Novel piperazine induces apoptosis in U937 cells

International Journal of Biochemistry and Molecular Biology

Volumn 2, Issue 1, 2011, Pages 78-88

  Sampson III, Josiah J ^a   Donkor, Isaac O ^b   Huang, Tien L ^c   Adunyah, Samuel E ^a  

^a MEHARRY MEDICAL COLLEGE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^c XAVIER UNIVERSITY OF LOUISIANA   (United States)

Author keywords

Apoptosis; Cancer; Caspase; Membrane potential; Mitochondria; Piperazine

Indexed keywords

1,4 BIS [4 (1H BENZO[D]IMIDAZOL 2YL PHENYL)]PIPERAZINE; CASPASE; CYTOCHROME C; LIPOCORTIN 5; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL STRAIN U937; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DNA FRAGMENTATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN SECRETION;

EID: 79952123326     PISSN: None     EISSN: 21524114     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Hanahan, Douglas and Robert A. Weinberg, The Hallmarks of Cancer, Cell, 2000, Vol. 100, January 7, pp. 57-70.
2. Ferreira, Carlos G., Mirjam Epping, Frank A.E. Kruyt, and Giuseppe Giaccone, Apoptosis: Target of Cancer Therapy, Clinical Cancer Research, 2002, July, Vol. 8, 2024-2034.
3. Cushion, Melanie T., Peter D. Walzer, Margaret S. Collins, Sandra Rebholz, Jean-Jacques Vanden Eynde, Annie Mayence, Tien L. Huang, Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds, 2004, Antimicrobial Agents and Chemotherapy, Vol. 48, No. 11, Nov., pp. 4209-4216.
4. [Committee For Veterinary Medicinal Products Final Report, Piperazine Summary Report, 2001, www.emea.europa.eu/pdfs/vet/mrls/080701en.pdf.
5. Mayence, Annie, Jean Jacques Vanden Eynde, Louis LeCour, Jr., Larry A. Walker, Babu L. Tekwani, Tien L. Huang, Piperazine-linked bisbenzamidines: a novel class of antileishmanial agents, European Journal of Medicinal Chemistry, 2004, 39, pp. 547-553.
6. Guo, Can-Cheng, Rong-Biao Tong, and Ke-Lai Li, Choroalkyl piperazine and nitrogen mustard porphyrins: synthesis and anticancer activity, Bioorganic and Medicinal Chemistry, 2004, 12, 2469-2475.
7. Gillet, Reynald, Pierre Jeannesson, Houcine Sefraoui, Marie-Luce Arnould-Guerin, Serge Kirkiacharian, Jean-Claude Jardillier, Francois Pieri, Piperazine derivatives of butyric acid as differentiating agents in human leukemic cells, Cancer Chemotherapy and Pharmacology, 1998, 41: 252-255.
8. Zornig, Martin, Annie-Odile Hueber, Wiebke Baum, Gerard Evan, Apoptosis regulators and their role in tumorigenesis, Biochimica et Biophysica Acta, 2001, Vol. 1551, F1-F37.
9. Eilon, Gabriel F., Jirong Gu, Lewis M. Slater, Kaoru Hara and John W. Jacobs, Tumor apoptosis induced by epoxide-containing piperazines, a new class of anti-cancer agents, Cancer Chemotherapy and Pharmacology, 2000, 45: 183-191.
10. Yi, E.Y., E.J. Jeong, H.S. Song, M.S. Lee, D.W. Kang, J.H. Joo, H.S. Kwon, S.H. Lee, S.K. Park, S.G. Chung, E.H. Cho, Y.J. Kim, Anti-angiogenic and anti-tumor apoptotic activities of SJ-8002, a new piperazine derivative, International Journal of Oncology, 2004, 25: 365-372.
11. Zhivotovsky, Boris and Sten Orrenius, Defects in the apoptotic machinery of cancer cells: role in drug resistance, Seminars in Cancer Biology, 2003, Vol. 13, pp. 125-134.
12. Kenis, Heidi, Hugo van Genderen, Abdel Bennaghmouch, Hilde A. Rinia, Peter Frederik, Jagat Narula, Leo Hofstra and Chris P.M. Reutelingsperger, Cell Surface-expressed Phosphatidylserine and Annexin A5 Open a Novel Portal of Cell Entry, Journal of Biological Chemistry, 2004, Vol. 279, No. 50, December 10, pp. 52623-52629.
13. Gidon-Jeangirard, Carole, Bénédicte Hugel, Vincent Holl, Florence Toti, Jean-Louis Laplanche, Dominique Meyer, J.M. Freyssinet, Annexin V. Delays Apoptosis While Exerting an External Constraint Preventing the Release of CD41 and PrPc1 Membrane Particles in a Human T Lymphocyte Model, Journal of Immunology, 1999, Vol. 162, pp. 5712-5718.
14. Warby, Simon C., Crystal N. Doty, Rona K. Graham, Jeffrey B. Carroll, Yu-Zhou Yang, Roshni R. Singaraja, et al., Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus, Human Molecular Genetics, 2008, Vol. 17, No. 15 pp. 2390-2404.
15. Cao, Guodong, Wei Pei, Jing Lan, R. Anne Stetler, Yumin Luo, Tetsuya Nagayama, Steven H. Graham, et al., Caspase-Activated DNase/ DNA Fragmentation Factor 40 Mediates Apoptotic DNA Fragmentation in Transient Cerebral Ischemia and in Neuronal Cultures, The Journal of Neuroscience, 2001, July 1, Vol. 21, No. 13, pp. 4678-4690.
16. [Creagh, E.M. and S. J. Martin, Caspases: cellular demolition experts, Biochemical Society Transactions, 2001, Vol. 29, part 6, pp. 696-702.
17. [Salganik, Rudolf I., The Benefits and Hazards of Antioxidants: Controlling Apoptosis and Other Protective Mechanisms in Cancer Patients and the Human Population, Journal of the American College of Nutrition, 2001, Vol. 20 No. 5 464S-472S.
18. Cummings, Jeff, Tim H. Ward, Malcolm Ransom, Caroline Dive, Apoptosis pathway-targeted drugs - from the bench to the clinic, Biochimica et Biophysics Acta, 2004, Vol. 1705, pp.53-66.
19. Henry-Mowatt, Judith, Caroline Dive, Jean-Claude Martinou and Dominic James, Role of mitochondrial membrane permeabilization in apoptosis and cancer, Oncogene, 2004, Vol. 23, pp. 2850-2860.
20. Razavi, Habib M., Joel A. Hamilton, Qingping Feng, Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure, Pharmacology & Therapeutics, 2005, Vol. 106, pp. 147-162.
21. Li, C.J. and T.H. Elsasser, Butyrate-induced apoptosis and cell cycle arrest in bovine kidney epithelial cells: Involvement of caspase and proteasome pathways, Journal of Animal Science, 2005, Vol. 83, pp. 89-97.
22. Denning, M.F., Y Wang, S Tibudan, S Alkan, BJ Nickoloff and J-Z Qin, Caspase activation and disruption of mitochondrial membrane potential during UV radiation-induced apoptosis of human keratinocytes requires activation of protein kinase C, Cell Death and Differentiation, 2002, Vol. 9, pp. 40-52.
23. Brown, J. Martin and Laura D. Attardi, The role of apoptosis in cancer development and treatment response, Nature Reviews Cancer, 2005, Vol. 5, March, pp. 231-237.
24. Denicourt, Catherine and Steven F. Dowdy, Targeting Apoptotic Pathways in Cancer Cells, Science, 2004, Vol. 305, pp. 1411-1413.
25. Zhivotovsky, Boris and Sten Orrenius, Defects in the apoptotic machinery of cancer cells: role in drug resistance, Seminars in Cancer Biology, 2003, Vol. 13, pp. 125-134.
26. Haupt, Susan, Michael Berger, Zehavit Goldberg and Ygal Haupt, Apoptosis - the p53 network, Journal of Cell Science, 2003, Vol. 116, pp. 4077-4085.