Three-dimensional quantitative structure-activity relationship (3D-QSAR) models for a novel class of piperazine-based stromelysin-1 (MMP-3) inhibitors: Applying a "divide and conquer" strategy

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3849-3855

  Amin, E A ^a   Welsh, W J ^b  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX METALLOPROTEINASE INHIBITOR; PIPERAZINE DERIVATIVE; STROMELYSIN;

ARTICLE; BINDING SITE; CORRELATION FUNCTION; CRYSTAL STRUCTURE; DRUG CONFORMATION; IC 50; LIGAND BINDING; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

CRYSTALLOGRAPHY, X-RAY; MATRIX METALLOPROTEINASE 3; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPERAZINES; PROTEASE INHIBITORS; PROTEIN BINDING; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035829429     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010236t     Document Type: Article

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