Synthesis and in vitro antiproliferative activity of novel 1-benzhydrylpiperazine derivatives against human cancer cell lines

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1223-1229

  Kumar, C S Ananda ^a   Prasad, S B Benaka ^a   Vinaya, K ^a   Chandrappa, S ^a   Thimmegowda, N R ^a   Kumar, Y C Sunil ^a   Swarup, Sanjay ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

1 Benzhydrylpiperazine derivatives; Antiproliferative activity; Carcinoma cell lines; Cell proliferation; MTT assay; Sulfonyl chlorides

Indexed keywords

(4 BENZHYDRYLPIPERAZIN 1 YL)(CYCLOPROPYL)METHANONE; (4 BENZHYDRYLPIPERAZIN 1 YL)(MORPHOLINO)METHANONE; (4 BENZHYDRYLPIPERAZIN 1 YL)(PYRROLIDIN 1 YL)METHANONE; 1 (4 BENZHYDRYLPIPERAZINE 1 SULFONYLMETHYL) 7,7 DIMETHYLBICYCLO[2,2,1]HEPTAN 2 ONE; 1 BENZENESULFONYL 4 BENZHYDRYLPIPERAZINE; 1 BENZHYDRYL 4 (2,2,2 TRIFLOROETHYANESULFONYL)PIPERAZINE; 1 BENZHYDRYL 4 (4 CHLORO 2 FLUOROBENZENESULFONYL)PIPERAZINE; 4 BENZHYDRYL N (2 CHLOROPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (2 METHOXYPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (2,4 DICHLOROPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (3 CHLOROPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (3 METHOXYPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (4 CHLOROPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (4 FLUOROPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYL N (4 METHOXYPHENYL)PIPERAZINE 1 CARBOTHIOAMIDE; 4 BENZHYDRYLPIPERAZINE 1 YL(ISOXAZOL 5 YL)METHANONE; ANTINEOPLASTIC AGENT; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CELL STRAIN HEPG2; CELL STRAIN HT29; CELL STRAIN MCF 7; CELL SURVIVAL; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIZINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SPECTROPHOTOMETRY, INFRARED;

EID: 60549097869     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.09.025     Document Type: Article

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