: Synthesis and antifungal activity of (2R,3S)-2-(2,4-difluorophenyl)-3-(5-[2-[4-aryl-piperazin-1-yl]-ethyl]-tetrazol-2-yl/1-yl)-1-[1,2,4]-triazol-1-yl-butan-2-ol. Bioorg. Med. Chem. 2004, 12, 2225-2238.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 2225-2238
-
-
Upadhayaya, R.S.1
Sinha, N.2
Jain, S.3
Kishore, N.4
Chandra, R.5
Arora, S.K.6
-
11
-
-
32044472790
-
Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives
-
Choudhary, P.; Kumar, R.; Verma, K. Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives. Bioorg. Med. Chem. 2006, 14, 1819-1826.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 1819-1826
-
-
Choudhary, P.1
Kumar, R.2
Verma, K.3
-
12
-
-
0027969994
-
The design of a potent and orally bioavailable HIV protease inhibitor
-
Dorsey, B.D.; Levin, R.B.; McDaniel, S.L.; Vacca, J.P.; Guare, J.P.; Darke, P.L.; Zugay, J.A.; Emini, E.A.; Schleif, W.A. The design of a potent and orally bioavailable HIV protease inhibitor. J. Med. Chem. 1994, 37, 3443-3451.
-
(1994)
J. Med. Chem
, vol.37
, pp. 3443-3451
-
-
Dorsey, B.D.1
Levin, R.B.2
McDaniel, S.L.3
Vacca, J.P.4
Guare, J.P.5
Darke, P.L.6
Zugay, J.A.7
Emini, E.A.8
Schleif, W.A.9
-
13
-
-
0028147531
-
Highly diasteroselective reaction of a chiral, non-racemic amide enolate with (S)-glycidyl tosylate. synthesis of the orally active HIV-1 protease inhibitor L-735,524
-
Askin, D.; Eng, K.K.; Rossen, K.; Purick, R.M.; Wells, K.M.; Volante, R.P.; Reider, P.J. Highly diasteroselective reaction of a chiral, non-racemic amide enolate with (S)-glycidyl tosylate. synthesis of the orally active HIV-1 protease inhibitor L-735,524. Tetrahedron Lett. 1994, 35, 673-676.
-
(1994)
Tetrahedron Lett
, vol.35
, pp. 673-676
-
-
Askin, D.1
Eng, K.K.2
Rossen, K.3
Purick, R.M.4
Wells, K.M.5
Volante, R.P.6
Reider, P.J.7
-
14
-
-
0029118635
-
Asymmetric Hydrogenation of tetrahydropyrazines: Synthesis of (S)-piperazine 2-tert-butylcarboxamide, an intermediate in the preparation of the HIV protease inhibitor indinavir
-
Rosen, K.; Weissman, S.A.; Sager, J.; Reamer, R.A.; Askin, D.; Volante, R.P.; Reider, P.J. Asymmetric Hydrogenation of tetrahydropyrazines: Synthesis of (S)-piperazine 2-tert-butylcarboxamide, an intermediate in the preparation of the HIV protease inhibitor indinavir. Tetrahedron Lett. 1995, 36, 6419-6422.
-
(1995)
Tetrahedron Lett
, vol.36
, pp. 6419-6422
-
-
Rosen, K.1
Weissman, S.A.2
Sager, J.3
Reamer, R.A.4
Askin, D.5
Volante, R.P.6
Reider, P.J.7
-
16
-
-
0033397898
-
MST-16, a novel bis-dioxopiperazine anticancer agent, ameliorates doxorubicin-induced acute toxicity while maintaining antitumor efficacy
-
Yoshida, M.; Maehara, Y.; Sugimachi, K. MST-16, a novel bis-dioxopiperazine anticancer agent, ameliorates doxorubicin-induced acute toxicity while maintaining antitumor efficacy. Clin. Cancer Res. 1999, 5, 4295-4300.
-
(1999)
Clin. Cancer Res
, vol.5
, pp. 4295-4300
-
-
Yoshida, M.1
Maehara, Y.2
Sugimachi, K.3
-
17
-
-
2942601916
-
Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: Selective dopamine D4 receptor agonists
-
Matulenko, M.A.; Hakeem, A.A.; Kolasa, T.; Nakane, M.; Terranova, M.A.; Uchic, M.E.; Miller, L.N.; Chang, R.; Donnelly-Roberts, D.L.; Namovic, M.T.; et al. Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: Selective dopamine D4 receptor agonists. Bioorg. Med. Chem. 2004, 12, 3471-3483.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 3471-3483
-
-
Matulenko, M.A.1
Hakeem, A.A.2
Kolasa, T.3
Nakane, M.4
Terranova, M.A.5
Uchic, M.E.6
Miller, L.N.7
Chang, R.8
Donnelly-Roberts, D.L.9
Namovic, M.T.10
-
18
-
-
0030961684
-
Substituted [(4-phenylpiperazinyl)-methyl]benzamides: Selective dopamine D4 agonists
-
Glase, S.A.; Akunne, H.C.; Georgic, L.M.; Haffner, T.G.; Mackenzie, R.G.; Manley, P.J.; Pugsley, T.A.; Wise, L.D. Substituted [(4-phenylpiperazinyl)-methyl]benzamides: Selective dopamine D4 agonists. J. Med. Chem. 1997, 40, 1771-1772.
-
(1997)
J. Med. Chem
, vol.40
, pp. 1771-1772
-
-
Glase, S.A.1
Akunne, H.C.2
Georgic, L.M.3
Haffner, T.G.4
Mackenzie, R.G.5
Manley, P.J.6
Pugsley, T.A.7
Wise, L.D.8
-
19
-
-
0034719396
-
A structure-affinity relationship study on derivatives of N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D4 receptor ligand
-
Perrone, R.; Berardi, F.; Colabufo, N.A.; Leopoldo, M.; Tortorella, V. A structure-affinity relationship study on derivatives of N-[2-[4-(4-chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a high-affinity and selective D4 receptor ligand. J. Med. Chem. 2000, 43, 270-277.
-
(2000)
J. Med. Chem
, vol.43
, pp. 270-277
-
-
Perrone, R.1
Berardi, F.2
Colabufo, N.A.3
Leopoldo, M.4
Tortorella, V.5
-
20
-
-
1942438497
-
Design, synthesis, and structure-activity relationship of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors
-
Chern, J.H.; Shia, K.S.; Hsu, T.A.; Tai, C.L.; Lee, C.C.; Lee, Y.C.; Chang, C.S.; Tseng, S.N.; Shih, S.R. Design, synthesis, and structure-activity relationship of pyrazolo[3,4-d]pyrimidines: A novel class of potent enterovirus inhibitors. Bioorg. Med. Chem. Lett. 2004, 14, 2519-2525.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 2519-2525
-
-
Chern, J.H.1
Shia, K.S.2
Hsu, T.A.3
Tai, C.L.4
Lee, C.C.5
Lee, Y.C.6
Chang, C.S.7
Tseng, S.N.8
Shih, S.R.9
-
21
-
-
12244283141
-
Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system
-
Kimura, M.; Masudaa, T.; Yamadaa, K.; Mitania, M.; Kubota, N.; Kawakatsua, N.; Kishii, K.; Inazub, M.; Kiuchic, Y.; Oguchid, K.; et al. Syntheses of novel diphenyl piperazine derivatives and their activities as inhibitors of dopamine uptake in the central nervous system. Bioorg. Med. Chem. 2003, 11, 1621-1630.
-
(2003)
Bioorg. Med. Chem
, vol.11
, pp. 1621-1630
-
-
Kimura, M.1
Masudaa, T.2
Yamadaa, K.3
Mitania, M.4
Kubota, N.5
Kawakatsua, N.6
Kishii, K.7
Inazub, M.8
Kiuchic, Y.9
Oguchid, K.10
-
22
-
-
0041589266
-
Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter
-
Kimura, M.; Masudaa, T.; Yamadaa, K.; Mitania, M.; Kubota, N.; Kawakatsua, N.; Kishii, K.; Inazu, M.; Kiuchi, Y.; Oguchi, K.; et al. Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter. Bioorg. Med. Chem. 2003, 11, 3953-3963.
-
(2003)
Bioorg. Med. Chem
, vol.11
, pp. 3953-3963
-
-
Kimura, M.1
Masudaa, T.2
Yamadaa, K.3
Mitania, M.4
Kubota, N.5
Kawakatsua, N.6
Kishii, K.7
Inazu, M.8
Kiuchi, Y.9
Oguchi, K.10
-
23
-
-
3142730590
-
Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter
-
Kimara, M.; Masuda, T.; Yamada, K. Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter. Bioorg. Med. Chem. Lett. 2004, 14, 4287-4290.
-
(2004)
Bioorg. Med. Chem. Lett
, vol.14
, pp. 4287-4290
-
-
Kimara, M.1
Masuda, T.2
Yamada, K.3
-
24
-
-
0035829429
-
Three-dimensional quantitative structure-Activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: Applying a "divide and conquer" strategy
-
Amin, E.A.; Welsh, W.J. Three-dimensional quantitative structure-Activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: Applying a "divide and conquer" strategy. J. Med. Chem. 2003, 44, 3849-3855.
-
(2003)
J. Med. Chem
, vol.44
, pp. 3849-3855
-
-
Amin, E.A.1
Welsh, W.J.2
-
25
-
-
0034488576
-
A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis
-
Braybrooke, J.P.; O'Byrne, K.J.; Propper, D.J.; Blann, A.; Saunders, M.; Dobbs, N.; Han, C.; Woodhull, J.; Mitchell, K.; Crew, J.; et al. A phase II study of razoxane, an antiangiogenic topoisomerase II inhibitor, in renal cell cancer with assessment of potential surrogate markers of angiogenesis. Clin. Cancer Res. 2000, 6, 4697-4704.
-
(2000)
Clin. Cancer Res
, vol.6
, pp. 4697-4704
-
-
Braybrooke, J.P.1
O'Byrne, K.J.2
Propper, D.J.3
Blann, A.4
Saunders, M.5
Dobbs, N.6
Han, C.7
Woodhull, J.8
Mitchell, K.9
Crew, J.10
-
26
-
-
0025289360
-
The interaction with DNA of unfused aromatic systems containing terminal piperazino substituents: Intercalation and groove-binding
-
Wilson, W.D.; Barton, H.J.; Tanious, F.A.; Kong, S.B.; Strekowski, L. The interaction with DNA of unfused aromatic systems containing terminal piperazino substituents: Intercalation and groove-binding. Biophys. Chem. 1990, 35, 227-243.
-
(1990)
Biophys. Chem
, vol.35
, pp. 227-243
-
-
Wilson, W.D.1
Barton, H.J.2
Tanious, F.A.3
Kong, S.B.4
Strekowski, L.5
-
27
-
-
79952123326
-
Novel piperazine induces apoptosis in U937 cells
-
Sampson, J.J.; Donkor, I.O.; Huang, T.L.; Adunyah, S.E. Novel piperazine induces apoptosis in U937 cells. Int. J. Biochem. Mol. Biol. 2011, 2, 78-88.
-
(2011)
Int. J. Biochem. Mol. Biol
, vol.2
, pp. 78-88
-
-
Sampson, J.J.1
Donkor, I.O.2
Huang, T.L.3
Adunyah, S.E.4
-
28
-
-
33747194780
-
Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine
-
Narendra Sharath Chandra, J.N.; Sadashiva, C.T.; Kavitha, C.V.; Rangappa, K.S. Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine. Bioorg. Med. Chem. 2006, 14, 6621-6627.
-
(2006)
Bioorg. Med. Chem
, vol.14
, pp. 6621-6627
-
-
Narendra, S.C.J.N.1
Sadashiva, C.T.2
Kavitha, C.V.3
Rangappa, K.S.4
-
29
-
-
40549101901
-
Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation
-
Ananda Kumar, C.S.; Nanjuda Swamy, S.; Thimmegawda, N.R.; Benaka Prasad, S.B.; Yip, G.W.; Rangappa, K.S. Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell proliferation. Med. Chem. Res. 2007, 16, 179-187.
-
(2007)
Med. Chem. Res
, vol.16
, pp. 179-187
-
-
Ananda, K.C.S.1
Nanjuda, S.S.2
Thimmegawda, N.R.3
Benaka Prasad, S.B.4
Yip, G.W.5
Rangappa, K.S.6
-
30
-
-
60549097869
-
Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines
-
Ananda Kumar, C.S.; Benaka Prasad, S.B.; Viyana, K.; Chandrappa, S.; Thimmegawda, R.; Sunil Kumar, Y.C.; Sanjay, S.; Rangappa, K.S. Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines. Eur. J. Med. Chem. 2009, 44, 1223-1229.
-
(2009)
Eur. J. Med. Chem
, vol.44
, pp. 1223-1229
-
-
Ananda, K.C.S.1
Benaka Prasad, S.B.2
Viyana, K.3
Chandrappa, S.4
Thimmegawda, R.5
Sunil Kumar, Y.C.6
Sanjay, S.7
Rangappa, K.S.8
-
31
-
-
0025341331
-
New colorimetric cytotoxicity assay for anticancer-drug screening
-
Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J.T.; Bokesch, H.; Kenney, S.; Boyd, M.R. New colorimetric cytotoxicity assay for anticancer-drug screening. J. Natl. Cancer. Inst. 1990, 4, 1107-1112.
-
(1990)
J. Natl. Cancer. Inst
, vol.4
, pp. 1107-1112
-
-
Skehan, P.1
Storeng, R.2
Scudiero, D.3
Monks, A.4
McMahon, J.5
Vistica, D.6
Warren, J.T.7
Bokesch, H.8
Kenney, S.9
Boyd, M.R.10
-
32
-
-
33845866361
-
Live cell quality control and utility of real-time cell electronic sensing for assay development
-
Kirstein, S.L.; Atienza, J.M.; Xi, B.; Zhu, J.; Yu, N.; Wang, X.; Xu, X.; Abassi, Y.A. Live cell quality control and utility of real-time cell electronic sensing for assay development. Assay Drug Dev. Technol. 2006, 4, 545-553.
-
(2006)
Assay Drug Dev. Technol
, vol.4
, pp. 545-553
-
-
Kirstein, S.L.1
Atienza, J.M.2
Xi, B.3
Zhu, J.4
Yu, N.5
Wang, X.6
Xu, X.7
Abassi, Y.A.8
-
33
-
-
84856032160
-
Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status
-
doi:10.1007/s10637-010-9486-3
-
Buontempo, F.; Ersahin, T.; Missiroli, S.; Senturk, S.; Etro, D.; Ozturk, M.; Capitani, S.; Cetin-Atalay, R.; Neri, M.L. Inhibition of Akt signaling in hepatoma cells induces apoptotic cell death independent of Akt activation status. Invest. New Drugs 2010, doi:10.1007/s10637-010-9486-3.
-
(2010)
Invest. New Drugs
-
-
Buontempo, F.1
Ersahin, T.2
Missiroli, S.3
Senturk, S.4
Etro, D.5
Ozturk, M.6
Capitani, S.7
Cetin-Atalay, R.8
Neri, M.L.9
|