Synthesis and in vitro antimicrobial studies of medicinally important novel N-alkyl and N-sulfonyl derivatives of 1-[bis(4-fluorophenyl)-methyl]piperazine

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 19, 2006, Pages 6621-6627

  Narendra Sharath Chandra, J N ^a   Sadashiva, C T ^a   Kavitha, C V ^a   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

Author keywords

1 Bis(4 fluorophenyl) methyl piperazine derivatives; Antibacterial; Minimum inhibitory concentration; Paper disc diffusion method

Indexed keywords

1 [BIS(4 FLUOROPHENYL)METHYL] 4 (2,6 DICHLOROBENZENESULFONYL)PIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 (4 CHLOROBENZENESULFONYL)PIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 (4 TERT BUTYLBENZENESULFONYL)PIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 BUTYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 ETHYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 HEPTYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 HEXYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 METHANESULFONYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 METHYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 PENTYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 PROPYLPIPERAZINE; 1 [BIS(4 FLUOROPHENYL)METHYL] 4 TOLUENE 4 SULFONYLPIPERAZINE; 1 BENZENESULFONYL 4 [BIS(4 FLUOROPHENYL)METHYL]PIPERAZINE; ANTIINFECTIVE AGENT; PIPERAZINE DERIVATIVE; STREPTOMYCIN; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL STRAIN; CONTROLLED STUDY; DILUTION; DRUG POTENCY; DRUG SYNTHESIS; ESCHERICHIA COLI; INFRARED SPECTROSCOPY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTEUS VULGARIS; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

ALKYLATION; ANTI-INFECTIVE AGENTS; BACTERIA; HETEROCYCLIC COMPOUNDS; INDICATOR DILUTION TECHNIQUES; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; NEPHELOMETRY AND TURBIDIMETRY; PIPERAZINES; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS CEREUS; BACILLUS SUBTILIS; ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA; PROTEUS VULGARIS; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 33747194780     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.05.064     Document Type: Article

References (15)

1. Appelbaum P.C., and Hunter P.A. Int. J. Antimicrob. Agents 16 (2000) 5
2. Ball P.J. Antimicrob. Chemother. 46 (2000) 17
3. Grasela T.H., Goodwin S.D., and Walawander M.K. Pharmacotherapy 10 (1990) 341
4. Fanos V., and Cataldi L. J. Chemother. 12 (2000) 463
5. Kimara M., Masuda T., and Yamada K. Bioorg. Med. Chem. 11 (2003) 3953-3963
6. Vacca J.P., Dorsey B.D., Schleif W.A., Levine R.B., McDaniel S.L., Darke P.L., Zugay J., Quintero J.C., Blahy O.M., Sardana B.B., Schlabach A.J., Graham P.I., Condra J.H., Gotlib L., Holloway M.K., Lin J., Chen I.W., Vastag K., Ostovic D., Anderson P.S., Emini E.A., and Hu J.R. J. Med. Chem. 37 (1994) 3443
7. Askin D., Eng K.K., Rossen K., Purick R.M., Wells K.M., Volante R.P., and Reider P.J. Tetrahedron Lett. 35 (1994) 673
8. Rossen K., Weissman S.A., Sagar J., Reamer A., Askin D.A., Volante R.P., and Reider P.J. Tetrahedron Lett. 36 (1995) 6419
9. Choudhary P., kumar R., and verma K. Bioorg. Med. Chem. 14 (2006) 1819-1826
10. Upadhayaya R.S., Sinha N., Jain S., Kishore N., Chandra R., and Arora S.K. Bioorg. Med. Chem. 12 (2004) 2225
11. Reese, R. E.; Belts, R. F.; Practical Approach to Infectious Disease. 1991, 94-964.
12. Elizabeth Ambrose Amin; William J. welsh. J. Med. Chem. 2001, 44, 3849-3855.
13. Ohtaka, kanazawa T., Ito K., and Tsukamoto G. Chem. Pharm. Bull. 35 (1987) 3270
14. Priya B.S., Basappa, Nanjunda swamy S., and Rangappa K.S. Bioorg. Med. Chem. 13 (2005) 2623-2628
15. Nanjunda swamy S., Basappa, Sarala G., Priya B.S., Gaonkar S.L., Prasad J.S., and Rangappa K.S. Bioorg. Med. Chem. Lett. 16 (2006) 999-1004